---
title: "DA-5: Azaindole GPX4 Inhibitor Inducing Ferroptosis for Targeted Therapy in Triple‑Negative Breast"
id: "pubmed-42048687"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42048687"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42048687/"
doi: "10.1016/j.bioorg.2026.109901"
published_at: "2026-08-05T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# DA-5: Azaindole GPX4 Inhibitor Inducing Ferroptosis for Targeted Therapy in Triple‑Negative Breast
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42048687
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42048687/)
- **DOI:** [10.1016/j.bioorg.2026.109901](https://doi.org/10.1016%2Fj.bioorg.2026.109901)
- **Published At:** 2026-08-05T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Triple‑negative breast cancer (TNBC) lacks ER, PR, and HER2 and has limited targeted treatments; **ferroptosis** is a promising therapeutic route for TNBC. - DA‑5 is a novel **3,5‑disubstituted azaindole** derivative designed by molecular docking and structural optimization, inspired by compounds in Shuganning injection (SGNI). - DA‑5 binds to **GPX4** with measured affinity (Kd = 10.04 μM) and inhibits GPX4 enzymatic activity (IC50 = 10.90 μM). - In vitro, DA‑5 induces **lipid peroxidation** and ferroptotic cell death in TNBC cells while showing relative sparing of normal mammary epithelial cells; ferroptosis inhibitors and iron chelators rescued cell death, supporting a ferroptosis mechanism. - Oral DA‑5 significantly inhibited growth of TNBC xenografts in vivo without observable systemic toxicity; pharmacokinetic and safety profiles were reported as favorable. - The study identifies DA‑5 as a targeted **GPX4 inhibitor** that promotes GPX4‑targeted lipid peroxidation and ferroptosis, suggesting potential as a therapeutic candidate for TNBC. - Conflict of interest: authors declared no competing financial interests or personal relationships related to the work.
## Clinical Analysis & Structured Key Points
Clipboard, Search History, and several other advanced features are temporarily unavailable. [ Skip to main page content ](https://pubmed.ncbi.nlm.nih.gov/42048687/#article-details) ![U.S. flag](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png) An official website of the United States government Here's how you know ![Dot gov](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg) **The .gov means it’s official.** Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. ![Https](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg) **The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [ ![NIH NLM Logo](https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg) ](https://www.ncbi.nlm.nih.gov/) [Log in](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42048687%2F) Show account info Close #### Account Logged in as: **username** * [Dashboard](https://www.ncbi.nlm.nih.gov/myncbi/) * [Publications](https://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/) * [Account settings](https://www.ncbi.nlm.nih.gov/account/settings/) * [Log out](https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/42048687/) [Access keys](https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys) [NCBI Homepage](https://www.ncbi.nlm.nih.gov) [MyNCBI Homepage](https://pubmed.ncbi.nlm.nih.gov/myncbi/) [Main Content](https://pubmed.ncbi.nlm.nih.gov/42048687/#maincontent) [Main Navigation](https://pubmed.ncbi.nlm.nih.gov/42048687/) [ ![pubmed logo](https://cdn.ncbi.nlm.nih.gov/pubmed/af7de7da-df5d-41c6-8de4-8c266af8ccfb/core/images/pubmed-logo-blue.svg) ](https://pubmed.ncbi.nlm.nih.gov/) [ ](https://pubmed.ncbi.nlm.nih.gov/42048687/ "Show search bar") Search: [](https://pubmed.ncbi.nlm.nih.gov/42048687/ "Clear search input")Search [Advanced](https://pubmed.ncbi.nlm.nih.gov/advanced/) [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/clipboard/) [ User Guide ](https://pubmed.ncbi.nlm.nih.gov/help/) Save Email Send to * [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/42048687/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42048687%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42048687%2F%23open-collections-panel) * [Citation manager](https://pubmed.ncbi.nlm.nih.gov/42048687/) Display options Display options Format Abstract PubMed PMID ## Save citation to file Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel ## Email citation Email address has not been verified. Go to [ My NCBI account settings ](https://account.ncbi.nlm.nih.gov/settings/) to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel ### Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42048687/) Add Cancel ### Add to My Bibliography * My Bibliography Unable to load your delegates due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42048687/) Add Cancel ## Your saved search Name of saved search: Search terms: [Test search terms](https://pubmed.ncbi.nlm.nih.gov/42048687/) Would you like email updates of new search results? Saved Search Alert Radio Buttons * Yes * No Email: ([change](https://www.ncbi.nlm.nih.gov/account/settings/)) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel ## Create a file for external citation management software Create file Cancel ## Your RSS Feed Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy ### Full text links [![Elsevier Science full text link](https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif) Elsevier Science ](https://linkinghub.elsevier.com/retrieve/pii/S0045-2068\(26\)00437-2 "See full text options at Elsevier Science") [ Full text links ](https://pubmed.ncbi.nlm.nih.gov/42048687/) ### Actions Cite Collections Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42048687/) Add Cancel Permalink Permalink Copy Display options Display options Format Abstract PubMed PMID ### Page navigation * [ Title & authors ](https://pubmed.ncbi.nlm.nih.gov/42048687/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42048687/#abstract) * [ Conflict of interest statement ](https://pubmed.ncbi.nlm.nih.gov/42048687/#conflict-of-interest) * [Similar articles](https://pubmed.ncbi.nlm.nih.gov/42048687/#similar) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42048687/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42048687/#substances) * [Related information](https://pubmed.ncbi.nlm.nih.gov/42048687/#related-links) * [ LinkOut - more resources ](https://pubmed.ncbi.nlm.nih.gov/42048687/#linkout) Title & authors Abstract Conflict of interest statement Similar articles MeSH terms Substances Related information LinkOut - more resources Bioorg Chem Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Bioorg+Chem%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Bioorg+Chem%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42048687/) . 2026 Aug 5:177:109901. doi: 10.1016/j.bioorg.2026.109901. Epub 2026 Apr 23. # DA-5: A novel azaindole-based GPX4 inhibitor inducing ferroptosis for targeted therapy of triple-negative breast cancer [Jingjing Du](https://pubmed.ncbi.nlm.nih.gov/?term=Du+J&cauthor_id=42048687)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42048687/#full-view-affiliation-1 "State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China; Nanhu Laboratory, Jiaxing 314051, Zhejiang, China."), [Kaiqiang Guo](https://pubmed.ncbi.nlm.nih.gov/?term=Guo+K&cauthor_id=42048687)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42048687/#full-view-affiliation-2 "State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China."), [ChaoJie Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+C&cauthor_id=42048687)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42048687/#full-view-affiliation-3 "Jiangxi Cancer Hospital \(The Second Affiliated Hospital of Nanchang Medical Colloge\), Nanchang 330029, Jiangxi, China."), [Xuening Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+X&cauthor_id=42048687)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42048687/#full-view-affiliation-4 "State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China; Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Hengqin Guangdong-Macao In-Depth Cooperation Zone, Zhuhai 519099, Guangdong, China."), [Yanchao Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+Y&cauthor_id=42048687)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42048687/#full-view-affiliation-4 "State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China; Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Hengqin Guangdong-Macao In-Depth Cooperation Zone, Zhuhai 519099, Guangdong, China."), [Tong Chu](https://pubmed.ncbi.nlm.nih.gov/?term=Chu+T&cauthor_id=42048687)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42048687/#full-view-affiliation-4 "State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China; Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Hengqin Guangdong-Macao In-Depth Cooperation Zone, Zhuhai 519099, Guangdong, China."), [Dongfan Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+D&cauthor_id=42048687)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42048687/#full-view-affiliation-4 "State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China; Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Hengqin Guangdong-Macao In-Depth Cooperation Zone, Zhuhai 519099, Guangdong, China."), [Dayuan Zheng](https://pubmed.ncbi.nlm.nih.gov/?term=Zheng+D&cauthor_id=42048687)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42048687/#full-view-affiliation-4 "State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China; Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Hengqin Guangdong-Macao In-Depth Cooperation Zone, Zhuhai 519099, Guangdong, China."), [Wenzhe Ma](https://pubmed.ncbi.nlm.nih.gov/?term=Ma+W&cauthor_id=42048687)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42048687/#full-view-affiliation-5 "State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China; Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Hengqin Guangdong-Macao In-Depth Cooperation Zone, Zhuhai 519099, Guangdong, China. Electronic address: wzma@must.edu.mo.") Affiliations Expand ### Affiliations * 1 State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China; Nanhu Laboratory, Jiaxing 314051, Zhejiang, China. * 2 State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China. * 3 Jiangxi Cancer Hospital (The Second Affiliated Hospital of Nanchang Medical Colloge), Nanchang 330029, Jiangxi, China. * 4 State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China; Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Hengqin Guangdong-Macao In-Depth Cooperation Zone, Zhuhai 519099, Guangdong, China. * 5 State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China; Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Hengqin Guangdong-Macao In-Depth Cooperation Zone, Zhuhai 519099, Guangdong, China. Electronic address: wzma@must.edu.mo. * PMID: **42048687** * DOI: [ 10.1016/j.bioorg.2026.109901 ](https://doi.org/10.1016/j.bioorg.2026.109901) Item in Clipboard # DA-5: A novel azaindole-based GPX4 inhibitor inducing ferroptosis for targeted therapy of triple-negative breast cancer Jingjing Du et al. Bioorg Chem. 2026. Show details Display options Display options Format Abstract PubMed PMID Bioorg Chem Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Bioorg+Chem%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Bioorg+Chem%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42048687/) . 2026 Aug 5:177:109901. doi: 10.1016/j.bioorg.2026.109901. Epub 2026 Apr 23. ### Authors [Jingjing Du](https://pubmed.ncbi.nlm.nih.gov/?term=Du+J&cauthor_id=42048687)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42048687/#short-view-affiliation-1 "State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China; Nanhu Laboratory, Jiaxing 314051, Zhejiang, China."), [Kaiqiang Guo](https://pubmed.ncbi.nlm.nih.gov/?term=Guo+K&cauthor_id=42048687)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42048687/#short-view-affiliation-2 "State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China."), [ChaoJie Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+C&cauthor_id=42048687)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42048687/#short-view-affiliation-3 "Jiangxi Cancer Hospital \(The Second Affiliated Hospital of Nanchang Medical Colloge\), Nanchang 330029, Jiangxi, China."), [Xuening Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+X&cauthor_id=42048687)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42048687/#short-view-affiliation-4 "State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China; Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Hengqin Guangdong-Macao In-Depth Cooperation Zone, Zhuhai 519099, Guangdong, China."), [Yanchao Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+Y&cauthor_id=42048687)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42048687/#short-view-affiliation-4 "State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China; Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Hengqin Guangdong-Macao In-Depth Cooperation Zone, Zhuhai 519099, Guangdong, China."), [Tong Chu](https://pubmed.ncbi.nlm.nih.gov/?term=Chu+T&cauthor_id=42048687)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42048687/#short-view-affiliation-4 "State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China; Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Hengqin Guangdong-Macao In-Depth Cooperation Zone, Zhuhai 519099, Guangdong, China."), [Dongfan Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+D&cauthor_id=42048687)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42048687/#short-view-affiliation-4 "State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China; Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Hengqin Guangdong-Macao In-Depth Cooperation Zone, Zhuhai 519099, Guangdong, China."), [Dayuan Zheng](https://pubmed.ncbi.nlm.nih.gov/?term=Zheng+D&cauthor_id=42048687)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42048687/#short-view-affiliation-4 "State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China; Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Hengqin Guangdong-Macao In-Depth Cooperation Zone, Zhuhai 519099, Guangdong, China."), [Wenzhe Ma](https://pubmed.ncbi.nlm.nih.gov/?term=Ma+W&cauthor_id=42048687)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42048687/#short-view-affiliation-5 "State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China; Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Hengqin Guangdong-Macao In-Depth Cooperation Zone, Zhuhai 519099, Guangdong, China. Electronic address: wzma@must.edu.mo.") ### Affiliations * 1 State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China; Nanhu Laboratory, Jiaxing 314051, Zhejiang, China. * 2 State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China. * 3 Jiangxi Cancer Hospital (The Second Affiliated Hospital of Nanchang Medical Colloge), Nanchang 330029, Jiangxi, China. * 4 State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China; Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Hengqin Guangdong-Macao In-Depth Cooperation Zone, Zhuhai 519099, Guangdong, China. * 5 State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China; Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Hengqin Guangdong-Macao In-Depth Cooperation Zone, Zhuhai 519099, Guangdong, China. Electronic address: wzma@must.edu.mo. * PMID: **42048687** * DOI: [ 10.1016/j.bioorg.2026.109901 ](https://doi.org/10.1016/j.bioorg.2026.109901) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Background:** Triple-negative breast cancer (TNBC) is an aggressive subtype lacking the ER, PR, and HER2 receptors, with limited treatment options and poor prognosis. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a promising therapeutic strategy for TNBC. Glutathione peroxidase 4 (GPX4) is a key ferroptosis suppressor, and its inhibition sensitizes TNBC cells to oxidative damage. **Purpose:** To discover and characterize DA-5, a novel 3,5-disubstituted azaindole derivative inspired by compounds from the traditional Chinese medicine Shuganning injection (SGNI), as a potent GPX4 inhibitor to induce ferroptosis in TNBC cells. **Methods:** Molecular docking and structural optimization were used to design DA-5. Its binding affinity (Kd) and enzymatic inhibitory activity (IC50) against GPX4 were evaluated. In vitro assays assessed DA-5's ability to induce ferroptosis in TNBC cells through lipid peroxidation while sparing normal mammary epithelial cells. In vivo studies evaluated the efficacy and safety of DA-5 in TNBC xenograft models via oral administration. Pharmacokinetic profiles were also analyzed. **Results:** DA-5 demonstrated high-affinity binding to GPX4 (Kd = 10.04 μM) and effectively suppressed its enzymatic activity (IC50 = 10.90 μM). In TNBC cells, DA-5 promoted lipid peroxidation and induced ferroptosis, which was rescued by ferroptosis inhibitors and by iron chelators. Oral administration of DA-5 significantly inhibited TNBC xenograft growth in vivo without systemic toxicity, supported by favorable pharmacokinetic and safety profiles. **Conclusion:** These findings identify DA-5 as a novel azaindole-based GPX4 inhibitor capable of inducing ferroptosis through GPX4-targeted lipid peroxidation. This breakthrough offers a promising targeted therapy for TNBC. **Keywords:** DA-5; Ferroptosis; GPX4; Shuganning injection (SGNI); Triple-negative breast cancer. Copyright © 2026 Elsevier Inc. All rights reserved. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this pa
## Related Clinical Research

- [Palmitoylation-related Signature Predicts Prognosis and Immune Microenvironment in DLBCL](https://medichelpline.com/clinical-feed/frontiers-in-immunology-8-a-palmitoylation-related-signature-predicts-prognosis-and-immune.md)
- [Postmastectomy Pain and Sociodemographic Factors: Prospective PPAM Study Results](https://medichelpline.com/clinical-feed/medrxiv-0-prospective-observational-study-of-post-surgical-pain-in-women-undergoing.md)
- [Targeting the tumour matrisome: advances in ECM biology, diagnostics and therapies](https://medichelpline.com/clinical-feed/nature-reviews-clinical-oncology-0-understanding-and-targeting-the-tumour-matrisome.md)
- [Breast Self-Examination and Clinical Breast Examination Knowledge and Practice in Buea, Cameroon](https://medichelpline.com/clinical-feed/medrxiv-20-knowledge-and-practice-of-breast-self-examination-and-clinical-breast.md)
- [Structured aerobic exercise linked to lower cancer recurrence and improved survival](https://medichelpline.com/clinical-feed/medical-news-today-0-aerobic-exercise-could-help-improve-outlook-after-cancer-treatment.md)

## Navigation
- [← Back to Oncology Feed](https://medichelpline.com/clinical-feed/oncology.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.