---
title: "Molecular Mechanisms Linking Obesity and Endometrial Cancer: Estrogen, Insulin Resistance, Inflamm"
id: "pubmed-42660843"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42660843"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42660843/"
doi: "10.3881/j.issn.1000-503X.16722"
published_at: "2026-08-30T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Molecular Mechanisms Linking Obesity and Endometrial Cancer: Estrogen, Insulin Resistance, Inflamm
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42660843
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42660843/)
- **DOI:** [10.3881/j.issn.1000-503X.16722](https://doi.org/10.3881%2Fj.issn.1000-503X.16722)
- **Published At:** 2026-08-30T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Obesity is a major, well-recognized risk factor for **endometrial cancer**, driving tumor initiation and progression through interconnected biological processes. - Three core, mutually reinforcing pathways—elevated **estrogen** levels, **insulin resistance**, and **chronic inflammation**—form a malignant positive feedback loop that promotes endometrial carcinogenesis. - Visceral and subcutaneous fat depots differentially influence adipokine secretion and the local metabolic microenvironment, which in turn affect molecular subtypes, pathological features, and treatment responses of endometrial cancer. - **Adipokines** and inflammatory signaling from adipose tissue alter tumor biology and the tumor microenvironment, linking metabolic state to immune responses and cancer progression. - Obesity-related changes in **estrogen metabolism** and insulin signaling pathways are central mediators connecting excess adiposity to endometrial tumor growth. - Epigenetic regulation is implicated as an additional mechanism by which obesity influences endometrial cancer risk and behavior, suggesting potential biomarker and therapeutic targets. - The review emphasizes the role of an integrated **adipose-immune-metabolic axis** in tumor initiation and progression, highlighting cross-talk among fat, immune cells, and metabolic signals. - Future research priorities include integrating multi-omics and tumor microenvironment analyses and developing precision therapeutic strategies tailored to obesity subtypes and epigenetic biomarkers to improve clinical management of obesity-related endometrial cancer.
## Clinical Analysis & Structured Key Points
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Affiliations Expand ### Affiliation * 1 National Clinical Research Center for Obstetrics & Gynecology，Department of Obstetrics and Gynecology，Peking Union Medical College Hospital，Chinese Academy of Medical Sciences & Peking Union Medical College，Beijing 100730，China. * PMID: **42660843** * DOI: [ 10.3881/j.issn.1000-503X.16722 ](https://doi.org/10.3881/j.issn.1000-503x.16722) Item in Clipboard Review # Progress in Molecular Biological Mechanism of Endometrial Cancer Induced by Obesity Ying Cao et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2026. Show details Display options Display options Format Abstract PubMed PMID Zhongguo Yi Xue Ke Xue Yuan Xue Bao Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Zhongguo+Yi+Xue+Ke+Xue+Yuan+Xue+Bao%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Zhongguo+Yi+Xue+Ke+Xue+Yuan+Xue+Bao%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660843/) . 2026 Aug 30;48(4):742-750. doi: 10.3881/j.issn.1000-503X.16722. ### Authors [Ying Cao](https://pubmed.ncbi.nlm.nih.gov/?term=Cao+Y&cauthor_id=42660843)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42660843/#short-view-affiliation-1 "National Clinical Research Center for Obstetrics & Gynecology，Department of Obstetrics and Gynecology，Peking Union Medical College Hospital，Chinese Academy of Medical Sciences & Peking Union Medical College，Beijing 100730，China."), [Qian Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+Q&cauthor_id=42660843)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42660843/#short-view-affiliation-1 "National Clinical Research Center for Obstetrics & Gynecology，Department of Obstetrics and Gynecology，Peking Union Medical College Hospital，Chinese Academy of Medical Sciences & Peking Union Medical College，Beijing 100730，China."), [Dong-Yan Cao](https://pubmed.ncbi.nlm.nih.gov/?term=Cao+DY&cauthor_id=42660843)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42660843/#short-view-affiliation-1 "National Clinical Research Center for Obstetrics & Gynecology，Department of Obstetrics and Gynecology，Peking Union Medical College Hospital，Chinese Academy of Medical Sciences & Peking Union Medical College，Beijing 100730，China.") ### Affiliation * 1 National Clinical Research Center for Obstetrics & Gynecology，Department of Obstetrics and Gynecology，Peking Union Medical College Hospital，Chinese Academy of Medical Sciences & Peking Union Medical College，Beijing 100730，China. * PMID: **42660843** * DOI: [ 10.3881/j.issn.1000-503X.16722 ](https://doi.org/10.3881/j.issn.1000-503x.16722) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract in [ English, ](https://pubmed.ncbi.nlm.nih.gov/42660843/#eng-abstract) [ Chinese ](https://pubmed.ncbi.nlm.nih.gov/42660843/#zho-abstract) Obesity is recognized as a major risk factor for endometrial cancer，and its tumor-promoting mechanisms have drawn increasing attention in recent years.Current evidence highlights that obesity drives the initiation and progression of endometrial cancer through three core pathways-elevated estrogen levels，insulin resistance，and chronic inflammation-which form a malignant positive feedback loop.Furthermore，visceral and subcutaneous obesity differentially regulate adipokine secretion and metabolic microenvironments to impact the molecular subtypes，pathological features，and treatment responses of endometrial cancer.This review summarizes recent advances in the molecular mechanisms linking obesity and endometrial cancer，with a focus on adipokines，inflammatory signaling，estrogen metabolism，insulin resistance，and epigenetic regulation.The roles of the adipose-immune-metabolic axis in the initiation and progression of endometrial cancer are expounded.Future research should integrate multi-omics and tumor microenvironment analyses to develop precision therapeutic strategies based on obesity subtypes and epigenetic biomarkers，offering novel insights for clinical management of obesity-related endometrial cancer. 肥胖作为子宫内膜癌最重要的危险因素之一，其促癌机制近年已成为研究热点。大量研究表明，肥胖通过雌激素水平升高、胰岛素抵抗与慢性炎症三大核心机制共同驱动子宫内膜癌发生与进展，三者形成“恶性三角”相互促进。此外，腹型与全身性肥胖通过差异调控脂肪因子分泌与代谢微环境，进一步影响子宫内膜癌的分子分型、病理特征及治疗反应。本文系统综述肥胖相关子宫内膜癌的分子机制研究进展，重点聚焦脂肪组织分泌因子、炎症通路、雌激素代谢、胰岛素抵抗及表观遗传调控等方面，阐明脂肪-免疫-代谢轴在肿瘤发生、发展中的作用。未来研究应进一步整合多组学与微环境研究，探索基于肥胖分型与表观遗传标志的精准治疗策略，以期为肥胖相关子宫内膜癌的临床干预与预后改善提供新思路。. **Keywords:** T-lymphocytes; endometrial cancer; gastrointestinal microbiome; molecular mechanism; obesity. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ Mechanisms underlying obesity-malignancy connection: a systematic narrative review. ](https://pubmed.ncbi.nlm.nih.gov/40408050/) Sultana A, Rana S.Sultana A, et al.J Physiol Biochem. 2025 May;81(2):403-439. doi: 10.1007/s13105-025-01084-9. Epub 2025 May 23.J Physiol Biochem. 2025.PMID: 40408050 * [ Biochemical pathways linking adiposity, diet, and endometrial carcinogenesis. ](https://pubmed.ncbi.nlm.nih.gov/41895370/) Labudda M, Sobieszek KA, Frankowski J, Trafiałek J, Czapla M.Labudda M, et al.Biochimie. 2026 May;244:147-160. doi: 10.1016/j.biochi.2026.03.008. 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