---
title: "Mendelian Randomisation Study Linking the Oral Microbiome to Oral, Oropharyngeal, and Tongue Cance"
id: "pubmed-42583788"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42583788"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42583788/"
doi: "10.3290/j.ohpd.c_2778"
published_at: "2026-08-12T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Mendelian Randomisation Study Linking the Oral Microbiome to Oral, Oropharyngeal, and Tongue Cance
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42583788
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42583788/)
- **DOI:** [10.3290/j.ohpd.c_2778](https://doi.org/10.3290%2Fj.ohpd.c_2778)
- **Published At:** 2026-08-12T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Objective: The study used two-sample **Mendelian randomisation** (MR) to test potential causal effects of the **oral microbiome** (dorsal tongue and saliva) on risks of oral, oropharyngeal, and tongue cancers and to evaluate reverse causation from cancers to microbial abundance. - Data sources and tools: Genome-wide association study (GWAS) summary statistics were drawn from CNGBdb, the FinnGen consortium, and other public sources; analyses were implemented with the R package **TwoSampleMR** using single-nucleotide polymorphisms (SNPs) as instrumental variables. - Instrument selection: SNPs reaching a significance threshold of p < 5 × 10^-6 were used as genetic instruments for microbial taxa. - Primary analysis: The inverse-variance-weighted MR approach was applied to estimate effects of dorsal-tongue and salivary microbial taxa on oral cavity, oropharyngeal, and tongue cancer risk. - Key causal findings: The MR analyses identified genetically supported associations implicating specific salivary- and tongue-derived taxa in cancer risk. Two taxa—**s Veillonella_rogosae_mgs_2008** and **s unclassified_mgs_1048**—were associated with a reduced risk of oropharyngeal and tongue cancers. - Sensitivity and robustness: Heterogeneity tests, pleiotropy evaluations, and other sensitivity analyses were performed and reportedly supported the robustness of the causal estimates. - Reverse MR results: Bidirectional analyses suggested that oral and tongue cancers may themselves alter the abundance of specific oral microbes, indicating possible bidirectional causal relationships. - Conclusion and implications: The authors conclude that large-scale publicly available genetic data support causal links between the **oral microbiota** and cancers of the oral cavity, oropharynx, and tongue; they recommend integrating metagenomic data in future studies to further validate these associations. - Limitations noted or implied: Specific details of instruments, effect sizes, confidence intervals, population characteristics, and full lists of implicated taxa were not reported in the abstract and require consultation of the full text for more granular data.
## Clinical Analysis & Structured Key Points
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Oral Health Prev Dent. 2026. Show details Display options Display options Format Abstract PubMed PMID Oral Health Prev Dent Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Oral+Health+Prev+Dent%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Oral+Health+Prev+Dent%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42583788/) . 2026 Aug 12:24:613-621. doi: 10.3290/j.ohpd.c_2778. ### Authors [Leng Han](https://pubmed.ncbi.nlm.nih.gov/?term=Han+L&cauthor_id=42583788), [Xinxuan Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+X&cauthor_id=42583788), [Beini Gong](https://pubmed.ncbi.nlm.nih.gov/?term=Gong+B&cauthor_id=42583788), [Xun Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+X&cauthor_id=42583788), [Xiao Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+X&cauthor_id=42583788), [Zhifa Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+Z&cauthor_id=42583788) * PMID: **42583788** * DOI: [ 10.3290/j.ohpd.c_2778 ](https://doi.org/10.3290/j.ohpd.c_2778) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Objective:** To assess the potential causal relationships of the oral microbiome with the risks of oral cancer, oropharyngeal cancer, and tongue cancer using two-sample Mendelian randomisation (MR) analysis, while distinguishing these from reverse causal effects of the cancers on microbial abundance. **Methods and materials:** Using single-nucleotide polymorphisms as instrumental variables, we applied the MR inverse-variance-weighted approach to evaluate the effects of the dorsal-tongue and salivary microbiomes on oral, oropharyngeal, and tongue cancers. Analyses were conducted with the R package TwoSampleMR, leveraging genome-wide association study (GWAS) summary statistics from CNGBdb, the FinnGen consortium, and other sources. Sensitivity, heterogeneity, and pleiotropy assessments were performed. Additionally, reverse MR sensitivity analyses were conducted to explore the possible causal influence of cancers on the oral microbiota. **Results:** Using a single nucleotide polymorphism (SNP) significance threshold of p 5 × 10-6, our large-scale MR study revealed genetically supported causal relationships between microbial taxa derived from saliva and the tongue and the risk of oral, oropharyngeal, and tongue cancers. Integrating these results, we found that both 's Veillonella_rogosae_mgs_2008' and 's unclassified_mgs_1048' conferred a reduced risk of oropharyngeal and tongue cancers. Sensitivity analyses based on heterogeneity tests and pleiotropy evaluations further corroborated the robustness of our findings, lending additional credibility to the conclusions. **Conclusion:** This study leveraged large-scale publicly available genetic data and identified significant causal relationships between the oral microbiota and cancers of the oral cavity, oropharynx, and tongue. Reverse MR analyses indicated that oral and tongue cancers may in turn alter the abundance of specific oral microbes, suggesting a potential bidirectional causal loop. Future work should integrate metagenomic data to further validate these microbiota-cancer associations. **Keywords:** Mendelian randomisation; causal relationship; oral and oropharyngeal cancer; oral cancer; tongue cancer. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ Evaluating the Effect of Telomere Length on Oral and Oropharyngeal Cancer Risk Using Mendelian Randomization. ](https://pubmed.ncbi.nlm.nih.gov/39307671/) Lan L, Zhang R, Liang Y, Chen H, Zhao H, Zhuo X.Lan L, et al.Int Dent J. 2025 Apr;75(2):575-585. doi: 10.1016/j.identj.2024.07.1218. Epub 2024 Sep 21.Int Dent J. 2025.PMID: 39307671Free PMC article. * [ Causal effects between gut microbiota and endometriosis: a two-sample Mendelian randomisation study. ](https://pubmed.ncbi.nlm.nih.gov/38885114/) Cao T, Wang Y, Huimin S.Cao T, et al.J Obstet Gynaecol. 2024 Dec;44(1):2362415. doi: 10.1080/01443615.2024.2362415. 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