---
title: "Functional genomics screen identifies mechanisms linking B-cell differentiation to inherited child"
id: "biorxiv-22-a-functional-genomics-screen-of-human-b-cell-differentiation-reveals-convergent"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-22-a-functional-genomics-screen-of-human-b-cell-differentiation-reveals-convergent"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.08.06.743305v1?rss=1"
published_at: "2026-08-07T12:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Functional genomics screen identifies mechanisms linking B-cell differentiation to inherited child
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-22-a-functional-genomics-screen-of-human-b-cell-differentiation-reveals-convergent
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.08.06.743305v1?rss=1)
- **Published At:** 2026-08-07T12:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- The source is a preprint titled “A functional genomics screen of human B-cell differentiation reveals convergent mechanisms of inherited childhood leukemia predisposition.” - The article is hosted on bioRxiv and has DOI https://doi.org/10.64898/2026.08.06.743305. - Authorship is led by Lara Wahlster and includes a multi-institutional team (Boston Children's Hospital, University of Southern California, Whitehead Institute, HHMI); Vijay G. Sankaran is listed for correspondence. - The title indicates the study performed a **functional genomics screen** focused on human **B-cell differentiation** and linked findings to convergent mechanisms of inherited **childhood leukemia predisposition**. - The source file available on bioRxiv includes an abstract link, article info, metrics, supplementary material, and a preview PDF, but the provided SOURCE JINA BODY did not include the abstract text or main manuscript content. - Because the SOURCE JINA BODY lacked the study methods, experimental results, specific genes or pathways, cohort descriptions, and conclusions, those details are not reported here and cannot be summarized or inferred. - The article is explicitly a preprint and has not been peer reviewed; the source page provides the standard bioRxiv notice about preprint status. - Contact for correspondence is sankaran@broadinstitute.org; supplementary materials and full PDF are available at the bioRxiv record but were not reproduced in the provided source content. - Any interpretation of experimental findings, statistical outcomes, or clinical implications beyond what is present in the provided source would require consulting the full preprint; such specifics were not reported in the SOURCE JINA BODY.
## Clinical Analysis & Structured Key Points
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Sankaran doi: https://doi.org/10.64898/2026.08.06.743305 This article is a preprint and has not been certified by peer review [[what does this mean?](https://www.biorxiv.org/about/FAQ#unrefereed)]. Lara Wahlster 1 Boston Children's Hospital; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Lara%2BWahlster%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Wahlster%20L&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ALara%2BWahlster%2B) * [ORCID record for Lara Wahlster](http://orcid.org/0000-0001-8409-7580 "Open in new tab") Anna-Lena Neehus 1 Boston Children's Hospital; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Anna-Lena%2BNeehus%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Neehus%20A&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AAnna-Lena%2BNeehus%2B) * [ORCID record for Anna-Lena Neehus](http://orcid.org/0000-0002-8573-6820 "Open in new tab") Andrew J Lee 1 Boston Children's Hospital; 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Sankaran](http://orcid.org/0000-0003-0044-443X "Open in new tab") * For correspondence: sankaran@broadinstitute.org * [Abstract](https://www.biorxiv.org/content/10.64898/2026.08.06.743305v1)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_art/node:5686962/1) * [Info/History](https://www.biorxiv.org/content/10.64898/2026.08.06.743305v1.article-info)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_info/node:5686962/1) * [Metrics](https://www.biorxiv.org/content/10.64898/2026.08.06.743305v1.article-metrics)[](https://www.biorxiv.org/panels_ajax_tab/article_tab_metrics/node:5686962/1) * [Supplementary material](https://www.biorxiv.org/content/10.64898/2026.08.06.743305v1.supplementary-material)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_data/node:5686962/1) * [ Preview PDF](https://www.biorxiv.org/content/10.64898/2026.08.06.743305v1.full.pdf+html)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_pdf/node:5686962/1) ![Loading](https://www.biorxiv.org/sites/all/modules/contrib/panels_ajax_tab/images
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