---
title: "Digital Health Interventions and Quality of Life in Women With Breast Cancer: Systematic Review Fi"
id: "pubmed-42627958"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42627958"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42627958/"
doi: "10.2196/96858"
published_at: "2026-08-21T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Digital Health Interventions and Quality of Life in Women With Breast Cancer: Systematic Review Fi
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42627958
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42627958/)
- **DOI:** [10.2196/96858](https://doi.org/10.2196%2F96858)
- **Published At:** 2026-08-21T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This systematic review (PROSPERO CRD420250578307) evaluated the effectiveness of **digital health** interventions on **quality of life (QoL)** and psychosocial outcomes in women with **breast cancer** during or up to 1 year after active treatment. - Searches of PsycINFO, Web of Science, Scopus, LILACS, and SciELO (September 2025) identified 408 records; 15 studies met inclusion: 14 randomized controlled trials (RCTs) and 1 quasi-experimental study. - Sample sizes ranged from 35 to 394 participants. Interventions included internet-based platforms (websites/apps) in 10 studies, text-messaging (WhatsApp/WeChat) in 3, virtual reality in 1, and an email listserve in 1. - QoL outcomes favored the digital intervention in 8 of 15 studies, indicating modest, often short-term improvements in some QoL dimensions. - Anxiety, depression, or emotional distress were measured in 13 studies; 5 showed favorable direction of effect for the digital intervention. - Self-efficacy was assessed in 5 studies and favored the intervention in only 1, and that effect was not sustained at follow-up. - Retention across studies ranged from 68.6% to 100%. - Risk of bias: among 14 RCTs, 3 were high risk and 11 raised some concerns; none were at low risk. The quasi-experimental study had a serious overall risk of bias. - Certainty of evidence was judged low for QoL and emotional outcomes and very low for self-efficacy. - Interventions with active therapeutic components or professional support more frequently showed favorable effects, but this observation is based on indirect comparisons across heterogeneous studies. - Authors conclude digital interventions are promising but current evidence is insufficient to draw strong or generalizable conclusions; acceptability and longer-term effects were insufficiently evaluated.
## Clinical Analysis & Structured Key Points
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Affiliations Expand ### Affiliations * 1 Facultad de Enfermería, Universidad Andres Bello, Talcahuano 7100, Concepción, 4260000, Chile, +56412662318. * 2 Psychology and Educational Sciences Department, Universitat Oberta de Catalunya, Barcelona, Spain. * PMID: **42627958** * DOI: [ 10.2196/96858 ](https://doi.org/10.2196/96858) Item in Clipboard Review # Digital Health Interventions and Psychosocial Outcomes in Women With Breast Cancer: Systematic Review Rocío Zúñiga-Tapia et al. JMIR Cancer. 2026. Show details Display options Display options Format Abstract PubMed PMID JMIR Cancer Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22JMIR+Cancer%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22JMIR+Cancer%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42627958/) . 2026 Aug 21:12:e96858. doi: 10.2196/96858. ### Authors [Rocío Zúñiga-Tapia](https://pubmed.ncbi.nlm.nih.gov/?term=Z%C3%BA%C3%B1iga-Tapia+R&cauthor_id=42627958)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42627958/#short-view-affiliation-1 "Facultad de Enfermería, Universidad Andres Bello, Talcahuano 7100, Concepción, 4260000, Chile, +56412662318.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42627958/#short-view-affiliation-2 "Psychology and Educational Sciences Department, Universitat Oberta de Catalunya, Barcelona, Spain."), [Mercè Boixadós](https://pubmed.ncbi.nlm.nih.gov/?term=Boixad%C3%B3s+M&cauthor_id=42627958)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42627958/#short-view-affiliation-2 "Psychology and Educational Sciences Department, Universitat Oberta de Catalunya, Barcelona, Spain."), [Eulàlia Hernández Encuentra](https://pubmed.ncbi.nlm.nih.gov/?term=Hern%C3%A1ndez+Encuentra+E&cauthor_id=42627958)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42627958/#short-view-affiliation-2 "Psychology and Educational Sciences Department, Universitat Oberta de Catalunya, Barcelona, Spain.") ### Affiliations * 1 Facultad de Enfermería, Universidad Andres Bello, Talcahuano 7100, Concepción, 4260000, Chile, +56412662318. * 2 Psychology and Educational Sciences Department, Universitat Oberta de Catalunya, Barcelona, Spain. * PMID: **42627958** * DOI: [ 10.2196/96858 ](https://doi.org/10.2196/96858) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Background:** Breast cancer and its treatment can negatively affect women's quality of life (QoL), including physical, psychological, and social well-being. Digital health interventions have been increasingly used to provide supportive care, but their effectiveness on QoL and related psychosocial outcomes remains unclear. **Objective:** This review aimed to evaluate the effectiveness of digital health interventions on QoL in women with breast cancer and to assess their effects on anxiety, depression, and self-efficacy. **Methods:** This systematic review was registered in PROSPERO (CRD420250578307) and conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 statement. PsycINFO, Web of Science, Scopus, LILACS, and SciELO were searched in September 2025. Eligible studies were randomized controlled trials (RCTs) or controlled quasi-experimental studies with preintervention and postintervention assessments that evaluated digital health interventions in women with breast cancer during or up to 1 year after active treatment and reported QoL outcomes. Two reviewers independently screened all records (interrater agreement >90%) and extracted data using a standardized template, with independent verification by a second reviewer. Risk of bias was assessed using the Cochrane Risk of Bias tool (RoB 2) for RCTs and the Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I) tool for the quasi-experimental study; findings were synthesized narratively following the Synthesis Without Meta-analysis (SWiM) guideline. **Results:** A total of 408 records were identified, and 15 studies were included: 14 RCTs and 1 quasi-experimental study. Sample sizes ranged from 35 to 394 participants. Ten studies evaluated internet-based approaches such as websites or apps; 3 used text messaging (eg, WhatsApp [WhatsApp LLC] or WeChat [Tencent Technology, Shenzhen Company Limited]), 1 used virtual reality, and 1 used an email listserve. The direction of effect favored the digital intervention for QoL in 8 of the 15 studies. Self-efficacy was assessed in 5 studies and favored the intervention in only 1, with the effect not maintained at follow-up. Anxiety, depression, or emotional distress were assessed in 13 studies, with a favorable direction of effect in 5. Retention rates ranged from 68.6% to 100%. Among the 14 RCTs, 3 were judged at high overall risk of bias, and 11 raised some concerns; none was at low risk. The quasi-experimental study had a serious overall risk of bias. Certainty of evidence was low for QoL and emotional outcomes and very low for self-efficacy. **Conclusions:** Digital health interventions may provide modest, short-term improvements in some dimensions of QoL in women with breast cancer. Favorable effects appeared more often in interventions with active therapeutic components or professional support; however, this pattern was based on indirect comparisons across heterogeneous studies. Effects on self-efficacy and mental health were inconsistent, and acceptability was insufficiently evaluated. Although promising, current evidence does not support strong or generalizable conclusions. **Keywords:** anxiety; breast neoplasms; depression; digital health; mental health; mobile apps; quality of life; self-efficacy; systematic review; telemedicine. © Rocío Zúñiga-Tapia, Mercè Boixadós, Eulàlia Hernández Encuentra. Originally published in JMIR Cancer (https://cancer.jmir.org). 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