---
title: "Fluorinated Nanohybrid Micelles with Lutetium-177 and Gold for Potentiated Internal Radiotherapy"
id: "pubmed-42476272"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42476272"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42476272/"
doi: "10.1016/j.ijpharm.2026.127219"
published_at: "2026-09-05T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Fluorinated Nanohybrid Micelles with Lutetium-177 and Gold for Potentiated Internal Radiotherapy
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42476272
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42476272/)
- **DOI:** [10.1016/j.ijpharm.2026.127219](https://doi.org/10.1016%2Fj.ijpharm.2026.127219)
- **Published At:** 2026-09-05T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The study reports development of a **micellar nanocarrier** assembled from fluorinated amphiphiles and engineered to carry three functional components: the therapeutic radionuclide **lutetium-177 (177Lu)**, **gold nanoparticles (AuNPs)** for radiosensitization, and molecular oxygen to address **tumor hypoxia**. - The platform is described as a multifunctional **nanohybrid micelle** intended for internal radiotherapy that integrates radiation emission, dose enhancement via high-Z material, and local oxygen delivery. - In vitro evaluation used B16F10 melanoma cells; micelles containing both AuNPs and [177Lu] demonstrated significantly greater **radiocytotoxicity** than micelles with [177Lu] alone, indicating a synergistic radiosensitizing effect of gold. - In vivo testing involved mice bearing subcutaneous B16F10 tumors. A single **intratumoral injection** of AuNP@[177Lu]Lu-micelles produced sustained tumor growth control in this radioresistant model. - Quantitatively, AuNP@[177Lu]Lu-micelles achieved approximately **78% inhibition of tumor growth at day 7** post-treatment in the B16F10 model. - The authors highlight the potential therapeutic value of combining **177Lu**, **gold-mediated dose enhancement**, and oxygen delivery within a single nanoplatform for improved radiotherapy outcomes. - The abstract does not report specific experimental parameters such as micelle size distribution, gold nanoparticle size or loading, activity of 177Lu, oxygen payload metrics, detailed dosing regimen, or comprehensive toxicity and biodistribution data; those details were not reported in the PubMed abstract. - Keywords listed by the authors include: Gold nanoparticles; Lutetium-177; Micelles; Nanomedicine; Radiotherapy. The authors declared no competing interests.
## Clinical Analysis & Structured Key Points
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Epub 2026 Jul 20. # Fluorinated nanohybrid micelles carrying 177Lu, gold, and oxygen for potentiated internal radiotherapy [Mathilde Ponchelle](https://pubmed.ncbi.nlm.nih.gov/?term=Ponchelle+M&cauthor_id=42476272)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42476272/#full-view-affiliation-1 "Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé \(DMTS\), SCBM, 91191 Gif-sur-Yvette, France; NOMATEN Centre of Excellence, National Centre for Nuclear Research, Otwock, Poland. Electronic address: mathilde.ponchelle76@gmail.com."), [Agnieszka Kulesza](https://pubmed.ncbi.nlm.nih.gov/?term=Kulesza+A&cauthor_id=42476272)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42476272/#full-view-affiliation-2 "Radioisotope Centre POLATOM, National Centre for Nuclear Research, Otwock, Poland. Electronic address: agnieszka.kulesza@polatom.pl."), [Marcin Zieliński](https://pubmed.ncbi.nlm.nih.gov/?term=Zieli%C5%84ski+M&cauthor_id=42476272)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42476272/#full-view-affiliation-3 "NOMATEN Centre of Excellence, National Centre for Nuclear Research, Otwock, Poland. Electronic address: marcin.zielinski@ncbj.gov.pl."), [Izabela Cieszykowska](https://pubmed.ncbi.nlm.nih.gov/?term=Cieszykowska+I&cauthor_id=42476272)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42476272/#full-view-affiliation-4 "Radioisotope Centre POLATOM, National Centre for Nuclear Research, Otwock, Poland. Electronic address: izabela.cieszykowska@polatom.pl."), [Gaspard Huber](https://pubmed.ncbi.nlm.nih.gov/?term=Huber+G&cauthor_id=42476272)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42476272/#full-view-affiliation-5 "Université Paris-Saclay, CEA, CNRS, NIMBE, 91191 Gif-sur-Yvette, France. Electronic address: gaspard.huber@cea.fr."), [Edmond Gravel](https://pubmed.ncbi.nlm.nih.gov/?term=Gravel+E&cauthor_id=42476272)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42476272/#full-view-affiliation-6 "Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé \(DMTS\), SCBM, 91191 Gif-sur-Yvette, France. Electronic address: edmond.gravel@cea.fr."), [Marek Pruszyński](https://pubmed.ncbi.nlm.nih.gov/?term=Pruszy%C5%84ski+M&cauthor_id=42476272)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42476272/#full-view-affiliation-7 "NOMATEN Centre of Excellence, National Centre for Nuclear Research, Otwock, Poland; Institute of Nuclear Chemistry and Technology, Warsaw, Poland. Electronic address: marek.pruszynski@ncbj.gov.pl."), [Eric Doris](https://pubmed.ncbi.nlm.nih.gov/?term=Doris+E&cauthor_id=42476272)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42476272/#full-view-affiliation-8 "Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé \(DMTS\), SCBM, 91191 Gif-sur-Yvette, France. Electronic address: eric.doris@cea.fr.") Affiliations Expand ### Affiliations * 1 Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SCBM, 91191 Gif-sur-Yvette, France; NOMATEN Centre of Excellence, National Centre for Nuclear Research, Otwock, Poland. Electronic address: mathilde.ponchelle76@gmail.com. * 2 Radioisotope Centre POLATOM, National Centre for Nuclear Research, Otwock, Poland. Electronic address: agnieszka.kulesza@polatom.pl. * 3 NOMATEN Centre of Excellence, National Centre for Nuclear Research, Otwock, Poland. Electronic address: marcin.zielinski@ncbj.gov.pl. * 4 Radioisotope Centre POLATOM, National Centre for Nuclear Research, Otwock, Poland. Electronic address: izabela.cieszykowska@polatom.pl. * 5 Université Paris-Saclay, CEA, CNRS, NIMBE, 91191 Gif-sur-Yvette, France. Electronic address: gaspard.huber@cea.fr. * 6 Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SCBM, 91191 Gif-sur-Yvette, France. Electronic address: edmond.gravel@cea.fr. * 7 NOMATEN Centre of Excellence, National Centre for Nuclear Research, Otwock, Poland; Institute of Nuclear Chemistry and Technology, Warsaw, Poland. Electronic address: marek.pruszynski@ncbj.gov.pl. * 8 Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SCBM, 91191 Gif-sur-Yvette, France. Electronic address: eric.doris@cea.fr. * PMID: **42476272** * DOI: [ 10.1016/j.ijpharm.2026.127219 ](https://doi.org/10.1016/j.ijpharm.2026.127219) Free article Item in Clipboard # Fluorinated nanohybrid micelles carrying 177Lu, gold, and oxygen for potentiated internal radiotherapy Mathilde Ponchelle et al. Int J Pharm. 2026. Free article Show details Display options Display options Format Abstract PubMed PMID Int J Pharm Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Int+J+Pharm%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Int+J+Pharm%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42476272/) . 2026 Sep 5:702:127219. doi: 10.1016/j.ijpharm.2026.127219. Epub 2026 Jul 20. ### Authors [Mathilde Ponchelle](https://pubmed.ncbi.nlm.nih.gov/?term=Ponchelle+M&cauthor_id=42476272)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42476272/#short-view-affiliation-1 "Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé \(DMTS\), SCBM, 91191 Gif-sur-Yvette, France; NOMATEN Centre of Excellence, National Centre for Nuclear Research, Otwock, Poland. Electronic address: mathilde.ponchelle76@gmail.com."), [Agnieszka Kulesza](https://pubmed.ncbi.nlm.nih.gov/?term=Kulesza+A&cauthor_id=42476272)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42476272/#short-view-affiliation-2 "Radioisotope Centre POLATOM, National Centre for Nuclear Research, Otwock, Poland. Electronic address: agnieszka.kulesza@polatom.pl."), [Marcin Zieliński](https://pubmed.ncbi.nlm.nih.gov/?term=Zieli%C5%84ski+M&cauthor_id=42476272)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42476272/#short-view-affiliation-3 "NOMATEN Centre of Excellence, National Centre for Nuclear Research, Otwock, Poland. Electronic address: marcin.zielinski@ncbj.gov.pl."), [Izabela Cieszykowska](https://pubmed.ncbi.nlm.nih.gov/?term=Cieszykowska+I&cauthor_id=42476272)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42476272/#short-view-affiliation-4 "Radioisotope Centre POLATOM, National Centre for Nuclear Research, Otwock, Poland. Electronic address: izabela.cieszykowska@polatom.pl."), [Gaspard Huber](https://pubmed.ncbi.nlm.nih.gov/?term=Huber+G&cauthor_id=42476272)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42476272/#short-view-affiliation-5 "Université Paris-Saclay, CEA, CNRS, NIMBE, 91191 Gif-sur-Yvette, France. Electronic address: gaspard.huber@cea.fr."), [Edmond Gravel](https://pubmed.ncbi.nlm.nih.gov/?term=Gravel+E&cauthor_id=42476272)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42476272/#short-view-affiliation-6 "Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé \(DMTS\), SCBM, 91191 Gif-sur-Yvette, France. Electronic address: edmond.gravel@cea.fr."), [Marek Pruszyński](https://pubmed.ncbi.nlm.nih.gov/?term=Pruszy%C5%84ski+M&cauthor_id=42476272)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42476272/#short-view-affiliation-7 "NOMATEN Centre of Excellence, National Centre for Nuclear Research, Otwock, Poland; Institute of Nuclear Chemistry and Technology, Warsaw, Poland. Electronic address: marek.pruszynski@ncbj.gov.pl."), [Eric Doris](https://pubmed.ncbi.nlm.nih.gov/?term=Doris+E&cauthor_id=42476272)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42476272/#short-view-affiliation-8 "Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé \(DMTS\), SCBM, 91191 Gif-sur-Yvette, France. Electronic address: eric.doris@cea.fr.") ### Affiliations * 1 Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SCBM, 91191 Gif-sur-Yvette, France; NOMATEN Centre of Excellence, National Centre for Nuclear Research, Otwock, Poland. Electronic address: mathilde.ponchelle76@gmail.com. * 2 Radioisotope Centre POLATOM, National Centre for Nuclear Research, Otwock, Poland. Electronic address: agnieszka.kulesza@polatom.pl. * 3 NOMATEN Centre of Excellence, National Centre for Nuclear Research, Otwock, Poland. Electronic address: marcin.zielinski@ncbj.gov.pl. * 4 Radioisotope Centre POLATOM, National Centre for Nuclear Research, Otwock, Poland. Electronic address: izabela.cieszykowska@polatom.pl. * 5 Université Paris-Saclay, CEA, CNRS, NIMBE, 91191 Gif-sur-Yvette, France. Electronic address: gaspard.huber@cea.fr. * 6 Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SCBM, 91191 Gif-sur-Yvette, France. Electronic address: edmond.gravel@cea.fr. * 7 NOMATEN Centre of Excellence, National Centre for Nuclear Research, Otwock, Poland; Institute of Nuclear Chemistry and Technology, Warsaw, Poland. Electronic address: marek.pruszynski@ncbj.gov.pl. * 8 Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SCBM, 91191 Gif-sur-Yvette, France. Electronic address: eric.doris@cea.fr. * PMID: **42476272** * DOI: [ 10.1016/j.ijpharm.2026.127219 ](https://doi.org/10.1016/j.ijpharm.2026.127219) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract We report the development of a micellar nanocarrier designed for internal radiotherapy applications. Fluorinated amphiphiles were self-assembled into stable micelles and engineered as multifunctional nanoplatforms by incorporating gold nanoparticles, molecular oxygen, and the therapeutic radionuclide lutetium-177. This integrated design combines radiotherapeutic emission from 177Lu, radiosensitization through gold-mediated dose enhancement, and local oxygen delivery to mitigate tumor hypoxia and improve radiation response. The resulting nanohybrid micelles were evaluated both in vitro and in vivo as radiation nanomedicines. With B16F10 melanoma cells, AuNP@[177Lu]Lu-micelles exhibited significantly enhanced radiocytotoxicity compared to [177Lu]Lu-micelles without gold, highlighting the synergistic effect of nanoparticle-mediated radiosensitization. In vivo, a single intratumoral injection in mice bearing subcutaneous B16F10 tumors enabled sustained tumor growth control. Notably, despite the intrinsic radioresistance of the B16F10 model, AuNP@[177Lu]Lu-micelles achieved approximately 78% inhibition of tumor growth at day 7 post-treatment, underscoring the therapeutic potential of this multifunctional system. **Keywords:** Gold nanoparticles; Lutetium-177; Micelles; Nanomedicine; Radiotherapy. Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ## Similar articles * [ Radiation Nanomedicine for EGFR-Positive Breast Cancer: Panitumumab-Modified Gold Nanoparticles Complexed to the β-Particle-Emitter, (177)Lu. ](https://pubmed.ncbi.nlm.nih.gov/26402157/) Yook S, Cai Z, Lu Y, Winnik MA, Pignol JP, Reilly RM.Yook S, et al.Mol Pharm. 2015 Nov 2;12(11):3963-72. doi: 10.1021/acs.molpharmaceut.5b00425. Epub 2015 Oct 7.Mol Pharm. 2015.PMID: 26402157 * [ Local Radiation Treatment of HER2-Positive Breast Cancer Using Trastuzumab-Modified Gold Nanoparticles Labeled with 177Lu. ](https://pubmed.ncbi.nlm.nih.gov/27987070/) Cai Z, Yook S, Lu Y, Bergstrom D, Winnik MA, Pignol JP, Reilly RM.Cai Z, et al.Pharm Res. 2017 Mar;34(3):579-590. doi: 10.1007/s11095-016-2082-2. Epub 2016 Dec 16.Pharm Res. 2017.PMID: 27987070 * [ Intratumorally Injected 177Lu-Labeled Gold Nanoparticles: Gold Nanoseed Brachytherapy with Application for Neoadjuvant Treatment of Locally Advanced Breast Cancer. ](https://pubmed.ncbi.nlm.nih.gov/26848176/) Yook S, Cai Z, Lu Y, Winnik MA, Pignol JP, Reilly RM.Yook S, et al.J Nucl Med. 2016 Jun;57(6):936-42. doi: 10.2967/jnumed.115.168906. Epub 2016 Feb 4.J Nucl Med. 2016.PMID: 26848176 * [ Radiation nanomedicines for cancer treatment: a scientific journey and view of the landscape. ](https://pubmed.ncbi.nlm.nih.gov/38703297/) Reilly RM, Georgiou CJ, Brown MK, Cai Z.Reilly RM, et al.EJNMMI Radiopharm Chem. 2024 May 4;9(1):37. doi: 10.1186/s41181-024-00266-y.EJNMMI Radiopharm Chem. 2024.PMID: 38703297Free PMC article.Review. * [ Nanoparticle-Mediated Radiosensitization in Breast Cancer: A Systematic Review of Preclinical Evidence and Translational Challenges. ](https://pubmed.ncbi.nlm.nih.gov/42511860/) Lunca S, Morarasu S, Dimofte GM.Lunca S, et al.Int J Mol Sci. 2026 Jul 22;27(14):6522. doi: 10.3390/ijms27146522.Int J Mol Sci. 2026.PMID: 42511860Free PMC article. 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