---
title: "Long-Term Follow-Up of JCOG1008: 3-Weekly vs Weekly Cisplatin Chemoradiotherapy in Postoperative H"
id: "pubmed-42361282"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42361282"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42361282/"
doi: "10.1200/JCO-25-01708"
published_at: "2026-09-20T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Long-Term Follow-Up of JCOG1008: 3-Weekly vs Weekly Cisplatin Chemoradiotherapy in Postoperative H
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42361282
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42361282/)
- **DOI:** [10.1200/JCO-25-01708](https://doi.org/10.1200%2FJCO-25-01708)
- **Published At:** 2026-09-20T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This article reports the long-term follow-up of **JCOG1008**, a randomized Phase II/III clinical trial comparing **3-weekly cisplatin** with **weekly cisplatin** given with **chemoradiotherapy** in the postoperative management of head and neck cancer. - The report is published in Journal of Clinical Oncology (J Clin Oncol), with DOI 10.1200/JCO-25-01708, PubMed ID 42361282 and PMCID PMC13581295. The electronic publication date is 2026 Jun 26 and the journal issue date is 2026 Sep 20;44(27):2574–2581. - Lead and senior authors include Makoto Tahara and Naomi Kiyota, among many coauthors from multiple Japanese cancer centers and universities; the study is associated with the Head and Neck Cancer Study Group of the Japan Clinical Oncology Group (JCOG-HNCSG). - Participating institutions span at least 29 named affiliations, including National Cancer Center Hospital East, Kobe University Hospital, Aichi Cancer Center Hospital, and others across Japan. - Full-text access is available through PubMed Central (Free PMC article link provided in the source). - The source excerpt does not include trial outcomes, numeric results, survival data, toxicity profiles, sample size, statistical analyses, or definitive conclusions; those details were not reported in the provided source text. - The article type is identified as a Clinical Trial and is explicitly titled as a randomized Phase II/III comparison of dosing schedules of **cisplatin** in the postoperative setting for head and neck cancer. - The collaborative author group and trial name (**JCOG1008**) are emphasized; additional collaborator lists and institutional affiliations are provided in the source metadata but outcome data are absent from the excerpt.
## Clinical Analysis & Structured Key Points
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Epub 2026 Jun 26. # Long-Term Follow-Up of JCOG1008, a Randomized Phase II/III Trial of Chemoradiotherapy Comparing 3-Weekly Cisplatin With Weekly Cisplatin in Postoperative Head and Neck Cancer [Makoto Tahara](https://pubmed.ncbi.nlm.nih.gov/?term=Tahara+M&cauthor_id=42361282)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-1 "National Cancer Center Hospital East, Kashiwa, Japan."), [Naomi Kiyota](https://pubmed.ncbi.nlm.nih.gov/?term=Kiyota+N&cauthor_id=42361282)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-2 "Kobe University Hospital, Cancer Center, Kobe, Japan."), [Takeshi Kodaira](https://pubmed.ncbi.nlm.nih.gov/?term=Kodaira+T&cauthor_id=42361282)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-3 "Aichi Cancer Center Hospital, Nagoya, Japan."), [Hiroshi Nishino](https://pubmed.ncbi.nlm.nih.gov/?term=Nishino+H&cauthor_id=42361282)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-4 "Jichi Medical University Hospital, Shimotsuke, Japan."), [Yukinori Asada](https://pubmed.ncbi.nlm.nih.gov/?term=Asada+Y&cauthor_id=42361282)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-5 "Miyagi Cancer Center, Natori, Japan."), [Hiroki Mitani](https://pubmed.ncbi.nlm.nih.gov/?term=Mitani+H&cauthor_id=42361282)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-6 "Cancer Institute Hospital, Tokyo, Japan."), [Yuji Hirayama](https://pubmed.ncbi.nlm.nih.gov/?term=Hirayama+Y&cauthor_id=42361282)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-7 "Hyogo Cancer Center, Akashi, Japan."), [Yusuke Onozawa](https://pubmed.ncbi.nlm.nih.gov/?term=Onozawa+Y&cauthor_id=42361282)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-8 "Shizuoka Cancer Center, Shizuoka, Japan."), [Naoki Nishio](https://pubmed.ncbi.nlm.nih.gov/?term=Nishio+N&cauthor_id=42361282)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-9 "Nagoya University Hospital, Nagoya, Japan."), [Nobuhiro Hanai](https://pubmed.ncbi.nlm.nih.gov/?term=Hanai+N&cauthor_id=42361282)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-3 "Aichi Cancer Center Hospital, Nagoya, Japan."), [Akira Ohkoshi](https://pubmed.ncbi.nlm.nih.gov/?term=Ohkoshi+A&cauthor_id=42361282)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-10 "Tohoku University Hospital, Sendai, Japan."), [Hiroki Hara](https://pubmed.ncbi.nlm.nih.gov/?term=Hara+H&cauthor_id=42361282)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-11 "Saitama Cancer Center, Ina, Japan."), [Nobuya Monden](https://pubmed.ncbi.nlm.nih.gov/?term=Monden+N&cauthor_id=42361282)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-12 "NHO Shikoku Cancer Center, Matsuyama, Japan."), [Masato Nagaoka](https://pubmed.ncbi.nlm.nih.gov/?term=Nagaoka+M&cauthor_id=42361282)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-13 "Jikei University School of Medicine, Tokyo, Japan."), [Shujiro Minami](https://pubmed.ncbi.nlm.nih.gov/?term=Minami+S&cauthor_id=42361282)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-14 "NHO Tokyo Medical Center, Tokyo, Japan."), [Kaoru Tanaka](https://pubmed.ncbi.nlm.nih.gov/?term=Tanaka+K&cauthor_id=42361282)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-15 "Kindai University Hospital, Sakai, Japan."), [Takashi Fujii](https://pubmed.ncbi.nlm.nih.gov/?term=Fujii+T&cauthor_id=42361282)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-16 "Osaka International Cancer Institute, Osaka, Japan."), [Seiichi Yoshimoto](https://pubmed.ncbi.nlm.nih.gov/?term=Yoshimoto+S&cauthor_id=42361282)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-17 "National Cancer Center Hospital, Tokyo, Japan."), [Tsutomu Ueda](https://pubmed.ncbi.nlm.nih.gov/?term=Ueda+T&cauthor_id=42361282)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-18 "Hiroshima University Hospital, Hiroshima, Japan."), [Yo Kishimoto](https://pubmed.ncbi.nlm.nih.gov/?term=Kishimoto+Y&cauthor_id=42361282)[ 19 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-19 "Kyoto University, Kyoto, Japan."), [Akihiro Homma](https://pubmed.ncbi.nlm.nih.gov/?term=Homma+A&cauthor_id=42361282)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-20 "Hokkaido University Hospital, Sapporo, Japan."), [Nobuhiko Oridate](https://pubmed.ncbi.nlm.nih.gov/?term=Oridate+N&cauthor_id=42361282)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-21 "Yokohama City University Hospital, Yokohama, Japan."), [Kenji Okami](https://pubmed.ncbi.nlm.nih.gov/?term=Okami+K&cauthor_id=42361282)[ 22 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-22 "Tokai University School of Medicine, Isehara, Japan."), [Hirokazu Uemura](https://pubmed.ncbi.nlm.nih.gov/?term=Uemura+H&cauthor_id=42361282)[ 23 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-23 "Nara Medical University, Kashihara, Japan."), [Katsunori Katagiri](https://pubmed.ncbi.nlm.nih.gov/?term=Katagiri+K&cauthor_id=42361282)[ 24 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-24 "Iwate Medical University, Shiwa, Japan."), [Tomoko Yamazaki](https://pubmed.ncbi.nlm.nih.gov/?term=Yamazaki+T&cauthor_id=42361282)[ 25 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-25 "Saitama Medical University International Medical Center, Hidaka, Japan."), [Takahiro Asakage](https://pubmed.ncbi.nlm.nih.gov/?term=Asakage+T&cauthor_id=42361282)[ 26 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-26 "Institute of Science Tokyo Hospital, Tokyo, Japan."), [Yuki Saito](https://pubmed.ncbi.nlm.nih.gov/?term=Saito+Y&cauthor_id=42361282)[ 27 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-27 "The University of Tokyo Hospital, Tokyo, Japan."), [Shigeyuki Murono](https://pubmed.ncbi.nlm.nih.gov/?term=Murono+S&cauthor_id=42361282)[ 28 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-28 "Fukushima Medical University Hospital, Fukushima, Japan."), [Junki Mizusawa](https://pubmed.ncbi.nlm.nih.gov/?term=Mizusawa+J&cauthor_id=42361282)[ 29 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-29 "Japan Clinical Oncology Group Data Center/Operations Office, National Cancer Center Hospital, Tokyo, Japan."), [Kenichi Nakamura](https://pubmed.ncbi.nlm.nih.gov/?term=Nakamura+K&cauthor_id=42361282)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-17 "National Cancer Center Hospital, Tokyo, Japan."), [Ryuichi Hayashi](https://pubmed.ncbi.nlm.nih.gov/?term=Hayashi+R&cauthor_id=42361282)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#full-view-affiliation-1 "National Cancer Center Hospital East, Kashiwa, Japan."); [Head and Neck Cancer Study Group of the Japan Clinical Oncology Group (JCOG-HNCSG)](https://pubmed.ncbi.nlm.nih.gov/?term=Head+and+Neck+Cancer+Study+Group+of+the+Japan+Clinical+Oncology+Group+%28JCOG-HNCSG%29%5BCorporate+Author%5D) Collaborators, Affiliations Expand ### Collaborators * **Head and Neck Cancer Study Group of the Japan Clinical Oncology Group (JCOG-HNCSG)** : [Akihiro Homma](https://pubmed.ncbi.nlm.nih.gov/?term=Homma+A), [Kiyoto Shiga](https://pubmed.ncbi.nlm.nih.gov/?term=Shiga+K), [Takenori Ogawa](https://pubmed.ncbi.nlm.nih.gov/?term=Ogawa+T), [Tomoko Yamazaki](https://pubmed.ncbi.nlm.nih.gov/?term=Yamazaki+T), [Shigeyuki Murono](https://pubmed.ncbi.nlm.nih.gov/?term=Murono+S), [Hiroshi Nishino](https://pubmed.ncbi.nlm.nih.gov/?term=Nishino+H), [Hiroki Hara](https://pubmed.ncbi.nlm.nih.gov/?term=Hara+H), [Masashi Sugasawa](https://pubmed.ncbi.nlm.nih.gov/?term=Sugasawa+M), [Makoto Tahara](https://pubmed.ncbi.nlm.nih.gov/?term=Tahara+M), [Seiichi Yoshimoto](https://pubmed.ncbi.nlm.nih.gov/?term=Yoshimoto+S), [Shujiro Minami](https://pubmed.ncbi.nlm.nih.gov/?term=Minami+S), [Takahiro Asakage](https://pubmed.ncbi.nlm.nih.gov/?term=Asakage+T), [Eiji Shimura](https://pubmed.ncbi.nlm.nih.gov/?term=Shimura+E), [Hiroki Mitani](https://pubmed.ncbi.nlm.nih.gov/?term=Mitani+H), [Mizuo Ando](https://pubmed.ncbi.nlm.nih.gov/?term=Ando+M), [Nobuhiko Oridate](https://pubmed.ncbi.nlm.nih.gov/?term=Oridate+N), [Kenji Okami](https://pubmed.ncbi.nlm.nih.gov/?term=Okami+K), [Yusuke Onozawa](https://pubmed.ncbi.nlm.nih.gov/?term=Onozawa+Y), [Nobuhiro Hanai](https://pubmed.ncbi.nlm.nih.gov/?term=Hanai+N), [Yasushi Fujimoto](https://pubmed.ncbi.nlm.nih.gov/?term=Fujimoto+Y), [Koichi Omori](https://pubmed.ncbi.nlm.nih.gov/?term=Omori+K), [Kazuhiko Nakagawa](https://pubmed.ncbi.nlm.nih.gov/?term=Nakagawa+K), [Takashi Fujii](https://pubmed.ncbi.nlm.nih.gov/?term=Fujii+T), [Naomi Kiyota](https://pubmed.ncbi.nlm.nih.gov/?term=Kiyota+N), [Shigemichi Iwae](https://pubmed.ncbi.nlm.nih.gov/?term=Iwae+S), [Ichiro Ota](https://pubmed.ncbi.nlm.nih.gov/?term=Ota+I), [Tsutomu Ueda](https://pubmed.ncbi.nlm.nih.gov/?term=Ueda+T), [Nobuya Monden](https://pubmed.ncbi.nlm.nih.gov/?term=Monden+N) ### Affiliations * 1 National Cancer Center Hospital East, Kashiwa, Japan. * 2 Kobe University Hospital, Cancer Center, Kobe, Japan. * 3 Aichi Cancer Center Hospital, Nagoya, Japan. * 4 Jichi Medical University Hospital, Shimotsuke, Japan. * 5 Miyagi Cancer Center, Natori, Japan. * 6 Cancer Institute Hospital, Tokyo, Japan. * 7 Hyogo Cancer Center, Akashi, Japan. * 8 Shizuoka Cancer Center, Shizuoka, Japan. * 9 Nagoya University Hospital, Nagoya, Japan. * 10 Tohoku University Hospital, Sendai, Japan. * 11 Saitama Cancer Center, Ina, Japan. * 12 NHO Shikoku Cancer Center, Matsuyama, Japan. * 13 Jikei University School of Medicine, Tokyo, Japan. * 14 NHO Tokyo Medical Center, Tokyo, Japan. * 15 Kindai University Hospital, Sakai, Japan. * 16 Osaka International Cancer Institute, Osaka, Japan. * 17 National Cancer Center Hospital, Tokyo, Japan. * 18 Hiroshima University Hospital, Hiroshima, Japan. * 19 Kyoto University, Kyoto, Japan. * 20 Hokkaido University Hospital, Sapporo, Japan. * 21 Yokohama City University Hospital, Yokohama, Japan. * 22 Tokai University School of Medicine, Isehara, Japan. * 23 Nara Medical University, Kashihara, Japan. * 24 Iwate Medical University, Shiwa, Japan. * 25 Saitama Medical University International Medical Center, Hidaka, Japan. * 26 Institute of Science Tokyo Hospital, Tokyo, Japan. * 27 The University of Tokyo Hospital, Tokyo, Japan. * 28 Fukushima Medical University Hospital, Fukushima, Japan. * 29 Japan Clinical Oncology Group Data Center/Operations Office, National Cancer Center Hospital, Tokyo, Japan. * PMID: **42361282** * PMCID: [ PMC13581295 ](https://pmc.ncbi.nlm.nih.gov/articles/PMC13581295/) * DOI: [ 10.1200/JCO-25-01708 ](https://doi.org/10.1200/jco-25-01708) Item in Clipboard Clinical Trial # Long-Term Follow-Up of JCOG1008, a Randomized Phase II/III Trial of Chemoradiotherapy Comparing 3-Weekly Cisplatin With Weekly Cisplatin in Postoperative Head and Neck Cancer Makoto Tahara et al. J Clin Oncol. 2026. Show details Display options Display options Format Abstract PubMed PMID J Clin Oncol Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22J+Clin+Oncol%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22J+Clin+Oncol%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42361282/) . 2026 Sep 20;44(27):2574-2581. doi: 10.1200/JCO-25-01708. Epub 2026 Jun 26. ### Authors [Makoto Tahara](https://pubmed.ncbi.nlm.nih.gov/?term=Tahara+M&cauthor_id=42361282)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#short-view-affiliation-1 "National Cancer Center Hospital East, Kashiwa, Japan."), [Naomi Kiyota](https://pubmed.ncbi.nlm.nih.gov/?term=Kiyota+N&cauthor_id=42361282)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#short-view-affiliation-2 "Kobe University Hospital, Cancer Center, Kobe, Japan."), [Takeshi Kodaira](https://pubmed.ncbi.nlm.nih.gov/?term=Kodaira+T&cauthor_id=42361282)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#short-view-affiliation-3 "Aichi Cancer Center Hospital, Nagoya, Japan."), [Hiroshi Nishino](https://pubmed.ncbi.nlm.nih.gov/?term=Nishino+H&cauthor_id=42361282)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#short-view-affiliation-4 "Jichi Medical University Hospital, Shimotsuke, Japan."), [Yukinori Asada](https://pubmed.ncbi.nlm.nih.gov/?term=Asada+Y&cauthor_id=42361282)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#short-view-affiliation-5 "Miyagi Cancer Center, Natori, Japan."), [Hiroki Mitani](https://pubmed.ncbi.nlm.nih.gov/?term=Mitani+H&cauthor_id=42361282)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42361282/#short-view-affiliation-6 "Cancer Institute Hospital, Tokyo, Japan."), [Yuji Hirayama](https://pubmed.ncbi.nlm.nih.gov/?term=Hirayama+Y&c
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