---
title: "DNMT1 Epigenetic Reprogramming and KMT2A Genomic Alterations — Preprint Summary"
id: "biorxiv-21-dnmt1-mediated-epigenetic-reprogramming-drives-kmt2a-amplifications-and"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-21-dnmt1-mediated-epigenetic-reprogramming-drives-kmt2a-amplifications-and"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.09.21.753283v1?rss=1"
published_at: "2026-09-22T12:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# DNMT1 Epigenetic Reprogramming and KMT2A Genomic Alterations — Preprint Summary
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-21-dnmt1-mediated-epigenetic-reprogramming-drives-kmt2a-amplifications-and
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.09.21.753283v1?rss=1)
- **Published At:** 2026-09-22T12:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- Source article is a preprint titled “DNMT1-Mediated Epigenetic Reprogramming Drives KMT2A Amplifications and Rearrangements,” with DOI https://doi.org/10.64898/2026.09.21.753283 and hosted on bioRxiv. - The manuscript lists many contributing authors and multiple institutional affiliations (e.g., Fox Chase Cancer Center, Massachusetts General Hospital, Mount Sinai Tisch Cancer Center, Temple University School of Medicine, Biomodal Ltd); full author list and affiliations are provided in the source. - The article is explicitly identified as an unrefereed preprint and has not been certified by peer review, as noted on bioRxiv. - The title indicates the study concerns **DNMT1**-mediated epigenetic changes and their relation to **KMT2A** copy-number amplifications and chromosomal rearrangements, implying a molecular/epigenetic focus relevant to oncology and genomics. - The provided source excerpt contains article metadata (title, authors, affiliations, DOI) and site navigation content but does not include the abstract, methods, results, figures, or conclusions. - Because experimental details, datasets, specific findings, statistical results, and conclusions were not included in the provided excerpt, no claims about study design, results, or clinical implications can be extracted or summarized from this source segment. - Any further interpretation of mechanisms, evidence for causality, experimental systems, or therapeutic implications is not reported in the supplied content and therefore cannot be presented here. - Readers should consult the full preprint text on bioRxiv for the study’s abstract, methods, data, and authors’ conclusions before drawing scientific or clinical inferences.
## Clinical Analysis & Structured Key Points
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Lineberger, Zach H. Gray, Benjamin I. Ferman, Erin O Donnell, Rebecca G. Smith, Kathleen Schiela, Anushka Udara, Kashish Chetal, Chloe Azadegan, Monika Maria Toma, Ethan Sumner, John Santoro, Christopher Miranda, Manna Ahmed, Jade Wilson, William Lautert-Dutra, Chencheng Li, Aidan McKelvey, H Umit Kaniskan, Wenyun Zhang, Jian Jin, Fabio Puddu, Mark Consugar, Martin Walsh, Alfonso Bellacosa, Cihangir Duy, Hayan Lee, Tomasz Skorski, Yu Liu, Ruslan I. Sadreyev, [ View ORCID Profile](http://orcid.org/0000-0003-0555-4283)Johnathan R Whetstine doi: https://doi.org/10.64898/2026.09.21.753283 This article is a preprint and has not been certified by peer review [[what does this mean?](https://www.biorxiv.org/about/FAQ#unrefereed)]. Madison A. Lineberger 1 Fox Chase Cancer Center; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Madison%2BA.%2BLineberger%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Lineberger%20MA&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AMadison%2BA.%2BLineberger%2B) Zach H. Gray 1 Fox Chase Cancer Center; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Zach%2BH.%2BGray%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Gray%20ZH&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AZach%2BH.%2BGray%2B) Benjamin I. 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