---
title: "Erianin and Doxorubicin in Diffuse Large B-Cell Lymphoma: Study Overview on GSDMD, PI3K/AKT, and S"
id: "pubmed-40830921"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-40830921"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/40830921/"
doi: "10.1097/CM9.0000000000003634"
published_at: "2026-09-20T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Erianin and Doxorubicin in Diffuse Large B-Cell Lymphoma: Study Overview on GSDMD, PI3K/AKT, and S
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-40830921
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/40830921/)
- **DOI:** [10.1097/CM9.0000000000003634](https://doi.org/10.1097%2FCM9.0000000000003634)
- **Published At:** 2026-09-20T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Publication details: article published in Chin Med J (Engl) with PMID 40830921 and DOI 10.1097/CM9.0000000000003634; citation lists multiple authors from Tianjin institutions. - Clinical context: **diffuse large B-cell lymphoma (DLBCL)** is identified as the most common non-Hodgkin lymphoma, noted for its aggressiveness and rapid growth. - Investigational agent: **Erianin**, a natural compound from the Chinese herb Dendrobium, is reported in the title to induce **GSDMD-dependent pyroptosis** and to synergistically enhance **doxorubicin** efficacy via the **PI3K/AKT** signaling pathway in DLBCL. - Authorship and affiliations: first and corresponding author(s) and multiple coauthors are affiliated with the Department of Oncology, Tianjin Union Medical Center / The First Affiliated Hospital of Nankai University and related Tianjin institutions, plus other collaborating departments and colleges listed in the PubMed entry. - Timing: article metadata shows electronic publication (Epub) 2025 Aug 20 and journal issue dated 2026 Sep 20; volume and page range given as 139(18):2808-2820. - Abstract availability: the abstract text in the PubMed record is truncated in the provided source; the Methods, Results, and Conclusions sections and experimental details are not available in the provided source content. - What is known from the provided source: the title and opening abstract sentences indicate the study hypothesis and focus (erianin effects on pyroptosis and interaction with doxorubicin through PI3K/AKT) but outcome data, experimental design, models, sample sizes, statistical findings, and safety or translational implications were not reported in the source excerpt. - Data gaps: specific mechanisms, evidence for **GSDMD-dependent pyroptosis**, measures of synergy with **doxorubicin**, and PI3K/AKT pathway data are not present in the provided source text and therefore cannot be summarized here. - How to follow up: consult the full text via the DOI or journal site for complete methods, results, and conclusions; PubMed record lists full-text links and DOI for access. - Metadata for clinicians: the record includes full author list and six institutional affiliations, useful for contact or follow-up; PMID and DOI enable retrieval of the complete article.
## Clinical Analysis & Structured Key Points
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Epub 2025 Aug 20. # Erianin induces GSDMD-dependent pyroptosis and synergistically enhances doxorubicin efficacy via the PI3K/AKT signaling pathway in diffuse large B-cell lymphoma [Hanwei Mei](https://pubmed.ncbi.nlm.nih.gov/?term=Mei+H&cauthor_id=40830921)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-1 "Department of Oncology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-2 "Department of Gastrointestinal Surgery 3, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 301617, China."), [Minghan Qiu](https://pubmed.ncbi.nlm.nih.gov/?term=Qiu+M&cauthor_id=40830921)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-1 "Department of Oncology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-3 "Tianjin Cancer Institute of Integrative Traditional Chinese and Western Medicine, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-4 "School of Medicine, Nankai University, Tianjin 300071, China."), [Ruxue Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+R&cauthor_id=40830921)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-1 "Department of Oncology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-5 "College of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300121, China."), [Teng Song](https://pubmed.ncbi.nlm.nih.gov/?term=Song+T&cauthor_id=40830921)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-1 "Department of Oncology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-4 "School of Medicine, Nankai University, Tianjin 300071, China."), [Zhanhua Gao](https://pubmed.ncbi.nlm.nih.gov/?term=Gao+Z&cauthor_id=40830921)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-4 "School of Medicine, Nankai University, Tianjin 300071, China."), [Qiaonan Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+Q&cauthor_id=40830921)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-4 "School of Medicine, Nankai University, Tianjin 300071, China."), [Yayun Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+Y&cauthor_id=40830921)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-5 "College of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300121, China."), [Jie Hao](https://pubmed.ncbi.nlm.nih.gov/?term=Hao+J&cauthor_id=40830921)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-3 "Tianjin Cancer Institute of Integrative Traditional Chinese and Western Medicine, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-6 "Department of Thyroid and Breast Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China."), [Ming Gao](https://pubmed.ncbi.nlm.nih.gov/?term=Gao+M&cauthor_id=40830921)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-3 "Tianjin Cancer Institute of Integrative Traditional Chinese and Western Medicine, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-6 "Department of Thyroid and Breast Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China."), [Zhen Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+Z&cauthor_id=40830921)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-3 "Tianjin Cancer Institute of Integrative Traditional Chinese and Western Medicine, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China."), [Huaqing Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+H&cauthor_id=40830921)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-1 "Department of Oncology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-3 "Tianjin Cancer Institute of Integrative Traditional Chinese and Western Medicine, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-4 "School of Medicine, Nankai University, Tianjin 300071, China.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#full-view-affiliation-5 "College of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300121, China.") Affiliations Expand ### Affiliations * 1 Department of Oncology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China. * 2 Department of Gastrointestinal Surgery 3, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 301617, China. * 3 Tianjin Cancer Institute of Integrative Traditional Chinese and Western Medicine, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China. * 4 School of Medicine, Nankai University, Tianjin 300071, China. * 5 College of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300121, China. * 6 Department of Thyroid and Breast Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China. * PMID: **40830921** * DOI: [ 10.1097/CM9.0000000000003634 ](https://doi.org/10.1097/cm9.0000000000003634) Item in Clipboard # Erianin induces GSDMD-dependent pyroptosis and synergistically enhances doxorubicin efficacy via the PI3K/AKT signaling pathway in diffuse large B-cell lymphoma Hanwei Mei et al. Chin Med J (Engl). 2026. Show details Display options Display options Format Abstract PubMed PMID Chin Med J (Engl) Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Chin+Med+J+%28Engl%29%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Chin+Med+J+%28Engl%29%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/40830921/) . 2026 Sep 20;139(18):2808-2820. doi: 10.1097/CM9.0000000000003634. Epub 2025 Aug 20. ### Authors [Hanwei Mei](https://pubmed.ncbi.nlm.nih.gov/?term=Mei+H&cauthor_id=40830921)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-1 "Department of Oncology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-2 "Department of Gastrointestinal Surgery 3, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 301617, China."), [Minghan Qiu](https://pubmed.ncbi.nlm.nih.gov/?term=Qiu+M&cauthor_id=40830921)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-1 "Department of Oncology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-3 "Tianjin Cancer Institute of Integrative Traditional Chinese and Western Medicine, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-4 "School of Medicine, Nankai University, Tianjin 300071, China."), [Ruxue Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+R&cauthor_id=40830921)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-1 "Department of Oncology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-5 "College of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300121, China."), [Teng Song](https://pubmed.ncbi.nlm.nih.gov/?term=Song+T&cauthor_id=40830921)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-1 "Department of Oncology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-4 "School of Medicine, Nankai University, Tianjin 300071, China."), [Zhanhua Gao](https://pubmed.ncbi.nlm.nih.gov/?term=Gao+Z&cauthor_id=40830921)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-4 "School of Medicine, Nankai University, Tianjin 300071, China."), [Qiaonan Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+Q&cauthor_id=40830921)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-4 "School of Medicine, Nankai University, Tianjin 300071, China."), [Yayun Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+Y&cauthor_id=40830921)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-5 "College of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300121, China."), [Jie Hao](https://pubmed.ncbi.nlm.nih.gov/?term=Hao+J&cauthor_id=40830921)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-3 "Tianjin Cancer Institute of Integrative Traditional Chinese and Western Medicine, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-6 "Department of Thyroid and Breast Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China."), [Ming Gao](https://pubmed.ncbi.nlm.nih.gov/?term=Gao+M&cauthor_id=40830921)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-3 "Tianjin Cancer Institute of Integrative Traditional Chinese and Western Medicine, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-6 "Department of Thyroid and Breast Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China."), [Zhen Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+Z&cauthor_id=40830921)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-3 "Tianjin Cancer Institute of Integrative Traditional Chinese and Western Medicine, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China."), [Huaqing Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+H&cauthor_id=40830921)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-1 "Department of Oncology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-3 "Tianjin Cancer Institute of Integrative Traditional Chinese and Western Medicine, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-4 "School of Medicine, Nankai University, Tianjin 300071, China.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/40830921/#short-view-affiliation-5 "College of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300121, China.") ### Affiliations * 1 Department of Oncology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China. * 2 Department of Gastrointestinal Surgery 3, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 301617, China. * 3 Tianjin Cancer Institute of Integrative Traditional Chinese and Western Medicine, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China. * 4 School of Medicine, Nankai University, Tianjin 300071, China. * 5 College of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300121, China. * 6 Department of Thyroid and Breast Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China. * PMID: **40830921** * DOI: [ 10.1097/CM9.0000000000003634 ](https://doi.org/10.1097/cm9.0000000000003634) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Background:** Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma and is characterized by high aggressiveness and rapid growth. Erianin, a natural compound derived from the Chinese herb Dendrobium , has been shown to exhibit anticancer effects in certain types of cancer; however, its role and mech
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