---
title: "Neural-Related Products in Cancer-Derived Mesenchymal Stem Cells: Expression and Prognostic Associ"
id: "pubmed-42670284"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42670284"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42670284/"
doi: "10.1002/cam4.72199"
published_at: "2026-09-01T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Neural-Related Products in Cancer-Derived Mesenchymal Stem Cells: Expression and Prognostic Associ
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42670284
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42670284/)
- **DOI:** [10.1002/cam4.72199](https://doi.org/10.1002%2Fcam4.72199)
- **Published At:** 2026-09-01T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The study reports that **cancer-derived mesenchymal stem cells (CA-MSCs)** display characteristics of **neural stem cells (NSCs)** and are abundant within tumors. - CA-MSCs express a wide array of **neural-related products**, including neurotrophic factors, neuropeptides, synapse-associated proteins, and axon guidance/axogenesis molecules. - Compared with human NSCs, CA-MSCs expressed higher levels of the neurotrophic factors **BDNF**, **GDNF**, and **NGF**. - Expression–prognosis analysis found that **MDK** and **MANF** were expressed at higher levels in cancer tissues. - Expression of **BDNF**, **NPTX1**, and **NGF** increased with advancing tumor stage. - Ten surveyed neuropeptides had lower expression in cancer compared with normal tissue. - Thirty synapse-related products showed varied expression patterns between cancer and normal tissues; among these, **SYPL1**, **SYBP2/3**, and **STX4** had significant associations with tumor prognosis. - Elevated levels of **syntaxin-4**, neugrin, and other axogenesis-related products correlated with worse prognosis in cancer. - Immunohistochemistry confirmed that NSC-like CA-MSCs are densely distributed in tumors and exert a clear tumor growth–promoting effect. - The authors conclude that CA-MSCs, abundant in cancer and with NSC features, express many nerve-related products that likely influence tumor progression and patient prognosis.
## Clinical Analysis & Structured Key Points
Clipboard, Search History, and several other advanced features are temporarily unavailable. [ Skip to main page content ](https://pubmed.ncbi.nlm.nih.gov/42670284/#article-details) ![U.S. flag](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png) An official website of the United States government Here's how you know ![Dot gov](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg) **The .gov means it’s official.** Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. ![Https](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg) **The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [ ![NIH NLM Logo](https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg) ](https://www.ncbi.nlm.nih.gov/) [Log in](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42670284%2F) Show account info Close #### Account Logged in as: **username** * [Dashboard](https://www.ncbi.nlm.nih.gov/myncbi/) * [Publications](https://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/) * [Account settings](https://www.ncbi.nlm.nih.gov/account/settings/) * [Log out](https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/42670284/) [Access keys](https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys) [NCBI Homepage](https://www.ncbi.nlm.nih.gov) [MyNCBI Homepage](https://pubmed.ncbi.nlm.nih.gov/myncbi/) [Main Content](https://pubmed.ncbi.nlm.nih.gov/42670284/#maincontent) [Main Navigation](https://pubmed.ncbi.nlm.nih.gov/42670284/) [ ![pubmed logo](https://cdn.ncbi.nlm.nih.gov/pubmed/af7de7da-df5d-41c6-8de4-8c266af8ccfb/core/images/pubmed-logo-blue.svg) ](https://pubmed.ncbi.nlm.nih.gov/) [ ](https://pubmed.ncbi.nlm.nih.gov/42670284/ "Show search bar") Search: [](https://pubmed.ncbi.nlm.nih.gov/42670284/ "Clear search input")Search [Advanced](https://pubmed.ncbi.nlm.nih.gov/advanced/) [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/clipboard/) [ User Guide ](https://pubmed.ncbi.nlm.nih.gov/help/) Save Email Send to * [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/42670284/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42670284%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42670284%2F%23open-collections-panel) * [Citation manager](https://pubmed.ncbi.nlm.nih.gov/42670284/) Display options Display options Format Abstract PubMed PMID ## Save citation to file Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel ## Email citation Email address has not been verified. Go to [ My NCBI account settings ](https://account.ncbi.nlm.nih.gov/settings/) to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel ### Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42670284/) Add Cancel ### Add to My Bibliography * My Bibliography Unable to load your delegates due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42670284/) Add Cancel ## Your saved search Name of saved search: Search terms: [Test search terms](https://pubmed.ncbi.nlm.nih.gov/42670284/) Would you like email updates of new search results? Saved Search Alert Radio Buttons * Yes * No Email: ([change](https://www.ncbi.nlm.nih.gov/account/settings/)) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel ## Create a file for external citation management software Create file Cancel ## Your RSS Feed Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy ### Actions Cite Collections Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42670284/) Add Cancel Permalink Permalink Copy Display options Display options Format Abstract PubMed PMID ### Page navigation * [ Title & authors ](https://pubmed.ncbi.nlm.nih.gov/42670284/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42670284/#abstract) * [Similar articles](https://pubmed.ncbi.nlm.nih.gov/42670284/#similar) * [ References ](https://pubmed.ncbi.nlm.nih.gov/42670284/#references) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42670284/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42670284/#substances) * [ Grants and funding ](https://pubmed.ncbi.nlm.nih.gov/42670284/#grants) Title & authors Abstract Similar articles References MeSH terms Substances Grants and funding Cancer Med Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cancer+Med%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Cancer+Med%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42670284/) . 2026 Sep;15(9):e72199. doi: 10.1002/cam4.72199. # Evaluation of the Expression and Prognosis of Neural-Related Products Expressed by Cancer-Derived Mesenchymal Stem Cells With the Characteristics of Neural Stem Cells [Liu Yongjun](https://pubmed.ncbi.nlm.nih.gov/?term=Yongjun+L&cauthor_id=42670284)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#full-view-affiliation-1 "Department of Endoscopy, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine \(HIM\), Chinese Academy of Sciences, Hangzhou, Zhejiang, China."), [Pan Zhiwen](https://pubmed.ncbi.nlm.nih.gov/?term=Zhiwen+P&cauthor_id=42670284)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#full-view-affiliation-2 "Clinical Laboratory Department, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine \(HIM\), Chinese Academy of Sciences, Hangzhou, Zhejiang, China."), [Fu Shangui](https://pubmed.ncbi.nlm.nih.gov/?term=Shangui+F&cauthor_id=42670284)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#full-view-affiliation-3 "National Clinical Research Center for Children and Adolescents' Health and Diseases, National Children's Regional Medical Center, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China."), [Zhai Jinjie](https://pubmed.ncbi.nlm.nih.gov/?term=Jinjie+Z&cauthor_id=42670284)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#full-view-affiliation-4 "Department of Gastrointestinal Surgery, Taizhou Cancer Hospital, Wenling, Zhejiang, China."), [Ying Rongbiao](https://pubmed.ncbi.nlm.nih.gov/?term=Rongbiao+Y&cauthor_id=42670284)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#full-view-affiliation-4 "Department of Gastrointestinal Surgery, Taizhou Cancer Hospital, Wenling, Zhejiang, China."), [Chen Zhongjian](https://pubmed.ncbi.nlm.nih.gov/?term=Zhongjian+C&cauthor_id=42670284)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#full-view-affiliation-5 "Institute of Cancer and Basic Medicine \(ICBM\), Zhejiang Cancer Hospital, Hangzhou Institute of Medicine \(HIM\), Chinese Academy of Sciences, Hangzhou, Zhejiang, China."), [Chen Wanyuan](https://pubmed.ncbi.nlm.nih.gov/?term=Wanyuan+C&cauthor_id=42670284)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#full-view-affiliation-6 "Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine \(HIM\), Chinese Academy of Sciences, Hangzhou, Zhejiang, China."), [Ju Haixing](https://pubmed.ncbi.nlm.nih.gov/?term=Haixing+J&cauthor_id=42670284)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#full-view-affiliation-6 "Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine \(HIM\), Chinese Academy of Sciences, Hangzhou, Zhejiang, China."), [Ma Dening](https://pubmed.ncbi.nlm.nih.gov/?term=Dening+M&cauthor_id=42670284)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#full-view-affiliation-6 "Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine \(HIM\), Chinese Academy of Sciences, Hangzhou, Zhejiang, China."), [Long Dan](https://pubmed.ncbi.nlm.nih.gov/?term=Dan+L&cauthor_id=42670284)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#full-view-affiliation-7 "Department of Radiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine \(HIM\), Chinese Academy of Sciences, Hangzhou, Zhejiang, China."), [Luo Cong](https://pubmed.ncbi.nlm.nih.gov/?term=Cong+L&cauthor_id=42670284)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#full-view-affiliation-8 "Department of Abdominal Oncology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine \(HIM\), Chinese Academy of Sciences, Hangzhou, Zhejiang, China."), [Fu Zhixuan](https://pubmed.ncbi.nlm.nih.gov/?term=Zhixuan+F&cauthor_id=42670284)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#full-view-affiliation-6 "Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine \(HIM\), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.") Affiliations Expand ### Affiliations * 1 Department of Endoscopy, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China. * 2 Clinical Laboratory Department, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China. * 3 National Clinical Research Center for Children and Adolescents' Health and Diseases, National Children's Regional Medical Center, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. * 4 Department of Gastrointestinal Surgery, Taizhou Cancer Hospital, Wenling, Zhejiang, China. * 5 Institute of Cancer and Basic Medicine (ICBM), Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China. * 6 Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China. * 7 Department of Radiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China. * 8 Department of Abdominal Oncology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China. * PMID: **42670284** * DOI: [ 10.1002/cam4.72199 ](https://doi.org/10.1002/cam4.72199) Item in Clipboard # Evaluation of the Expression and Prognosis of Neural-Related Products Expressed by Cancer-Derived Mesenchymal Stem Cells With the Characteristics of Neural Stem Cells Liu Yongjun et al. Cancer Med. 2026 Sep. Show details Display options Display options Format Abstract PubMed PMID Cancer Med Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cancer+Med%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Cancer+Med%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42670284/) . 2026 Sep;15(9):e72199. doi: 10.1002/cam4.72199. ### Authors [Liu Yongjun](https://pubmed.ncbi.nlm.nih.gov/?term=Yongjun+L&cauthor_id=42670284)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#short-view-affiliation-1 "Department of Endoscopy, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine \(HIM\), Chinese Academy of Sciences, Hangzhou, Zhejiang, China."), [Pan Zhiwen](https://pubmed.ncbi.nlm.nih.gov/?term=Zhiwen+P&cauthor_id=42670284)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#short-view-affiliation-2 "Clinical Laboratory Department, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine \(HIM\), Chinese Academy of Sciences, Hangzhou, Zhejiang, China."), [Fu Shangui](https://pubmed.ncbi.nlm.nih.gov/?term=Shangui+F&cauthor_id=42670284)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#short-view-affiliation-3 "National Clinical Research Center for Children and Adolescents' Health and Diseases, National Children's Regional Medical Center, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China."), [Zhai Jinjie](https://pubmed.ncbi.nlm.nih.gov/?term=Jinjie+Z&cauthor_id=42670284)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#short-view-affiliation-4 "Department of Gastrointestinal Surgery, Taizhou Cancer Hospital, Wenling, Zhejiang, China."), [Ying Rongbiao](https://pubmed.ncbi.nlm.nih.gov/?term=Rongbiao+Y&cauthor_id=42670284)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#short-view-affiliation-4 "Department of Gastrointestinal Surgery, Taizhou Cancer Hospital, Wenling, Zhejiang, China."), [Chen Zhongjian](https://pubmed.ncbi.nlm.nih.gov/?term=Zhongjian+C&cauthor_id=42670284)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#short-view-affiliation-5 "Institute of Cancer and Basic Medicine \(ICBM\), Zhejiang Cancer Hospital, Hangzhou Institute of Medicine \(HIM\), Chinese Academy of Sciences, Hangzhou, Zhejiang, China."), [Chen Wanyuan](https://pubmed.ncbi.nlm.nih.gov/?term=Wanyuan+C&cauthor_id=42670284)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#short-view-affiliation-6 "Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine \(HIM\), Chinese Academy of Sciences, Hangzhou, Zhejiang, China."), [Ju Haixing](https://pubmed.ncbi.nlm.nih.gov/?term=Haixing+J&cauthor_id=42670284)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#short-view-affiliation-6 "Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine \(HIM\), Chinese Academy of Sciences, Hangzhou, Zhejiang, China."), [Ma Dening](https://pubmed.ncbi.nlm.nih.gov/?term=Dening+M&cauthor_id=42670284)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#short-view-affiliation-6 "Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine \(HIM\), Chinese Academy of Sciences, Hangzhou, Zhejiang, China."), [Long Dan](https://pubmed.ncbi.nlm.nih.gov/?term=Dan+L&cauthor_id=42670284)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#short-view-affiliation-7 "Department of Radiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine \(HIM\), Chinese Academy of Sciences, Hangzhou, Zhejiang, China."), [Luo Cong](https://pubmed.ncbi.nlm.nih.gov/?term=Cong+L&cauthor_id=42670284)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#short-view-affiliation-8 "Department of Abdominal Oncology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine \(HIM\), Chinese Academy of Sciences, Hangzhou, Zhejiang, China."), [Fu Zhixuan](https://pubmed.ncbi.nlm.nih.gov/?term=Zhixuan+F&cauthor_id=42670284)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42670284/#short-view-affiliation-6 "Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine \(HIM\), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.") ### Affiliations * 1 Department of Endoscopy, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China. * 2 Clinical Laboratory Department, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China. * 3 National Clinical Research Center for Children and Adolescents' Health and Diseases, National Children's Regional Medical Center, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. * 4 Department of Gastrointestinal Surgery, Taizhou Cancer Hospital, Wenling, Zhejiang, China. * 5 Institute of Cancer and Basic Medicine (ICBM), Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China. * 6 Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China. * 7 Department of Radiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China. * 8 Department of Abdominal Oncology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China. * PMID: **42670284** * DOI: [ 10.1002/cam4.72199 ](https://doi.org/10.1002/cam4.72199) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract Studies have demonstrated that the nervous system plays an important role in cancer progression. Nevertheless, the effect of mesenchymal stem cells (MSCs) on cancer has yielded conflicting results. In this study, we discovered that cancer-derived MSCs (CA-MSCs) not only exhibit the properties of neural stem cells (NSCs) but also express a significant amount of neural-related products. These products include neurotrophic factors, neuropeptides, synapse-related products, and axon guidance factors. These identified products exhibit similar or different expression status among human NSCs, cancer and fat-derived MSCs. CA-MSCs expressed more BDNF, GDNF, and NGF than NSCs. Based on these neural-related products expressed by CA-MSCs, expression-prognostic analysis was conducted. It revealed that the expression of MDK and MANF was higher in cancer, and the expression of BDNF, NPTX1, and NGF increased as the tumor stage advanced. For ten neuropeptides, their expression levels were lower in cancer. Thirty synapse-related products displayed their respective expression status between cancer and normal tissues. SYPL1, SYBP2/3, and STX4 had a significant impact on tumor prognosis. Higher levels of syntaxin-4, neugrin, and other axogenesis products were associated with a worse prognosis in cancer. Moreover, immunohistochemistry revealed that NSC-like CA-MSCs were abundant in cancer and exhibited a clear growth-promoting effect on cancer. Briefly, CA-MSCs, which are densely distributed in cancer and have the characteristics of NSCs, express a large number of nerve-related products. These products may have significant effects on tumor progression and prognosis. **Keywords:** cancer neuroscience; mesenchymal stem cells; neural stem cells; neuropeptides; neurotrophic factors. © 2026 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ Comparison of the neural differentiation potential of human mesenchymal stem cells from amniotic fluid and adult bone marrow. ](https://pubmed.ncbi.nlm.nih.gov/23478940/) Yan ZJ, Hu YQ, Zhang HT, Zhang P, Xiao ZY, Sun XL, Cai YQ, Hu CC, Xu RX.Yan ZJ, et al.Cell Mol Neurobiol. 2013 May;33(4):465-75. doi: 10.1007/s10571-013-9922-y. Epub 2013 Mar 12.Cell Mol Neurobiol. 2013.PMID: 23478940Free PMC article. * [ Preconditioning with secretome of neural crest-derived stem cells enhanced neurotrophic expression in mesenchymal stem cells. ](https://pubmed.ncbi.nlm.nih.gov/35143889/) Karimi-Haghighi S, Chavoshinezhad S, Safari A, Razeghian-Jahromi I, Jamhiri I, Khodabandeh Z, Khajeh S, Zare S, Borhani-Haghighi A, Dianatpour M, Pandamooz S, Salehi MS.Karimi-Haghighi S, et al.Neurosci Lett. 2022 Mar 16;773:136511. doi: 10.1016/j.neulet.2022.136511. Epub 2022 Feb 7.Neu
## Related Clinical Research

- [Symptom network analysis in gastric cancer: tools, core and bridge symptoms, and temporal patterns](https://medichelpline.com/clinical-feed/plos-one-4-application-of-symptom-network-analysis-among-patients-with-gastric-cancer-a.md)
- [Impact of Adjuvant Immune Checkpoint Inhibitors on HRQoL in Renal Cell Carcinoma: Qualitative RAMP](https://medichelpline.com/clinical-feed/plos-one-10-health-related-quality-of-life-with-adjuvant-immune-checkpoint-inhibition-in.md)
- [Through-the-scope twin clip (TTS‑TC) vs titanium clips for gastric EFTR defect closure](https://medichelpline.com/clinical-feed/pubmed-42768943.md) (DOI: 10.1080/07853890.2026.2735108)
- [Insurance Coverage Falls Behind Genomic Advances in Rare Cancer Care](https://medichelpline.com/clinical-feed/kff-health-news-0-insurance-coverage-lags-as-cancer-science-treatment-move-forward.md)
- [Incidence and Impact of ALC-only Progression in Chronic Lymphocytic Leukemia](https://medichelpline.com/clinical-feed/pubmed-42466974.md) (DOI: 10.1182/bloodadvances.2026020680)

## Navigation
- [← Back to Oncology Feed](https://medichelpline.com/clinical-feed/oncology.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.