---
title: "MSI‑High Colorectal Cancer in an Adolescent: Integrated Surgical, Molecular, and Adjuvant Manageme"
id: "pubmed-42892709"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42892709"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42892709/"
doi: "10.12659/AJCR.953248"
published_at: "2026-10-18T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# MSI‑High Colorectal Cancer in an Adolescent: Integrated Surgical, Molecular, and Adjuvant Manageme
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42892709
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42892709/)
- **DOI:** [10.12659/AJCR.953248](https://doi.org/10.12659%2FAJCR.953248)
- **Published At:** 2026-10-18T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- A 16-year-old male presented with presumed appendicitis and underwent appendectomy; persistent obstruction prompted further imaging that identified a descending colon tumor requiring emergency surgery. - Emergency Hartmann's procedure was performed for acute intestinal obstruction caused by the tumor; pathology reported **mucinous adenocarcinoma**, staged pT4N0M0 with vascular invasion. - Immunohistochemistry demonstrated loss of **MSH2/MSH6** expression and retention of MLH1/PMS2, indicating **dMMR** and findings strongly suggestive of Lynch syndrome; germline testing was not available. - Molecular profiling detected a **KRAS** mutation; NRAS alterations were not reported. The source did not provide additional molecular variant details or sequencing methodology. - Given multiple high-risk features (T4 stage, obstruction, vascular invasion, mucinous histology, and very young age), the patient received 12 cycles of adjuvant **FOLFOX** chemotherapy; tolerability was reported as good. - Follow-up beyond adjuvant therapy showed the patient remained disease-free for more than five years after completing treatment, per the authors' report. - The case emphasizes routine **MMR/MSI** testing and comprehensive molecular profiling in young-onset colorectal cancer to identify hereditary syndromes and guide multidisciplinary care decisions. - Authors noted this report describes a single case and that germline genetic testing was unavailable, limiting confirmation of Lynch syndrome in this patient.
## Clinical Analysis & Structured Key Points
Clipboard, Search History, and several other advanced features are temporarily unavailable. [ Skip to main page content ](https://pubmed.ncbi.nlm.nih.gov/42892709/#article-details) ![U.S. flag](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png) An official website of the United States government Here's how you know ![Dot gov](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg) **The .gov means it’s official.** Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. ![Https](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg) **The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [ ![NIH NLM Logo](https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg) ](https://www.ncbi.nlm.nih.gov/) [Log in](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42892709%2F) Show account info Close #### Account Logged in as: **username** * [Dashboard](https://www.ncbi.nlm.nih.gov/myncbi/) * [Publications](https://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/) * [Account settings](https://www.ncbi.nlm.nih.gov/account/settings/) * [Log out](https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/42892709/) [Access keys](https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys) [NCBI Homepage](https://www.ncbi.nlm.nih.gov) [MyNCBI Homepage](https://pubmed.ncbi.nlm.nih.gov/myncbi/) [Main Content](https://pubmed.ncbi.nlm.nih.gov/42892709/#maincontent) [Main Navigation](https://pubmed.ncbi.nlm.nih.gov/42892709/) [ ![pubmed logo](https://cdn.ncbi.nlm.nih.gov/pubmed/a447896c-976f-490b-b86b-2668b65114a8/core/images/pubmed-logo-blue.svg) ](https://pubmed.ncbi.nlm.nih.gov/) [ ](https://pubmed.ncbi.nlm.nih.gov/42892709/ "Show search bar") Search: [](https://pubmed.ncbi.nlm.nih.gov/42892709/ "Clear search input")Search [Advanced](https://pubmed.ncbi.nlm.nih.gov/advanced/) [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/clipboard/) [ User Guide ](https://pubmed.ncbi.nlm.nih.gov/help/) Save Email Send to * [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/42892709/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42892709%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42892709%2F%23open-collections-panel) * [Citation manager](https://pubmed.ncbi.nlm.nih.gov/42892709/) Display options Display options Format Abstract PubMed PMID ## Save citation to file Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel ## Email citation Email address has not been verified. Go to [ My NCBI account settings ](https://account.ncbi.nlm.nih.gov/settings/) to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel ### Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42892709/) Add Cancel ### Add to My Bibliography * My Bibliography Unable to load your delegates due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42892709/) Add Cancel ## Your saved search Name of saved search: Search terms: [Test search terms](https://pubmed.ncbi.nlm.nih.gov/42892709/) Would you like email updates of new search results? Saved Search Alert Radio Buttons * Yes * No Email: ([change](https://www.ncbi.nlm.nih.gov/account/settings/)) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel ## Create a file for external citation management software Create file Cancel ## Your RSS Feed Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy ### Actions Cite Collections Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42892709/) Add Cancel Permalink Permalink Copy Display options Display options Format Abstract PubMed PMID ### Experimental Resource Linked Discoveries ### Page navigation * [ Title & authors ](https://pubmed.ncbi.nlm.nih.gov/42892709/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42892709/#abstract) * [ Publication types ](https://pubmed.ncbi.nlm.nih.gov/42892709/#publication-types) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42892709/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42892709/#substances) * [ Supplementary concepts ](https://pubmed.ncbi.nlm.nih.gov/42892709/#supplementary-concepts) Title & authors Abstract Publication types MeSH terms Substances Supplementary concepts Case Reports Am J Case Rep Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Am+J+Case+Rep%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Am+J+Case+Rep%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) . 2026 Oct 18:27:e953248. doi: 10.12659/AJCR.953248. # An Integrated Approach to MSI-High Colorectal Cancer Therapy in a Young Patient: A Clinical Case [Innara Turkpenova](https://pubmed.ncbi.nlm.nih.gov/?term=Turkpenova+I&cauthor_id=42892709)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42892709/#full-view-affiliation-1 "Department of Oncology, Kazakh Research Institute of Oncology and Radiology \(KazIOR\), Almaty, Kazakhstan.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42892709/#full-view-affiliation-2 "Кazakh-Russian Medical University, Almaty, Kazakhstan."), [Kaldygul Smagulova](https://pubmed.ncbi.nlm.nih.gov/?term=Smagulova+K&cauthor_id=42892709)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42892709/#full-view-affiliation-1 "Department of Oncology, Kazakh Research Institute of Oncology and Radiology \(KazIOR\), Almaty, Kazakhstan."), [Abay Jumanov](https://pubmed.ncbi.nlm.nih.gov/?term=Jumanov+A&cauthor_id=42892709)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42892709/#full-view-affiliation-1 "Department of Oncology, Kazakh Research Institute of Oncology and Radiology \(KazIOR\), Almaty, Kazakhstan.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42892709/#full-view-affiliation-3 "Al-Farabi Kazakh National University, Almaty, Kazakhstan."), [Aisha Moldasheva](https://pubmed.ncbi.nlm.nih.gov/?term=Moldasheva+A&cauthor_id=42892709)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42892709/#full-view-affiliation-1 "Department of Oncology, Kazakh Research Institute of Oncology and Radiology \(KazIOR\), Almaty, Kazakhstan."), [Rabiga Kadyrbayeva](https://pubmed.ncbi.nlm.nih.gov/?term=Kadyrbayeva+R&cauthor_id=42892709)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42892709/#full-view-affiliation-1 "Department of Oncology, Kazakh Research Institute of Oncology and Radiology \(KazIOR\), Almaty, Kazakhstan."), [Azhar Imanaliyeva](https://pubmed.ncbi.nlm.nih.gov/?term=Imanaliyeva+A&cauthor_id=42892709)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42892709/#full-view-affiliation-1 "Department of Oncology, Kazakh Research Institute of Oncology and Radiology \(KazIOR\), Almaty, Kazakhstan.") Affiliations Expand ### Affiliations * 1 Department of Oncology, Kazakh Research Institute of Oncology and Radiology (KazIOR), Almaty, Kazakhstan. * 2 Кazakh-Russian Medical University, Almaty, Kazakhstan. * 3 Al-Farabi Kazakh National University, Almaty, Kazakhstan. * PMID: **42892709** * DOI: [ 10.12659/AJCR.953248 ](https://doi.org/10.12659/ajcr.953248) Item in Clipboard Case Reports # An Integrated Approach to MSI-High Colorectal Cancer Therapy in a Young Patient: A Clinical Case Innara Turkpenova et al. Am J Case Rep. 2026. Show details Display options Display options Format Abstract PubMed PMID Am J Case Rep Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Am+J+Case+Rep%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Am+J+Case+Rep%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) . 2026 Oct 18:27:e953248. doi: 10.12659/AJCR.953248. ### Authors [Innara Turkpenova](https://pubmed.ncbi.nlm.nih.gov/?term=Turkpenova+I&cauthor_id=42892709)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42892709/#short-view-affiliation-1 "Department of Oncology, Kazakh Research Institute of Oncology and Radiology \(KazIOR\), Almaty, Kazakhstan.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42892709/#short-view-affiliation-2 "Кazakh-Russian Medical University, Almaty, Kazakhstan."), [Kaldygul Smagulova](https://pubmed.ncbi.nlm.nih.gov/?term=Smagulova+K&cauthor_id=42892709)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42892709/#short-view-affiliation-1 "Department of Oncology, Kazakh Research Institute of Oncology and Radiology \(KazIOR\), Almaty, Kazakhstan."), [Abay Jumanov](https://pubmed.ncbi.nlm.nih.gov/?term=Jumanov+A&cauthor_id=42892709)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42892709/#short-view-affiliation-1 "Department of Oncology, Kazakh Research Institute of Oncology and Radiology \(KazIOR\), Almaty, Kazakhstan.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42892709/#short-view-affiliation-3 "Al-Farabi Kazakh National University, Almaty, Kazakhstan."), [Aisha Moldasheva](https://pubmed.ncbi.nlm.nih.gov/?term=Moldasheva+A&cauthor_id=42892709)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42892709/#short-view-affiliation-1 "Department of Oncology, Kazakh Research Institute of Oncology and Radiology \(KazIOR\), Almaty, Kazakhstan."), [Rabiga Kadyrbayeva](https://pubmed.ncbi.nlm.nih.gov/?term=Kadyrbayeva+R&cauthor_id=42892709)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42892709/#short-view-affiliation-1 "Department of Oncology, Kazakh Research Institute of Oncology and Radiology \(KazIOR\), Almaty, Kazakhstan."), [Azhar Imanaliyeva](https://pubmed.ncbi.nlm.nih.gov/?term=Imanaliyeva+A&cauthor_id=42892709)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42892709/#short-view-affiliation-1 "Department of Oncology, Kazakh Research Institute of Oncology and Radiology \(KazIOR\), Almaty, Kazakhstan.") ### Affiliations * 1 Department of Oncology, Kazakh Research Institute of Oncology and Radiology (KazIOR), Almaty, Kazakhstan. * 2 Кazakh-Russian Medical University, Almaty, Kazakhstan. * 3 Al-Farabi Kazakh National University, Almaty, Kazakhstan. * PMID: **42892709** * DOI: [ 10.12659/AJCR.953248 ](https://doi.org/10.12659/ajcr.953248) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID Linked Discoveries ## Abstract BACKGROUND Colorectal cancer (CRC) is extremely rare in adolescents and often presents with advanced disease because of nonspecific symptoms. Deficient mismatch repair (dMMR) and microsatellite instability-high (MSI-H) are important biomarkers that influence prognosis, treatment selection, and the need for genetic evaluation. We report the case of an adolescent with MSI-H-associated CRC presenting with acute intestinal obstruction. CASE REPORT A 16-year-old male initially underwent appendectomy for presumed acute appendicitis. Persistent postoperative bowel obstruction prompted computed tomography (CT), revealing a descending colon tumor requiring emergency Hartmann's procedure. Histopathology demonstrated mucinous adenocarcinoma, pT4N0M0, with vascular invasion. Immunohistochemistry showed loss of MSH2/MSH6 expression with retained MLH1/PMS2, indicating dMMR and findings highly suggestive of Lynch syndrome, although germline testing was unavailable. Molecular analysis identified a KRAS mutation without NRAS alterations. Given his multiple high-risk features, including T4 disease, bowel obstruction, vascular invasion, mucinous histology, and very young age, he received 12 cycles of adjuvant FOLFOX chemotherapy. Treatment was well tolerated, and he remains disease-free more than 5 years after completion of therapy. CONCLUSIONS This case highlights the diagnostic complexity of adolescent CRC and the need to consider colorectal malignancy in young patients with persistent or atypical abdominal symptoms. Routine MMR/MSI testing and comprehensive molecular profiling are essential in young-onset CRC to identify patients who may have hereditary cancer syndromes and require genetic counseling. Although limited to a single case, this report underscores the importance of multidisciplinary decision-making and individualized treatment based on clinicopathological and molecular characteristics, which may contribute to favorable long-term outcomes. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Publication types * Case Reports Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Case+Reports%22%5Bpt%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Case+Reports) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) ## MeSH terms * Adenocarcinoma, Mucinous* / drug therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Adenocarcinoma%2C+Mucinous%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Adenocarcinoma%2C+Mucinous) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) * Adenocarcinoma, Mucinous* / genetics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Adenocarcinoma%2C+Mucinous%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Adenocarcinoma%2C+Mucinous) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) * Adenocarcinoma, Mucinous* / therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Adenocarcinoma%2C+Mucinous%2Ftherapy%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Adenocarcinoma%2C+Mucinous) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) * Adolescent Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Adolescent%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Adolescent) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) * Antineoplastic Combined Chemotherapy Protocols / therapeutic use Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Antineoplastic+Combined+Chemotherapy+Protocols%2Ftherapeutic+use%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Antineoplastic+Combined+Chemotherapy+Protocols) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) * Colorectal Neoplasms* / diagnosis Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Colorectal+Neoplasms%2Fdiagnosis%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Colorectal+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) * Colorectal Neoplasms* / drug therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Colorectal+Neoplasms%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Colorectal+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) * Colorectal Neoplasms* / genetics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Colorectal+Neoplasms%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Colorectal+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) * Colorectal Neoplasms* / therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Colorectal+Neoplasms%2Ftherapy%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Colorectal+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) * Fluorouracil / therapeutic use Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Fluorouracil%2Ftherapeutic+use%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Fluorouracil) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) * Humans Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Humans) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) * Intestinal Obstruction / etiology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Intestinal+Obstruction%2Fetiology%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Intestinal+Obstruction) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) * Leucovorin / therapeutic use Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Leucovorin%2Ftherapeutic+use%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Leucovorin) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) * Male Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Male%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Male) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) * Microsatellite Instability* Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Microsatellite+Instability%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Microsatellite+Instability) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) * Organoplatinum Compounds / therapeutic use Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Organoplatinum+Compounds%2Ftherapeutic+use%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Organoplatinum+Compounds) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) ## Substances * Leucovorin Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Leucovorin%22%5Bnm%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=%22Leucovorin%22) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) * Organoplatinum Compounds Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Organoplatinum+Compounds%22%5Bnm%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=%22Organoplatinum+Compounds%22) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42892709/) * Fluorouracil Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Fluorouracil%22%5Bnm%5D&sort=dat
## Related Clinical Research

- [Camupepimut (ELI-002 7P) in KRAS-mutant PDAC: Phase 2 AMPLIFY-7P results](https://medichelpline.com/clinical-feed/nature-1-lymph-node-targeted-mkras-specific-amphiphile-vaccine-in-pancreatic-cancer-the.md)
- [Chromosomal instability drives continual flux in cancer genomes: rates, distribution, and ploidy l](https://medichelpline.com/clinical-feed/biorxiv-9-chromosomal-instability-drives-continual-flux-in-cancer-genomes.md)
- [Cardiorespiratory fitness and sex modify colorectal cancer–suppressive effects of post-exercise se](https://medichelpline.com/clinical-feed/biorxiv-7-cardiorespiratory-fitness-and-sex-impact-the-colorectal-cancer-suppressive.md)
- [CXCL14+ fibroblasts drive IBD-associated fibrosis and cancer through collagen IV–SPP1+ macrophage](https://medichelpline.com/clinical-feed/british-journal-of-cancer-0-cxcl14-fibroblasts-promote-development-of-ibd-associated-fibrosis-and-cancer-by.md)
- [Ultra-processed food intake not linked to colorectal cancer incidence in large NIH‑AARP cohort](https://medichelpline.com/clinical-feed/plos-medicine-0-associations-of-food-processing-and-dietary-risk-factors-with-colorectal-cancer.md)

## Navigation
- [← Back to Oncology Feed](https://medichelpline.com/clinical-feed/oncology.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.