---
title: "Circulating Tumor DNA to Predict Response to Radiotherapy and Pembrolizumab in Localized Sarcomas"
id: "pubmed-42715505"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42715505"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42715505/"
doi: "10.1200/JCO-26-00769"
published_at: "2026-10-20T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Circulating Tumor DNA to Predict Response to Radiotherapy and Pembrolizumab in Localized Sarcomas
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42715505
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42715505/)
- **DOI:** [10.1200/JCO-26-00769](https://doi.org/10.1200%2FJCO-26-00769)
- **Published At:** 2026-10-20T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The publication reports an analysis titled "Personalized Circulating Tumor DNA Analysis for Predicting Outcomes and Tracking Response to Radiotherapy and Pembrolizumab in Localized Sarcomas," from the SU2C-SARC032 trial. - The article appears in J Clin Oncol (2026 Oct 20;44[30]:2941-2952) with DOI 10.1200/JCO-26-00769 and PubMed ID 42715505. - Authors include Ajay Subramanian and a multi-institutional team; affiliations span Stanford, Mayo Clinic, Duke, University of Toronto, and international radiation oncology centers. - The report name indicates use of **circulating tumor DNA** (ctDNA) assays to predict outcomes and monitor treatment response during radiotherapy combined with **pembrolizumab** in patients with **localized sarcomas**. - The source page lists the trial acronym **SU2C-SARC032**, implying a structured clinical trial framework, and categorizes the item as a Clinical Trial. - The PubMed entry provides bibliographic metadata (authors, affiliations, journal citation, DOI, PMID) but the abstract and trial-specific results, numeric endpoints, and detailed methods are not included on the displayed page. - The source did not report on sample size, ctDNA assay design, sensitivity thresholds, timepoints for sampling, radiotherapy dose/fractionation, pembrolizumab dosing schedule, statistical endpoints, or outcome data in the visible content. - Because the PubMed display lacks the abstract text on the captured page, investigators’ reported findings, hazard ratios, response rates, and safety data cannot be verified from this source alone. - The document is Epub Sep 9, 2026, and appears in the October 20, 2026 issue of J Clin Oncol; this confirms recent peer-reviewed publication but does not substitute for access to the full article for clinical interpretation. - Key next steps for readers: retrieve the full J Clin Oncol article (DOI provided) to review detailed methodology, ctDNA analytic validation, trial endpoints, statistical analysis plan, and the authors’ reported outcomes and limitations.
## Clinical Analysis & Structured Key Points
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Epub 2026 Sep 9. # Personalized Circulating Tumor DNA Analysis for Predicting Outcomes and Tracking Response to Radiotherapy and Pembrolizumab in Localized Sarcomas: Analysis of the SU2C-SARC032 Trial [Ajay Subramanian](https://pubmed.ncbi.nlm.nih.gov/?term=Subramanian+A&cauthor_id=42715505)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-1 "Department of Radiation Oncology, Stanford University, Stanford, CA."), [Serey C L Nouth](https://pubmed.ncbi.nlm.nih.gov/?term=Nouth+SCL&cauthor_id=42715505)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-1 "Department of Radiation Oncology, Stanford University, Stanford, CA."), [Neda Nemat-Gorgani](https://pubmed.ncbi.nlm.nih.gov/?term=Nemat-Gorgani+N&cauthor_id=42715505)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-1 "Department of Radiation Oncology, Stanford University, Stanford, CA."), [Shaghayegh Soudi](https://pubmed.ncbi.nlm.nih.gov/?term=Soudi+S&cauthor_id=42715505)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-1 "Department of Radiation Oncology, Stanford University, Stanford, CA."), [Karla V Ballman](https://pubmed.ncbi.nlm.nih.gov/?term=Ballman+KV&cauthor_id=42715505)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-2 "Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-3 "Biostatistics Core, Sarcoma Alliance for Research Through Collaboration, Ann Arbor, MI."), [Rachel S Heise](https://pubmed.ncbi.nlm.nih.gov/?term=Heise+RS&cauthor_id=42715505)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-4 "Department of Population Health Sciences, Weill Cornell Medicine, New York, NY."), [Claire Johns](https://pubmed.ncbi.nlm.nih.gov/?term=Johns+C&cauthor_id=42715505)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-5 "Division of Hematology, Oncology, Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA."), [Timothy J Sears](https://pubmed.ncbi.nlm.nih.gov/?term=Sears+TJ&cauthor_id=42715505)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-1 "Department of Radiation Oncology, Stanford University, Stanford, CA."), [Siyer Roohani](https://pubmed.ncbi.nlm.nih.gov/?term=Roohani+S&cauthor_id=42715505)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-6 "Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.")[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-7 "Department of Radiotherapy and Radiation Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany."), [Reinhardt Krcek](https://pubmed.ncbi.nlm.nih.gov/?term=Krcek+R&cauthor_id=42715505)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-6 "Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.")[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-8 "Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland."), [Angela M Hong](https://pubmed.ncbi.nlm.nih.gov/?term=Hong+AM&cauthor_id=42715505)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-9 "Department of Radiation Oncology, Chris O'Brien Lifehouse-Royal Prince Alfred Hospital, Sydney, NSW, Australia.")[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-10 "Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia."), [Kent J Weinhold](https://pubmed.ncbi.nlm.nih.gov/?term=Weinhold+KJ&cauthor_id=42715505)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-11 "Duke Cancer Institute, Duke University, Durham, NC.")[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-12 "Department of Surgery, Duke University, Durham, NC."), [Matt van de Rijn](https://pubmed.ncbi.nlm.nih.gov/?term=van+de+Rijn+M&cauthor_id=42715505)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-13 "Department of Pathology, Stanford University, Stanford, CA."), [Brian E Brigman](https://pubmed.ncbi.nlm.nih.gov/?term=Brigman+BE&cauthor_id=42715505)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-11 "Duke Cancer Institute, Duke University, Durham, NC.")[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-14 "Department of Orthopaedic Surgery, Duke University, Durham, NC."), [Richard F Riedel](https://pubmed.ncbi.nlm.nih.gov/?term=Riedel+RF&cauthor_id=42715505)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-11 "Duke Cancer Institute, Duke University, Durham, NC.")[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-15 "Division of Medical Oncology, Department of Medicine, Duke University, Durham, NC."), [Yvonne M Mowery](https://pubmed.ncbi.nlm.nih.gov/?term=Mowery+YM&cauthor_id=42715505)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-11 "Duke Cancer Institute, Duke University, Durham, NC.")[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-16 "Department of Radiation Oncology, UPMC Hillman Cancer Center-University of Pittsburgh, Pittsburgh, PA."), [David G Kirsch](https://pubmed.ncbi.nlm.nih.gov/?term=Kirsch+DG&cauthor_id=42715505)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-6 "Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.")[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-11 "Duke Cancer Institute, Duke University, Durham, NC.")[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-17 "Department of Radiation Oncology, Duke University, Durham, NC.")[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-18 "Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.")[ 19 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-19 "Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada."), [Everett J Moding](https://pubmed.ncbi.nlm.nih.gov/?term=Moding+EJ&cauthor_id=42715505)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-1 "Department of Radiation Oncology, Stanford University, Stanford, CA.")[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#full-view-affiliation-20 "Stanford Cancer Institute, Stanford University, Stanford, CA.") Affiliations Expand ### Affiliations * 1 Department of Radiation Oncology, Stanford University, Stanford, CA. * 2 Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN. * 3 Biostatistics Core, Sarcoma Alliance for Research Through Collaboration, Ann Arbor, MI. * 4 Department of Population Health Sciences, Weill Cornell Medicine, New York, NY. * 5 Division of Hematology, Oncology, Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA. * 6 Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. * 7 Department of Radiotherapy and Radiation Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. * 8 Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. * 9 Department of Radiation Oncology, Chris O'Brien Lifehouse-Royal Prince Alfred Hospital, Sydney, NSW, Australia. * 10 Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. * 11 Duke Cancer Institute, Duke University, Durham, NC. * 12 Department of Surgery, Duke University, Durham, NC. * 13 Department of Pathology, Stanford University, Stanford, CA. * 14 Department of Orthopaedic Surgery, Duke University, Durham, NC. * 15 Division of Medical Oncology, Department of Medicine, Duke University, Durham, NC. * 16 Department of Radiation Oncology, UPMC Hillman Cancer Center-University of Pittsburgh, Pittsburgh, PA. * 17 Department of Radiation Oncology, Duke University, Durham, NC. * 18 Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada. * 19 Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. * 20 Stanford Cancer Institute, Stanford University, Stanford, CA. * PMID: **42715505** * DOI: [ 10.1200/JCO-26-00769 ](https://doi.org/10.1200/jco-26-00769) Item in Clipboard Clinical Trial # Personalized Circulating Tumor DNA Analysis for Predicting Outcomes and Tracking Response to Radiotherapy and Pembrolizumab in Localized Sarcomas: Analysis of the SU2C-SARC032 Trial Ajay Subramanian et al. J Clin Oncol. 2026. Show details Display options Display options Format Abstract PubMed PMID J Clin Oncol Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22J+Clin+Oncol%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22J+Clin+Oncol%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42715505/) . 2026 Oct 20;44(30):2941-2952. doi: 10.1200/JCO-26-00769. Epub 2026 Sep 9. ### Authors [Ajay Subramanian](https://pubmed.ncbi.nlm.nih.gov/?term=Subramanian+A&cauthor_id=42715505)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#short-view-affiliation-1 "Department of Radiation Oncology, Stanford University, Stanford, CA."), [Serey C L Nouth](https://pubmed.ncbi.nlm.nih.gov/?term=Nouth+SCL&cauthor_id=42715505)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#short-view-affiliation-1 "Department of Radiation Oncology, Stanford University, Stanford, CA."), [Neda Nemat-Gorgani](https://pubmed.ncbi.nlm.nih.gov/?term=Nemat-Gorgani+N&cauthor_id=42715505)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#short-view-affiliation-1 "Department of Radiation Oncology, Stanford University, Stanford, CA."), [Shaghayegh Soudi](https://pubmed.ncbi.nlm.nih.gov/?term=Soudi+S&cauthor_id=42715505)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#short-view-affiliation-1 "Department of Radiation Oncology, Stanford University, Stanford, CA."), [Karla V Ballman](https://pubmed.ncbi.nlm.nih.gov/?term=Ballman+KV&cauthor_id=42715505)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#short-view-affiliation-2 "Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#short-view-affiliation-3 "Biostatistics Core, Sarcoma Alliance for Research Through Collaboration, Ann Arbor, MI."), [Rachel S Heise](https://pubmed.ncbi.nlm.nih.gov/?term=Heise+RS&cauthor_id=42715505)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#short-view-affiliation-4 "Department of Population Health Sciences, Weill Cornell Medicine, New York, NY."), [Claire Johns](https://pubmed.ncbi.nlm.nih.gov/?term=Johns+C&cauthor_id=42715505)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#short-view-affiliation-5 "Division of Hematology, Oncology, Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA."), [Timothy J Sears](https://pubmed.ncbi.nlm.nih.gov/?term=Sears+TJ&cauthor_id=42715505)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#short-view-affiliation-1 "Department of Radiation Oncology, Stanford University, Stanford, CA."), [Siyer Roohani](https://pubmed.ncbi.nlm.nih.gov/?term=Roohani+S&cauthor_id=42715505)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#short-view-affiliation-6 "Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.")[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#short-view-affiliation-7 "Department of Radiotherapy and Radiation Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany."), [Reinhardt Krcek](https://pubmed.ncbi.nlm.nih.gov/?term=Krcek+R&cauthor_id=42715505)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#short-view-affiliation-6 "Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.")[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#short-view-affiliation-8 "Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland."), [Angela M Hong](https://pubmed.ncbi.nlm.nih.gov/?term=Hong+AM&cauthor_id=42715505)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#short-view-affiliation-9 "Department of Radiation Oncology, Chris O'Brien Lifehouse-Royal Prince Alfred Hospital, Sydney, NSW, Australia.")[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#short-view-affiliation-10 "Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia."), [Kent J Weinhold](https://pubmed.ncbi.nlm.nih.gov/?term=Weinhold+KJ&cauthor_id=42715505)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#short-view-affiliation-11 "Duke Cancer Institute, Duke University, Durham, NC.")[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#short-view-affiliation-12 "Department of Surgery, Duke University, Durham, NC."), [Matt van de Rijn](https://pubmed.ncbi.nlm.nih.gov/?term=van+de+Rijn+M&cauthor_id=42715505)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42715505/#sho
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