---
title: "Cross-species spatial profiling implicates progranulin in immune-suppressive niches of brain metas"
id: "biorxiv-0-cross-species-spatial-profiling-links-progranulin-to-an-immune-suppressive"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-0-cross-species-spatial-profiling-links-progranulin-to-an-immune-suppressive"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.09.13.751277v1?rss=1"
published_at: "2026-09-19T12:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Cross-species spatial profiling implicates progranulin in immune-suppressive niches of brain metas
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-0-cross-species-spatial-profiling-links-progranulin-to-an-immune-suppressive
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.09.13.751277v1?rss=1)
- **Published At:** 2026-09-19T12:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- The source article is a preprint titled “Cross-species spatial profiling links progranulin to an immune suppressive niche in brain metastasis.” - Authors are primarily affiliated with NYU Grossman School of Medicine and Stanford University School of Medicine, and the work is posted on bioRxiv as a preprint (not peer reviewed). - The study’s central claim, as reflected in the title, is a link between **progranulin** and an **immune suppressive niche** within **brain metastasis**, identified using **cross-species spatial profiling** approaches. - The title implies comparative or translational analyses across species (likely human and one or more model organisms) to map spatial relationships between tumor, stroma, and immune cells in the brain metastatic microenvironment. - The approach highlighted—**spatial profiling**—suggests preservation of tissue architecture to localize **progranulin** expression and immune cell distributions, potentially identifying region-specific immune suppression. - The work involves investigators from pathology, neurosurgery, oncology, and neurology departments and includes members of melanoma and oncology-focused cooperative groups, indicating clinical and translational emphasis, likely with relevance to metastatic melanoma and/or other cancers that metastasize to brain. - The preprint context means methods, results, and conclusions have not been peer reviewed and should be interpreted cautiously. - Specific experimental methods, cohort sizes, species compared, spatial platforms used, quantitative findings, statistical analyses, and detailed conclusions were not reported in the provided source text. - Because details of experimental design, validation, and functional follow-up are not present in the provided extract, claims about mechanism or therapeutic implications cannot be independently verified from this source alone. - The affiliation list and author contributions indicate a multidisciplinary team capable of pathology-driven spatial analyses and clinical translation, but the provided text lacks outcome details and data supporting the title’s claim. - Readers interested in the study should consult the full preprint at the provided DOI/URL for complete methods, results, figures, and discussion; any clinical or therapeutic inferences require the full dataset and peer review confirmation.
## Clinical Analysis & Structured Key Points
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Eskow, [ View ORCID Profile](http://orcid.org/0000-0003-2845-2458)Kylie Prutisto-Chang, [ View ORCID Profile](http://orcid.org/0000-0002-6478-8197)Maria A. Gomez-Munoz, Minkyung Kang, Irineu Illa Bochaca, Milad Ibrahim, Sorin A.A. Shadaloey, Amanda Flores Yanke, Luiz Henrique Geraldo, [ View ORCID Profile](http://orcid.org/0000-0001-5598-1369)Giuseppe Barisano, Anuja Sathe, Pablo Nunez, David A. Solomon, Elif Tugce Karasu, Hanlee Ji, [ View ORCID Profile](http://orcid.org/0000-0001-7389-9983)Amanda Lund, [ View ORCID Profile](http://orcid.org/0000-0003-4087-3482)Maxine Umeh Garcia, [ View ORCID Profile](http://orcid.org/0000-0003-2965-9231)Melanie Hayden Gephart, [ View ORCID Profile](http://orcid.org/0000-0002-6346-2929)Jun Wang, [ View ORCID Profile](http://orcid.org/0000-0003-1023-0312)Eva Hernando doi: https://doi.org/10.64898/2026.09.13.751277 This article is a preprint and has not been certified by peer review [[what does this mean?](https://www.biorxiv.org/about/FAQ#unrefereed)]. Nicole M. Eskow 1 Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, United States; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY 10016, United States; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Nicole%2BM.%2BEskow%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Eskow%20NM&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ANicole%2BM.%2BEskow%2B) * [ORCID record for Nicole M. Eskow](http://orcid.org/0000-0003-1048-4769 "Open in new tab") Kylie Prutisto-Chang 1 Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, United States; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY 10016, United States; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Kylie%2BPrutisto-Chang%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Prutisto-Chang%20K&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AKylie%2BPrutisto-Chang%2B) * [ORCID record for Kylie Prutisto-Chang](http://orcid.org/0000-0003-2845-2458 "Open in new tab") Maria A. Gomez-Munoz 1 Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, United States; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY 10016, United States; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Maria%2BA.%2BGomez-Munoz%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Gomez-Munoz%20MA&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AMaria%2BA.%2BGomez-Munoz%2B) * [ORCID record for Maria A. Gomez-Munoz](http://orcid.org/0000-0002-6478-8197 "Open in new tab") Minkyung Kang 2 Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, United States; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Minkyung%2BKang%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Kang%20M&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AMinkyung%2BKang%2B) Irineu Illa Bochaca 1 Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, United States; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY 10016, United States; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Irineu%2BIlla%2BBochaca%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Illa%20Bochaca%20I&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AIrineu%2BIlla%2BBochaca%2B) Milad Ibrahim 1 Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, United States; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY 10016, United States; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Milad%2BIbrahim%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Ibrahim%20M&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AMilad%2BIbrahim%2B) Sorin A.A. Shadaloey 1 Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, United States; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY 10016, United States; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Sorin%2BA.A.%2BShadaloey%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Shadaloey%20SA&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ASorin%2BA.A.%2BShadaloey%2B) Amanda Flores Yanke 1 Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, United States; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY 10016, United States; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Amanda%2BFlores%2BYanke%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Flores%20Yanke%20A&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AAmanda%2BFlores%2BYanke%2B) Luiz Henrique Geraldo 3 Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY 10016, United States; Department of Neurology, NYU Grossman School of Medicine, New York, NY 10016, United States; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Luiz%2BHenrique%2BGeraldo%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Geraldo%20LH&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ALuiz%2BHenrique%2BGeraldo%2B) Giuseppe Barisano 2 Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, United States; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Giuseppe%2BBarisano%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Barisano%20G&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AGiuseppe%2BBarisano%2B) * [ORCID record for Giuseppe Barisano](http://orcid.org/0000-0001-5598-1369 "Open in new tab") Anuja Sathe 4 Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Anuja%2BSathe%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Sathe%20A&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AAnuja%2BSathe%2B) Pablo Nunez 2 Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, United States; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Pablo%2BNunez%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Nunez%20P&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3APablo%2BNunez%2B) David A. Solomon 5 Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, United States; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=David%2BA.%2BSolomon%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Solomon%20DA&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ADavid%2BA.%2BSolomon%2B) Elif Tugce Karasu 1 Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, United States; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY 10016, United States; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Elif%2BTugce%2BKarasu%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Karasu%20ET&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AElif%2BTugce%2BKarasu%2B) Hanlee Ji 4 Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Hanlee%2BJi%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Ji%20H&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AHanlee%2BJi%2B) Amanda Lund 1 Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, United States; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY 10016, United States; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5
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