---
title: "No cancer research without older adults: a manifesto for inclusion in oncology research"
id: "nature-reviews-clinical-oncology-0-no-cancer-research-without-older-adults-from-prevention-to-end-of-life-a"
canonical_url: "https://medichelpline.com/clinical-feed/nature-reviews-clinical-oncology-0-no-cancer-research-without-older-adults-from-prevention-to-end-of-life-a"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "Nature Reviews Clinical Oncology"
source_url: "https://www.nature.com/articles/s41571-026-01220-4"
published_at: "2026-10-20T12:00:00.000Z"
evidence_level: "Journal Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# No cancer research without older adults: a manifesto for inclusion in oncology research
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/nature-reviews-clinical-oncology-0-no-cancer-research-without-older-adults-from-prevention-to-end-of-life-a
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** Nature Reviews Clinical Oncology
- **Source URL:** [Original Journal Publication](https://www.nature.com/articles/s41571-026-01220-4)
- **Published At:** 2026-10-20T12:00:00.000Z
- **Evidence Rating:** Journal Feed
## Executive GIST (TL;DR)
- Older adults (defined in the article as individuals aged ≥65 years) make up the majority of people diagnosed with **cancer**, yet remain underrepresented across the research pathway. - The authors called on key stakeholders — funders, regulators, researchers and journals — to require systematic inclusion of **older adults** across studies spanning prevention to end-of-life care. - The commentary is framed as a manifesto urging policy and practice change rather than reporting original trial data; the article synthesizes prior literature and expert opinion to make its case. - The article references population- and burden-focused studies and working-group guidance to contextualize the problem, citing global incidence estimates and pragmatic trial strategies for older patients. - The authors noted barriers documented in previous literature that limit older adult participation in trials and the need for pragmatic trial designs and endpoints tailored to this group. - The manuscript acknowledges use of an AI language model for editing; the authors took responsibility for content accuracy and declared no competing interests. - The publicly available preview indicates that full article access may be limited behind subscription or institutional access, and the preview text did not include detailed operational recommendations, numeric prevalence data, or specific trial enrollment targets. - The manifesto does not present new experimental methods, dosing, or trial outcomes; it is an expert appeal to change research norms and policy around inclusion of older adults in oncology research.
## Clinical Analysis & Structured Key Points
## Your privacy, your choice We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media, as well as to allow video information to be shared for both marketing, analytics and editorial purposes. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection. See our [privacy policy](https://www.nature.com/info/privacy) for more information on the use of your personal data. Manage preferences for further information and to change your choices. Accept all cookies Reject optional cookies [Skip to main content](https://www.nature.com/articles/s41571-026-01220-4#content) Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Advertisement [ ![Nature Reviews Clinical Oncology](https://media.springernature.com/full/nature-cms/uploads/product/nrclinonc/header-6cacb5c22900eb4634682a8eae5b788c.svg) ](https://www.nature.com/nrclinonc) * [ View all journals ](https://www.nature.com/siteindex) * [ Saved research ](https://www.nature.com/saved-research) * [ Search ](javascript:;) ## Search Search articles by subject, keyword or author Show results from All journals This journal Search [ Advanced search ](https://www.nature.com/search/advanced) ### Quick links * [Explore articles by subject](https://www.nature.com/subjects) * [Find a job](https://www.nature.com/naturecareers) * [Guide to authors](https://www.nature.com/authors/index.html) * [Editorial policies](https://www.nature.com/authors/editorial_policies/) * [Log in](https://idp.nature.com/auth/personal/springernature?redirect_uri=https://www.nature.com/articles/s41571-026-01220-4) * [ Content Explore content ](javascript:;) ## Explore content * [ Research articles ](https://www.nature.com/nrclinonc/research-articles) * [ Reviews & Analysis ](https://www.nature.com/nrclinonc/reviews-and-analysis) * [ News & Comment ](https://www.nature.com/nrclinonc/news-and-comment) * [ Current issue ](https://www.nature.com/nrclinonc/current-issue) * [ Collections ](https://www.nature.com/nrclinonc/collections) * [Follow us on Facebook ](https://www.facebook.com/NatureReviews) * [Follow us on X ](https://twitter.com/NatRevClinOncol) * [ Subscribe ](https://www.nature.com/nrclinonc/subscribe) * [Sign up for alerts ](https://journal-alerts.springernature.com/subscribe?journal_id=41571) * [ RSS feed ](https://www.nature.com/nrclinonc.rss) * [ About the journal ](javascript:;) ## About the journal * [ Aims & Scope ](https://www.nature.com/nrclinonc/aims) * [ Journal Information ](https://www.nature.com/nrclinonc/journal-information) * [ Editors ](https://www.nature.com/nrclinonc/editors) * [ Editorial policies ](https://www.nature.com/nrclinonc/editorial-policies) * [ Reviews Cross-Journal Editorial Team ](https://www.nature.com/nrclinonc/reviews-cross-journal-editorial-team) * [ Journal Credits ](https://www.nature.com/nrclinonc/journal-credits) * [ Editorial input and checks ](https://www.nature.com/nrclinonc/editorial-input-and-checks) * [ Editorial Values Statement ](https://www.nature.com/nrclinonc/editorial-values-statement) * [ Journal Metrics ](https://www.nature.com/nrclinonc/journal-impact) * [ Publishing model ](https://www.nature.com/nrclinonc/publishing-model) * [ Conferences ](https://www.nature.com/nrclinonc/conferences) * [ Web Feeds ](https://www.nature.com/nrclinonc/web-feeds) * [ Contact ](https://www.nature.com/nrclinonc/contact) * [ Publish with us ](javascript:;) ## Publish with us * [ For Authors ](https://www.nature.com/nrclinonc/for-authors) * [ For Referees ](https://www.nature.com/nrclinonc/for-referees) * [Submit manuscript ](https://mts-nrclinonc.nature.com/cgi-bin/main.plex) * [ Subscribe ](https://www.nature.com/nrclinonc/subscribe) * [ Sign up for alerts ](https://journal-alerts.springernature.com/subscribe?journal_id=41571) * [ RSS feed ](https://www.nature.com/nrclinonc.rss) 1. [nature](https://www.nature.com/) 2. [nature reviews clinical oncology](https://www.nature.com/nrclinonc) 3. [comments](https://www.nature.com/nrclinonc/articles?type=comment) 4. article * Comment * Published: 20 October 2026 # No cancer research without older adults, from prevention to end of life: a manifesto * [Sophie Pilleron](https://www.nature.com/articles/s41571-026-01220-4#auth-Sophie-Pilleron-Aff1) [ORCID: orcid.org/0000-0001-7146-4740](https://orcid.org/0000-0001-7146-4740)[1](https://www.nature.com/articles/s41571-026-01220-4#Aff1), * [Enrique Soto-Perez-de-Celis](https://www.nature.com/articles/s41571-026-01220-4#auth-Enrique-Soto_Perez_de_Celis-Aff2) [ORCID: orcid.org/0000-0002-7301-2163](https://orcid.org/0000-0002-7301-2163)[2](https://www.nature.com/articles/s41571-026-01220-4#Aff2) & * [Nicolò Matteo Luca Battisti](https://www.nature.com/articles/s41571-026-01220-4#auth-Nicol__Matteo_Luca-Battisti-Aff3-Aff4)[3](https://www.nature.com/articles/s41571-026-01220-4#Aff3),[4](https://www.nature.com/articles/s41571-026-01220-4#Aff4) [_Nature Reviews Clinical Oncology_](https://www.nature.com/nrclinonc) (2026) [Cite this article](https://www.nature.com/articles/s41571-026-01220-4#citeas) Save article [ View saved research ](https://www.nature.com/saved-research) Older adults (aged ≥65 years) comprise the majority of people diagnosed with cancer, yet they remain proportionally underrepresented in cancer research at every stage of the pathway. We call on funders, regulators, researchers and journals to make systematic inclusion of older adults the norm, across studies spanning from cancer prevention to end-of-life care. This is a preview of subscription content, [access via your institution](https://wayf.springernature.com?redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41571-026-01220-4) ## Access options [ Access through your institution ](https://wayf.springernature.com?redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41571-026-01220-4) Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 27,99 € / 30 days cancel any time [Learn more](https://shop.nature.com/products/plus/?region=ROW) Subscribe to this journal Receive 12 print issues and online access 176,64 € per year only 14,72 € per issue [Learn more](https://www.nature.com/nrclinonc/subscribe) Buy this article * Purchase on SpringerLink * Instant access to the full article PDF. 39,95 € Prices may be subject to local taxes which are calculated during checkout ### Additional access options: * [Log in](https://idp.nature.com/auth/personal/springernature?client_id=grover&redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41571-026-01220-4) * [Learn about institutional subscriptions](https://www.springernature.com/gp/librarians/licensing/license-options) * [Read our FAQs](https://support.nature.com/en/support/home) * [Contact customer support](https://www.springernature.com/gp/contact) ## References 1. Pilleron, S. et al. Global cancer incidence in older adults, 2012 and 2035: a population-based study. _Int. J. Cancer_ **144** , 49–58 (2019). [Article](https://doi.org/10.1002%2Fijc.31664) [CAS](https://www.nature.com/articles/cas-redirect/1:CAS:528:DC%2BC1cXitVaqsLjJ) [PubMed](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=29978474) [ Google Scholar](http://scholar.google.com/scholar_lookup?&title=Global%20cancer%20incidence%20in%20older%20adults%2C%202012%20and%202035%3A%20a%20population-based%20study&journal=Int.%20J.%20Cancer&doi=10.1002%2Fijc.31664&volume=144&pages=49-58&publication_year=2019&author=Pilleron%2CS) 2. Shah, R. et al. Updated cancer burden in oldest old: a population-based study using 2022 Globocan estimates. _Cancer Epidemiol._ **95** , 102716 (2025). [Article](https://doi.org/10.1016%2Fj.canep.2024.102716) [PubMed](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=39603975) [ Google Scholar](http://scholar.google.com/scholar_lookup?&title=Updated%20cancer%20burden%20in%20oldest%20old%3A%20a%20population-based%20study%20using%202022%20Globocan%20estimates&journal=Cancer%20Epidemiol.&doi=10.1016%2Fj.canep.2024.102716&volume=95&publication_year=2025&author=Shah%2CR) 3. Fink, H. et al. Global and regional cancer burden attributable to modifiable risk factors to inform prevention. _Nat. Med._ **32** , 1306–1315 (2026). [Article](https://doi.org/10.1038%2Fs41591-026-04219-7) [CAS](https://www.nature.com/articles/cas-redirect/1:CAS:528:DC%2BB28XjsVygtrg%3D) [PubMed](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=41634393) [ Google Scholar](http://scholar.google.com/scholar_lookup?&title=Global%20and%20regional%20cancer%20burden%20attributable%20to%20modifiable%20risk%20factors%20to%20inform%20prevention&journal=Nat.%20Med.&doi=10.1038%2Fs41591-026-04219-7&volume=32&pages=1306-1315&publication_year=2026&author=Fink%2CH) 4. McIntosh, S. A. et al. Global funding for cancer research between 2016 and 2020: a content analysis of public and philanthropic investments. _Lancet Oncol._ **24** , 636–645 (2023). [Article](https://doi.org/10.1016%2FS1470-2045%2823%2900182-1) [PubMed](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=37269844) [ Google Scholar](http://scholar.google.com/scholar_lookup?&title=Global%20funding%20for%20cancer%20research%20between%202016%20and%202020%3A%20a%20content%20analysis%20of%20public%20and%20philanthropic%20investments&journal=Lancet%20Oncol.&doi=10.1016%2FS1470-2045%2823%2900182-1&volume=24&pages=636-645&publication_year=2023&author=McIntosh%2CSA) 5. Javid, S. H. et al. A prospective analysis of the influence of older age on physician and patient decision-making when considering enrollment in breast cancer clinical trials (SWOG S0316). _Oncologist_ **17** , 1180–1190 (2012). [Article](https://doi.org/10.1634%2Ftheoncologist.2011-0384) [PubMed](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22723506) [PubMed Central](http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448411) [ Google Scholar](http://scholar.google.com/scholar_lookup?&title=A%20prospective%20analysis%20of%20the%20influence%20of%20older%20age%20on%20physician%20and%20patient%20decision-making%20when%20considering%20enrollment%20in%20breast%20cancer%20clinical%20trials%20%28SWOG%20S0316%29&journal=Oncologist&doi=10.1634%2Ftheoncologist.2011-0384&volume=17&pages=1180-1190&publication_year=2012&author=Javid%2CSH) 6. Kemeny, M. M. et al. Barriers to clinical trial participation by older women with breast cancer. _J. Clin. Oncol._ **21** , 2268–2275 (2003). [Article](https://doi.org/10.1200%2FJCO.2003.09.124) [PubMed](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12805325) [ Google Scholar](http://scholar.google.com/scholar_lookup?&title=Barriers%20to%20clinical%20trial%20participation%20by%20older%20women%20with%20breast%20cancer&journal=J.%20Clin.%20Oncol.&doi=10.1200%2FJCO.2003.09.124&volume=21&pages=2268-2275&publication_year=2003&author=Kemeny%2CMM) 7. Sedrak, M. S. et al. Older adult participation in cancer clinical trials: a systematic review of barriers and interventions. _CA Cancer J. Clin._ **71** , 78–92 (2021). [PubMed](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=33002206) [ Google Scholar](http://scholar.google.com/scholar_lookup?&title=Older%20adult%20participation%20in%20cancer%20clinical%20trials%3A%20a%20systematic%20review%20of%20barriers%20and%20interventions&journal=CA%20Cancer%20J.%20Clin.&volume=71&pages=78-92&publication_year=2021&author=Sedrak%2CMS) 8. Department of Economic and Social Affairs, Population Division. World population prospects 2024. _UN_ (2026). 9. Pilleron, S., Gnangnon, F., Noronha, V. & Soto-Perez-de-Celis, E. Cancer incidence estimates in adults aged 60 years and older living in low-and-middle-income countries for the years 2020 and 2040. _Ecancermedicalscience_ **17** , 1594 (2023). [Article](https://doi.org/10.3332%2Fecancer.2023.1594) [PubMed](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=37799947) [PubMed Central](http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550290) [ Google Scholar](http://scholar.google.com/scholar_lookup?&title=Cancer%20incidence%20estimates%20in%20adults%20aged%2060%20years%20and%20older%20living%20in%20low-and-middle-income%20countries%20for%20the%20years%202020%20and%202040&journal=Ecancermedicalscience&doi=10.3332%2Fecancer.2023.1594&volume=17&publication_year=2023&author=Pilleron%2CS&author=Gnangnon%2CF&author=Noronha%2CV&author=Soto-Perez-de-Celis%2CE) 10. Baldini, C. et al. The ESMO/SIOG Cancer in the Elderly Working Group pragmatic strategies for clinical trial designs and endpoints in older adults with cancer. _ESMO Open_ **11** , 105940 (2026). [Article](https://doi.org/10.1016%2Fj.esmoop.2025.105940) [CAS](https://www.nature.com/articles/cas-redirect/1:STN:280:DC%2BA3MbitlCrsg%3D%3D) [PubMed](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=41895874) [PubMed Central](http://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040903) [ Google Scholar](http://scholar.google.com/scholar_lookup?&title=The%20ESMO%2FSIOG%20Cancer%20in%20the%20Elderly%20Working%20Group%20pragmatic%20strategies%20for%20clinical%20trial%20designs%20and%20endpoints%20in%20older%20adults%20with%20cancer&journal=ESMO%20Open&doi=10.1016%2Fj.esmoop.2025.105940&volume=11&publication_year=2026&author=Baldini%2CC) [Download references](https://citation-needed.springer.com/v2/references/10.1038/s41571-026-01220-4?format=refman&flavour=references) ## Acknowledgements The work of S.P. is supported by the Luxembourg National Research Fund (FNR), project no. 16731054. The authors used Claude (Anthropic), an artificial intelligence (AI) large language model, to assist with language editing of this manuscript (improving flow, clarity and readability). All content was reviewed, verified and revised by the authors, who take full responsibility for the accuracy of the arguments, data and references presented. The AI tool was not involved in conceptualization of the article, data generation or interpretation, and is not credited as an author. ## Author information ### Authors and Affiliations 1. Ageing, Cancer and Disparities Research Unit, Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg Sophie Pilleron 2. Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA Enrique Soto-Perez-de-Celis 3. Department of Medicine, Breast Unit & Senior Adult Oncology Programme, The Royal Marsden NHS Foundation Trust, Sutton, UK Nicolò Matteo Luca Battisti 4. Breast Cancer Research Division, The Institute of Cancer Research, London, UK Nicolò Matteo Luca Battisti Authors 1. Sophie Pilleron [View author publications](https://www.nature.com/search?author=Sophie%20Pilleron) Search author on:[PubMed](https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sophie%20Pilleron)[Google Scholar](https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Sophie%20Pilleron%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en) 2. Enrique Soto-Perez-de-Celis [View author publications](https://www.nature.com/search?author=Enrique%20Soto-Perez-de-Celis) Search author on:[PubMed](https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Enrique%20Soto-Perez-de-Celis)[Google Scholar](https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Enrique%20Soto-Perez-de-Celis%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en) 3. Nicolò Matteo Luca Battisti [View author publications](https://www.nature.com/search?author=Nicol%C3%B2%20Matteo%20Luca%20Battisti) Search author on:[PubMed](https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Nicol%C3%B2%20Matteo%20Luca%20Battisti)[Google Scholar](https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Nicol%C3%B2%20Matteo%20Luca%20Battisti%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en) ### Corresponding author Correspondence to Sophie Pilleron. ## Ethics declarations ### Competing interests The authors declare no competing interests. ## Rights and permissions [Reprints and permissions](https://s100.copyright.com/AppDispatchServlet?title=No%20cancer%20research%20without%20older%20adults%2C%20from%20prevention%20to%20end%20of%20life%3A%20a%20manifesto&author=Sophie%20Pilleron%20et%20al&contentID=10.1038%2Fs41571-026-01220-4&copyright=Springer%20Nature%20Limited&publication=1759-4774&publicationDate=2026-10-20&publisherName=SpringerNature&orderBeanReset=true) ## About this article [![Check for updates. Verify currency and authenticity via CrossMark](https://www.nature.com/articles/s41571-026-01220-4)](https://crossmark.crossref.org/dialog/?doi=10.1038/s41571-026-01220-4) ### Cite this article Pilleron, S., Soto-Perez-de-Celis, E. & Battisti, N.M.L. No cancer research without older adults, from prevention to end of life: a manifesto. _Nat Rev Clin Oncol_ (2026). https://doi.org/10.1038/s41571-026-01220-4 [Download citation](https://citation-needed.springer.com/v2/references/10.1038/s41571-026-01220-4?format=refman&flavour=citation) * Published: 20 October 2026 * Version of record: 20 October 2026 * DOI: https://doi.org/10.1038/s41571-026-01220-4 ### Share this article Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy shareable link to clipboard Provided by the Springer Nature SharedIt content-sharing initiative ### Subjects * [Cancer](https://www.nature.com/subjects/cancer) * [Medical research](https://www.nature.com/subjects/medical-research) * [Oncology](https://www.nature.com/subjects/oncology) [ Access through your institution ](https://wayf.springernature.com?redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41571-026-01220-4) [ Buy or subscribe ](https://www.nature.com/articles/s41571-026-01220-4#access-options) * Sections * References * [References](https://www.nature.com/articles/s41571-026-01220-4#Bib1) * [Acknowledgements](https://www.nature.com/articles/s41571-026-01220-4#Ack1) * [Author information](https://www.nature.com/articles/s41571-026-01220-4#author-information) * [Ethics declarations](https://www.nature.com/articles/s41571-026-01220-4#ethics) * [Rights and permissions](https://www.nature.com/articles/s41571-026-01220-4#rightslink) * [About this article](https://www.nature.com/articles/s41571-026-01220-4#article-info) Advertisement 1. Pilleron, S. et al. Global cancer incidence in older adults, 2012 and 2035: a population-based study. _Int. J. Cancer_ **144** , 49–58 (2019). [Article](https://doi.org/10.1002%2Fijc.31664) [CAS](https://www.nature.com/articles/cas-redirect/1:CAS:528:DC%2BC1cXitVaqsLjJ) [PubMed](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=29978474) [ Google Scholar](http://scholar.google.com/scholar_look
## Related Clinical Research

- [Cipepofol induces ferroptosis and limits breast cancer cell growth](https://medichelpline.com/clinical-feed/pubmed-42731367.md) (DOI: 10.1016/j.bbrc.2026.154570)
- [NeoGen-BC: PLM-driven pipeline for shared breast cancer neoantigen design](https://medichelpline.com/clinical-feed/pubmed-42721858.md) (DOI: 10.1016/j.bbrc.2026.154567)
- [Rare Variant Burden and Polygenic Risk in Breast Cancer: Association with Earlier Diagnosis](https://medichelpline.com/clinical-feed/medrxiv-17-rare-variant-burden-complements-polygenic-risk-in-breast-cancer-and-is.md)
- [Phenotype-cloud Reorganization in Cancer — Preprint Details and Access](https://medichelpline.com/clinical-feed/biorxiv-0-phenotype-cloud-reorganization-shapes-cancer-progression-and-therapeutic.md)
- [WHO issues training manual to expand access to early breast cancer care](https://medichelpline.com/clinical-feed/who-0-2-who-releases-training-manual-to-expand-access-to-early-breast-cancer-care.md)

## Navigation
- [← Back to Oncology Feed](https://medichelpline.com/clinical-feed/oncology.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.