---
title: "Daraxonrasib in Previously Treated RAS‑Mutant Non‑Small‑Cell Lung Cancer — NEJM Clinical Trial Rep"
id: "pubmed-42685317"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42685317"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42685317/"
doi: "10.1056/NEJMoa2504059"
published_at: "2026-09-03T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Daraxonrasib in Previously Treated RAS‑Mutant Non‑Small‑Cell Lung Cancer — NEJM Clinical Trial Rep
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42685317
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42685317/)
- **DOI:** [10.1056/NEJMoa2504059](https://doi.org/10.1056%2FNEJMoa2504059)
- **Published At:** 2026-09-03T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- A clinical trial titled “Daraxonrasib for Previously Treated RAS‑Mutant Non‑Small‑Cell Lung Cancer” was published in the New England Journal of Medicine (N Engl J Med) on 3 September 2026 (Vol. 395, pp. 882–893). - The PubMed identifier (PMID) is 42685317 and the DOI is 10.1056/NEJMoa2504059. - The manuscript lists Kathryn C. Arbour and many coauthors across academic centers and industry; authorship includes clinicians and investigators from major U.S. cancer centers and from Revolution Medicines. - Institutional affiliations reported include Memorial Sloan Kettering, Weill Cornell, NYU Langone, Dana‑Farber, Brigham and Women’s, Harvard Medical School, Moffitt, Johns Hopkins, M.D. Anderson, and Revolution Medicines among others. - The article is indexed as a Clinical Trial on PubMed. - The provided PubMed page excerpt does not include the study abstract, methods, patient population, efficacy outcomes, safety data, or detailed conclusions. Those clinical details were not reported in the source excerpt and must be obtained from the full NEJM article or the journal abstract. - For clinicians and decision makers, the key items needed but not available in the excerpt are trial design (phase, randomization, control), eligibility criteria, RAS‑mutation subtypes included, prior therapies, primary and secondary endpoints, efficacy results (response rates, progression‑free survival, overall survival), and adverse‑event profile. - The presence of multiple academic and industry affiliations suggests a multicenter effort; Revolution Medicines is listed among the authors’ affiliations, indicating industry involvement in the investigational agent’s development. - To review clinical recommendations or consider practice implications, readers must consult the full text via the NEJM DOI or PubMed record for complete data and supplementary materials.
## Clinical Analysis & Structured Key Points
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](https://pubmed.ncbi.nlm.nih.gov/42685317/#abstract) * [ Publication types ](https://pubmed.ncbi.nlm.nih.gov/42685317/#publication-types) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42685317/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42685317/#substances) * [ Associated data ](https://pubmed.ncbi.nlm.nih.gov/42685317/#supplemental-data) Title & authors Abstract Publication types MeSH terms Substances Associated data Clinical Trial N Engl J Med Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22N+Engl+J+Med%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22N+Engl+J+Med%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42685317/) . 2026 Sep 3;395(9):882-893. doi: 10.1056/NEJMoa2504059. # Daraxonrasib for Previously Treated _RAS_ -Mutant Non-Small-Cell Lung Cancer [Kathryn C Arbour](https://pubmed.ncbi.nlm.nih.gov/?term=Arbour+KC&cauthor_id=42685317)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-1 "Memorial Sloan Kettering Cancer Center, New York.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-2 "Weill Cornell Medical College, New York."), [Salman Punekar](https://pubmed.ncbi.nlm.nih.gov/?term=Punekar+S&cauthor_id=42685317)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-3 "NYU Langone Health, New York."), [Jia Luo](https://pubmed.ncbi.nlm.nih.gov/?term=Luo+J&cauthor_id=42685317)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-4 "Dana-Farber Cancer Institute, Boston.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-5 "Brigham and Women's Hospital, Boston.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-6 "Harvard Medical School, Boston."), [Melissa Johnson](https://pubmed.ncbi.nlm.nih.gov/?term=Johnson+M&cauthor_id=42685317)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-7 "Sarah Cannon Research Institute, Nashville."), [Alexander Spira](https://pubmed.ncbi.nlm.nih.gov/?term=Spira+A&cauthor_id=42685317)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-8 "NEXT Oncology Virginia, Virginia Cancer Specialists Research Institute, Fairfax."), [Benjamin Herzberg](https://pubmed.ncbi.nlm.nih.gov/?term=Herzberg+B&cauthor_id=42685317)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-9 "Columbia University, New York."), [Alexander Starodub](https://pubmed.ncbi.nlm.nih.gov/?term=Starodub+A&cauthor_id=42685317)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-10 "The Christ Hospital, Cincinnati."), [David Sommerhalder](https://pubmed.ncbi.nlm.nih.gov/?term=Sommerhalder+D&cauthor_id=42685317)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-11 "NEXT Oncology, San Antonio, TX."), [Joel Randolph Hecht](https://pubmed.ncbi.nlm.nih.gov/?term=Hecht+JR&cauthor_id=42685317)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-12 "David Geffen School of Medicine at UCLA, Los Angeles."), [Ignacio Garrido-Laguna](https://pubmed.ncbi.nlm.nih.gov/?term=Garrido-Laguna+I&cauthor_id=42685317)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-13 "Huntsman Cancer Institute, University of Utah, Salt Lake City."), [Minal Barve](https://pubmed.ncbi.nlm.nih.gov/?term=Barve+M&cauthor_id=42685317)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-14 "Mary Crowley Cancer Research, Dallas."), [Sai-Hong Ignatius Ou](https://pubmed.ncbi.nlm.nih.gov/?term=Ou+SI&cauthor_id=42685317)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-15 "University of California, Irvine, Irvine."), [Sumit Kar](https://pubmed.ncbi.nlm.nih.gov/?term=Kar+S&cauthor_id=42685317)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-16 "Revolution Medicines, Redwood City, CA."), [Lei Bao](https://pubmed.ncbi.nlm.nih.gov/?term=Bao+L&cauthor_id=42685317)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-16 "Revolution Medicines, Redwood City, CA."), [Lin Tao](https://pubmed.ncbi.nlm.nih.gov/?term=Tao+L&cauthor_id=42685317)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-16 "Revolution Medicines, Redwood City, CA."), [Rashmi Vora](https://pubmed.ncbi.nlm.nih.gov/?term=Vora+R&cauthor_id=42685317)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-16 "Revolution Medicines, Redwood City, CA."), [Aparna Hegde](https://pubmed.ncbi.nlm.nih.gov/?term=Hegde+A&cauthor_id=42685317)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-16 "Revolution Medicines, Redwood City, CA."), [Andreas Saltos](https://pubmed.ncbi.nlm.nih.gov/?term=Saltos+A&cauthor_id=42685317)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-17 "Moffitt Cancer Center, Tampa, FL."), [Nilofer S Azad](https://pubmed.ncbi.nlm.nih.gov/?term=Azad+NS&cauthor_id=42685317)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-18 "Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore."), [David S Hong](https://pubmed.ncbi.nlm.nih.gov/?term=Hong+DS&cauthor_id=42685317)[ 19 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#full-view-affiliation-19 "M.D. Anderson Cancer Center, Houston."); [RMC-6236-001 Investigators](https://pubmed.ncbi.nlm.nih.gov/?term=RMC-6236-001+Investigators%5BCorporate+Author%5D) Collaborators, Affiliations Expand ### Collaborators * **RMC-6236-001 Investigators** : [Kathryn Arbour](https://pubmed.ncbi.nlm.nih.gov/?term=Arbour+K), [Zhaohui Arter](https://pubmed.ncbi.nlm.nih.gov/?term=Arter+Z), [Nilofer S Azad](https://pubmed.ncbi.nlm.nih.gov/?term=Azad+NS), [Vaia Florou](https://pubmed.ncbi.nlm.nih.gov/?term=Florou+V), [Joel Rudolph Hecht](https://pubmed.ncbi.nlm.nih.gov/?term=Hecht+JR), [Benjamin Randolph Herzberg](https://pubmed.ncbi.nlm.nih.gov/?term=Herzberg+BR), [David Hong](https://pubmed.ncbi.nlm.nih.gov/?term=Hong+D), [Dae Won Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+DW), [Brian Mannion](https://pubmed.ncbi.nlm.nih.gov/?term=Mannion+B), [Douglas Orr](https://pubmed.ncbi.nlm.nih.gov/?term=Orr+D), [Meredith Pelster](https://pubmed.ncbi.nlm.nih.gov/?term=Pelster+M), [Salman R Punekar](https://pubmed.ncbi.nlm.nih.gov/?term=Punekar+SR), [David Sommerhalder](https://pubmed.ncbi.nlm.nih.gov/?term=Sommerhalder+D), [Alexander Spira](https://pubmed.ncbi.nlm.nih.gov/?term=Spira+A), [Brian Wolpin](https://pubmed.ncbi.nlm.nih.gov/?term=Wolpin+B) ### Affiliations * 1 Memorial Sloan Kettering Cancer Center, New York. * 2 Weill Cornell Medical College, New York. * 3 NYU Langone Health, New York. * 4 Dana-Farber Cancer Institute, Boston. * 5 Brigham and Women's Hospital, Boston. * 6 Harvard Medical School, Boston. * 7 Sarah Cannon Research Institute, Nashville. * 8 NEXT Oncology Virginia, Virginia Cancer Specialists Research Institute, Fairfax. * 9 Columbia University, New York. * 10 The Christ Hospital, Cincinnati. * 11 NEXT Oncology, San Antonio, TX. * 12 David Geffen School of Medicine at UCLA, Los Angeles. * 13 Huntsman Cancer Institute, University of Utah, Salt Lake City. * 14 Mary Crowley Cancer Research, Dallas. * 15 University of California, Irvine, Irvine. * 16 Revolution Medicines, Redwood City, CA. * 17 Moffitt Cancer Center, Tampa, FL. * 18 Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore. * 19 M.D. Anderson Cancer Center, Houston. * PMID: **42685317** * DOI: [ 10.1056/NEJMoa2504059 ](https://doi.org/10.1056/nejmoa2504059) Item in Clipboard Clinical Trial # Daraxonrasib for Previously Treated _RAS_ -Mutant Non-Small-Cell Lung Cancer Kathryn C Arbour et al. N Engl J Med. 2026. Show details Display options Display options Format Abstract PubMed PMID N Engl J Med Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22N+Engl+J+Med%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22N+Engl+J+Med%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42685317/) . 2026 Sep 3;395(9):882-893. doi: 10.1056/NEJMoa2504059. ### Authors [Kathryn C Arbour](https://pubmed.ncbi.nlm.nih.gov/?term=Arbour+KC&cauthor_id=42685317)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-1 "Memorial Sloan Kettering Cancer Center, New York.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-2 "Weill Cornell Medical College, New York."), [Salman Punekar](https://pubmed.ncbi.nlm.nih.gov/?term=Punekar+S&cauthor_id=42685317)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-3 "NYU Langone Health, New York."), [Jia Luo](https://pubmed.ncbi.nlm.nih.gov/?term=Luo+J&cauthor_id=42685317)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-4 "Dana-Farber Cancer Institute, Boston.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-5 "Brigham and Women's Hospital, Boston.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-6 "Harvard Medical School, Boston."), [Melissa Johnson](https://pubmed.ncbi.nlm.nih.gov/?term=Johnson+M&cauthor_id=42685317)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-7 "Sarah Cannon Research Institute, Nashville."), [Alexander Spira](https://pubmed.ncbi.nlm.nih.gov/?term=Spira+A&cauthor_id=42685317)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-8 "NEXT Oncology Virginia, Virginia Cancer Specialists Research Institute, Fairfax."), [Benjamin Herzberg](https://pubmed.ncbi.nlm.nih.gov/?term=Herzberg+B&cauthor_id=42685317)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-9 "Columbia University, New York."), [Alexander Starodub](https://pubmed.ncbi.nlm.nih.gov/?term=Starodub+A&cauthor_id=42685317)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-10 "The Christ Hospital, Cincinnati."), [David Sommerhalder](https://pubmed.ncbi.nlm.nih.gov/?term=Sommerhalder+D&cauthor_id=42685317)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-11 "NEXT Oncology, San Antonio, TX."), [Joel Randolph Hecht](https://pubmed.ncbi.nlm.nih.gov/?term=Hecht+JR&cauthor_id=42685317)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-12 "David Geffen School of Medicine at UCLA, Los Angeles."), [Ignacio Garrido-Laguna](https://pubmed.ncbi.nlm.nih.gov/?term=Garrido-Laguna+I&cauthor_id=42685317)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-13 "Huntsman Cancer Institute, University of Utah, Salt Lake City."), [Minal Barve](https://pubmed.ncbi.nlm.nih.gov/?term=Barve+M&cauthor_id=42685317)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-14 "Mary Crowley Cancer Research, Dallas."), [Sai-Hong Ignatius Ou](https://pubmed.ncbi.nlm.nih.gov/?term=Ou+SI&cauthor_id=42685317)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-15 "University of California, Irvine, Irvine."), [Sumit Kar](https://pubmed.ncbi.nlm.nih.gov/?term=Kar+S&cauthor_id=42685317)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-16 "Revolution Medicines, Redwood City, CA."), [Lei Bao](https://pubmed.ncbi.nlm.nih.gov/?term=Bao+L&cauthor_id=42685317)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-16 "Revolution Medicines, Redwood City, CA."), [Lin Tao](https://pubmed.ncbi.nlm.nih.gov/?term=Tao+L&cauthor_id=42685317)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-16 "Revolution Medicines, Redwood City, CA."), [Rashmi Vora](https://pubmed.ncbi.nlm.nih.gov/?term=Vora+R&cauthor_id=42685317)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-16 "Revolution Medicines, Redwood City, CA."), [Aparna Hegde](https://pubmed.ncbi.nlm.nih.gov/?term=Hegde+A&cauthor_id=42685317)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-16 "Revolution Medicines, Redwood City, CA."), [Andreas Saltos](https://pubmed.ncbi.nlm.nih.gov/?term=Saltos+A&cauthor_id=42685317)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-17 "Moffitt Cancer Center, Tampa, FL."), [Nilofer S Azad](https://pubmed.ncbi.nlm.nih.gov/?term=Azad+NS&cauthor_id=42685317)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-18 "Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore."), [David S Hong](https://pubmed.ncbi.nlm.nih.gov/?term=Hong+DS&cauthor_id=42685317)[ 19 ](https://pubmed.ncbi.nlm.nih.gov/42685317/#short-view-affiliation-19 "M.D. Anderson Cancer Center, Houston."); [RMC-6236-001 Investigators](https://pubmed.ncbi.nlm.nih.gov/?term=RMC-6236-001+Investigators%5BCorporate+Author%5D) ### Collaborators * **RMC-6236-001 Investigators** : [Kathryn Arbour](https://pubmed.ncbi.nlm.nih.gov/?term=Arbour+K), [Zhaohui Arter](https://pubmed.ncbi.nlm.nih.gov/?term=Arter+Z), [Nilofer S Azad](https://pubmed.ncbi.nlm.nih.gov/?term=Azad+NS), [Vaia Florou](https://pubmed.ncbi.nlm.nih.gov/?term=Florou+V), [Joel Rudolph Hecht](https://pubmed.ncbi.nlm.nih.gov/?term=Hecht+JR), [Benjamin Randolph Herzberg](https://pubmed.ncbi.nlm.nih.gov/?term=Herzberg+BR), [David Hong](https://pubmed.ncbi.nlm.nih.gov/?term=Hong+D), [Dae Won Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+DW), [Brian Mannion](https://pubmed.ncbi.nlm.nih.gov/?term=Mannion+B), [Douglas Orr](https://pubmed.ncbi.nlm.nih.gov/?term=Orr+D), [Meredith Pelster](https://pubmed.ncbi.nlm.nih.gov/?term=Pelster+M), [Salman R Punekar](https://pubmed.ncbi.nlm.nih.gov/?term=Punekar+SR), [David Sommerhalder](https://pubmed.ncbi.nlm.nih.gov/?term=Sommerhalder+D), [Alexander Spira](https://pubmed.ncbi.nlm.nih.gov/?term=Spira+A), [Brian Wolpin](https://pubmed.ncbi.nlm.nih.gov/?term=Wolpin+B) ### Affiliations * 1 Memorial Sloan Kettering Cancer Center, New York. * 2 Weill Cornell Medical College, New York. * 3 NYU Langone Health, New York. * 4 Dana-Farber Cancer Institute, Boston. * 5 Brigham and Women's Hospital, Boston. * 6 Harvard Medical School, Boston. * 7 Sarah Cannon Research Institute, Nashville. * 8 NEXT Oncology Virginia, Virginia Cancer Specialists Research Institute, Fairfax. * 9 Columbia University, New York. * 10 The Christ Hospital, Cincinnati. * 11 NEXT Oncology, San Antonio, TX. * 12 David Geffen School of Medicine at UCLA, Los Angeles. * 13 Huntsman Cancer Institute, University of Utah, Salt Lake City. * 14 Mary Crowley Cancer Research, Dallas. * 15 University of California, Irvine, Irvine. * 16 Revolution Medicines, Redwood City, CA. * 17 Moffitt Cancer Center, Tampa, FL. * 18 Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore. * 19 M
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