---
title: "Laparoscopic Resection for Vaginal Cuff Recurrence After Endometrial Cancer Surgery"
id: "pubmed-42669945"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42669945"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42669945/"
published_at: "2026-09-20T00:00:00.000Z"
evidence_level: "Case Reports"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Laparoscopic Resection for Vaginal Cuff Recurrence After Endometrial Cancer Surgery
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42669945
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42669945/)
- **Published At:** 2026-09-20T00:00:00.000Z
- **Evidence Rating:** Case Reports
## Executive GIST (TL;DR)
- Vaginal cuff recurrence after primary surgery for **endometrial cancer** is usually treated with radiotherapy; surgical approaches are uncommon and infrequently reported. - The report describes a case of an isolated **vaginal cuff recurrence** detected 9 months after initial laparoscopic hysterectomy and bilateral salpingo-oophorectomy for grade 1 endometrioid carcinoma (FIGO stage IA) without adjuvant therapy. - Preoperative imaging suggested recurrence at the vaginal cuff and enlarged pelvic lymph nodes, with no invasion of adjacent organs and nodes deemed resectable. - The team performed a laparoscopic resection of the vaginal cuff lesion combined with pelvic lymphadenectomy following principles of radical hysterectomy. - Surgical steps included division of bilateral cardinal ligaments, uterosacral ligaments, and anterior and posterior layers of the vesicouterine ligaments; circumferential vaginal incision and excision of the recurrent tumor; preservation of hypogastric nerves because paravaginal tissue invasion was not suspected. - Specimens were removed transvaginally using protective retrieval bags to reduce contamination/tumor spillage. - Final pathology showed recurrent grade 3 endometrioid carcinoma at the cuff with negative resection margins and pelvic nodal metastases. - The patient received postoperative chemotherapy; at the time of report the patient remained disease-free. - The authors conclude that **laparoscopic resection** is a viable therapeutic option for selected patients with isolated vaginal cuff recurrence, offering safe and definitive resection when anatomy and imaging permit. - Specific operative times, intraoperative blood loss, detailed chemotherapy regimen, follow-up duration, and long-term outcomes beyond 'disease-free' were not reported in the source abstract.
## Clinical Analysis & Structured Key Points
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Tokai J Exp Clin Med. 2026. Free article Show details Display options Display options Format Abstract PubMed PMID Tokai J Exp Clin Med Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Tokai+J+Exp+Clin+Med%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Tokai+J+Exp+Clin+Med%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42669945/) . 2026 Sep 20;51(3):138-141. ### Authors [Chinami Makinoda](https://pubmed.ncbi.nlm.nih.gov/?term=Makinoda+C&cauthor_id=42669945)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42669945/#short-view-affiliation-1 "Department of Obstetrics and Gynecology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. 329118@tokai.ac.jp."), [Miwa Yasaka](https://pubmed.ncbi.nlm.nih.gov/?term=Yasaka+M&cauthor_id=42669945), [Yumi Kawaguchi](https://pubmed.ncbi.nlm.nih.gov/?term=Kawaguchi+Y&cauthor_id=42669945), [Mayuka Onomura](https://pubmed.ncbi.nlm.nih.gov/?term=Onomura+M&cauthor_id=42669945), [Kanade Hasegawa](https://pubmed.ncbi.nlm.nih.gov/?term=Hasegawa+K&cauthor_id=42669945), [Shinnosuke Hara](https://pubmed.ncbi.nlm.nih.gov/?term=Hara+S&cauthor_id=42669945), [Takatoshi Manabe](https://pubmed.ncbi.nlm.nih.gov/?term=Manabe+T&cauthor_id=42669945), [Arata Kobayashi](https://pubmed.ncbi.nlm.nih.gov/?term=Kobayashi+A&cauthor_id=42669945), [Hiroko Machida](https://pubmed.ncbi.nlm.nih.gov/?term=Machida+H&cauthor_id=42669945), [Takeshi Hirasawa](https://pubmed.ncbi.nlm.nih.gov/?term=Hirasawa+T&cauthor_id=42669945), [Hiroyuki Nomura](https://pubmed.ncbi.nlm.nih.gov/?term=Nomura+H&cauthor_id=42669945) ### Affiliation * 1 Department of Obstetrics and Gynecology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. 329118@tokai.ac.jp. * PMID: **42669945** Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Objective:** Vaginal cuff recurrence of endometrial cancer is generally managed with radiotherapy, and surgical reports are scarce. We report a laparoscopic resection technique for isolated vaginal cuff recurrence. **Methods:** A 57-year-old woman underwent laparoscopic hysterectomy with bilateral salpingo-oophorectomy for grade 1 endometrioid carcinoma (FIGO stage IA) without adjuvant therapy. Nine months postoperatively, she was referred to our hospital with suspected vaginal cuff and pelvic lymph node recurrence. Imaging revealed no invasion of adjacent organs, and lymph nodes were deemed resectable. **Results:** Laparoscopic resection of the vaginal cuff tumor and pelvic lymphadenectomy were performed. Following the principles of radical hysterectomy, the bilateral cardinal ligaments, uterosacral ligaments, and the anterior and posterior layers of the vesicouterine ligaments were divided. The vaginal canal was circumferentially incised, and the recurrent tumor was excised. As paravaginal tissue invasion was not suspected, the hypogastric nerves were preserved. Specimens were retrieved transvaginally in protective bags. Histopathological examination confirmed recurrent grade 3 endometrioid carcinoma with negative margins and pelvic nodal metastases. Postoperative chemotherapy was administered, and the patient remains disease-free. **Conclusion:** This technique represents a valuable therapeutic option, providing safe and definitive resection for patients with vaginal cuff recurrence. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ Ultrastaging of 'negative' pelvic lymph nodes in patients with low- and intermediate-risk endometrioid endometrial cancer who developed non-vaginal recurrences. ](https://pubmed.ncbi.nlm.nih.gov/34706876/) Gill SE, Garzon S, Multinu F, Hokenstad AN, Casarin J, Cappuccio S, McGree ME, Weaver AL, Cliby WA, Keeney GL, Mariani A.Gill SE, et al.Int J Gynecol Cancer. 2021 Dec;31(12):1541-1548. doi: 10.1136/ijgc-2021-002924. Epub 2021 Oct 27.Int J Gynecol Cancer. 2021.PMID: 34706876 * [ Predictive factors of recurrence following adjuvant vaginal cuff brachytherapy alone for stage I endometrial cancer. ](https://pubmed.ncbi.nlm.nih.gov/24657301/) Dunn EF, Geye H, Platta CS, Gondi V, Rose S, Bradley KA, Anderson BM.Dunn EF, et al.Gynecol Oncol. 2014 Jun;133(3):494-8. doi: 10.1016/j.ygyno.2014.03.554. Epub 2014 Mar 20.Gynecol Oncol. 2014.PMID: 24657301 * [ Outcomes and relapse patterns of stage IB grade 2 or 3 endometrial cancer treated with adjuvant vaginal brachytherapy. ](https://pubmed.ncbi.nlm.nih.gov/31722964/) Hochreiter A, Kelly JR, Young MR, Litkouhi B, Black JD, Stromberger C, Higgins S, Schwartz PE, Damast S.Hochreiter A, et al.Int J Gynecol Cancer. 2020 Jan;30(1):48-55. doi: 10.1136/ijgc-2019-000675. Epub 2019 Nov 12.Int J Gynecol Cancer. 2020.PMID: 31722964 * [ Protective Maneuver to Avoid Tumor Spillage during Laparoscopic Radical Hysterectomy: Vaginal Cuff Closure. ](https://pubmed.ncbi.nlm.nih.gov/32540498/) Lago V, Tiermes M, Padilla-Iserte P, Matute L, Gurrea M, Domingo S.Lago V, et al.J Minim Invasive Gynecol. 2021 Feb;28(2):174-175. doi: 10.1016/j.jmig.2020.06.007. Epub 2020 Jun 12.J Minim Invasive Gynecol. 2021.PMID: 32540498 * [ [Synchronous primary cancers of the endometrium and ovary: review of 43 cases]. ](https://pubmed.ncbi.nlm.nih.gov/19173912/) Ma SK, Zhang HT, Sun YC, Wu LY.Ma SK, et al.Zhonghua Zhong Liu Za Zhi. 2008 Sep;30(9):690-4.Zhonghua Zhong Liu Za Zhi. 2008.PMID: 19173912Chinese. 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