---
title: "Mendelian Randomization Study of Oral Cavity Cancer and Lymphoma: No Broad Causal Link"
id: "pubmed-42644523"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42644523"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42644523/"
doi: "10.3290/j.ohpd.c_2780"
published_at: "2026-08-26T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Mendelian Randomization Study of Oral Cavity Cancer and Lymphoma: No Broad Causal Link
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42644523
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42644523/)
- **DOI:** [10.3290/j.ohpd.c_2780](https://doi.org/10.3290%2Fj.ohpd.c_2780)
- **Published At:** 2026-08-26T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This study used a two-sample bidirectional **Mendelian randomization** (MR) design to evaluate whether genetic liability to **oral cavity cancer (OCC)** causally influences risk of lymphoma and vice versa. Instrumental variables (IVs) were derived from genome-wide association studies (GWAS) for each disease. - The inverse variance weighted (IVW) method served as the primary MR estimator. Additional MR approaches were applied and sensitivity analyses, heterogeneity testing, and pleiotropy checks were performed to assess robustness and validity of findings. - Overall, the analysis found no evidence of a bidirectional causal association between OCC and **Hodgkin lymphoma (HL)** or overall **non-Hodgkin lymphoma (NHL)**. - Subgroup analyses of NHL subtypes likewise did not show noteworthy bidirectional causal relationships with OCC, according to the reported results. - An exception was identified: a statistically significant inverse association between genetic liability to **mature T/NK-cell lymphoma** and OCC (IVW odds ratio [OR] 0.985, 95% confidence interval [CI] 0.820–0.978, p = 0.013), indicating patients first diagnosed with mature T/NK-cell lymphoma had a decreased risk of OCC in this analysis. - The authors conclude that a causal relationship between OCC and lymphoma broadly was not supported by this MR study. They recommend replication in future multiethnic studies with larger sample sizes to confirm these results. - Keywords and scope included Mendelian randomization, causal relationship, lymphoma, and oral cavity cancer; the analysis focused on genetic associations and did not report details beyond the MR framework in the abstract.
## Clinical Analysis & Structured Key Points
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Oral Health Prev Dent. 2026. Show details Display options Display options Format Abstract PubMed PMID Oral Health Prev Dent Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Oral+Health+Prev+Dent%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Oral+Health+Prev+Dent%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42644523/) . 2026 Aug 26:24:649-657. doi: 10.3290/j.ohpd.c_2780. ### Authors [Yayan Deng](https://pubmed.ncbi.nlm.nih.gov/?term=Deng+Y&cauthor_id=42644523), [Min Kang](https://pubmed.ncbi.nlm.nih.gov/?term=Kang+M&cauthor_id=42644523) * PMID: **42644523** * DOI: [ 10.3290/j.ohpd.c_2780 ](https://doi.org/10.3290/j.ohpd.c_2780) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Purpose:** Emerging evidence suggests a potential association between oral cavity cancer (OCC) and lymphoma. This study aimed to investigate whether this association reflects a causal relationship. **Materials and methods:** A two-sample bidirectional Mendelian randomization (MR) approach was utilized to screen genetic instrumental variables (IVs) obtained from genome-wide association studies (GWAS) of OCC and lymphoma, applied various MR methods (inverse variance weighted [IVW] as the main method) to assess the causal relationship between the two malignancies, and performed sensitivity, heterogeneity, and pleiotropic tests to evaluate reliability. **Results:** No bidirectional causal association between OCC and Hodgkin lymphoma (HL) or overall non-Hodgkin lymphoma (NHL) was found. Subgroup analysis also showed that no noteworthy bidirectional causal relationship between OCC and NHL subtypes. However, we identified a statistically significant inverse correlation between mature T/NK-cell lymphoma and OCC (IVW: odds ratio [OR] 0.985, 95% confidence interval [CI]: 0.820-0.978, p=0.013). Patients initially diagnosed with mature T/NK-cell lymphoma would have a decreased risk of OCC. **Conclusion:** This MR study ruled out the causal relationship between OCC and lymphoma. Future multiethnic studies with substantial sample sizes are need to replicate our findings. **Keywords:** Mendelian randomization; causal relationship; lymphoma; oral cavity cancer. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ Correlation study of malignant lymphoma and breast Cancer in different gender European populations: mendelian randomization analysis. ](https://pubmed.ncbi.nlm.nih.gov/37814219/) Chen X, Hu G.Chen X, et al.BMC Genom Data. 2023 Oct 9;24(1):59. doi: 10.1186/s12863-023-01162-1.BMC Genom Data. 2023.PMID: 37814219Free PMC article. * [ No genetic causal association between human papillomavirus and lung cancer risk: a bidirectional two-sample Mendelian randomization analysis. ](https://pubmed.ncbi.nlm.nih.gov/39227966/) Chen Y, Xu Z, Zhang Z, Wang X, Dong M.Chen Y, et al.Trials. 2024 Sep 3;25(1):582. doi: 10.1186/s13063-024-08366-5.Trials. 2024.PMID: 39227966Free PMC article. * [ Male infertility and the risk of developing prostate cancer: a bidirectional two-sample Mendelian randomization study. ](https://pubmed.ncbi.nlm.nih.gov/41327353/) Shao J, Apizi A, Zheng X, Tao N, An H.Shao J, et al.Eur J Med Res. 2025 Dec 1;31(1):21. doi: 10.1186/s40001-025-03461-y.Eur J Med Res. 2025.PMID: 41327353Free PMC article. * [ [Genetic Causation Analysis of Hyperandrogenemia Testing Indicators and Preeclampsia]. ](https://pubmed.ncbi.nlm.nih.gov/38948277/) Lin C, Chen J, Zhao X.Lin C, et al.Sichuan Da Xue Xue Bao Yi Xue Ban. 2024 May 20;55(3):566-573. doi: 10.12182/20240560106.Sichuan Da Xue Xue Bao Yi Xue Ban. 2024.PMID: 38948277Free PMC article.Chinese. * [ No causal association between gut microbiota and kawasaki disease: a two-sample mendelian randomization study. ](https://pubmed.ncbi.nlm.nih.gov/39863782/) Wang S, Luo G, Ji Z, Pan S.Wang S, et al.Pediatr Res. 2025 Aug;98(2):423-430. doi: 10.1038/s41390-025-03878-5. 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