---
title: "CNS Activity of Lazertinib in EGFR‑Mutated NSCLC: Pooled Analysis of KCSG-LU20-15 and LU21-01"
id: "pubmed-42670582"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42670582"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42670582/"
doi: "10.1111/1759-7714.70387"
published_at: "2026-09-01T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# CNS Activity of Lazertinib in EGFR‑Mutated NSCLC: Pooled Analysis of KCSG-LU20-15 and LU21-01
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42670582
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42670582/)
- **DOI:** [10.1111/1759-7714.70387](https://doi.org/10.1111%2F1759-7714.70387)
- **Published At:** 2026-09-01T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This PubMed entry reports a pooled analysis titled “Central Nervous System Activity of Lazertinib in EGFR‑Mutated NSCLC With Prior EGFR TKI Exposure,” combining the KCSG‑LU20‑15 and LU21‑01 studies. - The article is published in Thorac Cancer (2026 Sep;17[17]:e70387) with DOI 10.1111/1759-7714.70387 and PMID 42670582. - The analysis focuses on **lazertinib** and its **CNS activity** in patients with **EGFR‑mutated NSCLC** who had prior exposure to EGFR tyrosine kinase inhibitors. - Authors are led by Dong Hyun Kim and include a multi‑institutional Korean investigator group from major academic centers (Seoul National University Hospital, Yonsei Cancer Center, Samsung Medical Center, National Cancer Center, and others). - Affiliations and author list are fully reported; the title identifies the two contributing trials (KCSG‑LU20‑15 and LU21‑01). - The PubMed record includes bibliographic metadata (journal, date, DOI, PMID) but the abstract, methods, results, quantitative outcomes, and safety data are not included in the provided source text. - Because outcome data and trial details (design, sample size, inclusion/exclusion criteria, endpoints, CNS response rates, progression‑free survival, overall survival, adverse events) are not present in this source excerpt, those specifics cannot be summarized or interpreted here. - Readers should consult the full article via the DOI or journal site for complete methods, statistical analyses, efficacy measures for **CNS activity**, and safety findings. - This summary preserves the original article intent—reporting CNS activity of **lazertinib** in a previously EGFR TKI‑treated EGFR‑mutant NSCLC population—while noting that trial results were not available in the provided record.
## Clinical Analysis & Structured Key Points
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](https://pubmed.ncbi.nlm.nih.gov/42670582/#abstract) * [Similar articles](https://pubmed.ncbi.nlm.nih.gov/42670582/#similar) * [ References ](https://pubmed.ncbi.nlm.nih.gov/42670582/#references) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42670582/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42670582/#substances) * [ Grants and funding ](https://pubmed.ncbi.nlm.nih.gov/42670582/#grants) Title & authors Abstract Similar articles References MeSH terms Substances Grants and funding Thorac Cancer Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Thorac+Cancer%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Thorac+Cancer%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42670582/) . 2026 Sep;17(17):e70387. doi: 10.1111/1759-7714.70387. # Central Nervous System Activity of Lazertinib in EGFR-Mutated NSCLC With Prior EGFR TKI Exposure: A Pooled Analysis of KCSG-LU20-15 and LU21-01 [Dong Hyun Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+DH&cauthor_id=42670582)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-1 "Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-2 "Department of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea."), [Min Hee Hong](https://pubmed.ncbi.nlm.nih.gov/?term=Hong+MH&cauthor_id=42670582)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-3 "Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea."), [Hyun Ae Jung](https://pubmed.ncbi.nlm.nih.gov/?term=Jung+HA&cauthor_id=42670582)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-4 "Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea."), [Tae Min Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+TM&cauthor_id=42670582)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-1 "Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-5 "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea."), [Chang Gon Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+CG&cauthor_id=42670582)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-3 "Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea."), [Hee Kyung Ahn](https://pubmed.ncbi.nlm.nih.gov/?term=Ahn+HK&cauthor_id=42670582)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-6 "Division of Medical Oncology, Gachon University Gil Medical Center, Incheon, Republic of Korea."), [Youngjoo Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+Y&cauthor_id=42670582)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-7 "Center for Lung Cancer, National Cancer Center, Goyang, Gyeonggi, Republic of Korea."), [Yu Jung Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+YJ&cauthor_id=42670582)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-8 "Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea."), [Miso Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+M&cauthor_id=42670582)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-1 "Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-5 "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea."), [Jeonghwan Youk](https://pubmed.ncbi.nlm.nih.gov/?term=Youk+J&cauthor_id=42670582)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-1 "Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-5 "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea."), [Jong-Mu Sun](https://pubmed.ncbi.nlm.nih.gov/?term=Sun+JM&cauthor_id=42670582)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-4 "Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea."), [Se-Hoon Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+SH&cauthor_id=42670582)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-4 "Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea."), [Jin Seok Ahn](https://pubmed.ncbi.nlm.nih.gov/?term=Ahn+JS&cauthor_id=42670582)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-4 "Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea."), [Dong-Wan Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+DW&cauthor_id=42670582)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-1 "Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-5 "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea."), [Myung-Ju Ahn](https://pubmed.ncbi.nlm.nih.gov/?term=Ahn+MJ&cauthor_id=42670582)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-4 "Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea."), [Yoon Ji Choi](https://pubmed.ncbi.nlm.nih.gov/?term=Choi+YJ&cauthor_id=42670582)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-9 "Division of Medical Oncology and Hematology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea."), [Sun Min Lim](https://pubmed.ncbi.nlm.nih.gov/?term=Lim+SM&cauthor_id=42670582)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-3 "Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea."), [Jin Hyoung Kang](https://pubmed.ncbi.nlm.nih.gov/?term=Kang+JH&cauthor_id=42670582)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-10 "Division of Medical Oncology, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea."), [Bhumsuk Keam](https://pubmed.ncbi.nlm.nih.gov/?term=Keam+B&cauthor_id=42670582)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-1 "Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-5 "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea."), [Hye Ryun Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+HR&cauthor_id=42670582)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#full-view-affiliation-3 "Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.") Affiliations Expand ### Affiliations * 1 Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea. * 2 Department of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. * 3 Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. * 4 Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. * 5 Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. * 6 Division of Medical Oncology, Gachon University Gil Medical Center, Incheon, Republic of Korea. * 7 Center for Lung Cancer, National Cancer Center, Goyang, Gyeonggi, Republic of Korea. * 8 Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea. * 9 Division of Medical Oncology and Hematology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea. * 10 Division of Medical Oncology, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. * PMID: **42670582** * DOI: [ 10.1111/1759-7714.70387 ](https://doi.org/10.1111/1759-7714.70387) Item in Clipboard # Central Nervous System Activity of Lazertinib in EGFR-Mutated NSCLC With Prior EGFR TKI Exposure: A Pooled Analysis of KCSG-LU20-15 and LU21-01 Dong Hyun Kim et al. Thorac Cancer. 2026 Sep. Show details Display options Display options Format Abstract PubMed PMID Thorac Cancer Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Thorac+Cancer%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Thorac+Cancer%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42670582/) . 2026 Sep;17(17):e70387. doi: 10.1111/1759-7714.70387. ### Authors [Dong Hyun Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+DH&cauthor_id=42670582)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#short-view-affiliation-1 "Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#short-view-affiliation-2 "Department of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea."), [Min Hee Hong](https://pubmed.ncbi.nlm.nih.gov/?term=Hong+MH&cauthor_id=42670582)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#short-view-affiliation-3 "Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea."), [Hyun Ae Jung](https://pubmed.ncbi.nlm.nih.gov/?term=Jung+HA&cauthor_id=42670582)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#short-view-affiliation-4 "Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea."), [Tae Min Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+TM&cauthor_id=42670582)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#short-view-affiliation-1 "Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#short-view-affiliation-5 "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea."), [Chang Gon Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+CG&cauthor_id=42670582)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#short-view-affiliation-3 "Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea."), [Hee Kyung Ahn](https://pubmed.ncbi.nlm.nih.gov/?term=Ahn+HK&cauthor_id=42670582)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#short-view-affiliation-6 "Division of Medical Oncology, Gachon University Gil Medical Center, Incheon, Republic of Korea."), [Youngjoo Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+Y&cauthor_id=42670582)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#short-view-affiliation-7 "Center for Lung Cancer, National Cancer Center, Goyang, Gyeonggi, Republic of Korea."), [Yu Jung Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+YJ&cauthor_id=42670582)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#short-view-affiliation-8 "Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea."), [Miso Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+M&cauthor_id=42670582)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#short-view-affiliation-1 "Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#short-view-affiliation-5 "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea."), [Jeonghwan Youk](https://pubmed.ncbi.nlm.nih.gov/?term=Youk+J&cauthor_id=42670582)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#short-view-affiliation-1 "Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#short-view-affiliation-5 "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea."), [Jong-Mu Sun](https://pubmed.ncbi.nlm.nih.gov/?term=Sun+JM&cauthor_id=42670582)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#short-view-affiliation-4 "Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea."), [Se-Hoon Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+SH&cauthor_id=42670582)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#short-view-affiliation-4 "Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea."), [Jin Seok Ahn](https://pubmed.ncbi.nlm.nih.gov/?term=Ahn+JS&cauthor_id=42670582)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#short-view-affiliation-4 "Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea."), [Dong-Wan Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+DW&cauthor_id=42670582)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42670582/#short-view-affiliation-1 "Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/4267
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