---
title: "MZT1 Identified as a Proliferation-Associated Prognostic Marker in Lung Adenocarcinoma via Transcr"
id: "pubmed-42674820"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42674820"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42674820/"
doi: "10.21873/cgp.20613"
published_at: "2026-09-01T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# MZT1 Identified as a Proliferation-Associated Prognostic Marker in Lung Adenocarcinoma via Transcr
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42674820
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42674820/)
- **DOI:** [10.21873/cgp.20613](https://doi.org/10.21873%2Fcgp.20613)
- **Published At:** 2026-09-01T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The study title reports that **MZT1** was identified as a **proliferation-associated prognostic marker** in **lung adenocarcinoma** using multi-level **transcriptomic** and **machine-learning** analyses. - The work was published in Cancer Genomics Proteomics (2026 Sep–Oct;23(5):996–1020) and is indexed with PMID 42674820 and DOI 10.21873/cgp.20613. - Authors include Dahlak Daniel Solomon and multiple collaborators from Taipei Medical University, National Sun Yat-sen University, Kaohsiung Armed Forces General Hospital, Tri-Service General Hospital/National Defense Medical University, University of South Florida, and other institutions. - Affiliations span academic and clinical departments in Taiwan, the United States, India, and Vietnam, reflecting a multidisciplinary and multi-institutional collaboration. - The article’s stated methodology in the title includes multi-level transcriptomic data interrogation combined with machine-learning approaches, implying integrative genomic analyses and computational modeling were central to marker discovery. - The central claimed outcome is the identification of **MZT1** as associated with cellular proliferation and prognostic performance in lung adenocarcinoma; however, the source text provided does not include the abstract, numerical results, performance metrics, cohort sizes, validation strategy, or specific machine-learning models used. - Because the PubMed page content supplied lacks the article abstract and full text details, specifics such as statistical significance, hazard ratios, cross-validation, independent validation cohorts, expression platforms, or experimental validation were not reported in the available source. - The metadata (journal, volume, pages, DOI, PMID, authors, and affiliations) is available and confirms publication but does not permit extraction of study design, cohort characteristics, or clinical recommendations from the source text provided. - Any further interpretation of study methods, results, or clinical implications beyond the title-level claim would require access to the full article or abstract, which were not present in the supplied source content.
## Clinical Analysis & Structured Key Points
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](https://pubmed.ncbi.nlm.nih.gov/42674820/#abstract) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42674820/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42674820/#substances) Title & authors Abstract MeSH terms Substances Cancer Genomics Proteomics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cancer+Genomics+Proteomics%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Cancer+Genomics+Proteomics%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42674820/) . 2026 Sep-Oct;23(5):996-1020. doi: 10.21873/cgp.20613. # Multi-level Transcriptomic and Machine-learning Analyses Identify _MZT1_ as a Proliferation-associated Prognostic Marker in Lung Adenocarcinoma [Dahlak Daniel Solomon](https://pubmed.ncbi.nlm.nih.gov/?term=Solomon+DD&cauthor_id=42674820)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-1 "Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei, Taiwan, R.O.C.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-2 "Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, R.O.C."), [Hui-Ru Lin](https://pubmed.ncbi.nlm.nih.gov/?term=Lin+HR&cauthor_id=42674820)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-3 "Nursing Department, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, R.O.C.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-4 "Department of Emergency Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, R.O.C.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-5 "Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan, R.O.C."), [Yung-Kuo Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+YK&cauthor_id=42674820)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-5 "Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan, R.O.C.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-6 "Division of Experimental Surgery Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan, R.O.C.")[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-7 "School of Medicine, National Defense Medical University, Taipei, Taiwan, R.O.C.")[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-8 "Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, R.O.C."), [Sachin Kumar](https://pubmed.ncbi.nlm.nih.gov/?term=Kumar+S&cauthor_id=42674820)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-1 "Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei, Taiwan, R.O.C.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-2 "Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, R.O.C.")[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-9 "Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Himachal Pradesh, India."), [Ching-Chung Ko](https://pubmed.ncbi.nlm.nih.gov/?term=Ko+CC&cauthor_id=42674820)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-10 "Department of Medical Imaging, Chi-Mei Medical Center, Tainan, Taiwan, R.O.C.")[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-11 "Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan, R.O.C.")[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-12 "School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan, R.O.C."), [Kai-Fu Chang](https://pubmed.ncbi.nlm.nih.gov/?term=Chang+KF&cauthor_id=42674820)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-5 "Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan, R.O.C.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-6 "Division of Experimental Surgery Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan, R.O.C."), [Chung-Hsien Lin](https://pubmed.ncbi.nlm.nih.gov/?term=Lin+CH&cauthor_id=42674820)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-5 "Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan, R.O.C.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-6 "Division of Experimental Surgery Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan, R.O.C."), [Ngoc Uyen Nhi Nguyen](https://pubmed.ncbi.nlm.nih.gov/?term=Nhi+Nguyen+NU&cauthor_id=42674820)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-13 "Center for Regenerative Medicine, University of South Florida Health Heart Institute, Tampa, FL, U.S.A.")[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-14 "Division of Cardiology, Department of Internal Medicine, Morsani School of Medicine, University of South Florida, Tampa, FL, U.S.A."), [DO Thi Minh Xuan](https://pubmed.ncbi.nlm.nih.gov/?term=Minh+Xuan+DT&cauthor_id=42674820)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-15 "Faculty of Pharmacy, Van Lang University, Binh Loi Trung Ward, Ho Chi Minh City, Vietnam."), [Neethu Palekkode](https://pubmed.ncbi.nlm.nih.gov/?term=Palekkode+N&cauthor_id=42674820)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-1 "Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei, Taiwan, R.O.C.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-2 "Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, R.O.C."), [Chih-Yang Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+CY&cauthor_id=42674820)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-16 "Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei, Taiwan, R.O.C.; chihyang@tmu.edu.tw mysing@gmail.com.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-2 "Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, R.O.C.")[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-17 "TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan, R.O.C."), [Yun-Shih Lin](https://pubmed.ncbi.nlm.nih.gov/?term=Lin+YS&cauthor_id=42674820)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#full-view-affiliation-18 "Department of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, R.O.C. chihyang@tmu.edu.tw mysing@gmail.com.") Affiliations Expand ### Affiliations * 1 Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei, Taiwan, R.O.C. * 2 Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, R.O.C. * 3 Nursing Department, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, R.O.C. * 4 Department of Emergency Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, R.O.C. * 5 Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan, R.O.C. * 6 Division of Experimental Surgery Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan, R.O.C. * 7 School of Medicine, National Defense Medical University, Taipei, Taiwan, R.O.C. * 8 Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, R.O.C. * 9 Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Himachal Pradesh, India. * 10 Department of Medical Imaging, Chi-Mei Medical Center, Tainan, Taiwan, R.O.C. * 11 Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan, R.O.C. * 12 School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan, R.O.C. * 13 Center for Regenerative Medicine, University of South Florida Health Heart Institute, Tampa, FL, U.S.A. * 14 Division of Cardiology, Department of Internal Medicine, Morsani School of Medicine, University of South Florida, Tampa, FL, U.S.A. * 15 Faculty of Pharmacy, Van Lang University, Binh Loi Trung Ward, Ho Chi Minh City, Vietnam. * 16 Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei, Taiwan, R.O.C.; chihyang@tmu.edu.tw mysing@gmail.com. * 17 TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan, R.O.C. * 18 Department of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, R.O.C. chihyang@tmu.edu.tw mysing@gmail.com. * PMID: **42674820** * DOI: [ 10.21873/cgp.20613 ](https://doi.org/10.21873/cgp.20613) Item in Clipboard # Multi-level Transcriptomic and Machine-learning Analyses Identify _MZT1_ as a Proliferation-associated Prognostic Marker in Lung Adenocarcinoma Dahlak Daniel Solomon et al. Cancer Genomics Proteomics. 2026 Sep-Oct. Show details Display options Display options Format Abstract PubMed PMID Cancer Genomics Proteomics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cancer+Genomics+Proteomics%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Cancer+Genomics+Proteomics%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42674820/) . 2026 Sep-Oct;23(5):996-1020. doi: 10.21873/cgp.20613. ### Authors [Dahlak Daniel Solomon](https://pubmed.ncbi.nlm.nih.gov/?term=Solomon+DD&cauthor_id=42674820)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#short-view-affiliation-1 "Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei, Taiwan, R.O.C.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#short-view-affiliation-2 "Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, R.O.C."), [Hui-Ru Lin](https://pubmed.ncbi.nlm.nih.gov/?term=Lin+HR&cauthor_id=42674820)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#short-view-affiliation-3 "Nursing Department, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, R.O.C.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#short-view-affiliation-4 "Department of Emergency Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, R.O.C.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#short-view-affiliation-5 "Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan, R.O.C."), [Yung-Kuo Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+YK&cauthor_id=42674820)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#short-view-affiliation-5 "Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan, R.O.C.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#short-view-affiliation-6 "Division of Experimental Surgery Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan, R.O.C.")[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#short-view-affiliation-7 "School of Medicine, National Defense Medical University, Taipei, Taiwan, R.O.C.")[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#short-view-affiliation-8 "Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, R.O.C."), [Sachin Kumar](https://pubmed.ncbi.nlm.nih.gov/?term=Kumar+S&cauthor_id=42674820)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#short-view-affiliation-1 "Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei, Taiwan, R.O.C.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#short-view-affiliation-2 "Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, R.O.C.")[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#short-view-affiliation-9 "Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Himachal Pradesh, India."), [Ching-Chung Ko](https://pubmed.ncbi.nlm.nih.gov/?term=Ko+CC&cauthor_id=42674820)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#short-view-affiliation-10 "Department of Medical Imaging, Chi-Mei Medical Center, Tainan, Taiwan, R.O.C.")[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#short-view-affiliation-11 "Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan, R.O.C.")[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#short-view-affiliation-12 "School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan, R.O.C."), [Kai-Fu Chang](https://pubmed.ncbi.nlm.nih.gov/?term=Chang+KF&cauthor_id=42674820)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#short-view-affiliation-5 "Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan, R.O.C.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#short-view-affiliation-6 "Division of Experimental Surgery Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan, R.O.C."), [Chung-Hsien Lin](https://pubmed.ncbi.nlm.nih.gov/?term=Lin+CH&cauthor_id=42674820)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#short-view-affiliation-5 "Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan, R.O.C.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42674820/#short-view-affiliation-6 "Division of Experimental Surgery Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan, R.O.C."), [Ngoc Uyen Nhi Nguyen](https://pubmed.ncbi.nlm.nih.go
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