---
title: "MAGI3 promotes TAZ ubiquitination to suppress NSCLC by inhibiting the Wnt pathway"
id: "pubmed-42757476"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42757476"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42757476/"
doi: "10.3892/ijo.2026.5939"
published_at: "2026-09-18T12:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# MAGI3 promotes TAZ ubiquitination to suppress NSCLC by inhibiting the Wnt pathway
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42757476
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42757476/)
- **DOI:** [10.3892/ijo.2026.5939](https://doi.org/10.3892%2Fijo.2026.5939)
- **Published At:** 2026-09-18T12:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The study evaluates the tumor suppressor role of **MAGI3** in non‑small cell lung cancer (NSCLC) using patient samples, TCGA data, cell lines, in vitro functional assays, and in vivo models. - **MAGI3** expression is downregulated in NSCLC clinical samples, TCGA datasets, and cell lines; lower MAGI3 correlates with poorer prognosis according to the source. - Inducible overexpression of MAGI3 in NSCLC cells reduced viability, clonogenicity, sphere formation, migration and invasion, and induced G1 arrest and cellular senescence; MAGI3 silencing increased metastatic nodules in vivo. - Mechanistically, MAGI3 interacts with **TAZ** via its PDZ domain and promotes **TAZ ubiquitination**, shortening TAZ half‑life and decreasing TAZ protein levels. - MAGI3‑mediated TAZ degradation impaired **β‑catenin** nuclear translocation and decreased activity of the **Wnt pathway**, including reductions in DVL2 and phosphorylated GSK3β and decreased TCF/LEF transcriptional output. - Reintroducing TAZ reversed MAGI3's inhibitory effects on Wnt pathway targets (cMYC, c‑JUN, WISP1, PPARD), supporting that TAZ is a functional mediator of MAGI3 effects. - In situ and xenograft models showed that MAGI3 overexpression suppressed tumor growth and lung metastasis; MAGI3 knockdown increased metastasis. - Keywords and focal points: **MAGI3**, **TAZ**, **ubiquitination**, **Wnt pathway**, **β‑catenin**, tumorigenesis and metastasis in NSCLC. - Details such as sample sizes, statistical values, specific cell lines used, exact ubiquitination sites, and full experimental conditions were not reported in the provided source text.
## Clinical Analysis & Structured Key Points
Clipboard, Search History, and several other advanced features are temporarily unavailable. [ Skip to main page content ](https://pubmed.ncbi.nlm.nih.gov/42757476/#article-details) ![U.S. flag](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png) An official website of the United States government Here's how you know ![Dot gov](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg) **The .gov means it’s official.** Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. ![Https](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg) **The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [ ![NIH NLM Logo](https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg) ](https://www.ncbi.nlm.nih.gov/) [Log in](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42757476%2F) Show account info Close #### Account Logged in as: **username** * [Dashboard](https://www.ncbi.nlm.nih.gov/myncbi/) * [Publications](https://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/) * [Account settings](https://www.ncbi.nlm.nih.gov/account/settings/) * [Log out](https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/42757476/) [Access keys](https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys) [NCBI Homepage](https://www.ncbi.nlm.nih.gov) [MyNCBI Homepage](https://pubmed.ncbi.nlm.nih.gov/myncbi/) [Main Content](https://pubmed.ncbi.nlm.nih.gov/42757476/#maincontent) [Main Navigation](https://pubmed.ncbi.nlm.nih.gov/42757476/) [ ![pubmed logo](https://cdn.ncbi.nlm.nih.gov/pubmed/c24ab723-7c80-48cd-9c68-022ded852586/core/images/pubmed-logo-blue.svg) ](https://pubmed.ncbi.nlm.nih.gov/) [ ](https://pubmed.ncbi.nlm.nih.gov/42757476/ "Show search bar") Search: [](https://pubmed.ncbi.nlm.nih.gov/42757476/ "Clear search input")Search [Advanced](https://pubmed.ncbi.nlm.nih.gov/advanced/) [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/clipboard/) [ User Guide ](https://pubmed.ncbi.nlm.nih.gov/help/) Save Email Send to * [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42757476%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42757476%2F%23open-collections-panel) * [Citation manager](https://pubmed.ncbi.nlm.nih.gov/42757476/) Display options Display options Format Abstract PubMed PMID ## Save citation to file Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel ## Email citation Email address has not been verified. Go to [ My NCBI account settings ](https://account.ncbi.nlm.nih.gov/settings/) to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel ### Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42757476/) Add Cancel ### Add to My Bibliography * My Bibliography Unable to load your delegates due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42757476/) Add Cancel ## Your saved search Name of saved search: Search terms: [Test search terms](https://pubmed.ncbi.nlm.nih.gov/42757476/) Would you like email updates of new search results? Saved Search Alert Radio Buttons * Yes * No Email: ([change](https://www.ncbi.nlm.nih.gov/account/settings/)) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel ## Create a file for external citation management software Create file Cancel ## Your RSS Feed Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy ### Actions Cite Collections Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42757476/) Add Cancel Permalink Permalink Copy Display options Display options Format Abstract PubMed PMID ### Page navigation * [ Title & authors ](https://pubmed.ncbi.nlm.nih.gov/42757476/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42757476/#abstract) * [Similar articles](https://pubmed.ncbi.nlm.nih.gov/42757476/#similar) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42757476/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42757476/#substances) Title & authors Abstract Similar articles MeSH terms Substances Int J Oncol Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Int+J+Oncol%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Int+J+Oncol%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) . 2026 Nov;69(5):126. doi: 10.3892/ijo.2026.5939. Epub 2026 Sep 18. # E3 ubiquitin ligase MAGI3‑mediated TAZ ubiquitination suppresses the non‑small cell lung cancer occurrence and development by targeting the Wnt pathway [Ye Liang](https://pubmed.ncbi.nlm.nih.gov/?term=Liang+Y&cauthor_id=42757476)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42757476/#full-view-affiliation-1 "Department of Allergy, Qingdao Integrated Chinese and Western Medicine Hospital, Qingdao, Shandong 266000, P.R. China."), [Jie Zhuang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhuang+J&cauthor_id=42757476)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42757476/#full-view-affiliation-2 "Department of Rehabilitation Medicine, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China.") Affiliations Expand ### Affiliations * 1 Department of Allergy, Qingdao Integrated Chinese and Western Medicine Hospital, Qingdao, Shandong 266000, P.R. China. * 2 Department of Rehabilitation Medicine, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China. * PMID: **42757476** * DOI: [ 10.3892/ijo.2026.5939 ](https://doi.org/10.3892/ijo.2026.5939) Item in Clipboard # E3 ubiquitin ligase MAGI3‑mediated TAZ ubiquitination suppresses the non‑small cell lung cancer occurrence and development by targeting the Wnt pathway Ye Liang et al. Int J Oncol. 2026 Nov. Show details Display options Display options Format Abstract PubMed PMID Int J Oncol Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Int+J+Oncol%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Int+J+Oncol%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) . 2026 Nov;69(5):126. doi: 10.3892/ijo.2026.5939. Epub 2026 Sep 18. ### Authors [Ye Liang](https://pubmed.ncbi.nlm.nih.gov/?term=Liang+Y&cauthor_id=42757476)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42757476/#short-view-affiliation-1 "Department of Allergy, Qingdao Integrated Chinese and Western Medicine Hospital, Qingdao, Shandong 266000, P.R. China."), [Jie Zhuang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhuang+J&cauthor_id=42757476)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42757476/#short-view-affiliation-2 "Department of Rehabilitation Medicine, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China.") ### Affiliations * 1 Department of Allergy, Qingdao Integrated Chinese and Western Medicine Hospital, Qingdao, Shandong 266000, P.R. China. * 2 Department of Rehabilitation Medicine, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China. * PMID: **42757476** * DOI: [ 10.3892/ijo.2026.5939 ](https://doi.org/10.3892/ijo.2026.5939) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract Membrane associated guanylate kinase WW and PDZ domain containing 3 (MAGI3) functions as a tumor suppressor in lung cancer, but its role and mechanism in non‑small cell lung cancer (NSCLC) progression remain unclear. MAGI3 expression was detected in NSCLC tissues (immunohistochemistry) and cell lines (western blotting). Tet‑on inducible MAGI3 overexpression was used to assess effects on NSCLC cells via Cell Counting Kit‑8, Transwell, colony/sphere formation, β‑Galactosidase staining and flow cytometry. Ubiquitination/half‑life assays analyzed MAGI3‑TAZ (transcriptional co‑activator with PDZ‑binding motif) interaction. _In situ_ and xenograft tumor models evaluated tumor growth and metastasis. The Cancer Genome Atlas data, clinical samples, and cell lines showed downregulated MAGI3 in NSCLC, correlating with poor prognosis. MAGI3 overexpression reduced cell viability, clonogenicity, sphere formation, migration and invasion; induced G1 phase arrest (reduced CyclinD1) and cellular senescence. MAGI3 specifically promoted TAZ ubiquitination via PDZ domain‑mediated interaction, which subsequently blocked β‑catenin nuclear translocation, dampened Wnt signaling components (DVL2/phosphorylated GSK3β), and reduced TCF/LEF transcriptional output. Reconstitution of TAZ reversed MAGI3‑mediated inhibition of Wnt pathway markers (cMYC, c‑JUN, WISP1 and PPARD). _In vivo_ , MAGI3 overexpression suppressed tumor growth and lung metastasis, while MAGI3 silencing increased metastatic nodules. The present study identified that MAGI3, as a suppressor in NSCLC progression, repressed the Wnt pathway‑including TAZ degradation, impaired β‑catenin nuclear translocation, and diminished TCF/LEF transcription‑thereby restraining tumorigenesis and metastasis of NSCLC. **Keywords:** TAZ; Wnt pathway; membrane associated guanylate kinase WW and PDZ domain containing 3; metastasis; non‑small cell lung cancer; ubiquitination and degradation. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ Nucleolar and spindle‑associated protein 1 promotes non‑small cell lung cancer progression and serves as an effector of myocyte enhancer factor 2D. ](https://pubmed.ncbi.nlm.nih.gov/33650655/) Ling B, Wei P, Xiao J, Cen B, Wei H, Feng X, Ye G, Li S, Zhang Z, Liang W, Huang S, Huang W.Ling B, et al.Oncol Rep. 2021 Mar;45(3):1044-1058. doi: 10.3892/or.2020.7918. Epub 2020 Dec 30.Oncol Rep. 2021.PMID: 33650655Free PMC article. * [ IL‑21/IL‑21R inhibit tumor growth and invasion in non‑small cell lung cancer cells via suppressing Wnt/β‑catenin signaling and PD‑L1 expression. ](https://pubmed.ncbi.nlm.nih.gov/31573051/) Xue D, Yang P, Wei Q, Li X, Lin L, Lin T.Xue D, et al.Int J Mol Med. 2019 Nov;44(5):1697-1706. doi: 10.3892/ijmm.2019.4354. Epub 2019 Sep 26.Int J Mol Med. 2019.PMID: 31573051Free PMC article. * [ RNF125 suppresses stem cell-like properties and metastasis in non-small cell lung cancer by promoting ubiquitination and degradation of DDX5. ](https://pubmed.ncbi.nlm.nih.gov/41605025/) Leng X, Hu Z, Zhang M, Chen Q, Xu K, Zhao J.Leng X, et al.Pathol Res Pract. 2026 Mar;279:156378. doi: 10.1016/j.prp.2026.156378. Epub 2026 Jan 23.Pathol Res Pract. 2026.PMID: 41605025 * [ Interferon Consensus Sequence-Binding Protein 8, a Tumor Suppressor, Suppresses Tumor Growth and Invasion of Non-Small Cell Lung Cancer by Interacting with the Wnt/β-Catenin Pathway. ](https://pubmed.ncbi.nlm.nih.gov/30466106/) Ye L, Xiang T, Zhu J, Li D, Shao Q, Peng W, Tang J, Li L, Ren G.Ye L, et al.Cell Physiol Biochem. 2018;51(2):961-978. doi: 10.1159/000495399. Epub 2018 Nov 22.Cell Physiol Biochem. 2018.PMID: 30466106 * [ The Ubiquitin E3 Ligase FBXO33 Suppresses Stem Cell-Like Properties and Metastasis in Non-Small-Cell Lung Cancer by Promoting Ubiquitination and Degradation of Myc. ](https://pubmed.ncbi.nlm.nih.gov/39206900/) Wei Q, Liu Z, Zhu J, Jiang W, Xie H, Feng G, Wang K.Wei Q, et al.Front Biosci (Landmark Ed). 2024 Aug 21;29(8):296. doi: 10.31083/j.fbl2908296.Front Biosci (Landmark Ed). 2024.PMID: 39206900 [ See all similar articles ](https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed&from_uid=42757476) ## MeSH terms * Aged Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Aged%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Aged) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Animals Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Animals%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Animals) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Carcinoma, Non-Small-Cell Lung* / genetics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Carcinoma%2C+Non-Small-Cell+Lung%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Carcinoma%2C+Non-Small-Cell+Lung) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Carcinoma, Non-Small-Cell Lung* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Carcinoma%2C+Non-Small-Cell+Lung%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Carcinoma%2C+Non-Small-Cell+Lung) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Carcinoma, Non-Small-Cell Lung* / pathology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Carcinoma%2C+Non-Small-Cell+Lung%2Fpathology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Carcinoma%2C+Non-Small-Cell+Lung) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Cell Line, Tumor Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell+Line%2C+Tumor%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Line%2C+Tumor) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Cell Movement Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell+Movement%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Movement) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Cell Proliferation Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell+Proliferation%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Proliferation) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Female Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Female%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Female) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Gene Expression Regulation, Neoplastic Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Gene+Expression+Regulation%2C+Neoplastic%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Gene+Expression+Regulation%2C+Neoplastic) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Guanylate Kinases* / genetics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Guanylate+Kinases%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Guanylate+Kinases) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Guanylate Kinases* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Guanylate+Kinases%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Guanylate+Kinases) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Humans Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Humans) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Lung Neoplasms* / genetics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Lung+Neoplasms%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Lung+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Lung Neoplasms* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Lung+Neoplasms%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Lung+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Lung Neoplasms* / pathology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Lung+Neoplasms%2Fpathology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Lung+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Male Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Male%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Male) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Membrane Proteins Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Membrane+Proteins%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Membrane+Proteins) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Mice Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Mice%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Mice) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Middle Aged Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Middle+Aged%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Middle+Aged) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Trans-Activators* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Trans-Activators%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Trans-Activators) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Transcriptional Coactivator with PDZ-Binding Motif Proteins Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Transcriptional+Coactivator+with+PDZ-Binding+Motif+Proteins%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Transcriptional+Coactivator+with+PDZ-Binding+Motif+Proteins) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42757476/) * Ubiquitin-Protein Ligases* / genetics Actions * [ Search in PubMed ](https://pubme
## Related Clinical Research

- [Immune-pressure redistribution as a framework for resistance to PD-1/PD-L1 blockade](https://medichelpline.com/clinical-feed/pubmed-42763389.md) (DOI: 10.1186/s12943-026-02786-4)
- [LongPhase-TO: tumor-only long-read method for somatic haplotype reconstruction and variant recalib](https://medichelpline.com/clinical-feed/biorxiv-8-somatic-haplotype-reconstruction-and-variant-recalibration-from-tumor-only-long.md)
- [Genomic and transcriptomic features of STAS in stage 1 lung adenocarcinoma](https://medichelpline.com/clinical-feed/british-journal-of-cancer-0-genomic-and-transcriptomic-landscape-of-spread-through-air-spaces-in-stage-1.md)
- [Four-gene persister signature and ZLN005-triggered GSDME pyroptosis in EGFR‑mutant lung cancer](https://medichelpline.com/clinical-feed/pubmed-42757482.md) (DOI: 10.3892/mmr.2026.14017)
- [Rare genetic variant linked to 25-fold higher lung cancer risk in never-smokers](https://medichelpline.com/clinical-feed/stat-news-0-stat-why-do-never-smokers-get-lung-cancer-in-some-cases-rare-genetic-variant.md)

## Navigation
- [← Back to Oncology Feed](https://medichelpline.com/clinical-feed/oncology.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.