---
title: "Coumarin derivative X6632: a pan‑ID protein inhibitor that targets tumor cells and tumor‑associate"
id: "biorxiv-8-the-coumarin-derivative-x6632-is-a-pan-id-protein-inhibitor-that-suppresses"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-8-the-coumarin-derivative-x6632-is-a-pan-id-protein-inhibitor-that-suppresses"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.08.05.742008v1?rss=1"
published_at: "2026-08-05T12:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Coumarin derivative X6632: a pan‑ID protein inhibitor that targets tumor cells and tumor‑associate
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-8-the-coumarin-derivative-x6632-is-a-pan-id-protein-inhibitor-that-suppresses
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.08.05.742008v1?rss=1)
- **Published At:** 2026-08-05T12:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- The source is a bioRxiv preprint reporting that the coumarin derivative **X6632** functions as a **pan‑ID protein inhibitor** and suppresses tumor growth by acting on both cancer cells and the **tumor‑associated microvasculature**. - The work is presented as a research article with multiple academic coauthors and a DOI on bioRxiv; the manuscript is a preprint and has not undergone peer review. - Authors and affiliations are listed across institutions including the Medical Faculty Mannheim (Heidelberg University), Technion – Israel Institute of Technology, Huntsman Cancer Institute (University of Utah), Francis Crick Institute, Karlsruhe Institute of Technology, and others. - The title indicates dual targeting: direct effects on cancer cells and effects on the tumor microvascular compartment, which the authors report together produce tumor growth suppression. - Specific experimental methods, quantitative results, dosing, tumor models, mechanistic data, safety or toxicity findings, and statistical outcomes were not reported in the provided source excerpt. - As this is a preprint, conclusions reported in the title should be considered preliminary until peer review and full data are available. - The article DOI and author list are provided in the source; further details would require consulting the full preprint on bioRxiv.
## Clinical Analysis & Structured Key Points
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Götz, [ View ORCID Profile](http://orcid.org/0000-0002-7999-1868)Abhilash Deo, [ View ORCID Profile](http://orcid.org/0000-0002-7943-8595)Sandra D. Scherer, Luigi D'Antonio, [ View ORCID Profile](http://orcid.org/0009-0001-3612-8490)Hanna T. Weber, [ View ORCID Profile](http://orcid.org/0000-0002-2966-237X)Georg Sedlmeier, [ View ORCID Profile](http://orcid.org/0009-0009-2520-4759)Landy P. Torre Flores, Ulrike Kaiser, Elian Far, Ziv Raviv, [ View ORCID Profile](http://orcid.org/0000-0002-8978-4192)Wilko Thiele, [ View ORCID Profile](http://orcid.org/0000-0001-8246-5431)Sonja Thaler, [ View ORCID Profile](http://orcid.org/0000-0001-9513-2468)Nicole Jung, Stefan Bräse, [ View ORCID Profile](http://orcid.org/0000-0002-8632-0480)Caroline S Hill, Alana L. Welm, [ View ORCID Profile](http://orcid.org/0000-0001-9037-3895)Yuval Shaked, [ View ORCID Profile](http://orcid.org/0000-0003-0013-9064)Boyan K. Garvalov, [ View ORCID Profile](http://orcid.org/0000-0003-1718-7687)Jonathan P. Sleeman doi: https://doi.org/10.64898/2026.08.05.742008 This article is a preprint and has not been certified by peer review [[what does this mean?](https://www.biorxiv.org/about/FAQ#unrefereed)]. Lea S. Götz 1 Medical Faculty Mannheim of the University of Heidelberg; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Lea%2BS.%2BG%C3%B6tz%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=G%C3%B6tz%20LS&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ALea%2BS.%2BG%25C3%25B6tz%2B) Abhilash Deo 2 Rappaport Faculty of Medicine, Technion - Israel Institute of Technology; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Abhilash%2BDeo%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Deo%20A&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AAbhilash%2BDeo%2B) * [ORCID record for Abhilash Deo](http://orcid.org/0000-0002-7999-1868 "Open in new tab") Sandra D. 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