---
title: "Combined vaccine-strain measles and mumps viruses show oncolytic activity against colorectal cancer"
id: "pubmed-42700211"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42700211"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42700211/"
doi: "10.1007/s11033-026-12724-8"
published_at: "2026-09-05T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Combined vaccine-strain measles and mumps viruses show oncolytic activity against colorectal cancer
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42700211
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42700211/)
- **DOI:** [10.1007/s11033-026-12724-8](https://doi.org/10.1007%2Fs11033-026-12724-8)
- **Published At:** 2026-09-05T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This experimental study evaluated combined vaccine-strain **measles virus (MeV)** and **mumps virus (MuV)** (MM; 1:1, v/v) against colorectal cancer (CRC) using HT-29 cells in vitro and a nude mouse xenograft model in vivo. - In vitro assays included MTT for cell viability and flow cytometry for apoptosis; the combination demonstrated **synergistic effects** with combination index (CI) values at 48, 72, and 96 hours of 0.473, 0.692, and 0.633, respectively. - The MM-treated HT-29 cells had significantly lower viability (p < 0.05) and a markedly higher apoptotic rate (p < 0.01) than cells infected with either virus alone. - An in vivo nude mouse xenograft model showed that MM treatment led to significantly slower tumor growth (p ≤ 0.001), prolonged survival (p < 0.05), and reduced mortality compared with single-virus treatments. - MM treatment in the xenograft model increased proportions of innate immune cell populations in the spleen relative to single-virus groups. - The authors conclude the combined MeV and MuV therapy had superior and synergistic oncolytic efficacy against HT-29 colorectal cancer cells in both experimental settings. - The report lists HT-29 cells, **oncolytic virotherapy**, apoptosis, and xenograft model outcomes as central elements; conflict-of-interest declarations state no author conflicts. - Details not reported in the abstract (for example, exact dosing, schedule, viral strains beyond 'vaccine-strain', full immune cell phenotyping, or adverse effects) are not available in the provided source text.
## Clinical Analysis & Structured Key Points
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Affiliations Expand ### Affiliations * 1 Department of Gastrointestinal Endoscopy, 108 Military Central Hospital; 1st Tran Hung Dao Street, Hai Ba Trung Ward, Hanoi City, Vietnam. * 2 Department of Quality Management, 108 Military Central Hospital; 1st Tran Hung Dao Street, Hai Ba Trung Ward, Hanoi City, Vietnam. * 3 Department of Hepatobiliary, 108 Military Central Hospital, 1st Tran Hung Dao Street, Hai Ba Trung Ward, Hanoi City, Vietnam. * 4 Department of Experimental Medicine, 108 Military Central Hospital; 1st Tran Hung Dao Street, Hai Ba Trung Ward, Hanoi City, Vietnam. * 5 Department of Experimental Medicine, 108 Military Central Hospital; 1st Tran Hung Dao Street, Hai Ba Trung Ward, Hanoi City, Vietnam. leduycuong76@gmail.com. * PMID: **42700211** * DOI: [ 10.1007/s11033-026-12724-8 ](https://doi.org/10.1007/s11033-026-12724-8) Item in Clipboard # Anti-cancer efficacy of combined vaccine-strain measles and mumps viruses against colorectal cancer: an experimental study Trinh Xuan Hung et al. Mol Biol Rep. 2026. Show details Display options Display options Format Abstract PubMed PMID Mol Biol Rep Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Mol+Biol+Rep%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Mol+Biol+Rep%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700211/) . 2026 Sep 5;53(1):1537. doi: 10.1007/s11033-026-12724-8. ### Authors [Trinh Xuan Hung](https://pubmed.ncbi.nlm.nih.gov/?term=Hung+TX&cauthor_id=42700211)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42700211/#short-view-affiliation-1 "Department of Gastrointestinal Endoscopy, 108 Military Central Hospital; 1st Tran Hung Dao Street, Hai Ba Trung Ward, Hanoi City, Vietnam."), [Nguyen Dang Tung](https://pubmed.ncbi.nlm.nih.gov/?term=Tung+ND&cauthor_id=42700211)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42700211/#short-view-affiliation-2 "Department of Quality Management, 108 Military Central Hospital; 1st Tran Hung Dao Street, Hai Ba Trung Ward, Hanoi City, Vietnam."), [Nguyen Thi Huong](https://pubmed.ncbi.nlm.nih.gov/?term=Huong+NT&cauthor_id=42700211)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42700211/#short-view-affiliation-3 "Department of Hepatobiliary, 108 Military Central Hospital, 1st Tran Hung Dao Street, Hai Ba Trung Ward, Hanoi City, Vietnam."), [Dong Thai Hoa](https://pubmed.ncbi.nlm.nih.gov/?term=Hoa+DT&cauthor_id=42700211)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42700211/#short-view-affiliation-4 "Department of Experimental Medicine, 108 Military Central Hospital; 1st Tran Hung Dao Street, Hai Ba Trung Ward, Hanoi City, Vietnam."), [Le Duy Cuong](https://pubmed.ncbi.nlm.nih.gov/?term=Cuong+LD&cauthor_id=42700211)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42700211/#short-view-affiliation-5 "Department of Experimental Medicine, 108 Military Central Hospital; 1st Tran Hung Dao Street, Hai Ba Trung Ward, Hanoi City, Vietnam. leduycuong76@gmail.com.") ### Affiliations * 1 Department of Gastrointestinal Endoscopy, 108 Military Central Hospital; 1st Tran Hung Dao Street, Hai Ba Trung Ward, Hanoi City, Vietnam. * 2 Department of Quality Management, 108 Military Central Hospital; 1st Tran Hung Dao Street, Hai Ba Trung Ward, Hanoi City, Vietnam. * 3 Department of Hepatobiliary, 108 Military Central Hospital, 1st Tran Hung Dao Street, Hai Ba Trung Ward, Hanoi City, Vietnam. * 4 Department of Experimental Medicine, 108 Military Central Hospital; 1st Tran Hung Dao Street, Hai Ba Trung Ward, Hanoi City, Vietnam. * 5 Department of Experimental Medicine, 108 Military Central Hospital; 1st Tran Hung Dao Street, Hai Ba Trung Ward, Hanoi City, Vietnam. leduycuong76@gmail.com. * PMID: **42700211** * DOI: [ 10.1007/s11033-026-12724-8 ](https://doi.org/10.1007/s11033-026-12724-8) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Objectives:** This study aimed to evaluate the oncolytic efficacy of a combination of vaccine-strain measles virus (MeV) and mumps virus (MuV) against colorectal cancer (CRC) cells in vitro and in a nude mouse xenograft model. **Materials and methods:** HT-29 cells were cultured in Dulbecco's Modified Eagle Medium (DMEM) and infected with MeV, MuV, or a combination of MeV and MuV (MM; MeV: MuV = 1:1, v/v). Cell viability, synergistic effects, and apoptosis were assessed using MTT and flow cytometry assays, respectively, in vitro. A nude mouse xenograft model was established to evaluate the in vivo oncolytic efficacy of the MM against CRC xenograft tumors. **Results:** The MM demonstrated synergistic effects at 48, 72, and 96 h (CI = 0.473, 0.692, and 0.633, respectively). The MM-treated group showed significantly lower cell viability (p - [DOI](https://doi.org/10.3322/caac.21834) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/38572751/) 2. 1. International Agency for Research on Cancer (IARC) GLOBOCAN (2022) : Viet Nam. Global Cancer Observatory; 2024.https://gcoiarcwhoint/media/globocan/factsheets/populations/704-viet-nam-fact-sheetpdf 3. 1. Delpeut S, Noyce R, Richardson C (2014) The tumor-associated marker, PVRL4 (nectin-4), is the epithelial receptor for morbilliviruses. Viruses 6(6):2268–2286. - [DOI](https://doi.org/10.3390/v6062268) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/24892636/) - [PMC](https://pmc.ncbi.nlm.nih.gov/articles/4074928/) 4. 1. Anderson BD, Nakamura T, Russell SJ et al (2004) High CD46 receptor density determines preferential killing of tumor cells by oncolytic measles virus. Cancer Res 64(14):4919–4926. - [DOI](https://doi.org/10.1158/0008-5472.can-04-0884) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/15256464/) 5. 1. Kubota M, Takeuchi K, Watanabe S et al (2016) Trisaccharide containing α2, 3-linked sialic acid is a receptor for mumps virus. Proc Natl Acad Sci 113(41):11579–11584. - [DOI](https://doi.org/10.1073/pnas.1608383113) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/27671656/) - [PMC](https://pmc.ncbi.nlm.nih.gov/articles/5068328/) Show all 45 references ## MeSH terms * Animals Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Animals%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Animals) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700211/) * Apoptosis Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Apoptosis%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Apoptosis) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700211/) * Cell Line, Tumor Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell+Line%2C+Tumor%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Line%2C+Tumor) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700211/) * Cell Survival Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell+Survival%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Survival) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700211/) * Colorectal Neoplasms* / therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Colorectal+Neoplasms%2Ftherapy%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Colorectal+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700211/) * Colorectal Neoplasms* / virology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Colorectal+Neoplasms%2Fvirology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Colorectal+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700211/) * HT29 Cells Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22HT29+Cells%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=HT29+Cells) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700211/) * Humans Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Humans) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700211/) * Measles virus* / immunology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Measles+virus%2Fimmunology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Measles+virus) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700211/) * Mice Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Mice%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Mice) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700211/) * Mice, Inbred BALB C Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Mice%2C+Inbred+BALB+C%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Mice%2C+Inbred+BALB+C) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700211/) * Mice, Nude Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Mice%2C+Nude%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Mice%2C+Nude) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700211/) * Mumps virus* / immunology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Mumps+virus%2Fimmunology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Mumps+virus) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700211/) * Oncolytic Virotherapy* / methods Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Oncolytic+Virotherapy%2Fmethods%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Oncolytic+Virotherapy) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700211/) * Oncolytic Viruses Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Oncolytic+Viruses%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Oncolytic+Viruses) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700211/) * Xenograft Model Antitumor Assays Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Xenograft+Model+Antitumor+Assays%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Xenograft+Model+Antitumor+Assays) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700211/) [x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM **Send To** * [
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