---
title: "Dual-Responsive Biomimetic Nanoplatform Using GOD-Fe3+&DOX for Endometrial Cancer Therapy"
id: "pubmed-42702983"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42702983"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42702983/"
doi: "10.1021/acsabm.6c00563"
published_at: "2026-09-07T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Dual-Responsive Biomimetic Nanoplatform Using GOD-Fe3+&DOX for Endometrial Cancer Therapy
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42702983
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42702983/)
- **DOI:** [10.1021/acsabm.6c00563](https://doi.org/10.1021%2Facsabm.6c00563)
- **Published At:** 2026-09-07T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Study develops a dual-responsive biomimetic nanoplatform, named GOD-Fe3+&DOX-Membrane@Polymer (GOD-Fe3+&DM@Poly.), targeting **endometrial cancer** (HEC-1A) to overcome limitations of conventional chemotherapy such as poor targeting and dose-limiting toxicity. - The nanoplatform was synthesized using **RAFT polymerization** to incorporate functional polymer side chains and backbone units that enable covalent enzyme immobilization and reversible membrane targeting. - Pyridine disulfide bonds were installed as polymer side chains to permit precise covalent immobilization of **glucose oxidase (GOD)**, reducing enzyme leakage associated with physical encapsulation. - Benzylboronic acid moieties were integrated into the polymer backbone to form reversible borate ester linkages with **sialic acid** on HEC-1A cancer cell membranes, promoting homologous targeting and improved intratumoral enrichment. - The construct co-loads **Fe3+** and **doxorubicin (DOX)** to combine chemotherapy with a cascade catalytic therapeutic mechanism: GOD-mediated glucose consumption produces H2O2, which Fe3+ converts via Fenton chemistry into hydroxyl radicals, amplifying oxidative stress to induce **ferroptosis**. - The design leverages a cascade synergistic approach—**starvation therapy** (GOD) plus **chemodynamic therapy** (Fe3+)—to intensify tumor oxidative damage and promote cell death pathways complementary to DOX cytotoxicity. - The platform is presented as a technical framework for multifunctional, stimuli-responsive nanomedicines; specific experimental outcomes, quantitative efficacy, safety, and in vivo data were not reported in the provided abstract.
## Clinical Analysis & Structured Key Points
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R. China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#full-view-affiliation-2 "School of Medicine and Health, Harbin Institute of Technology , Harbin150040, P. R. China."), [Zhuorong Miao](https://pubmed.ncbi.nlm.nih.gov/?term=Miao+Z&cauthor_id=42702983)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#full-view-affiliation-3 "Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University , Shenzhen518028, P. R. China.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#full-view-affiliation-4 "Shenzhen School of Clinical Medicine, Southern Medical University , Shenzhen518028, P. R. China."), [Meng Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+M&cauthor_id=42702983)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#full-view-affiliation-5 "School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen518055, P. R. China."), [Tianyi Guo](https://pubmed.ncbi.nlm.nih.gov/?term=Guo+T&cauthor_id=42702983)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#full-view-affiliation-6 "The First Affiliated Hospital of Zhengzhou University , Zhengzhou450000, P. R. China."), [Deyuan Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+D&cauthor_id=42702983)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#full-view-affiliation-7 "Department of Endocrinology, The Second Affiliated Hospital of Anhui Medical University, Hefei230601, P. R. China."), [Zhengbao Zha](https://pubmed.ncbi.nlm.nih.gov/?term=Zha+Z&cauthor_id=42702983)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#full-view-affiliation-1 "School of Medicine and Health, Zhengzhou Advanced Research Institute of Harbin Institute of Technology, Zhengzhou450000, P. R. China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#full-view-affiliation-2 "School of Medicine and Health, Harbin Institute of Technology , Harbin150040, P. R. China."), [Ping Jin](https://pubmed.ncbi.nlm.nih.gov/?term=Jin+P&cauthor_id=42702983)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#full-view-affiliation-3 "Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University , Shenzhen518028, P. R. China.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#full-view-affiliation-4 "Shenzhen School of Clinical Medicine, Southern Medical University , Shenzhen518028, P. R. China.") Affiliations Expand ### Affiliations * 1 School of Medicine and Health, Zhengzhou Advanced Research Institute of Harbin Institute of Technology, Zhengzhou450000, P. R. China. * 2 School of Medicine and Health, Harbin Institute of Technology , Harbin150040, P. R. China. * 3 Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University , Shenzhen518028, P. R. China. * 4 Shenzhen School of Clinical Medicine, Southern Medical University , Shenzhen518028, P. R. China. * 5 School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen518055, P. R. China. * 6 The First Affiliated Hospital of Zhengzhou University , Zhengzhou450000, P. R. China. * 7 Department of Endocrinology, The Second Affiliated Hospital of Anhui Medical University, Hefei230601, P. R. China. * PMID: **42702983** * DOI: [ 10.1021/acsabm.6c00563 ](https://doi.org/10.1021/acsabm.6c00563) Item in Clipboard # Dual-Responsive Biomimetic Nanoplatform for Cascade Synergistic Therapy of Endometrial Cancer Huaibin Yu et al. ACS Appl Bio Mater. 2026. Show details Display options Display options Format Abstract PubMed PMID ACS Appl Bio Mater Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22ACS+Appl+Bio+Mater%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22ACS+Appl+Bio+Mater%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42702983/) . 2026 Sep 7;9(17):8030-8043. doi: 10.1021/acsabm.6c00563. ### Authors [Huaibin Yu](https://pubmed.ncbi.nlm.nih.gov/?term=Yu+H&cauthor_id=42702983)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#short-view-affiliation-1 "School of Medicine and Health, Zhengzhou Advanced Research Institute of Harbin Institute of Technology, Zhengzhou450000, P. R. China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#short-view-affiliation-2 "School of Medicine and Health, Harbin Institute of Technology , Harbin150040, P. R. China."), [Zhuorong Miao](https://pubmed.ncbi.nlm.nih.gov/?term=Miao+Z&cauthor_id=42702983)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#short-view-affiliation-3 "Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University , Shenzhen518028, P. R. China.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#short-view-affiliation-4 "Shenzhen School of Clinical Medicine, Southern Medical University , Shenzhen518028, P. R. China."), [Meng Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+M&cauthor_id=42702983)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#short-view-affiliation-5 "School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen518055, P. R. China."), [Tianyi Guo](https://pubmed.ncbi.nlm.nih.gov/?term=Guo+T&cauthor_id=42702983)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#short-view-affiliation-6 "The First Affiliated Hospital of Zhengzhou University , Zhengzhou450000, P. R. China."), [Deyuan Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+D&cauthor_id=42702983)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#short-view-affiliation-7 "Department of Endocrinology, The Second Affiliated Hospital of Anhui Medical University, Hefei230601, P. R. China."), [Zhengbao Zha](https://pubmed.ncbi.nlm.nih.gov/?term=Zha+Z&cauthor_id=42702983)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#short-view-affiliation-1 "School of Medicine and Health, Zhengzhou Advanced Research Institute of Harbin Institute of Technology, Zhengzhou450000, P. R. China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#short-view-affiliation-2 "School of Medicine and Health, Harbin Institute of Technology , Harbin150040, P. R. China."), [Ping Jin](https://pubmed.ncbi.nlm.nih.gov/?term=Jin+P&cauthor_id=42702983)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#short-view-affiliation-3 "Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University , Shenzhen518028, P. R. China.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42702983/#short-view-affiliation-4 "Shenzhen School of Clinical Medicine, Southern Medical University , Shenzhen518028, P. R. China.") ### Affiliations * 1 School of Medicine and Health, Zhengzhou Advanced Research Institute of Harbin Institute of Technology, Zhengzhou450000, P. R. China. * 2 School of Medicine and Health, Harbin Institute of Technology , Harbin150040, P. R. China. * 3 Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University , Shenzhen518028, P. R. China. * 4 Shenzhen School of Clinical Medicine, Southern Medical University , Shenzhen518028, P. R. China. * 5 School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen518055, P. R. China. * 6 The First Affiliated Hospital of Zhengzhou University , Zhengzhou450000, P. R. China. * 7 Department of Endocrinology, The Second Affiliated Hospital of Anhui Medical University, Hefei230601, P. R. China. * PMID: **42702983** * DOI: [ 10.1021/acsabm.6c00563 ](https://doi.org/10.1021/acsabm.6c00563) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract Endometrial cancer is a common malignant tumor in the female reproductive system. Traditional chemotherapy has limitations such as poor targeting, dose-limiting toxicity, and treatment intensity restrictions. To address these issues, this study constructed an intelligent nanoplatform-GOD-Fe3+&DOX-Membrane@Polymer (GOD-Fe3+&DM@Poly.)-based on reversible addition-fragmentation chain transfer (RAFT) polymerization technology. The incorporation of pyridine disulfide bonds as polymer side chains through RAFT polymerization facilitated the precise covalent immobilization of glucose oxidase (GOD), effectively mitigating the leakage issues commonly observed with physical encapsulation methods. Concurrently, benzylboronic acid moieties were integrated into the polymer backbone, enabling the formation of reversible borate ester linkages with sialic acid residues present on the membranes of HEC-1A cancer cells. This interaction promoted homologous targeting and substantially improved their intratumoral enrichment efficiency. In addition, GOD-mediated starvation therapy and Fe3+-triggered chemodynamic therapy construct a cascade reaction: GOD consumes tumor glucose to produce H2O2, which is converted into highly toxic hydroxyl radicals through the Fe3+-mediated Fenton reaction, amplifying tumor oxidative stress to initiate ferroptosis. This integration establishes a valuable technical framework for the development of multifunctional and stimuli-responsive nanomedicines. **Keywords:** HEC-1A cancer cell membrane; RAFT block polymer; doxorubicin (DOX); endometrial cancer; ferroptosis. © 2026 American Chemical Society. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## MeSH terms * Animals Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Animals%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Animals) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42702983/) * Antibiotics, Antineoplastic* / chemistry Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Antibiotics%2C+Antineoplastic%2Fchemistry%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Antibiotics%2C+Antineoplastic) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42702983/) * Antibiotics, Antineoplastic* / pharmacology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Antibiotics%2C+Antineoplastic%2Fpharmacology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Antibiotics%2C+Antineoplastic) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42702983/) * Biocompatible Materials* / chemical synthesis Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biocompatible+Materials%2Fchemical+synthesis%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Biocompatible+Materials) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42702983/) * Biocompatible Materials* / chemistry Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biocompatible+Materials%2Fchemistry%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Biocompatible+Materials) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42702983/) * Biocompatible Materials* / pharmacology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biocompatible+Materials%2Fpharmacology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Biocompatible+Materials) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42702983/) * Biomimetic Materials* / chemical synthesis Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biomimetic+Materials%2Fchemical+synthesis%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Biomimetic+Materials) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42702983/) * Biomimetic Materials* / chemistry Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biomimetic+Materials%2Fchemistry%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Biomimetic+Materials) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42702983/) * Biomimetic Materials* / pharmacology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biomimetic+Materials%2Fpharmacology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Biomimetic+Materials) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42702983/) * Cell Proliferation / drug effects Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell+Proliferation%2Fdrug+effects%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Proliferation) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42702983/) * Cell Survival / drug effects Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell+Survival%2Fdrug+effects%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Survival) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42702983/) * Doxorubicin* / chemistry Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Doxorubicin%2Fchemistry%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Doxorubicin) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42702983/) * Doxorubicin* / pharmacology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Doxorubicin%2Fpharmacology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Doxorubicin) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42702983/) * Drug Screening Assays, Antitumor Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Drug+Scre
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