---
title: "Cipepofol induces ferroptosis and limits breast cancer cell growth"
id: "pubmed-42731367"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42731367"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42731367/"
doi: "10.1016/j.bbrc.2026.154570"
published_at: "2026-10-22T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Cipepofol induces ferroptosis and limits breast cancer cell growth
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42731367
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42731367/)
- **DOI:** [10.1016/j.bbrc.2026.154570](https://doi.org/10.1016%2Fj.bbrc.2026.154570)
- **Published At:** 2026-10-22T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Investigators evaluated **Cipepofol** in the MDA-MB-231 triple-negative breast cancer cell line using viability, colony formation, migration and invasion assays. - The compound reduced cell viability in a dose-dependent fashion and suppressed colony formation, transwell invasion, and wound closure compared with controls. - Flow cytometry showed S-phase cell-cycle arrest after treatment; the study team reported reduced proliferation markers in treated cultures. - Multiple ferroptosis-focused assays were applied: FerroOrange staining for Fe2+ accumulation, JC-1 staining for mitochondrial membrane effects, and Western blot for protein markers. - Data indicated accumulation of Fe2+ and lipid peroxides, a lowered **GSH/GSSG ratio**, and increased expression of ASCL4 and TFRC in treated cells. - A xenograft mouse model was used to test in vivo activity; animal data reportedly showed dose-dependent tumor growth inhibition and changes in serum/tumor biochemical markers. - In vivo findings included reduced serum GSH, higher MDA levels, decreased tumor Ki67 staining, and modulation of ferroptosis markers within tumor tissue. - The authors proposed perioperative anesthetic relevance but the source did not report clinical dosing, safety in humans, or long-term outcomes; translational and regulatory gaps remain. - The paper declared no competing interests and provided methods limited to cell-line assays, biochemical staining, Western blot, flow cytometry, and an unspecified xenograft protocol.
## Clinical Analysis & Structured Key Points
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Epub 2026 Sep 10. # Cipepofol inhibits the proliferation, migration and invasion of breast cancer cells by inducing ferroptosis [Yanping Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+Y&cauthor_id=42731367)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42731367/#full-view-affiliation-1 "Department of Anesthesiology, Yuyao Maternal and Child Health Care Hospital \(Yuyao Second People's Hospital\), Zhejiang, China."), [Qingyang Xu](https://pubmed.ncbi.nlm.nih.gov/?term=Xu+Q&cauthor_id=42731367)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42731367/#full-view-affiliation-1 "Department of Anesthesiology, Yuyao Maternal and Child Health Care Hospital \(Yuyao Second People's Hospital\), Zhejiang, China."), [Libo Zhao](https://pubmed.ncbi.nlm.nih.gov/?term=Zhao+L&cauthor_id=42731367)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42731367/#full-view-affiliation-1 "Department of Anesthesiology, Yuyao Maternal and Child Health Care Hospital \(Yuyao Second People's Hospital\), Zhejiang, China."), [Yan Tang](https://pubmed.ncbi.nlm.nih.gov/?term=Tang+Y&cauthor_id=42731367)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42731367/#full-view-affiliation-2 "Department of Thyroid and Breast Surgery, Yuyao Maternal and Child Health Care Hospital \(Yuyao Second People's Hospital\), Zhejiang, China."), [Hongjian Pan](https://pubmed.ncbi.nlm.nih.gov/?term=Pan+H&cauthor_id=42731367)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42731367/#full-view-affiliation-3 "Department of Anesthesiology, Yuyao Maternal and Child Health Care Hospital \(Yuyao Second People's Hospital\), Zhejiang, China. Electronic address: 13777154680@163.com.") Affiliations Expand ### Affiliations * 1 Department of Anesthesiology, Yuyao Maternal and Child Health Care Hospital (Yuyao Second People's Hospital), Zhejiang, China. * 2 Department of Thyroid and Breast Surgery, Yuyao Maternal and Child Health Care Hospital (Yuyao Second People's Hospital), Zhejiang, China. * 3 Department of Anesthesiology, Yuyao Maternal and Child Health Care Hospital (Yuyao Second People's Hospital), Zhejiang, China. Electronic address: 13777154680@163.com. * PMID: **42731367** * DOI: [ 10.1016/j.bbrc.2026.154570 ](https://doi.org/10.1016/j.bbrc.2026.154570) Item in Clipboard # Cipepofol inhibits the proliferation, migration and invasion of breast cancer cells by inducing ferroptosis Yanping Zhang et al. Biochem Biophys Res Commun. 2026. Show details Display options Display options Format Abstract PubMed PMID Biochem Biophys Res Commun Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biochem+Biophys+Res+Commun%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Biochem+Biophys+Res+Commun%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42731367/) . 2026 Oct 22:836:154570. doi: 10.1016/j.bbrc.2026.154570. Epub 2026 Sep 10. ### Authors [Yanping Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+Y&cauthor_id=42731367)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42731367/#short-view-affiliation-1 "Department of Anesthesiology, Yuyao Maternal and Child Health Care Hospital \(Yuyao Second People's Hospital\), Zhejiang, China."), [Qingyang Xu](https://pubmed.ncbi.nlm.nih.gov/?term=Xu+Q&cauthor_id=42731367)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42731367/#short-view-affiliation-1 "Department of Anesthesiology, Yuyao Maternal and Child Health Care Hospital \(Yuyao Second People's Hospital\), Zhejiang, China."), [Libo Zhao](https://pubmed.ncbi.nlm.nih.gov/?term=Zhao+L&cauthor_id=42731367)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42731367/#short-view-affiliation-1 "Department of Anesthesiology, Yuyao Maternal and Child Health Care Hospital \(Yuyao Second People's Hospital\), Zhejiang, China."), [Yan Tang](https://pubmed.ncbi.nlm.nih.gov/?term=Tang+Y&cauthor_id=42731367)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42731367/#short-view-affiliation-2 "Department of Thyroid and Breast Surgery, Yuyao Maternal and Child Health Care Hospital \(Yuyao Second People's Hospital\), Zhejiang, China."), [Hongjian Pan](https://pubmed.ncbi.nlm.nih.gov/?term=Pan+H&cauthor_id=42731367)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42731367/#short-view-affiliation-3 "Department of Anesthesiology, Yuyao Maternal and Child Health Care Hospital \(Yuyao Second People's Hospital\), Zhejiang, China. Electronic address: 13777154680@163.com.") ### Affiliations * 1 Department of Anesthesiology, Yuyao Maternal and Child Health Care Hospital (Yuyao Second People's Hospital), Zhejiang, China. * 2 Department of Thyroid and Breast Surgery, Yuyao Maternal and Child Health Care Hospital (Yuyao Second People's Hospital), Zhejiang, China. * 3 Department of Anesthesiology, Yuyao Maternal and Child Health Care Hospital (Yuyao Second People's Hospital), Zhejiang, China. Electronic address: 13777154680@163.com. * PMID: **42731367** * DOI: [ 10.1016/j.bbrc.2026.154570 ](https://doi.org/10.1016/j.bbrc.2026.154570) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID Linked Discoveries ## Abstract Breast cancer is one of the most common malignant tumors in women. Optimizing perioperative anesthesia management contributes to reducing the risk of breast cancer recurrence and improving patient prognosis. The effects of Cipepofol on the proliferation, invasion/migration ability, and cell cycle of MDA-MB-231 cells were determined by CCK-8 assay, colony formation assay, transwell assay, wound healing assay, and flow cytometry. Results showed that Cipepofol effectively inhibited the viability of MDA-MB-231 cells in a dose-dependent manner. Moreover, it suppressed cell proliferation, invasion, and migration abilities, while inducing S-phase arrest. Subsequently, the regulatory role of Cipepofol in ferroptosis was evaluated through FerroOrange staining, JC-1 staining, and Western blot. It was revealed that Cipepofol promoted the accumulation of Fe2+ and lipid peroxides by reducing the GSH/GSSG ratio and upregulating the expression of ASCL4 and TFRC. In addition, a xenograft mouse model was established, and the anti-breast cancer activity of Cipepofol in vivo was further assessed via immunohistochemistry. Animal experiments demonstrated that Cipepofol also dose-dependently inhibited tumor growth in vivo, reduced serum GSH levels and Ki67 expression, increased MDA levels, and modulated ferroptosis markers in tumors. In conclusion, cipepofol can inhibit the proliferation, invasion, and migration of breast cancer by inducing ferroptosis, and it may act as an anesthesia drug option during the perioperative period. **Keywords:** Anesthetic drugs; Breast cancer; Cipepofol; Ferroptosis; Lipid peroxides. Copyright © 2026 Elsevier Inc. All rights reserved. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ## Similar articles * [ Jianpi Huayu decoction exerts antitumor effects in pancreatic cancer via SCD1-mediated lipid metabolism remodeling/ferroptosis axis. ](https://pubmed.ncbi.nlm.nih.gov/41101075/) Chen X, Ren Y, Yao R, Liu S, Fang C, Luo R, Shi H, Zhu X, Lai Y, Zhao X, Zhong C.Chen X, et al.Phytomedicine. 2025 Nov 25;148:157389. doi: 10.1016/j.phymed.2025.157389. Epub 2025 Oct 8.Phytomedicine. 2025.PMID: 41101075 * [ TFRC promotes ferroptosis to suppress breast cancer bone metastasis via the activation of HIF-1 pathway. ](https://pubmed.ncbi.nlm.nih.gov/41987313/) Liu L, Gao Y, Yu D, Li D, Liu S, He C, Xiao C, Ye Y, Zhao K, Xu F, Hao Y.Liu L, et al.Breast Cancer Res. 2026 Apr 15;28(1):104. doi: 10.1186/s13058-026-02269-w.Breast Cancer Res. 2026.PMID: 41987313Free PMC article. * [ Taxifolin inhibits breast cancer cells proliferation, migration and invasion by promoting mesenchymal to epithelial transition via β-catenin signaling. ](https://pubmed.ncbi.nlm.nih.gov/31260685/) Li J, Hu L, Zhou T, Gong X, Jiang R, Li H, Kuang G, Wan J, Li H.Li J, et al.Life Sci. 2019 Sep 1;232:116617. doi: 10.1016/j.lfs.2019.116617. Epub 2019 Jun 29.Life Sci. 2019.PMID: 31260685 * [ FBR-NDs: a ferroptosis-inducing nanocomplex for targeted breast cancer therapy via immune modulation and redox-responsive drug delivery. ](https://pubmed.ncbi.nlm.nih.gov/41749332/) Chen J, Ma L, Yin M, Sun J, Sun Y.Chen J, et al.Breast Cancer Res. 2026 Feb 26;28(1):68. doi: 10.1186/s13058-026-02247-2.Breast Cancer Res. 2026.PMID: 41749332Free PMC article. * [ Cimicifuga dahurica extract inhibits the proliferation, migration and invasion of breast cancer cells MDA-MB-231 and MCF-7 in vitro and in vivo. ](https://pubmed.ncbi.nlm.nih.gov/33771643/) Jia H, Wang X, Liu W, Qin X, Hu B, Ma Q, Lv C, Lu J.Jia H, et al.J Ethnopharmacol. 2021 Sep 15;277:114057. doi: 10.1016/j.jep.2021.114057. 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