---
title: "Burden and Trends of Malignant Neoplasms of Bone and Articular Cartilage in East Asia (1990–2023)"
id: "pubmed-42764219"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42764219"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42764219/"
doi: "10.3760/cma.j.cn112152-20251130-00594"
published_at: "2026-09-23T00:00:00.000Z"
evidence_level: "English Abstract"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Burden and Trends of Malignant Neoplasms of Bone and Articular Cartilage in East Asia (1990–2023)
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42764219
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42764219/)
- **DOI:** [10.3760/cma.j.cn112152-20251130-00594](https://doi.org/10.3760%2Fcma.j.cn112152-20251130-00594)
- **Published At:** 2026-09-23T00:00:00.000Z
- **Evidence Rating:** English Abstract
## Executive GIST (TL;DR)
- This study analyzed the disease burden of **malignant neoplasms of bone and articular cartilage (MNBAC)** in five East Asian countries (China, DPRK, Japan, Mongolia, South Korea) from 1990 to 2023 using Global Burden of Disease–derived metrics reported in the article. - Trends were quantified by the **average annual percentage change (AAPC)** for standardized prevalence, **disability-adjusted life years (DALYs)** rate, and mortality rate across the study period. - In 2023, disease burden varied markedly across countries: **China, DPRK, and Mongolia** carried heavier burdens compared with **Japan** and **South Korea**. - From 1990–2023, China and DPRK experienced upward trends in standardized prevalence, DALYs rate and mortality (China AAPC: 2.86%, 1.74%, 1.96%; DPRK AAPC: 1.15%, 0.84%, 1.26%). - Japan and Mongolia showed downward trends across the same three indicators (Japan AAPC: -0.36%, -1.40%, -1.37%; Mongolia AAPC: -0.58%, -0.77%, -0.82%), while South Korea remained relatively stable (AAPC = 0.12% for standardized prevalence). - Decomposition analysis attributed increases in prevalence and DALYs in China and DPRK primarily to **epidemiological changes**, whereas epidemiological factors negatively contributed to Mongolia's burden trends. - Sex-specific analysis showed a consistently higher overall burden in **males** than females across East Asia. - Age-specific patterns: prevalence and DALYs rate exhibited an **M-shaped** relationship with age, while mortality rate rose progressively with age. - Using an **ARIMA** model, the authors projected that the standardized burden measures for MNBAC in **China** will decline over the next decade (2024–2033). - Authors conclude that MNBAC burden differs by country, sex, and age, and recommend targeted prevention and treatment strategies tailored to burden distribution characteristics. - Conflict of interest: all authors declared no conflicts. Details such as specific numeric rates by age group or country-year tables were not reported in the abstract and would require the full text for granular data.
## Clinical Analysis & Structured Key Points
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Affiliations Expand ### Affiliations * 1 Institute of Clinical Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China. * 2 Department of Radiotherapy, Zhongshan Hospital, Fudan University, Shanghai 200032, China. * PMID: **42764219** * DOI: [ 10.3760/cma.j.cn112152-20251130-00594 ](https://doi.org/10.3760/cma.j.cn112152-20251130-00594) Item in Clipboard # [Analysis and prediction study on the burden of malignant neoplasms of bone and articular cartilage in East Asian countries from 1990 to 2023] [Article in Chinese] L Liu et al. Zhonghua Zhong Liu Za Zhi. 2026. Show details Display options Display options Format Abstract PubMed PMID Zhonghua Zhong Liu Za Zhi Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Zhonghua+Zhong+Liu+Za+Zhi%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Zhonghua+Zhong+Liu+Za+Zhi%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42764219/) . 2026 Sep 23;48(9):1139-1146. doi: 10.3760/cma.j.cn112152-20251130-00594. ### Authors [L Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+L&cauthor_id=42764219)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764219/#short-view-affiliation-1 "Institute of Clinical Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China."), [J Ma](https://pubmed.ncbi.nlm.nih.gov/?term=Ma+J&cauthor_id=42764219)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42764219/#short-view-affiliation-2 "Department of Radiotherapy, Zhongshan Hospital, Fudan University, Shanghai 200032, China.") ### Affiliations * 1 Institute of Clinical Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China. * 2 Department of Radiotherapy, Zhongshan Hospital, Fudan University, Shanghai 200032, China. * PMID: **42764219** * DOI: [ 10.3760/cma.j.cn112152-20251130-00594 ](https://doi.org/10.3760/cma.j.cn112152-20251130-00594) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract in [ English, ](https://pubmed.ncbi.nlm.nih.gov/42764219/#eng-abstract) [ Chinese ](https://pubmed.ncbi.nlm.nih.gov/42764219/#zho-abstract) **Objective:** To analyze the disease burden of malignant neoplasms of bone and articular cartilage (MNBAC) in the East Asian (China, Democratic People's Republic of Korea, Japan, Mongolia, and South Korea) from 1990 to 2023, so as to formulate and adjust prevention and treatment strategies for MNBAC. **Methods:** The average annual percentage change (AAPC) was used to comprehensively evaluate the changing trend of MNBAC disease burden from 1990 to 2023. Decomposition analysis was conducted on the corresponding burden of MNBAC in Ease Asian countries, along with subgroup analyses by age and gender. Based on the autoregressive integrated moving average (ARIMA) model, the future standardized rates of MNBAC in China were predicted. **Results:** In 2023, there were significant differences in the disease burden of MNBAC among East Asia countries, with China, Democratic People's Republic of Korea, and Mongolia bearing the heavier burden. From 1990 to 2023, the standardized prevalence, disability-adjusted life years (DALYs) rate, and mortality rate of MNBAC in China and Democratic People's Republic of Korea all showed upward trends (AAPC value of 2.86%, 1.74%, 1.96% for China; and 1.15%, 0.84%, 1.26% for Democratic People's Republic of Korea, respectively), whereas those in Japan and Mongolia showed downward trends (AAPC values of -0.36%, -1.40%, -1.37% for Japan; and -0.58%, -0.77%, -0.82% for Mongolia, respectively). The standardized prevalence, DALYs rate, and mortality rate in South Korea remained relatively stable (AAPC=0.12%). Decomposition analysis indicated that epidemiological changes were the main drivers of the increases in prevalence and DALYs burden in China and Democratic People's Republic of Korea, but were negative contributors to the prevalence, DALYs and mortality burden in Mongolia. Gender subgroup analysis showed that the overall burden of MNBAC in males was significantly higher than that in females in East Asia. Age subgroup analysis indicated that the prevalence and DALYs rate exhibited an M-shaped pattern with increasing age, while the mortality rate increased with age. Additionally, over the next the corresponding burden of MNBAC in China is projected to show a downward trend. **Conclusions:** The disease burden of MNBAC varies significantly cross countries, genders, and age groups. It is necessary to further develop more targeted prevention and treatment measures based on the distribution characteristics of the disease burden, so as to effectively reduce the burden of MNBAC. **目的：** 分析1990—2023年东亚地区（中国、朝鲜、日本、蒙古国和韩国）骨和关节软骨恶性肿瘤（MNBAC）的疾病负担，从而制定和调整MNBAC的防治策略。 **方法：** 使用平均年度变化百分比（AAPC）变化综合评价1990—2023年MNBAC疾病负担的变化趋势，对东亚地区MNBAC的相应负担进行分解分析以及亚组（年龄和性别）分析，并基于差分自回归移动平均模型预测中国MNBAC的未来标化疾病率。 **结果：** 2023年，东亚不同国家MNBAC的疾病负担存在差异，相应负担较重的国家是中国、朝鲜和蒙古国。1990—2023年，中国和朝鲜MNBAC的标化患病率、伤残调整寿命年（DALYs）和死亡率均呈上升趋势（中国AAPC分别为2.86%、1.74%、1.96%，朝鲜AAPC分别为1.15%、0.84%、1.26%），而日本和蒙古国MNBAC的标化患病率、DALYs率和死亡率均呈下降趋势（日本AAPC分别为-0.36%、-1.40%、-1.37%，蒙古国AAPC分别为-0.58%、-0.77%、-0.82%），韩国MNBAC的标化患病率保持相对稳定（AAPC=0.12%）。分解分析表明，流行病学改变是中国和朝鲜MNBAC患病率和DALYs负担上升的主要驱动因素，相反是蒙古国MNBAC患病率、DALYs和死亡率负担的负影响因素。性别亚组分析表明，东亚地区男性MNBAC的总体负担明显高于女性。年龄亚组分析表明，患病率和DALYs率随年龄的增大呈M型变化，而死亡率随年龄的增大而上升。此外，未来10年（2024—2033年）中国MNBAC的相应负担将呈下降趋势。 **结论：** MNBAC的疾病负担在不同国家、性别和年龄段中存在明显区别。需进一步结合疾病负担分布特点制定更具针对性的防治措施，从而有效降低MNBAC的疾病负担。. 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- [Performance of a Multi-Cancer Early Detection Test in the NHS‑Galleri Randomized Trial](https://medichelpline.com/clinical-feed/nature-3-performance-of-a-multi-cancer-early-detection-test-in-the-randomized-controlled.md)

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