---
title: "JCOG2405 (ELDER-WEEKLY): Phase III trial of weekly cisplatin chemoradiotherapy versus radiotherapy"
id: "pubmed-42341154"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42341154"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42341154/"
doi: "10.1093/jjco/hyag097"
published_at: "2026-10-08T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# JCOG2405 (ELDER-WEEKLY): Phase III trial of weekly cisplatin chemoradiotherapy versus radiotherapy
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42341154
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42341154/)
- **DOI:** [10.1093/jjco/hyag097](https://doi.org/10.1093%2Fjjco%2Fhyag097)
- **Published At:** 2026-10-08T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The article reports a multicenter, randomized **phase III** clinical trial named **JCOG2405 (ELDER-WEEKLY)** evaluating **weekly cisplatin** combined with **radiotherapy** versus **radiotherapy** alone in elderly patients with head and neck squamous cell carcinoma (HNSCC) who are judged unfit for high‑dose cisplatin. - The trial is reported as a Clinical Trial in Jpn J Clin Oncol (2026 Oct 8;56[10]:1272–1279) with PMID 42341154 and DOI 10.1093/jjco/hyag097. - The publication lists multiple Japanese investigators and institutions, and identifies the Head and Neck Cancer Study Group and the Radiation Therapy Study Group of the Japan Clinical Oncology Group as corporate authors. - The source provides title, authors, journal citation, DOI, PMID and affiliations, but the abstract text or trial results, including primary and secondary endpoints, eligibility criteria, treatment schedules, sample size, outcomes, safety data, and statistical findings, are not reported in the content provided. - Because the excerpt contains bibliographic and author information but not the trial data or conclusions, key methodological and outcome details are unavailable from this source and are explicitly not reported here.
## Clinical Analysis & Structured Key Points
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* [ LinkOut - more resources ](https://pubmed.ncbi.nlm.nih.gov/42341154/#linkout) Title & authors Abstract Similar articles Cited by Publication types MeSH terms Substances Related information Grants and funding LinkOut - more resources Clinical Trial Jpn J Clin Oncol Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Jpn+J+Clin+Oncol%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Jpn+J+Clin+Oncol%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42341154/) . 2026 Oct 8;56(10):1272-1279. doi: 10.1093/jjco/hyag097. # A multicenter randomized phase III trial of weekly cisplatin chemoradiotherapy versus radiotherapy in elderly patients with head and neck squamous cell carcinoma unfit for high-dose cisplatin: JCOG2405 (ELDER-WEEKLY) [Kota Kawabata](https://pubmed.ncbi.nlm.nih.gov/?term=Kawabata+K&cauthor_id=42341154)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#full-view-affiliation-1 "Japan Clinical Oncology Group Data Center/Operations Office, National Cancer Center Hospital, Tokyo, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan."), [Koichi Yasuda](https://pubmed.ncbi.nlm.nih.gov/?term=Yasuda+K&cauthor_id=42341154)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#full-view-affiliation-2 "Department of Radiation Oncology, Hokkaido University Hospital, North-15 West-7, Sapporo, Hokkaido 060-8638, Japan."), [Satoaki Nakamura](https://pubmed.ncbi.nlm.nih.gov/?term=Nakamura+S&cauthor_id=42341154)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#full-view-affiliation-3 "Division of Radiation Oncology, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka 573-1010, Japan."), [Yoshitaka Honma](https://pubmed.ncbi.nlm.nih.gov/?term=Honma+Y&cauthor_id=42341154)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#full-view-affiliation-4 "Department of Head and Neck, Esophageal Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan."), [Ryusuke Suzuki](https://pubmed.ncbi.nlm.nih.gov/?term=Suzuki+R&cauthor_id=42341154)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#full-view-affiliation-5 "Department of Medical Physics, Hokkaido University Hospital, North-15 West-7, Sapporo, Hokkaido 060-8638, Japan."), [Yuri Ueda](https://pubmed.ncbi.nlm.nih.gov/?term=Ueda+Y&cauthor_id=42341154)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#full-view-affiliation-6 "Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan."), [Satoshi Saito](https://pubmed.ncbi.nlm.nih.gov/?term=Saito+S&cauthor_id=42341154)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#full-view-affiliation-7 "Department of Radiation Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan."), [Kazuto Matsuura](https://pubmed.ncbi.nlm.nih.gov/?term=Matsuura+K&cauthor_id=42341154)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#full-view-affiliation-8 "Department of Head and Neck Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan."), [Nobuhiro Hanai](https://pubmed.ncbi.nlm.nih.gov/?term=Hanai+N&cauthor_id=42341154)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#full-view-affiliation-9 "Department of Head and Neck Surgery, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, Japan."), [Naoki Nakamura](https://pubmed.ncbi.nlm.nih.gov/?term=Nakamura+N&cauthor_id=42341154)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#full-view-affiliation-10 "Department of Radiation Oncology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511, Japan."), [Junki Mizusawa](https://pubmed.ncbi.nlm.nih.gov/?term=Mizusawa+J&cauthor_id=42341154)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#full-view-affiliation-1 "Japan Clinical Oncology Group Data Center/Operations Office, National Cancer Center Hospital, Tokyo, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan."), [Keita Sasaki](https://pubmed.ncbi.nlm.nih.gov/?term=Sasaki+K&cauthor_id=42341154)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#full-view-affiliation-1 "Japan Clinical Oncology Group Data Center/Operations Office, National Cancer Center Hospital, Tokyo, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan."), [Haruhiko Fukuda](https://pubmed.ncbi.nlm.nih.gov/?term=Fukuda+H&cauthor_id=42341154)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#full-view-affiliation-1 "Japan Clinical Oncology Group Data Center/Operations Office, National Cancer Center Hospital, Tokyo, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan."), [Takashi Mizowaki](https://pubmed.ncbi.nlm.nih.gov/?term=Mizowaki+T&cauthor_id=42341154)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#full-view-affiliation-11 "Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."), [Naomi Kiyota](https://pubmed.ncbi.nlm.nih.gov/?term=Kiyota+N&cauthor_id=42341154)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#full-view-affiliation-12 "Department of Medical Oncology and Hematology, Cancer Center, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan."); [Head and Neck Cancer Study Group and the Radiation Therapy Study Group of the Japan Clinical Oncology Group](https://pubmed.ncbi.nlm.nih.gov/?term=Head+and+Neck+Cancer+Study+Group+and+the+Radiation+Therapy+Study+Group+of+the+Japan+Clinical+Oncology+Group%5BCorporate+Author%5D) Affiliations Expand ### Affiliations * 1 Japan Clinical Oncology Group Data Center/Operations Office, National Cancer Center Hospital, Tokyo, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. * 2 Department of Radiation Oncology, Hokkaido University Hospital, North-15 West-7, Sapporo, Hokkaido 060-8638, Japan. * 3 Division of Radiation Oncology, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka 573-1010, Japan. * 4 Department of Head and Neck, Esophageal Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. * 5 Department of Medical Physics, Hokkaido University Hospital, North-15 West-7, Sapporo, Hokkaido 060-8638, Japan. * 6 Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. * 7 Department of Radiation Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan. * 8 Department of Head and Neck Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan. * 9 Department of Head and Neck Surgery, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, Japan. * 10 Department of Radiation Oncology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511, Japan. * 11 Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan. * 12 Department of Medical Oncology and Hematology, Cancer Center, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan. * PMID: **42341154** * DOI: [ 10.1093/jjco/hyag097 ](https://doi.org/10.1093/jjco/hyag097) Free article Item in Clipboard Clinical Trial # A multicenter randomized phase III trial of weekly cisplatin chemoradiotherapy versus radiotherapy in elderly patients with head and neck squamous cell carcinoma unfit for high-dose cisplatin: JCOG2405 (ELDER-WEEKLY) Kota Kawabata et al. Jpn J Clin Oncol. 2026. Free article Show details Display options Display options Format Abstract PubMed PMID Jpn J Clin Oncol Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Jpn+J+Clin+Oncol%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Jpn+J+Clin+Oncol%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42341154/) . 2026 Oct 8;56(10):1272-1279. doi: 10.1093/jjco/hyag097. ### Authors [Kota Kawabata](https://pubmed.ncbi.nlm.nih.gov/?term=Kawabata+K&cauthor_id=42341154)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#short-view-affiliation-1 "Japan Clinical Oncology Group Data Center/Operations Office, National Cancer Center Hospital, Tokyo, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan."), [Koichi Yasuda](https://pubmed.ncbi.nlm.nih.gov/?term=Yasuda+K&cauthor_id=42341154)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#short-view-affiliation-2 "Department of Radiation Oncology, Hokkaido University Hospital, North-15 West-7, Sapporo, Hokkaido 060-8638, Japan."), [Satoaki Nakamura](https://pubmed.ncbi.nlm.nih.gov/?term=Nakamura+S&cauthor_id=42341154)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#short-view-affiliation-3 "Division of Radiation Oncology, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka 573-1010, Japan."), [Yoshitaka Honma](https://pubmed.ncbi.nlm.nih.gov/?term=Honma+Y&cauthor_id=42341154)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#short-view-affiliation-4 "Department of Head and Neck, Esophageal Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan."), [Ryusuke Suzuki](https://pubmed.ncbi.nlm.nih.gov/?term=Suzuki+R&cauthor_id=42341154)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#short-view-affiliation-5 "Department of Medical Physics, Hokkaido University Hospital, North-15 West-7, Sapporo, Hokkaido 060-8638, Japan."), [Yuri Ueda](https://pubmed.ncbi.nlm.nih.gov/?term=Ueda+Y&cauthor_id=42341154)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#short-view-affiliation-6 "Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan."), [Satoshi Saito](https://pubmed.ncbi.nlm.nih.gov/?term=Saito+S&cauthor_id=42341154)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#short-view-affiliation-7 "Department of Radiation Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan."), [Kazuto Matsuura](https://pubmed.ncbi.nlm.nih.gov/?term=Matsuura+K&cauthor_id=42341154)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#short-view-affiliation-8 "Department of Head and Neck Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan."), [Nobuhiro Hanai](https://pubmed.ncbi.nlm.nih.gov/?term=Hanai+N&cauthor_id=42341154)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#short-view-affiliation-9 "Department of Head and Neck Surgery, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, Japan."), [Naoki Nakamura](https://pubmed.ncbi.nlm.nih.gov/?term=Nakamura+N&cauthor_id=42341154)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#short-view-affiliation-10 "Department of Radiation Oncology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511, Japan."), [Junki Mizusawa](https://pubmed.ncbi.nlm.nih.gov/?term=Mizusawa+J&cauthor_id=42341154)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#short-view-affiliation-1 "Japan Clinical Oncology Group Data Center/Operations Office, National Cancer Center Hospital, Tokyo, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan."), [Keita Sasaki](https://pubmed.ncbi.nlm.nih.gov/?term=Sasaki+K&cauthor_id=42341154)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#short-view-affiliation-1 "Japan Clinical Oncology Group Data Center/Operations Office, National Cancer Center Hospital, Tokyo, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan."), [Haruhiko Fukuda](https://pubmed.ncbi.nlm.nih.gov/?term=Fukuda+H&cauthor_id=42341154)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#short-view-affiliation-1 "Japan Clinical Oncology Group Data Center/Operations Office, National Cancer Center Hospital, Tokyo, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan."), [Takashi Mizowaki](https://pubmed.ncbi.nlm.nih.gov/?term=Mizowaki+T&cauthor_id=42341154)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#short-view-affiliation-11 "Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."), [Naomi Kiyota](https://pubmed.ncbi.nlm.nih.gov/?term=Kiyota+N&cauthor_id=42341154)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42341154/#short-view-affiliation-12 "Department of Medical Oncology and Hematology, Cancer Center, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan."); [Head and Neck Cancer Study Group and the Radiation Therapy Study Group of the Japan Clinical Oncology Group](https://pubmed.ncbi.nlm.nih.gov/?term=Head+and+Neck+Cancer+Study+Group+and+the+Radiation+Therapy+Study+Group+of+the+Japan+Clinical+Oncology+Group%5BCorporate+Author%5D) ### Affiliations * 1 Japan Clinical Oncology Group Data Center/Operations Office, National Cancer Center Hospital, Tokyo, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. * 2 Department of Radiation Oncology, Hokkaido University Hospital, North-15 West-7, Sapporo, Hokkaido 060-8638, Japan. * 3 Division of Radiation Oncology, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka 573-1010, Japan. * 4 Department of Head and Neck, Esophageal Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. * 5 Department of Medical Physics, Hokkaido University Hospital, North-15 West-7, Sapporo, Hokkaido 060-8638, Japan. * 6 Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. * 7 Department of Radiation Oncology, National Cancer Center Hospit
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