---
title: "Editorial Expression of Concern: Image concerns in EphA2–arachidonic acid prostate cancer paper"
id: "british-journal-of-cancer-0-editorial-expression-of-concern-ligand-independent-activation-of-epha2-by"
canonical_url: "https://medichelpline.com/clinical-feed/british-journal-of-cancer-0-editorial-expression-of-concern-ligand-independent-activation-of-epha2-by"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "British Journal of Cancer"
source_url: "https://www.nature.com/articles/s41416-026-03650-4"
published_at: "2026-10-22T12:00:00.000Z"
evidence_level: "Journal Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Editorial Expression of Concern: Image concerns in EphA2–arachidonic acid prostate cancer paper
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/british-journal-of-cancer-0-editorial-expression-of-concern-ligand-independent-activation-of-epha2-by
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** British Journal of Cancer
- **Source URL:** [Original Journal Publication](https://www.nature.com/articles/s41416-026-03650-4)
- **Published At:** 2026-10-22T12:00:00.000Z
- **Evidence Rating:** Journal Feed
## Executive GIST (TL;DR)
- The British Journal of Cancer published an Editorial Expression of Concern on 22 October 2026 about a 2012 article reporting ligand-independent activation of **EphA2** by **arachidonic acid** in **prostate cancer** cells. - The editor identified apparent similarities between the Src panels in Figures 2A and 4G and between portions of the FAK panels in the same figures. - The concerns relate specifically to the visual data presented in those Western blot or immunoblot panels; the notice does not report other methodological or outcome issues. - The authors informed the publisher that original underlying data are no longer available because of the article’s age. - Two authors, M D Brown and N W Clarke, did not respond to the publisher’s correspondence; the publisher was unable to contact T Tawadros and C A Hart. - Readers are advised to interpret the affected data with caution given the reported panel similarities and the unavailability of original data for verification. - The expression of concern links back to the original 2012 article and provides author and affiliation details but does not present corrective actions, retraction, or additional editorial findings. - The notice is a formal flag intended to alert the community; it stops short of definitive editorial action because of missing original data and incomplete author engagement.
## Clinical Analysis & Structured Key Points
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Advertisement [ ![British Journal of Cancer](https://media.springernature.com/full/nature-cms/uploads/product/bjc/header-76ac17391903a21e28f15ff5df31f5fa.svg) ](https://www.nature.com/bjc) * [ View all journals ](https://www.nature.com/siteindex) * [ Saved research ](https://www.nature.com/saved-research) * [ Search ](javascript:;) ## Search Search articles by subject, keyword or author Show results from All journals This journal Search [ Advanced search ](https://www.nature.com/search/advanced) ### Quick links * [Explore articles by subject](https://www.nature.com/subjects) * [Find a job](https://www.nature.com/naturecareers) * [Guide to authors](https://www.nature.com/authors/index.html) * [Editorial policies](https://www.nature.com/authors/editorial_policies/) * [Log in](https://idp.nature.com/auth/personal/springernature?redirect_uri=https://www.nature.com/articles/s41416-026-03650-4) * [ Content Explore content ](javascript:;) ## Explore content * [ Research articles ](https://www.nature.com/bjc/research-articles) * [ Reviews & Analysis ](https://www.nature.com/bjc/reviews-and-analysis) * [ News & Comment ](https://www.nature.com/bjc/news-and-comment) * [ Current issue ](https://www.nature.com/bjc/current-issue) * [ Collections ](https://www.nature.com/bjc/collections) * [Follow us on X ](https://twitter.com/BrJCancer) * [Sign up for alerts ](https://journal-alerts.springernature.com/subscribe?journal_id=41416) * [ RSS feed ](https://www.nature.com/bjc.rss) * [ About the journal ](javascript:;) ## About the journal * [ Journal Information ](https://www.nature.com/bjc/journal-information) * [ Open access publishing ](https://www.nature.com/bjc/open-access) * [ Editors ](https://www.nature.com/bjc/editors) * [ Contact ](https://www.nature.com/bjc/contact) * [ Special Issues ](https://www.nature.com/bjc/special-issues) * [ For Advertisers ](https://www.nature.com/bjc/advertising) * [ Subscribe ](https://www.nature.com/bjc/subscribe) * [ Publish with us ](javascript:;) ## Publish with us * [ For Authors & Referees ](https://www.nature.com/bjc/authors-and-referees) * [ Language editing services ](https://authorservices.springernature.com/go/sn/?utm_source=For+Authors&utm_medium=Website_Nature&utm_campaign=Platform+Experimentation+2022&utm_id=PE2022) * [Open access funding](https://www.nature.com/bjc/open-access-funding) * [Submit manuscript ](https://mts-bjcancer.nature.com/) * [ Sign up for alerts ](https://journal-alerts.springernature.com/subscribe?journal_id=41416) * [ RSS feed ](https://www.nature.com/bjc.rss) 1. [nature](https://www.nature.com/) 2. [british journal of cancer](https://www.nature.com/bjc) 3. [editorial expression of concerns](https://www.nature.com/bjc/articles?type=editorial-expression-of-concern) 4. article Editorial Expression of Concern: Ligand-independent activation of EphA2 by arachidonic acid induces metastasis-like behaviour in prostate cancer cells [ Download PDF ](https://www.nature.com/articles/s41416-026-03650-4.pdf) [ Download PDF ](https://www.nature.com/articles/s41416-026-03650-4.pdf) * Editorial Expression of Concern * Published: 22 October 2026 # Editorial Expression of Concern: Ligand-independent activation of EphA2 by arachidonic acid induces metastasis-like behaviour in prostate cancer cells * [T. Tawadros](https://www.nature.com/articles/s41416-026-03650-4#auth-T_-Tawadros-Aff1)[1](https://www.nature.com/articles/s41416-026-03650-4#Aff1), * [M. D. Brown](https://www.nature.com/articles/s41416-026-03650-4#auth-M__D_-Brown-Aff1)[1](https://www.nature.com/articles/s41416-026-03650-4#Aff1), * [C. A. Hart](https://www.nature.com/articles/s41416-026-03650-4#auth-C__A_-Hart-Aff1)[1](https://www.nature.com/articles/s41416-026-03650-4#Aff1) & * … * [N. W. Clarke](https://www.nature.com/articles/s41416-026-03650-4#auth-N__W_-Clarke-Aff1-Aff2)[1](https://www.nature.com/articles/s41416-026-03650-4#Aff1),[2](https://www.nature.com/articles/s41416-026-03650-4#Aff2) Show authors [_British Journal of Cancer_](https://www.nature.com/bjc) (2026) [Cite this article](https://www.nature.com/articles/s41416-026-03650-4#citeas) Save article [ View saved research ](https://www.nature.com/saved-research) Editorial Expression of Concern to: _British Journal of Cancer_ , published online 4 October 2012 The Editor-in-Chief would like to alert readers that concerns were raised regarding similarities between _Src_ panels of Figures 2A and 4G and between sections of _FAK_ panels of Figures 2A and 4G. The authors have stated that original data are no longer available due to the age of the article. Therefore, readers are advised to interpret the data listed above with caution. M D Brown and N W Clarke did not respond to correspondence from the Publisher about this Editorial Expression of Concern. The Publisher was unable to contact T Tawadros and C A Hart. ## Author information ### Authors and Affiliations 1. Genito Urinary Cancer Research Group, School of Cancer and Enabling Sciences, Paterson Institute for Cancer Research, The University of Manchester, Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK T. Tawadros, M. D. Brown, C. A. Hart & N. W. Clarke 2. Department of Urology, Salford Royal Hospital NHS Foundation Trust, Stott Lane, Salford, M6 8HD, UK N. W. Clarke Authors 1. T. Tawadros [View author publications](https://www.nature.com/search?author=T.%20Tawadros) Search author on:[PubMed](https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=T.%20Tawadros)[Google Scholar](https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22T.%20Tawadros%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en) 2. M. D. Brown [View author publications](https://www.nature.com/search?author=M.%20D.%20Brown) Search author on:[PubMed](https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=M.%20D.%20Brown)[Google Scholar](https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22M.%20D.%20Brown%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en) 3. C. A. Hart [View author publications](https://www.nature.com/search?author=C.%20A.%20Hart) Search author on:[PubMed](https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=C.%20A.%20Hart)[Google Scholar](https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22C.%20A.%20Hart%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en) 4. N. W. Clarke [View author publications](https://www.nature.com/search?author=N.%20W.%20Clarke) Search author on:[PubMed](https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=N.%20W.%20Clarke)[Google Scholar](https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22N.%20W.%20Clarke%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en) ### Corresponding author Correspondence to M. D. 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