---
title: "EuroNet-PHL-LP1 Trial: Complete Resection Versus Low-Dose Chemotherapy for Pediatric Low-Risk NLPHL"
id: "pubmed-42234940"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42234940"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42234940/"
doi: "10.1182/bloodadvances.2026019765"
published_at: "2026-09-08T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# EuroNet-PHL-LP1 Trial: Complete Resection Versus Low-Dose Chemotherapy for Pediatric Low-Risk NLPHL
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42234940
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42234940/)
- **DOI:** [10.1182/bloodadvances.2026019765](https://doi.org/10.1182%2Fbloodadvances.2026019765)
- **Published At:** 2026-09-08T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The article reports the clinical trial EuroNet-PHL-LP1, comparing **complete resection** with **low-dose chemotherapy** for pediatric low-risk **nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL)**. - Publication details: Blood Advances, 2026 Sep 8; volume 10(17):5865-5873, doi: 10.1182/bloodadvances.2026019765; PMID 42234940; PMCID PMC13544184. - The paper is identified as a Clinical Trial. - A large multi-author, multi-center European collaboration authored the report, with affiliations across pediatric oncology, pathology, radiology, nuclear medicine, and related specialties. - The title indicates the trial compared surgical complete resection against a parenchymal/medical approach of **low-dose chemotherapy** in children classified as having low-risk NLPHL. - The PubMed entry provides bibliographic, authorship, affiliation, and linking information but the PubMed record shown does not include the trial abstract, methods, numerical results, participant counts, or outcomes in the supplied source text. - Specific details on eligibility criteria, randomization, chemotherapy regimen, surgical criteria, primary and secondary endpoints, follow-up duration, efficacy outcomes, toxicity, and statistical analyses were not reported in the provided source excerpt. - For full methods and results, the PMCID link to the free full text (PMC13544184) is provided in the PubMed record; readers should consult the full-text article for complete trial data and conclusions. - Key clinical topics covered by the record: pediatric lymphoma management strategies, treatment de-escalation for low-risk disease, surgical management versus systemic therapy, and European collaborative pediatric oncology trials.
## Clinical Analysis & Structured Key Points
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Hodgkin lymphoma [Ananth Shankar](https://pubmed.ncbi.nlm.nih.gov/?term=Shankar+A&cauthor_id=42234940)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-1 "Children and Young People's Cancer Services, University College London Hospitals NHS Foundation Trust, London, United Kingdom."), [Judith Landman-Parker](https://pubmed.ncbi.nlm.nih.gov/?term=Landman-Parker+J&cauthor_id=42234940)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-2 "Hôpital Armand-Trousseau, Assistance Publique- Hopitaux de Paris, SIRIC CURAMUS, Sorbonne Université, and Paris, France."), [Maurizio Mascarin](https://pubmed.ncbi.nlm.nih.gov/?term=Mascarin+M&cauthor_id=42234940)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-3 "Department Radiation Oncology and Pediatric Radiotherapy Unit, Centro di Riferimento Oncologico IRCCS, Aviano, Italy."), [Andishe Attarbaschi](https://pubmed.ncbi.nlm.nih.gov/?term=Attarbaschi+A&cauthor_id=42234940)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-4 "St. Anna Children's Hospital, Medical University of Vienna, St. Anna Children's Cancer Research Institute, Vienna, Austria."), [Sabah Boudjemaa](https://pubmed.ncbi.nlm.nih.gov/?term=Boudjemaa+S&cauthor_id=42234940)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-5 "Department of Pathology, Armand Trousseau and Pitié Salpêtrière University Hospitals, AP-HP, Sorbonne Université, Paris, France."), [Roberta Burnelli](https://pubmed.ncbi.nlm.nih.gov/?term=Burnelli+R&cauthor_id=42234940)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-6 "Pediatric Hemato-Oncology Unit, Azienda Ospedaliero-Universitaria Sant'Anna, Ferrara, Italy."), [Auke Beishuizen](https://pubmed.ncbi.nlm.nih.gov/?term=Beishuizen+A&cauthor_id=42234940)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-7 "Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.")[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-8 "Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands."), [Michaela Cepelova](https://pubmed.ncbi.nlm.nih.gov/?term=Cepelova+M&cauthor_id=42234940)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-9 "Department of Paediatric Haematology and Oncology, University Hospital Motol, Prague, Czech Republic."), [Francesco Ceppi](https://pubmed.ncbi.nlm.nih.gov/?term=Ceppi+F&cauthor_id=42234940)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-10 "Pediatric Hematology-Oncology Unit, Division of Pediatrics, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland."), [Thomas Georgi](https://pubmed.ncbi.nlm.nih.gov/?term=Georgi+T&cauthor_id=42234940)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-11 "Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany."), [Georgina Hall](https://pubmed.ncbi.nlm.nih.gov/?term=Hall+G&cauthor_id=42234940)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-12 "Paediatric Haematology Oncology Unit, Oxford Children's Hospital, John Radcliffe Hospital, Oxford, United Kingdom."), [Wolfram Klapper](https://pubmed.ncbi.nlm.nih.gov/?term=Klapper+W&cauthor_id=42234940)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-13 "Institute for Pathology, Section Haematopathology and Lymph Node Registry, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany."), [Regine Kluge](https://pubmed.ncbi.nlm.nih.gov/?term=Kluge+R&cauthor_id=42234940)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-14 "St. Georg Hospital, Leipzig, Germany."), [Egesta Lopci](https://pubmed.ncbi.nlm.nih.gov/?term=Lopci+E&cauthor_id=42234940)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-15 "Dipartimento di Diagnostica per Immagini, IRCCS Humanitas Research Hospital, Rozzano, Italy."), [Monika L Metzger](https://pubmed.ncbi.nlm.nih.gov/?term=Metzger+ML&cauthor_id=42234940)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-16 "Section of Leukemia and Lymphoma, Division of Hematology, Oncology, and Blood and Marrow Transplantation, Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ."), [Alan Ramsay](https://pubmed.ncbi.nlm.nih.gov/?term=Ramsay+A&cauthor_id=42234940)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-17 "Moorfields Eye Hospital, London, United Kingdom."), [Jonas Steglich](https://pubmed.ncbi.nlm.nih.gov/?term=Steglich+J&cauthor_id=42234940)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-18 "Department of Diagnostic and Interventional Radiology, Heart Center Leipzig, Leipzig, Germany."), [Dietrich Stoevesandt](https://pubmed.ncbi.nlm.nih.gov/?term=Stoevesandt+D&cauthor_id=42234940)[ 19 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-19 "Department of Diagnostic and Interventional Radiology, University Hospital Halle, Halle, Germany."), [Lars Kurch](https://pubmed.ncbi.nlm.nih.gov/?term=Kurch+L&cauthor_id=42234940)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-11 "Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany."), [Dieter Körholz](https://pubmed.ncbi.nlm.nih.gov/?term=K%C3%B6rholz+D&cauthor_id=42234940)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-20 "Department of Paediatric Hematology, Oncology, and Immunodeficiency, Justus Liebig University Giessen, Giessen, Germany."), [Dirk Hasenclever](https://pubmed.ncbi.nlm.nih.gov/?term=Hasenclever+D&cauthor_id=42234940)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-21 "Institute for Medical Informatics, Statistics, and Epidemiology, University of Leipzig, Leipzig, Germany."), [Christine Mauz-Körholz](https://pubmed.ncbi.nlm.nih.gov/?term=Mauz-K%C3%B6rholz+C&cauthor_id=42234940)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-20 "Department of Paediatric Hematology, Oncology, and Immunodeficiency, Justus Liebig University Giessen, Giessen, Germany.")[ 22 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#full-view-affiliation-22 "Medical Faculty, Martin Luther University Halle-Wittenberg, Halle, Germany.") Affiliations Expand ### Affiliations * 1 Children and Young People's Cancer Services, University College London Hospitals NHS Foundation Trust, London, United Kingdom. * 2 Hôpital Armand-Trousseau, Assistance Publique- Hopitaux de Paris, SIRIC CURAMUS, Sorbonne Université, and Paris, France. * 3 Department Radiation Oncology and Pediatric Radiotherapy Unit, Centro di Riferimento Oncologico IRCCS, Aviano, Italy. * 4 St. Anna Children's Hospital, Medical University of Vienna, St. Anna Children's Cancer Research Institute, Vienna, Austria. * 5 Department of Pathology, Armand Trousseau and Pitié Salpêtrière University Hospitals, AP-HP, Sorbonne Université, Paris, France. * 6 Pediatric Hemato-Oncology Unit, Azienda Ospedaliero-Universitaria Sant'Anna, Ferrara, Italy. * 7 Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. * 8 Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands. * 9 Department of Paediatric Haematology and Oncology, University Hospital Motol, Prague, Czech Republic. * 10 Pediatric Hematology-Oncology Unit, Division of Pediatrics, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. * 11 Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany. * 12 Paediatric Haematology Oncology Unit, Oxford Children's Hospital, John Radcliffe Hospital, Oxford, United Kingdom. * 13 Institute for Pathology, Section Haematopathology and Lymph Node Registry, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany. * 14 St. Georg Hospital, Leipzig, Germany. * 15 Dipartimento di Diagnostica per Immagini, IRCCS Humanitas Research Hospital, Rozzano, Italy. * 16 Section of Leukemia and Lymphoma, Division of Hematology, Oncology, and Blood and Marrow Transplantation, Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ. * 17 Moorfields Eye Hospital, London, United Kingdom. * 18 Department of Diagnostic and Interventional Radiology, Heart Center Leipzig, Leipzig, Germany. * 19 Department of Diagnostic and Interventional Radiology, University Hospital Halle, Halle, Germany. * 20 Department of Paediatric Hematology, Oncology, and Immunodeficiency, Justus Liebig University Giessen, Giessen, Germany. * 21 Institute for Medical Informatics, Statistics, and Epidemiology, University of Leipzig, Leipzig, Germany. * 22 Medical Faculty, Martin Luther University Halle-Wittenberg, Halle, Germany. * PMID: **42234940** * PMCID: [ PMC13544184 ](https://pmc.ncbi.nlm.nih.gov/articles/PMC13544184/) * DOI: [ 10.1182/bloodadvances.2026019765 ](https://doi.org/10.1182/bloodadvances.2026019765) Item in Clipboard Clinical Trial # EuroNet-PHL-LP1: complete resection or low-dose chemotherapy for pediatric low-risk nodular lymphocyte-predominant Hodgkin lymphoma Ananth Shankar et al. Blood Adv. 2026. Show details Display options Display options Format Abstract PubMed PMID Blood Adv Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Blood+Adv%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Blood+Adv%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42234940/) . 2026 Sep 8;10(17):5865-5873. doi: 10.1182/bloodadvances.2026019765. ### Authors [Ananth Shankar](https://pubmed.ncbi.nlm.nih.gov/?term=Shankar+A&cauthor_id=42234940)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#short-view-affiliation-1 "Children and Young People's Cancer Services, University College London Hospitals NHS Foundation Trust, London, United Kingdom."), [Judith Landman-Parker](https://pubmed.ncbi.nlm.nih.gov/?term=Landman-Parker+J&cauthor_id=42234940)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#short-view-affiliation-2 "Hôpital Armand-Trousseau, Assistance Publique- Hopitaux de Paris, SIRIC CURAMUS, Sorbonne Université, and Paris, France."), [Maurizio Mascarin](https://pubmed.ncbi.nlm.nih.gov/?term=Mascarin+M&cauthor_id=42234940)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#short-view-affiliation-3 "Department Radiation Oncology and Pediatric Radiotherapy Unit, Centro di Riferimento Oncologico IRCCS, Aviano, Italy."), [Andishe Attarbaschi](https://pubmed.ncbi.nlm.nih.gov/?term=Attarbaschi+A&cauthor_id=42234940)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#short-view-affiliation-4 "St. Anna Children's Hospital, Medical University of Vienna, St. Anna Children's Cancer Research Institute, Vienna, Austria."), [Sabah Boudjemaa](https://pubmed.ncbi.nlm.nih.gov/?term=Boudjemaa+S&cauthor_id=42234940)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#short-view-affiliation-5 "Department of Pathology, Armand Trousseau and Pitié Salpêtrière University Hospitals, AP-HP, Sorbonne Université, Paris, France."), [Roberta Burnelli](https://pubmed.ncbi.nlm.nih.gov/?term=Burnelli+R&cauthor_id=42234940)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#short-view-affiliation-6 "Pediatric Hemato-Oncology Unit, Azienda Ospedaliero-Universitaria Sant'Anna, Ferrara, Italy."), [Auke Beishuizen](https://pubmed.ncbi.nlm.nih.gov/?term=Beishuizen+A&cauthor_id=42234940)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#short-view-affiliation-7 "Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.")[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#short-view-affiliation-8 "Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands."), [Michaela Cepelova](https://pubmed.ncbi.nlm.nih.gov/?term=Cepelova+M&cauthor_id=42234940)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#short-view-affiliation-9 "Department of Paediatric Haematology and Oncology, University Hospital Motol, Prague, Czech Republic."), [Francesco Ceppi](https://pubmed.ncbi.nlm.nih.gov/?term=Ceppi+F&cauthor_id=42234940)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#short-view-affiliation-10 "Pediatric Hematology-Oncology Unit, Division of Pediatrics, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland."), [Thomas Georgi](https://pubmed.ncbi.nlm.nih.gov/?term=Georgi+T&cauthor_id=42234940)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#short-view-affiliation-11 "Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany."), [Georgina Hall](https://pubmed.ncbi.nlm.nih.gov/?term=Hall+G&cauthor_id=42234940)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42234940/#short-view-affiliation-12 "Paediatric Haematology On
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