---
title: "Cold atmospheric plasma causes selective oxidative toxicity in prostate cancer cells"
id: "pubmed-42259195"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42259195"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42259195/"
doi: "10.1016/j.bbrc.2026.154110"
published_at: "2026-08-27T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Cold atmospheric plasma causes selective oxidative toxicity in prostate cancer cells
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42259195
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42259195/)
- **DOI:** [10.1016/j.bbrc.2026.154110](https://doi.org/10.1016%2Fj.bbrc.2026.154110)
- **Published At:** 2026-08-27T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Study objective: assess whether a dielectric barrier discharge (DBD) **cold atmospheric plasma (CAP)** jet selectively induces cytotoxicity in human prostate cancer cells compared with non-tumoral prostate cells and to investigate associated redox changes. - Models used: human prostate cancer cell line **PC3** and non-tumoral prostate epithelial cell line **RWPE-1**. - CAP exposure: cells treated with a DBD-generated CAP jet for durations between 5 and 60 seconds; outcomes assessed at 4 and 24 hours post-treatment. - Viability assay: MTS assay showed a time-dependent reduction in viability of PC3 cells with significant effects at exposures ≥30 seconds; RWPE-1 cells were relatively resistant under the same conditions. - Membrane integrity and morphology: Propidium iodide (PI) staining indicated greater plasma membrane damage in PC3 than RWPE-1; phase-contrast microscopy revealed more pronounced rounding and detachment in PC3 cells. - Intracellular ROS: DHE staining demonstrated marked increases in intracellular reactive oxygen species in PC3 cells (up to 73% DHE-positive after 60 s CAP); RWPE-1 showed a less pronounced ROS response. - Antioxidant enzyme activities: PC3 cells displayed upregulation of **superoxide dismutase (SOD)** activity and decreased **catalase** and **glutathione peroxidase (GPx)** activities after CAP; RWPE-1 preserved antioxidant enzyme activities to a greater extent. - Interpretation: Differential sensitivity to DBD-CAP between cancerous and non-tumoral prostate cells is associated with altered cellular redox status and oxidative stress in PC3 cells. - Clinical implication: The authors propose that DBD-generated **CAP** could represent a targeted therapeutic approach for prostate cancer; details on in vivo efficacy, safety, and clinical translation were not reported in the source. - Limitations/notes: Specific experimental parameters beyond exposure time (e.g., exact CAP composition, power settings), quantitative enzyme activity values, and mechanistic signaling pathways were not provided in the abstract.
## Clinical Analysis & Structured Key Points
Clipboard, Search History, and several other advanced features are temporarily unavailable. [ Skip to main page content ](https://pubmed.ncbi.nlm.nih.gov/42259195/#article-details) ![U.S. flag](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png) An official website of the United States government Here's how you know ![Dot gov](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg) **The .gov means it’s official.** Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. ![Https](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg) **The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [ ![NIH NLM Logo](https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg) ](https://www.ncbi.nlm.nih.gov/) [Log in](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42259195%2F) Show account info Close #### Account Logged in as: **username** * [Dashboard](https://www.ncbi.nlm.nih.gov/myncbi/) * [Publications](https://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/) * [Account settings](https://www.ncbi.nlm.nih.gov/account/settings/) * [Log out](https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/42259195/) [Access keys](https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys) [NCBI Homepage](https://www.ncbi.nlm.nih.gov) [MyNCBI Homepage](https://pubmed.ncbi.nlm.nih.gov/myncbi/) [Main Content](https://pubmed.ncbi.nlm.nih.gov/42259195/#maincontent) [Main Navigation](https://pubmed.ncbi.nlm.nih.gov/42259195/) [ ![pubmed logo](https://cdn.ncbi.nlm.nih.gov/pubmed/af7de7da-df5d-41c6-8de4-8c266af8ccfb/core/images/pubmed-logo-blue.svg) ](https://pubmed.ncbi.nlm.nih.gov/) [ ](https://pubmed.ncbi.nlm.nih.gov/42259195/ "Show search bar") Search: [](https://pubmed.ncbi.nlm.nih.gov/42259195/ "Clear search input")Search [Advanced](https://pubmed.ncbi.nlm.nih.gov/advanced/) [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/clipboard/) [ User Guide ](https://pubmed.ncbi.nlm.nih.gov/help/) Save Email Send to * [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/42259195/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42259195%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42259195%2F%23open-collections-panel) * [Citation manager](https://pubmed.ncbi.nlm.nih.gov/42259195/) Display options Display options Format Abstract PubMed PMID ## Save citation to file Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel ## Email citation Email address has not been verified. Go to [ My NCBI account settings ](https://account.ncbi.nlm.nih.gov/settings/) to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel ### Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42259195/) Add Cancel ### Add to My Bibliography * My Bibliography Unable to load your delegates due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42259195/) Add Cancel ## Your saved search Name of saved search: Search terms: [Test search terms](https://pubmed.ncbi.nlm.nih.gov/42259195/) Would you like email updates of new search results? Saved Search Alert Radio Buttons * Yes * No Email: ([change](https://www.ncbi.nlm.nih.gov/account/settings/)) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel ## Create a file for external citation management software Create file Cancel ## Your RSS Feed Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy ### Full text links [![Elsevier Science full text link](https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--linkinghub.elsevier.com-ihub-images-elsevieroa.png) Elsevier Science ](https://linkinghub.elsevier.com/retrieve/pii/S0006-291X\(26\)00874-0 "See full text options at Elsevier Science") [ Full text links ](https://pubmed.ncbi.nlm.nih.gov/42259195/) ### Actions Cite Collections Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42259195/) Add Cancel Permalink Permalink Copy Display options Display options Format Abstract PubMed PMID ### Page navigation * [ Title & authors ](https://pubmed.ncbi.nlm.nih.gov/42259195/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42259195/#abstract) * [ Conflict of interest statement ](https://pubmed.ncbi.nlm.nih.gov/42259195/#conflict-of-interest) * [Similar articles](https://pubmed.ncbi.nlm.nih.gov/42259195/#similar) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42259195/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42259195/#substances) * [Related information](https://pubmed.ncbi.nlm.nih.gov/42259195/#related-links) * [ LinkOut - more resources ](https://pubmed.ncbi.nlm.nih.gov/42259195/#linkout) Title & authors Abstract Conflict of interest statement Similar articles MeSH terms Substances Related information LinkOut - more resources Biochem Biophys Res Commun Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biochem+Biophys+Res+Commun%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Biochem+Biophys+Res+Commun%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42259195/) . 2026 Aug 27:828:154110. doi: 10.1016/j.bbrc.2026.154110. Epub 2026 Jun 5. # Cold atmospheric plasma selectively induces toxicity of prostate cancer cells associated with oxidative stress [Imen Ghzaiel](https://pubmed.ncbi.nlm.nih.gov/?term=Ghzaiel+I&cauthor_id=42259195)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42259195/#full-view-affiliation-1 "Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, F-63000, France."), [Maxime Moreau](https://pubmed.ncbi.nlm.nih.gov/?term=Moreau+M&cauthor_id=42259195)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42259195/#full-view-affiliation-1 "Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, F-63000, France."), [Souwaidi Ali](https://pubmed.ncbi.nlm.nih.gov/?term=Ali+S&cauthor_id=42259195)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42259195/#full-view-affiliation-1 "Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, F-63000, France."), [Rohan Quoniou](https://pubmed.ncbi.nlm.nih.gov/?term=Quoniou+R&cauthor_id=42259195)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42259195/#full-view-affiliation-1 "Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, F-63000, France."), [Silvère Baron](https://pubmed.ncbi.nlm.nih.gov/?term=Baron+S&cauthor_id=42259195)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42259195/#full-view-affiliation-2 "Université Clermont Auvergne, CNRS, Inserm, GReD, Clermont-Ferrand, F-63000, France."), [Frédéric Perisse](https://pubmed.ncbi.nlm.nih.gov/?term=Perisse+F&cauthor_id=42259195)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42259195/#full-view-affiliation-1 "Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, F-63000, France."), [Jean-Marc Lobaccaro](https://pubmed.ncbi.nlm.nih.gov/?term=Lobaccaro+JM&cauthor_id=42259195)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42259195/#full-view-affiliation-2 "Université Clermont Auvergne, CNRS, Inserm, GReD, Clermont-Ferrand, F-63000, France."), [Sébastien Menecier](https://pubmed.ncbi.nlm.nih.gov/?term=Menecier+S&cauthor_id=42259195)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42259195/#full-view-affiliation-3 "Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, F-63000, France. Electronic address: sebastien.menecier@uca.fr.") Affiliations Expand ### Affiliations * 1 Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, F-63000, France. * 2 Université Clermont Auvergne, CNRS, Inserm, GReD, Clermont-Ferrand, F-63000, France. * 3 Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, F-63000, France. Electronic address: sebastien.menecier@uca.fr. * PMID: **42259195** * DOI: [ 10.1016/j.bbrc.2026.154110 ](https://doi.org/10.1016/j.bbrc.2026.154110) Free article Item in Clipboard # Cold atmospheric plasma selectively induces toxicity of prostate cancer cells associated with oxidative stress Imen Ghzaiel et al. Biochem Biophys Res Commun. 2026. Free article Show details Display options Display options Format Abstract PubMed PMID Biochem Biophys Res Commun Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biochem+Biophys+Res+Commun%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Biochem+Biophys+Res+Commun%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42259195/) . 2026 Aug 27:828:154110. doi: 10.1016/j.bbrc.2026.154110. Epub 2026 Jun 5. ### Authors [Imen Ghzaiel](https://pubmed.ncbi.nlm.nih.gov/?term=Ghzaiel+I&cauthor_id=42259195)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42259195/#short-view-affiliation-1 "Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, F-63000, France."), [Maxime Moreau](https://pubmed.ncbi.nlm.nih.gov/?term=Moreau+M&cauthor_id=42259195)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42259195/#short-view-affiliation-1 "Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, F-63000, France."), [Souwaidi Ali](https://pubmed.ncbi.nlm.nih.gov/?term=Ali+S&cauthor_id=42259195)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42259195/#short-view-affiliation-1 "Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, F-63000, France."), [Rohan Quoniou](https://pubmed.ncbi.nlm.nih.gov/?term=Quoniou+R&cauthor_id=42259195)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42259195/#short-view-affiliation-1 "Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, F-63000, France."), [Silvère Baron](https://pubmed.ncbi.nlm.nih.gov/?term=Baron+S&cauthor_id=42259195)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42259195/#short-view-affiliation-2 "Université Clermont Auvergne, CNRS, Inserm, GReD, Clermont-Ferrand, F-63000, France."), [Frédéric Perisse](https://pubmed.ncbi.nlm.nih.gov/?term=Perisse+F&cauthor_id=42259195)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42259195/#short-view-affiliation-1 "Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, F-63000, France."), [Jean-Marc Lobaccaro](https://pubmed.ncbi.nlm.nih.gov/?term=Lobaccaro+JM&cauthor_id=42259195)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42259195/#short-view-affiliation-2 "Université Clermont Auvergne, CNRS, Inserm, GReD, Clermont-Ferrand, F-63000, France."), [Sébastien Menecier](https://pubmed.ncbi.nlm.nih.gov/?term=Menecier+S&cauthor_id=42259195)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42259195/#short-view-affiliation-3 "Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, F-63000, France. Electronic address: sebastien.menecier@uca.fr.") ### Affiliations * 1 Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, F-63000, France. * 2 Université Clermont Auvergne, CNRS, Inserm, GReD, Clermont-Ferrand, F-63000, France. * 3 Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, F-63000, France. Electronic address: sebastien.menecier@uca.fr. * PMID: **42259195** * DOI: [ 10.1016/j.bbrc.2026.154110 ](https://doi.org/10.1016/j.bbrc.2026.154110) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract Cold atmospheric plasma (CAP) is an ionized gas generated at atmospheric pressure in which the temperature of heavy particles (ions, molecules, atoms) remains close to room temperature. CAP produces a complex mixture of reactive oxygen and nitrogen species (RONS). Recent studies have demonstrated its ability to induce cell death in various cancer cell lines, both in vitro and in vivo. Interestingly, non-tumoral cells appear to be relatively less affected by CAP treatments, this phenomenon is referred to as CAP selectivity. This study aimed to investigate the differential selectivity of a CAP jet generated by dielectric barrier discharge (DBD) in human prostate cells, comparing prostate cancer PC3 cells with non-tumoral RWPE-1 cells. Cells were exposed to a CAP treatment for 5-60 s and cell viability (MTS assay), plasma membrane integrity (Propidium iodide, PI staining), morphology (phase-contrast microscopy), intracellular ROS production (DHE staining), and antioxidant enzyme activities (SOD (superoxide dismutase), catalase, GPx (glutathione peroxidase)) were assessed 4 h and 24 h post-treatment. CAP exposure induced a time-dependent decrease in PC3 cell viability, with significant effect on viability observed at exposures ≥30 s, whereas RWPE-1 cells showed relative resistance. PI staining confirmed greater plasma membrane damage in PC3 compared to RWPE-1 cells. Morphological alterations such as cell rounding and detachment were more pronounced in PC3 cells than RWPE-1. CAP markedly increased intracellular ROS levels in PC3 cells (up to 73% DHE-positive after 60 s), accompanied by SOD upregulation and reduced catalase and GPx activities. In contrast, RWPE-1 cells exhibited a less pronounced oxidative response and preserved antioxidant enzyme activities. In summary, these results demonstrate differential sensitivity to CAP treatment between prostate cancer cells and non-tumoral cells under the tested conditions, associated with alterations in cellular redox status. These findings suggest that DBD-generated CAP may represent a promising targeted therapeutic approach for prostate cancer treatment. **Keywords:** Antioxidant enzymes; Cell viability; Cold atmospheric plasma; Dielectric barrier discharge; Oxidative stress; Prostate cancer; Reactive oxygen and nitrogen species; Selective cytotoxicity. Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ## Similar articles * [ Cold Atmospheric Pressure Plasma-Activated Medium Induces Selective Cell Death in Human Hepatocellular Carcinoma Cells Independently of Singlet Oxygen, Hydrogen Peroxide, Nitric Oxide and Nitrite/Nitrate. ](https://pubmed.ncbi.nlm.nih.gov/34074016/) Li Y, Tang T, Lee H, Song K.Li Y, et al.Int J Mol Sci. 2021 May 24;22(11):5548. doi: 10.3390/ijms22115548.Int J Mol Sci. 2021.PMID: 34074016Free PMC article. * [ Riboceine and N-acetylcysteine protect normal prostate cells from chemotherapy-induced oxidative stress while selectively modulating the cytotoxicity of methotrexate and docetaxel in prostate (PC-3) and breast cancer (MCF-7) cells. ](https://pubmed.ncbi.nlm.nih.gov/40690881/) Philips TJ, N'guessan BB, Dotse E, Abankwah JK, Appiah-Opong R.Philips TJ, et al.Biomed Pharmacother. 2025 Sep;190:118355. doi: 10.1016/j.biopha.2025.118355. Epub 2025 Jul 20.Biomed Pharmacother. 2025.PMID: 40690881 * [ Pre-clinical Safety Study of Cold Atmospheric Plasma (CAP) Produced by an Inbuilt CAP Device and ROS Mediated Apoptotic Activity in Human Skin Melanoma Cells. ](https://pubmed.ncbi.nlm.nih.gov/40070328/) Chakraborty R, Gohain RB, Talukdar P, Changkakoti L, Biswas S, Mukherjee AK, Bala A.Chakraborty R, et al.Curr Pharm Des. 2026;32(4):306-319. doi: 10.2174/0113816128335012250122221541.Curr Pharm Des. 2026.PMID: 40070328 * [ Is Cold Atmospheric Plasma Selective for Breast Tumor Cells? A Systematic Review. ](https://pubmed.ncbi.nlm.nih.gov/41751852/) Pinheiro I, Almeida-Ferreira C, Marto CM, Rodrigues F, Caramelo F, Botelho MF, Laranjo M.Pinheiro I, et al.Int J Mol Sci. 2026 Feb 10;27(4):1710. doi: 10.3390/ijms27041710.Int J Mol Sci. 2026.PMID: 41751852Free PMC article. * [ 3D Cancer Cell Model: A New Tool to More Accurately Evaluate the Biological Effect of Cold Plasma. ](https://pubmed.ncbi.nlm.nih.gov/42203347/) Quoniou R, Menecier S.Quoniou R, et al.Anticancer Res. 2026 Jun;46(6):2965-2975. doi: 10.21873/anticanres.18173.Anticancer Res. 2026.PMID: 42203347Review. [ See all similar articles ](https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed&from_uid=42259195) ## MeSH terms * Catalase / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Catalase%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Catalase) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42259195/) * Cell Line, Tumor Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell+Line%2C+Tumor%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Line%2C+Tumor) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42259195/) * Cell Membrane / drug effects Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell+Membrane%2Fdrug+effects%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Membrane) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42259195/) * Cell Membrane / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell+Membrane%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Membrane) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42259195/) * Cell Survival / drug effects Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell+Survival%2Fdrug+effects%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Survival) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42259195/) * Glutathione Peroxidase / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Glutathione+Peroxidase%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Glutathione+Peroxidase) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42259195/) * Humans Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term
## Related Clinical Research

- [Predicting Cancer Immunotherapy Response Using Dynamic CD8+ T Cell Changes — Pan‑Cancer Retrospect](https://medichelpline.com/clinical-feed/frontiers-in-immunology-13-a-predictive-model-for-immunotherapy-efficacy-in-cancer-based-on-dynamic.md)
- [Fluorinated Nanohybrid Micelles with Lutetium-177 and Gold for Potentiated Internal Radiotherapy](https://medichelpline.com/clinical-feed/pubmed-42476272.md) (DOI: 10.1016/j.ijpharm.2026.127219)
- [Induced proximity therapies: PROTACs, molecular glues and RIPTACs in oncology](https://medichelpline.com/clinical-feed/nature-3-induced-proximity-comes-of-age.md)
- [Three-Dimensional Malignant Transition: Spatial Profiling Links Precancer to Invasion in Breast an](https://medichelpline.com/clinical-feed/pubmed-42676100.md) (DOI: 10.1158/2159-8290.CD-26-1266)
- [Moderna and Merck's mRNA Cancer Vaccine: Inside the Melanoma Trial Breakthrough](https://medichelpline.com/clinical-feed/stat-news-0-stat-inside-moderna-and-merck-s-cancer-vaccine-triumph.md)

## Navigation
- [← Back to Oncology Feed](https://medichelpline.com/clinical-feed/oncology.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.