---
title: "Brain Metastasis From Giant Cell Tumor of Bone: Case Report and Management Considerations"
id: "pubmed-42844792"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42844792"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42844792/"
doi: "10.12659/AJCR.953858"
published_at: "2026-10-08T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Brain Metastasis From Giant Cell Tumor of Bone: Case Report and Management Considerations
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42844792
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42844792/)
- **DOI:** [10.12659/AJCR.953858](https://doi.org/10.12659%2FAJCR.953858)
- **Published At:** 2026-10-08T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Giant cell tumors of bone (**GCTB**) are typically indolent but can be locally aggressive and, rarely, metastasize, most often to the lungs. - The source reports a 39-year-old patient with a left distal femur GCTB treated with preoperative **denosumab** and surgical resection with large prosthetic reconstruction. - Fifteen months after initial treatment the patient developed tremors and a partial seizure; workup identified a right parietal **brain metastasis**. - Histopathology of the intracranial lesion confirmed it as a metastatic site of the original **GCTB**, establishing central nervous system involvement. - Management of the brain lesion consisted of surgical excision followed by surveillance with serial brain **MRI**; no adjuvant radiotherapy was given. - According to the authors, this is the third reported case in the literature of **GCTB** metastasizing to the central nervous system; previously reported cases included an intramedullary thoracic lesion and bilateral parietal lesions. - The authors emphasize prolonged clinical and radiological follow-up and individualized multidisciplinary care for patients with **GCTB**, while noting current evidence does not support routine brain imaging or a standardized follow-up protocol. - At the time of report, the patient was in clinical and radiological remission following surgical management of the brain metastasis. - The report highlights the rarity and diagnostic challenge of secondary central nervous system involvement in **GCTB** and calls for case-by-case decision making rather than routine screening.
## Clinical Analysis & Structured Key Points
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Affiliations Expand ### Affiliations * 1 Department of Medical Oncology, Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy, France. * 2 Université de Lorraine, Nancy, France. * 3 Department of Neuro-Oncology, University Hospital (CHU) of Nancy, Nancy, France. * 4 Department of Orthopedic Surgery, University Hospital (CHU) of Nancy, Nancy, France. * PMID: **42844792** * DOI: [ 10.12659/AJCR.953858 ](https://doi.org/10.12659/ajcr.953858) Item in Clipboard Case Reports # Histologically Confirmed Brain Metastasis Arising From Giant Cell Tumor of Bone: an Uncommon Entity and a Challenging Condition Arthur Claessens et al. Am J Case Rep. 2026. Show details Display options Display options Format Abstract PubMed PMID Am J Case Rep Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Am+J+Case+Rep%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Am+J+Case+Rep%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42844792/) . 2026 Oct 8:27:e953858. doi: 10.12659/AJCR.953858. ### Authors [Arthur Claessens](https://pubmed.ncbi.nlm.nih.gov/?term=Claessens+A&cauthor_id=42844792)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42844792/#short-view-affiliation-1 "Department of Medical Oncology, Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy, France.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42844792/#short-view-affiliation-2 "Université de Lorraine, Nancy, France."), [Sophie Martin](https://pubmed.ncbi.nlm.nih.gov/?term=Martin+S&cauthor_id=42844792)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42844792/#short-view-affiliation-1 "Department of Medical Oncology, Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy, France."), [Victoire Thiebaut](https://pubmed.ncbi.nlm.nih.gov/?term=Thiebaut+V&cauthor_id=42844792)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42844792/#short-view-affiliation-1 "Department of Medical Oncology, Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy, France."), [Marie-Hélène Maillot Baron](https://pubmed.ncbi.nlm.nih.gov/?term=Maillot+Baron+MH&cauthor_id=42844792)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42844792/#short-view-affiliation-3 "Department of Neuro-Oncology, University Hospital \(CHU\) of Nancy, Nancy, France."), [François Sirveaux](https://pubmed.ncbi.nlm.nih.gov/?term=Sirveaux+F&cauthor_id=42844792)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42844792/#short-view-affiliation-2 "Université de Lorraine, Nancy, France.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42844792/#short-view-affiliation-4 "Department of Orthopedic Surgery, University Hospital \(CHU\) of Nancy, Nancy, France."), [Anne Kieffer](https://pubmed.ncbi.nlm.nih.gov/?term=Kieffer+A&cauthor_id=42844792)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42844792/#short-view-affiliation-1 "Department of Medical Oncology, Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy, France.") ### Affiliations * 1 Department of Medical Oncology, Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy, France. * 2 Université de Lorraine, Nancy, France. * 3 Department of Neuro-Oncology, University Hospital (CHU) of Nancy, Nancy, France. * 4 Department of Orthopedic Surgery, University Hospital (CHU) of Nancy, Nancy, France. * PMID: **42844792** * DOI: [ 10.12659/AJCR.953858 ](https://doi.org/10.12659/ajcr.953858) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID Linked Discoveries ## Abstract BACKGROUND Giant cell tumors of bone (GCTBs), while classified as indolent, are characterized by their locally aggressive nature and their ability to form metastases in rare cases, mainly in the lungs. To our knowledge, this case is the third reported case of GCTB central nervous system involvement in the literature. CASE REPORT We report the exceptional case of a 39-year-old patient with no significant medical history who presented with a GCTB of the left distal femur, treated with preoperative denosumab and surgical resection with massive prosthetic reconstruction. Fifteen months later, the onset of tremors and a partial seizure revealed a right parietal brain metastasis, histologically confirmed as a secondary site of GCTB. Management included surgical excision of the brain lesion, followed by close monitoring with brain MRI, without adjuvant radiotherapy. Before the present report, only 2 cases of GCTB metastasis involving the central nervous system have been reported, including an intramedullary thoracic lesion and bilateral parietal lesions. CONCLUSIONS This case is the third reported case of GCTB metastasis with central nervous system involvement, highlighting the importance of prolonged follow-up and an individualized multidisciplinary approach for these tumors, which usually metastasize to the lungs. Although these 3 case reports help to characterize this rare condition of secondary central nervous system involvement in GCTBs, they do not justify routine brain imaging or a set standard for follow-up strategies; instead, a multidisciplinary and individualized approach is recommended. The patient is currently in clinical and radiological remission. 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