---
title: "Metabolomics Advances for Thyroid Cancer Diagnosis and Treatment"
id: "pubmed-42660840"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42660840"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42660840/"
doi: "10.3881/j.issn.1000-503X.16892"
published_at: "2026-08-30T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Metabolomics Advances for Thyroid Cancer Diagnosis and Treatment
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42660840
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42660840/)
- **DOI:** [10.3881/j.issn.1000-503X.16892](https://doi.org/10.3881%2Fj.issn.1000-503X.16892)
- **Published At:** 2026-08-30T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Thyroid cancer is a common endocrine malignancy characterized by high incidence and pronounced heterogeneity. The disease presents diagnostic challenges that contribute to unnecessary procedures. - Current clinical diagnosis relies primarily on ultrasound-guided **fine-needle aspiration biopsy**, which yields indeterminate results in approximately **15%–30%** of lesions, leading to repeat biopsies and additional surgeries. - **Metabolomics** is an emerging discipline that analyzes differential metabolites across biological samples (for example, tissue and blood) to characterize metabolic changes associated with thyroid cancer. - Metabolomic profiling can contribute to earlier diagnosis, inform treatment decisions, and support prognostic assessment by revealing altered metabolic pathways in thyroid neoplasms. - The reviewed literature focuses on studies published in the past five years, summarizing progress in identifying candidate **biomarkers**, mapping metabolic pathway alterations, and exploring potential therapeutic targets for thyroid cancer. - The review aims to provide a theoretical foundation for screening diagnostic metabolic biomarkers and for subsequent exploration of metabolically targeted treatment strategies in thyroid cancer. - Keywords emphasized in the source include **biomarker**, **metabolomics**, **thyroid carcinoma**, and **tumor marker**. - Details on specific differential metabolites, particular metabolic pathways, study cohorts, analytical platforms, assay performance, or clinical validation steps were not reported in the abstract and therefore are not described here.
## Clinical Analysis & Structured Key Points
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Affiliations Expand ### Affiliation * 1 Department of Head and Neck Surgery，The Affiliated Cancer Hospital of Nanjing Medical University，Jiangsu Cancer Hospital，Nanjing 210009，China. * PMID: **42660840** * DOI: [ 10.3881/j.issn.1000-503X.16892 ](https://doi.org/10.3881/j.issn.1000-503x.16892) Item in Clipboard Review # Research Progress in Metabolomics for Thyroid Cancer Diagnosis and Treatment Hai-Yang Zhang et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2026. Show details Display options Display options Format Abstract PubMed PMID Zhongguo Yi Xue Ke Xue Yuan Xue Bao Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Zhongguo+Yi+Xue+Ke+Xue+Yuan+Xue+Bao%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Zhongguo+Yi+Xue+Ke+Xue+Yuan+Xue+Bao%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660840/) . 2026 Aug 30;48(4):711-721. doi: 10.3881/j.issn.1000-503X.16892. ### Authors [Hai-Yang Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+HY&cauthor_id=42660840)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42660840/#short-view-affiliation-1 "Department of Head and Neck Surgery，The Affiliated Cancer Hospital of Nanjing Medical University，Jiangsu Cancer Hospital，Nanjing 210009，China."), [Yao Yao](https://pubmed.ncbi.nlm.nih.gov/?term=Yao+Y&cauthor_id=42660840)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42660840/#short-view-affiliation-1 "Department of Head and Neck Surgery，The Affiliated Cancer Hospital of Nanjing Medical University，Jiangsu Cancer Hospital，Nanjing 210009，China.") ### Affiliation * 1 Department of Head and Neck Surgery，The Affiliated Cancer Hospital of Nanjing Medical University，Jiangsu Cancer Hospital，Nanjing 210009，China. * PMID: **42660840** * DOI: [ 10.3881/j.issn.1000-503X.16892 ](https://doi.org/10.3881/j.issn.1000-503x.16892) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract in [ English, ](https://pubmed.ncbi.nlm.nih.gov/42660840/#eng-abstract) [ Chinese ](https://pubmed.ncbi.nlm.nih.gov/42660840/#zho-abstract) Thyroid cancer （TC） is one of the most common endocrine malignancies with high incidence and heterogeneity.Its diagnosis mainly relies on ultrasound-guided fine-needle aspiration biopsy，while it still fails to give a definitive diagnosis in 15%-30% of lesions，leading to a large number of unnecessary repeat biopsies and surgical procedures.Metabolomics，as a newly developed discipline，plays a role in the early diagnosis，treatment，and prognosis of TC by detecting differential metabolites in a variety of biological samples，such as tissue and blood，and researching the differential expression of metabolic pathways in TC.This review summarizes the research progress of metabolomics in the last 5 years，aiming to provide a theoretical basis for the screening of diagnostic biomarkers and exploring potential therapeutic targets for TC. 甲状腺癌是最常见的内分泌恶性肿瘤，具有高发病率、高异质性的特点。甲状腺癌诊断主要依赖超声引导下细针穿刺活检，其中15%~30%的病变无法给出明确诊断，导致大量不必要的重复活检和外科手术。代谢组学作为新近发展起来的一门学科，通过检测组织、血液等多种生物样本中的差异表达代谢物，研究甲状腺癌发生、发展的代谢相关机制，在甲状腺癌的早期诊断、治疗及预后判断中发挥作用。本文主要综述近5年甲状腺癌相关的代谢组学研究进展，以期为甲状腺癌生物学诊断标志物及潜在治疗靶点的筛选提供理论依据。. **Keywords:** biomarker; metabolomics; thyroid carcinoma; tumor marker. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ The metabolomics and lipidomics window into thyroid cancer research. ](https://pubmed.ncbi.nlm.nih.gov/27805426/) Farrokhi Yekta R, Rezaie Tavirani M, Arefi Oskouie A, Mohajeri-Tehrani MR, Soroush AR.Farrokhi Yekta R, et al.Biomarkers. 2017 Nov;22(7):595-603. doi: 10.1080/1354750X.2016.1256429. Epub 2016 Nov 15.Biomarkers. 2017.PMID: 27805426 * [ Advances in metabolomics of thyroid cancer diagnosis and metabolic regulation. ](https://pubmed.ncbi.nlm.nih.gov/30937722/) Abooshahab R, Gholami M, Sanoie M, Azizi F, Hedayati M.Abooshahab R, et al.Endocrine. 2019 Jul;65(1):1-14. doi: 10.1007/s12020-019-01904-1. Epub 2019 Apr 1.Endocrine. 2019.PMID: 30937722Review. * [ The Potential of Metabolomics in the Diagnosis of Thyroid Cancer. ](https://pubmed.ncbi.nlm.nih.gov/32722293/) Coelho M, Raposo L, Goodfellow BJ, Atzori L, Jones J, Manadas B.Coelho M, et al.Int J Mol Sci. 2020 Jul 24;21(15):5272. doi: 10.3390/ijms21155272.Int J Mol Sci. 2020.PMID: 32722293Free PMC article.Review. * [ High-resolution proteomics and metabolomics in thyroid cancer: Deciphering novel biomarkers. ](https://pubmed.ncbi.nlm.nih.gov/29084467/) Navas-Carrillo D, Rodriguez JM, Montoro-García S, Orenes-Piñero E.Navas-Carrillo D, et al.Crit Rev Clin Lab Sci. 2017 Nov-Dec;54(7-8):446-457. doi: 10.1080/10408363.2017.1394266. Epub 2017 Oct 30.Crit Rev Clin Lab Sci. 2017.PMID: 29084467Review. * [ Diagnosis of post-surgical fine-needle aspiration biopsies of thyroid lesions with indeterminate cytology using HRMAS NMR-based metabolomics. ](https://pubmed.ncbi.nlm.nih.gov/30830426/) Rezig L, Servadio A, Torregrossa L, Miccoli P, Basolo F, Shintu L, Caldarelli S.Rezig L, et al.Metabolomics. 2018 Oct 10;14(10):141. doi: 10.1007/s11306-018-1437-6.Metabolomics. 2018.PMID: 30830426 [ See all similar articles ](https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed&from_uid=42660840) ## Publication types * Review Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Review%22%5Bpt%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Review) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660840/) ## MeSH terms * Biomarkers, Tumor Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biomarkers%2C+Tumor%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Biomarkers%2C+Tumor) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660840/) * Humans Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Humans) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660840/) * Metabolomics* Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Metabolomics%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Metabolomics) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660840/) * Thyroid Neoplasms* / diagnosis Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Thyroid+Neoplasms%2Fdiagnosis%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Thyroid+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660840/) * Thyroid Neoplasms* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Thyroid+Neoplasms%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Thyroid+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660840/) * Thyroid Neoplasms* / therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Thyroid+Neoplasms%2Ftherapy%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Thyroid+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660840/) ## Substances * Biomarkers, Tumor Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biomarkers%2C+Tumor%22%5Bnm%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=%22Biomarkers%2C+Tumor%22) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660840/) [x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM **Send To** * [Clipboard](https://pubmed.ncbi.nlm.nih.gov/42660840/) * [Email](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42660840%2F%23open-email-panel) * [Save](https://pubmed.ncbi.nlm.nih.gov/42660840/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42660840%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42660840%2F%23open-collections-panel) * [Citation Manager](https://pubmed.ncbi.nlm.nih.gov/42660840/) [x] NCBI Literature Resources [MeSH](https://www.ncbi.nlm.nih.gov/mesh/) [PMC](https://www.ncbi.nlm.nih.gov/pmc/) [Bookshelf](https://www.ncbi.nlm.nih.gov/books) [Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 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