---
title: "Cardiac metastasis in colorectal cancer: clinical features, cardiac involvement, and outcomes"
id: "pubmed-42700272"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42700272"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42700272/"
doi: "10.1007/s10585-026-10428-8"
published_at: "2026-09-05T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Cardiac metastasis in colorectal cancer: clinical features, cardiac involvement, and outcomes
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42700272
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42700272/)
- **DOI:** [10.1007/s10585-026-10428-8](https://doi.org/10.1007%2Fs10585-026-10428-8)
- **Published At:** 2026-09-05T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This systematic review collected 53 published case reports/series of **cardiac metastasis** from **colorectal cancer (CRC)** identified through a systematic search of PubMed, Scopus, and Web of Science up to October 2025, following PRISMA 2020 guidelines. - Mean patient age was 62.7 ± 11.75 years (median 66; IQR 55.5–71); 53.8% were male. - Primary tumor location distribution: left-sided colon 50.9%, rectum 26.4%, right-sided colon 15.1% (other locations or unspecified make up remaining cases). - Most cardiac lesions were **intracardiac** (78%) and solitary (92.2%). There was a strong predilection for right-sided cardiac chambers: **right ventricle** 45.8% and **right atrium** 35.4%. - Clinical presentation: **dyspnea** was the most frequent symptom (65.4%); 19.2% of patients were asymptomatic at detection. - In 60.8% of cases, extracardiac metastases preceded cardiac involvement, most commonly to the liver (46%) and lungs (32%). - Management approaches varied: curative-intent treatment was attempted in 52.8% of cases, while palliative care was reported in 28.3%. - Outcomes were poor overall, with an observed mortality rate of 64.2% in the pooled cases. - Authors conclude that CRC cardiac metastasis typically appears as a solitary, right-sided intracavitary lesion within systemic disease and carries a poor prognosis; they recommend early multimodality imaging, individualized multidisciplinary care, and creation of collaborative registries to guide evidence-based management. - Methods and analysis details: data extraction used a standardized template; descriptive statistics performed in Jamovi v2.7; no inferential analyses were performed because of the case-based dataset. - Limitations and further needs noted by the authors include rarity of cases, reliance on case reports/series, and lack of high-level evidence—hence need for registries and collaborative efforts.
## Clinical Analysis & Structured Key Points
Clipboard, Search History, and several other advanced features are temporarily unavailable. [ Skip to main page content ](https://pubmed.ncbi.nlm.nih.gov/42700272/#article-details) ![U.S. flag](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png) An official website of the United States government Here's how you know ![Dot gov](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg) **The .gov means it’s official.** Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. ![Https](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg) **The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [ ![NIH NLM Logo](https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg) ](https://www.ncbi.nlm.nih.gov/) [Log in](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42700272%2F) Show account info Close #### Account Logged in as: **username** * [Dashboard](https://www.ncbi.nlm.nih.gov/myncbi/) * [Publications](https://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/) * [Account settings](https://www.ncbi.nlm.nih.gov/account/settings/) * [Log out](https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/42700272/) [Access keys](https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys) [NCBI Homepage](https://www.ncbi.nlm.nih.gov) [MyNCBI Homepage](https://pubmed.ncbi.nlm.nih.gov/myncbi/) [Main Content](https://pubmed.ncbi.nlm.nih.gov/42700272/#maincontent) [Main Navigation](https://pubmed.ncbi.nlm.nih.gov/42700272/) [ ![pubmed logo](https://cdn.ncbi.nlm.nih.gov/pubmed/c24ab723-7c80-48cd-9c68-022ded852586/core/images/pubmed-logo-blue.svg) ](https://pubmed.ncbi.nlm.nih.gov/) [ ](https://pubmed.ncbi.nlm.nih.gov/42700272/ "Show search bar") Search: [](https://pubmed.ncbi.nlm.nih.gov/42700272/ "Clear search input")Search [Advanced](https://pubmed.ncbi.nlm.nih.gov/advanced/) [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/clipboard/) [ User Guide ](https://pubmed.ncbi.nlm.nih.gov/help/) Save Email Send to * [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/42700272/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42700272%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42700272%2F%23open-collections-panel) * [Citation manager](https://pubmed.ncbi.nlm.nih.gov/42700272/) Display options Display options Format Abstract PubMed PMID ## Save citation to file Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel ## Email citation Email address has not been verified. Go to [ My NCBI account settings ](https://account.ncbi.nlm.nih.gov/settings/) to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel ### Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42700272/) Add Cancel ### Add to My Bibliography * My Bibliography Unable to load your delegates due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42700272/) Add Cancel ## Your saved search Name of saved search: Search terms: [Test search terms](https://pubmed.ncbi.nlm.nih.gov/42700272/) Would you like email updates of new search results? Saved Search Alert Radio Buttons * Yes * No Email: ([change](https://www.ncbi.nlm.nih.gov/account/settings/)) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel ## Create a file for external citation management software Create file Cancel ## Your RSS Feed Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy ### Actions Cite Collections Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42700272/) Add Cancel Permalink Permalink Copy Display options Display options Format Abstract PubMed PMID ### Page navigation * [ Title & authors ](https://pubmed.ncbi.nlm.nih.gov/42700272/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42700272/#abstract) * [ Conflict of interest statement ](https://pubmed.ncbi.nlm.nih.gov/42700272/#conflict-of-interest) * [ References ](https://pubmed.ncbi.nlm.nih.gov/42700272/#references) * [ Publication types ](https://pubmed.ncbi.nlm.nih.gov/42700272/#publication-types) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42700272/#mesh-terms) Title & authors Abstract Conflict of interest statement References Publication types MeSH terms Review Clin Exp Metastasis Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Clin+Exp+Metastasis%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Clin+Exp+Metastasis%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700272/) . 2026 Sep 5;43(5):47. doi: 10.1007/s10585-026-10428-8. # Cardiac metastases from colorectal cancer: a comprehensive systematic review of clinical presentation, cardiac involvement, and outcomes [Hamza A Abdul-Hafez](https://pubmed.ncbi.nlm.nih.gov/?term=Abdul-Hafez+HA&cauthor_id=42700272)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#full-view-affiliation-1 "Department of Medicine, Faculty of Medicine and Health Sciences, An- Najah National University, Nablus, Palestine. Hamzaakrm12@gmail.com."), [Ameer Awashra](https://pubmed.ncbi.nlm.nih.gov/?term=Awashra+A&cauthor_id=42700272)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#full-view-affiliation-2 "Department of Medicine, Faculty of Medicine and Health Sciences, An- Najah National University, Nablus, Palestine."), [Mohamed S Elgendy](https://pubmed.ncbi.nlm.nih.gov/?term=Elgendy+MS&cauthor_id=42700272)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#full-view-affiliation-3 "Faculty of Medicine, Tanta University, Tanta, Egypt."), [Mohamed Saad Rakab](https://pubmed.ncbi.nlm.nih.gov/?term=Rakab+MS&cauthor_id=42700272)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#full-view-affiliation-4 "Faculty of Medicine, Mansoura University, Mansoura, Egypt."), [Abd Alkarim Ali](https://pubmed.ncbi.nlm.nih.gov/?term=Ali+AA&cauthor_id=42700272)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#full-view-affiliation-2 "Department of Medicine, Faculty of Medicine and Health Sciences, An- Najah National University, Nablus, Palestine."), [Bayan Mahafdah](https://pubmed.ncbi.nlm.nih.gov/?term=Mahafdah+B&cauthor_id=42700272)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#full-view-affiliation-5 "Faculty of Medicine, Yarmouk University, Irbid, Jordan."), [Anwar Zahran](https://pubmed.ncbi.nlm.nih.gov/?term=Zahran+A&cauthor_id=42700272)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#full-view-affiliation-2 "Department of Medicine, Faculty of Medicine and Health Sciences, An- Najah National University, Nablus, Palestine."), [Reem A Abualrob](https://pubmed.ncbi.nlm.nih.gov/?term=Abualrob+RA&cauthor_id=42700272)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#full-view-affiliation-2 "Department of Medicine, Faculty of Medicine and Health Sciences, An- Najah National University, Nablus, Palestine."), [Ahmed Emara](https://pubmed.ncbi.nlm.nih.gov/?term=Emara+A&cauthor_id=42700272)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#full-view-affiliation-6 "Faculty of Medicine, Al-Azhar University, Cairo, Egypt."), [Abdalhakim Shubietah](https://pubmed.ncbi.nlm.nih.gov/?term=Shubietah+A&cauthor_id=42700272)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#full-view-affiliation-7 "Department of Medicine, Advocate Illinois Medical Center, Chicago, IL, USA."), [Hasan Alkhatib](https://pubmed.ncbi.nlm.nih.gov/?term=Alkhatib+H&cauthor_id=42700272)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#full-view-affiliation-8 "Department of Cardiac Surgery, Al-Makassed Hospital, Jerusalem, Israel.") Affiliations Expand ### Affiliations * 1 Department of Medicine, Faculty of Medicine and Health Sciences, An- Najah National University, Nablus, Palestine. Hamzaakrm12@gmail.com. * 2 Department of Medicine, Faculty of Medicine and Health Sciences, An- Najah National University, Nablus, Palestine. * 3 Faculty of Medicine, Tanta University, Tanta, Egypt. * 4 Faculty of Medicine, Mansoura University, Mansoura, Egypt. * 5 Faculty of Medicine, Yarmouk University, Irbid, Jordan. * 6 Faculty of Medicine, Al-Azhar University, Cairo, Egypt. * 7 Department of Medicine, Advocate Illinois Medical Center, Chicago, IL, USA. * 8 Department of Cardiac Surgery, Al-Makassed Hospital, Jerusalem, Israel. * PMID: **42700272** * DOI: [ 10.1007/s10585-026-10428-8 ](https://doi.org/10.1007/s10585-026-10428-8) Item in Clipboard Review # Cardiac metastases from colorectal cancer: a comprehensive systematic review of clinical presentation, cardiac involvement, and outcomes Hamza A Abdul-Hafez et al. Clin Exp Metastasis. 2026. Show details Display options Display options Format Abstract PubMed PMID Clin Exp Metastasis Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Clin+Exp+Metastasis%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Clin+Exp+Metastasis%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700272/) . 2026 Sep 5;43(5):47. doi: 10.1007/s10585-026-10428-8. ### Authors [Hamza A Abdul-Hafez](https://pubmed.ncbi.nlm.nih.gov/?term=Abdul-Hafez+HA&cauthor_id=42700272)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#short-view-affiliation-1 "Department of Medicine, Faculty of Medicine and Health Sciences, An- Najah National University, Nablus, Palestine. Hamzaakrm12@gmail.com."), [Ameer Awashra](https://pubmed.ncbi.nlm.nih.gov/?term=Awashra+A&cauthor_id=42700272)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#short-view-affiliation-2 "Department of Medicine, Faculty of Medicine and Health Sciences, An- Najah National University, Nablus, Palestine."), [Mohamed S Elgendy](https://pubmed.ncbi.nlm.nih.gov/?term=Elgendy+MS&cauthor_id=42700272)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#short-view-affiliation-3 "Faculty of Medicine, Tanta University, Tanta, Egypt."), [Mohamed Saad Rakab](https://pubmed.ncbi.nlm.nih.gov/?term=Rakab+MS&cauthor_id=42700272)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#short-view-affiliation-4 "Faculty of Medicine, Mansoura University, Mansoura, Egypt."), [Abd Alkarim Ali](https://pubmed.ncbi.nlm.nih.gov/?term=Ali+AA&cauthor_id=42700272)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#short-view-affiliation-2 "Department of Medicine, Faculty of Medicine and Health Sciences, An- Najah National University, Nablus, Palestine."), [Bayan Mahafdah](https://pubmed.ncbi.nlm.nih.gov/?term=Mahafdah+B&cauthor_id=42700272)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#short-view-affiliation-5 "Faculty of Medicine, Yarmouk University, Irbid, Jordan."), [Anwar Zahran](https://pubmed.ncbi.nlm.nih.gov/?term=Zahran+A&cauthor_id=42700272)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#short-view-affiliation-2 "Department of Medicine, Faculty of Medicine and Health Sciences, An- Najah National University, Nablus, Palestine."), [Reem A Abualrob](https://pubmed.ncbi.nlm.nih.gov/?term=Abualrob+RA&cauthor_id=42700272)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#short-view-affiliation-2 "Department of Medicine, Faculty of Medicine and Health Sciences, An- Najah National University, Nablus, Palestine."), [Ahmed Emara](https://pubmed.ncbi.nlm.nih.gov/?term=Emara+A&cauthor_id=42700272)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#short-view-affiliation-6 "Faculty of Medicine, Al-Azhar University, Cairo, Egypt."), [Abdalhakim Shubietah](https://pubmed.ncbi.nlm.nih.gov/?term=Shubietah+A&cauthor_id=42700272)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#short-view-affiliation-7 "Department of Medicine, Advocate Illinois Medical Center, Chicago, IL, USA."), [Hasan Alkhatib](https://pubmed.ncbi.nlm.nih.gov/?term=Alkhatib+H&cauthor_id=42700272)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42700272/#short-view-affiliation-8 "Department of Cardiac Surgery, Al-Makassed Hospital, Jerusalem, Israel.") ### Affiliations * 1 Department of Medicine, Faculty of Medicine and Health Sciences, An- Najah National University, Nablus, Palestine. Hamzaakrm12@gmail.com. * 2 Department of Medicine, Faculty of Medicine and Health Sciences, An- Najah National University, Nablus, Palestine. * 3 Faculty of Medicine, Tanta University, Tanta, Egypt. * 4 Faculty of Medicine, Mansoura University, Mansoura, Egypt. * 5 Faculty of Medicine, Yarmouk University, Irbid, Jordan. * 6 Faculty of Medicine, Al-Azhar University, Cairo, Egypt. * 7 Department of Medicine, Advocate Illinois Medical Center, Chicago, IL, USA. * 8 Department of Cardiac Surgery, Al-Makassed Hospital, Jerusalem, Israel. * PMID: **42700272** * DOI: [ 10.1007/s10585-026-10428-8 ](https://doi.org/10.1007/s10585-026-10428-8) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract Cardiac metastasis from colorectal cancer (CRC) is exceedingly rare and remains poorly defined in the literature. As survival improves and metastatic patterns evolve, recognizing the clinical and anatomical characteristics of cardiac involvement is increasingly important. This systematic review synthesizes published cases of CRC with cardiac metastases identified through a systematic search to clarify presentation, metastatic pathways, management, and outcomes. Following PRISMA 2020 guidelines, we systematically searched PubMed, Scopus, and Web of Science from inception to October 2025 for case reports and case series describing CRC metastasis to the heart. Eligible reports were screened by two independent authors. Detailed clinical, pathological, imaging, management, and outcome data were extracted using a standardized template. Descriptive statistics were performed using Jamovi v2.7 without inferential analyses given the nature of the data. Fifty-three cases met inclusion. The mean age was 62.7 ± 11.75 years (median 66; IQR 55.5-71), with a slight male predominance (53.8%). Left-sided primaries were most common (50.9%), followed by rectal (26.4%) and right-sided tumors (15.1%). Most cardiac lesions were intracardiac (78%) and solitary (92.2%), with a marked predilection for the right ventricle (45.8%) and right atrium (35.4%). Dyspnea was the leading symptom (65.4%), while 19.2% were asymptomatic. Extra-cardiac metastases preceded cardiac involvement in 60.8%, mainly to the liver (46%) and lungs (32%). Curative-intent treatment was attempted in 52.8%; palliative care in 28.3%. Overall mortality was 64.2%. CRC cardiac metastasis typically manifests as a solitary right-sided intracavitary lesion in the context of systemic disease and carries a poor prognosis. Early multimodality imaging and individualized multidisciplinary management are essential. Collaborative registries are needed to establish evidence-based guidance. **Keywords:** Atrium; Cardiac metastasis; Colorectal cancer; Metastasis; Ventricles. © 2026. The Author(s), under exclusive licence to Springer Nature B.V. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declarations. Conflict of interest: The authors declare no competing interests. We affirm that this work is original, has not been published previously, and is not under consideration for publication elsewhere. None of the paper’s contents has been previously published. All authors have read and approved the manuscript. We also provide full disclosure of any relationships with industry. Ethical approval: Ethical approval is not required for this review article. Informed consent: Not applicable. Clinical trial number: Not applicable. ## References 1. 1. Qiu M, Hu J, Yang D, Cosgrove DP, Xu R (2015) Pattern of distant metastases in colorectal cancer: a SEER based study. Oncotarget 6(36):38658–38666. - [DOI](https://doi.org/10.18632/oncotarget.6130) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/26484417/) - [PMC](https://pmc.ncbi.nlm.nih.gov/articles/4770727/) 2. 1. Holch JW, Demmer M, Lamersdorf C, Michl M, Schulz C, von Einem JC et al (2017) Pattern and dynamics of distant metastases in metastatic colorectal cancer. Visc Med 33(1):70–75 - [DOI](https://doi.org/10.1159/000454687) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/28612020/) - [PMC](https://pmc.ncbi.nlm.nih.gov/articles/5465778/) 3. 1. Nouri A, Awashra A, Hamdan D, Rajab I, Shubietah A, Ismail Y, Rmilah AA (2025) Cardiovascular toxicity of Fruquintinib in patients with colorectal and other cancers: a systematic review and meta-analysis. Cardio-Oncol 11(1):82. - [DOI](https://doi.org/10.1186/s40959-025-00347-0) 4. 1. Lucà F, Parrini I, Canale ML, Rao CM, Nucara M, Pelaggi G et al (2025) Cardiac metastasis: epidemiology, pathophysiology, and clinical management. Life 15(2):291. - [DOI](https://doi.org/10.3390/life15020291) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/40003702/) - [PMC](https://pmc.ncbi.nlm.nih.gov/articles/11857090/) 5. 1. Lin Z, Xiao H, Liu J, Chen L, Zhang H, Huang Y et al (2023) Clinical features and prognosis of cardiac metastatic tumors. BMC Cancer 23(1):1235. - [DOI](https://doi.org/10.1186/s12885-023-11733-1) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/38102550/) - [PMC](https://pmc.ncbi.nlm.nih.gov/articles/10722672/) Show all 80 references ## Publication types * Systematic Review Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Systematic+Review%22%5Bpt%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Systematic+Review) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700272/) * Review Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Review%22%5Bpt%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Review) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700272/) ## MeSH terms * Aged Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Aged%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Aged) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700272/) * Colorectal Neoplasms* / mortality Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Colorectal+Neoplasms%2Fmortality%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Colorectal+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700272/) * C
## Related Clinical Research

- [CDCTNet: Transformer–CNN hybrid for colorectal lesion diagnosis](https://medichelpline.com/clinical-feed/plos-one-7-colorectal-lesion-diagnosis-using-transformer-and-deep-learning-with-multiscale.md)
- [Screening-threshold framework shows 45–49-year-olds as threshold-adjacent in global colorectal can](https://medichelpline.com/clinical-feed/pubmed-42700379.md) (DOI: 10.1080/07853890.2026.2728455)
- [Smartphone-based educational program reduces supportive care needs of family caregivers of colorec](https://medichelpline.com/clinical-feed/pubmed-42700222.md) (DOI: 10.1007/s00520-026-11149-0)
- [Traditional Chinese Medicine and the Immune Microenvironment in Colorectal Cancer: Mechanisms and](https://medichelpline.com/clinical-feed/frontiers-in-immunology-15-traditional-chinese-medicine-remodels-the-immune-microenvironment-of-colorectal.md)
- [Early pathology input in biologically driven cancer trials: why it matters](https://medichelpline.com/clinical-feed/british-journal-of-cancer-0-why-early-pathology-input-matters-in-biologically-rich-cancer-trials.md)

## Navigation
- [← Back to Oncology Feed](https://medichelpline.com/clinical-feed/oncology.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.