---
title: "Colonoscopy Intervals and Colorectal Cancer Risk After Adenoma Removal — RCT Report"
id: "pubmed-42748427"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42748427"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42748427/"
doi: "10.1056/NEJMoa2603816"
published_at: "2026-09-17T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Colonoscopy Intervals and Colorectal Cancer Risk After Adenoma Removal — RCT Report
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42748427
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42748427/)
- **DOI:** [10.1056/NEJMoa2603816](https://doi.org/10.1056%2FNEJMoa2603816)
- **Published At:** 2026-09-17T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The article titled "Colonoscopy Intervals and Colorectal Cancer Incidence after Adenoma Removal" was published in the New England Journal of Medicine (NEJM), 2026;395(11):1051-1061 with DOI 10.1056/NEJMoa2603816. - The publication is classified on PubMed as a **Randomized Controlled Trial**. - The multi-author paper lists numerous international contributors from centers in Spain, Norway, Denmark, Poland, the Netherlands, Austria, Portugal, and the United Kingdom. - Lead and corresponding authors include Rodrigo Jover and collaborators affiliated with Spanish institutions and a broad collaborative group including clinical effectiveness and gastroenterology research units. - The subject focus is on **colonoscopy intervals**, **adenoma removal**, and **colorectal cancer incidence**. - The PubMed record provides full author list, affiliations, journal citation, and DOI, but the SOURCE JINA BODY does not include the study abstract text, results, numerical outcomes, or specific conclusions. - Because outcome data, methods details (randomization scheme, sample size, follow-up duration, endpoints), and statistical findings are not present in the provided source text, those specifics cannot be reported here. - The PubMed entry links to associated data and related information sections on the NCBI site; however, those sections were not accessible in the captured source content. - Readers seeking study methods, primary and secondary outcomes, and authors’ conclusions should consult the full NEJM article or the PubMed abstract page, since the required details were not reported in the provided source excerpt.
## Clinical Analysis & Structured Key Points
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](https://pubmed.ncbi.nlm.nih.gov/42748427/#abstract) * [ Publication types ](https://pubmed.ncbi.nlm.nih.gov/42748427/#publication-types) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42748427/#mesh-terms) * [ Associated data ](https://pubmed.ncbi.nlm.nih.gov/42748427/#supplemental-data) * [ Grants and funding ](https://pubmed.ncbi.nlm.nih.gov/42748427/#grants) Title & authors Abstract Publication types MeSH terms Associated data Grants and funding Randomized Controlled Trial N Engl J Med Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22N+Engl+J+Med%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22N+Engl+J+Med%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42748427/) . 2026 Sep 17;395(11):1051-1061. doi: 10.1056/NEJMoa2603816. # Colonoscopy Intervals and Colorectal Cancer Incidence after Adenoma Removal [Rodrigo Jover](https://pubmed.ncbi.nlm.nih.gov/?term=Jover+R&cauthor_id=42748427)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-1 "Servicio de Medicina Digestiva, Hospital General Universitario Dr. Balmis, CIBERehd, Alicante, Spain.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-2 "Instituto de Investigación Sanitaria y Biomédica de Alicante \(ISABIAL\), Alicante, Spain.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-3 "Departamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, Spain."), [Michael Bretthauer](https://pubmed.ncbi.nlm.nih.gov/?term=Bretthauer+M&cauthor_id=42748427)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-4 "Clinical Effectiveness Research Group, Institute of Health and Society and Institute of Clinical Medicine, University of Oslo, Oslo.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-5 "Department of Transplantation Medicine, Oslo University Hospital, Oslo."), [Joaquin Cubiella](https://pubmed.ncbi.nlm.nih.gov/?term=Cubiella+J&cauthor_id=42748427)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-6 "Department of Gastroenterology, Hospital Universitario de Ourense, Grupo de Investigación en Oncología Digestiva-Ourense, CIBERehd, Ourense, Spain."), [Sarah J E Barry](https://pubmed.ncbi.nlm.nih.gov/?term=Barry+SJE&cauthor_id=42748427)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-7 "Frontier Science Scotland, Kincraig, United Kingdom."), [Anna Macios](https://pubmed.ncbi.nlm.nih.gov/?term=Macios+A&cauthor_id=42748427)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-4 "Clinical Effectiveness Research Group, Institute of Health and Society and Institute of Clinical Medicine, University of Oslo, Oslo.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-5 "Department of Transplantation Medicine, Oslo University Hospital, Oslo."), [Lauren Barnett](https://pubmed.ncbi.nlm.nih.gov/?term=Barnett+L&cauthor_id=42748427)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-7 "Frontier Science Scotland, Kincraig, United Kingdom."), [Rune Erichsen](https://pubmed.ncbi.nlm.nih.gov/?term=Erichsen+R&cauthor_id=42748427)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-8 "Department of Surgery, Randers Regional Hospital, Randers, Denmark.")[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-9 "University Clinic for Coloproctology and Endoscopy, Randers Regional Hospital, Randers, Denmark.")[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-10 "Department of Clinical Medicine, Aarhus University, Aarhus, Denmark."), [Michal F Kaminski](https://pubmed.ncbi.nlm.nih.gov/?term=Kaminski+MF&cauthor_id=42748427)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-11 "Department of Oncological Gastroenterology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.")[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-12 "Center of Postgraduate Medical Education, Warsaw, Poland.")[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-13 "Department of Surgical Oncology, Transplant Surgery, and General Surgery, Medical University of Gdańsk, Gdańsk, Poland."), [Hans-Olov Adami](https://pubmed.ncbi.nlm.nih.gov/?term=Adami+HO&cauthor_id=42748427)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-4 "Clinical Effectiveness Research Group, Institute of Health and Society and Institute of Clinical Medicine, University of Oslo, Oslo.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-5 "Department of Transplantation Medicine, Oslo University Hospital, Oslo.")[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-14 "Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm."), [Øyvind Holme](https://pubmed.ncbi.nlm.nih.gov/?term=Holme+%C3%98&cauthor_id=42748427)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-4 "Clinical Effectiveness Research Group, Institute of Health and Society and Institute of Clinical Medicine, University of Oslo, Oslo.")[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-15 "Research Unit, Sørlandet Hospital, Kristiansand, Norway."), [Joep Ijspeert](https://pubmed.ncbi.nlm.nih.gov/?term=Ijspeert+J&cauthor_id=42748427)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-16 "Department of Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam."), [Monika Ferlitsch](https://pubmed.ncbi.nlm.nih.gov/?term=Ferlitsch+M&cauthor_id=42748427)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-17 "Department of Gastroenterology and Hepatology, Medical University of Vienna, Vienna.")[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-18 "Department of Internal Medicine, Gastroenterology, and Geriatrics, Klinik Floridsdorf, Vienna."), [Mario Dinis-Ribeiro](https://pubmed.ncbi.nlm.nih.gov/?term=Dinis-Ribeiro+M&cauthor_id=42748427)[ 19 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-19 "Porto Comprehensive Cancer Center, University of Porto, Porto, Portugal.")[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-20 "Rede de Investigação em Saúde \(RISE\), University of Porto, Porto, Portugal.")[ 21 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-21 "Centro de Investigação do Instituto Português de Oncologia do Porto \(CI-IPOP\), University of Porto, Porto, Portugal."), [Maria Pellise](https://pubmed.ncbi.nlm.nih.gov/?term=Pellise+M&cauthor_id=42748427)[ 22 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-22 "Department of Gastroenterology, Hospital Clínic of Barcelona and the Institut d'Investigacions Biomediques August Pi I Sunyer \(IDIBAPS\), CIBERehd, University of Barcelona, Barcelona."), [Alejandro Martínez-Roca](https://pubmed.ncbi.nlm.nih.gov/?term=Mart%C3%ADnez-Roca+A&cauthor_id=42748427)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-1 "Servicio de Medicina Digestiva, Hospital General Universitario Dr. Balmis, CIBERehd, Alicante, Spain.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-2 "Instituto de Investigación Sanitaria y Biomédica de Alicante \(ISABIAL\), Alicante, Spain.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-3 "Departamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, Spain."), [Sandra Baile-Maxía](https://pubmed.ncbi.nlm.nih.gov/?term=Baile-Max%C3%ADa+S&cauthor_id=42748427)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-1 "Servicio de Medicina Digestiva, Hospital General Universitario Dr. Balmis, CIBERehd, Alicante, Spain.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-2 "Instituto de Investigación Sanitaria y Biomédica de Alicante \(ISABIAL\), Alicante, Spain.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-3 "Departamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, Spain."), [Luisa de-Castro](https://pubmed.ncbi.nlm.nih.gov/?term=de-Castro+L&cauthor_id=42748427)[ 23 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-23 "Department of Gastroenterology, University Hospital Álvaro Cunqueiro, Vigo, Spain."), [Luis Bujanda](https://pubmed.ncbi.nlm.nih.gov/?term=Bujanda+L&cauthor_id=42748427)[ 24 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-24 "Department of Hepatology and Gastroenterology, Biogipuzkoa Health Research Institute-Donostia University Hospital, Universidad del País Vasco, CIBERehd, San Sebastián, Spain."), [Pilar Díez-Redondo](https://pubmed.ncbi.nlm.nih.gov/?term=D%C3%ADez-Redondo+P&cauthor_id=42748427)[ 25 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-25 "Department of Gastroenterology, Hospital Río-Hortega, Valladolid, Spain."), [Jens Aksel Nordberg Nilsen](https://pubmed.ncbi.nlm.nih.gov/?term=Nilsen+JAN&cauthor_id=42748427)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-4 "Clinical Effectiveness Research Group, Institute of Health and Society and Institute of Clinical Medicine, University of Oslo, Oslo.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-5 "Department of Transplantation Medicine, Oslo University Hospital, Oslo.")[ 26 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-26 "Department of Medicine, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway."), [Hong Dung Nguyen](https://pubmed.ncbi.nlm.nih.gov/?term=Nguyen+HD&cauthor_id=42748427)[ 27 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-27 "Department of Medicine, Østføld Hospital, Kalnes, Norway."), [Linn Bernklev](https://pubmed.ncbi.nlm.nih.gov/?term=Bernklev+L&cauthor_id=42748427)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-4 "Clinical Effectiveness Research Group, Institute of Health and Society and Institute of Clinical Medicine, University of Oslo, Oslo.")[ 28 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-28 "Department of Gastroenterology, Akershus University Hospital, Akershus, Norway."), [Jørgen Tilma](https://pubmed.ncbi.nlm.nih.gov/?term=Tilma+J&cauthor_id=42748427)[ 29 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-29 "Department of Surgery, Horsens Regional Hospital, Horsens, Denmark."), [Uffe Schou Løve](https://pubmed.ncbi.nlm.nih.gov/?term=L%C3%B8ve+US&cauthor_id=42748427)[ 30 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-30 "Department of Surgery, Viborg Regional Hospital, Viborg, Denmark."), [Claudia Jaensch](https://pubmed.ncbi.nlm.nih.gov/?term=Jaensch+C&cauthor_id=42748427)[ 31 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-31 "Surgical Research Department, Gødstrup Hospital, Gødstrup, Denmark.")[ 32 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-32 "NIDO Center for Research and Education, Gødstrup Hospital, Gødstrup, Denmark."), [Nastazja D Pilonis](https://pubmed.ncbi.nlm.nih.gov/?term=Pilonis+ND&cauthor_id=42748427)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-11 "Department of Oncological Gastroenterology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland."), [Mirosław Szura](https://pubmed.ncbi.nlm.nih.gov/?term=Szura+M&cauthor_id=42748427)[ 33 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-33 "Department of Surgery, Faculty of Health Sciences, Jagiellonian University, Kraków, Poland."), [Andrzej Bialek](https://pubmed.ncbi.nlm.nih.gov/?term=Bialek+A&cauthor_id=42748427)[ 34 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-34 "Department of Gastroenterology, Pomeranian Medical University, Szczecin, Poland."), [Annemarie van Berkel](https://pubmed.ncbi.nlm.nih.gov/?term=van+Berkel+A&cauthor_id=42748427)[ 35 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-35 "Department of Gastroenterology and Hepatology, Noordwest Ziekenhuisgroep, Alkmaar, the Netherlands."), [Manon C W Spaander](https://pubmed.ncbi.nlm.nih.gov/?term=Spaander+MCW&cauthor_id=42748427)[ 36 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-36 "Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands."), [Frank Ter Borg](https://pubmed.ncbi.nlm.nih.gov/?term=Ter+Borg+F&cauthor_id=42748427)[ 37 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-37 "Department of Gastroenterology and Hepatology, Deventer Ziekenhuis, Deventer, the Netherlands."), [Monique E van Leerdam](https://pubmed.ncbi.nlm.nih.gov/?term=van+Leerdam+ME&cauthor_id=42748427)[ 38 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-38 "Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands."), [Miguel A Hernán](https://pubmed.ncbi.nlm.nih.gov/?term=Hern%C3%A1n+MA&cauthor_id=42748427)[ 39 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-39 "CAUSALab, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston."), [Jaroslaw Regula](https://pubmed.ncbi.nlm.nih.gov/?term=Regula+J&cauthor_id=42748427)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-11 "Department of Oncological Gastroenterology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.")[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-12 "Center of Postgraduate Medical Education, Warsaw, Poland."), [Magnus Løberg](https://pubmed.ncbi.nlm.nih.gov/?term=L%C3%B8berg+M&cauthor_id=42748427)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-4 "Clinical Effectiveness Research Group, Institute of Health and Society and Institute of Clinical Medicine, University of Oslo, Oslo.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-5 "Department of Transplantation Medicine, Oslo University Hospital, Oslo."), [Evelien Dekker](https://pubmed.ncbi.nlm.nih.gov/?term=Dekker+E&cauthor_id=42748427)[ 40 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-40 "Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, Amsterdam."), [Mette Kalager](https://pubmed.ncbi.nlm.nih.gov/?term=Kalager+M&cauthor_id=42748427)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-4 "Clinical Effectiveness Research Group, Institute of Health and Society and Institute of Clinical Medicine, University of Oslo, Oslo.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42748427/#full-view-affiliation-5 "Department of Transplantation Medicine, Oslo University Hospital, Oslo."); [EPoS Study
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