---
title: "Nurse navigation increases self-efficacy during colorectal cancer treatment: randomized trial"
id: "pubmed-42557451"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42557451"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42557451/"
doi: "10.1007/s00520-026-11035-9"
published_at: "2026-08-06T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Nurse navigation increases self-efficacy during colorectal cancer treatment: randomized trial
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42557451
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42557451/)
- **DOI:** [10.1007/s00520-026-11035-9](https://doi.org/10.1007%2Fs00520-026-11035-9)
- **Published At:** 2026-08-06T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This randomized controlled trial tested whether a structured **nurse navigation** intervention from diagnosis through follow-up improved patient **self-efficacy** versus standard care in people with suspected colorectal cancer. - Participants were adults with physician-verified suspicion of colorectal cancer after colonoscopy who met inclusion criteria and consented to randomization; 271 were randomized and 222 completed follow-up (115 standard care, 107 intervention). - Five specially trained nurse navigators delivered the intervention, which included needs assessment, distress evaluation, and emotional support spanning the treatment trajectory. - Self-efficacy was measured with the short form of the **Cancer Behavior Inventory (CBI-B)** at baseline (before randomization) and at treatment completion or within 1 year. - Analysis used a population-averaged linear regression model with generalized estimating equations to compare change in CBI-B from baseline to follow-up between groups, based on 4,888 observations. - Results: mean CBI-B change under standard care increased by 2.06 (95% CI −0.84 to 4.97); under the nurse navigation intervention it increased by 6.98 (95% CI 3.99 to 9.97). - The estimated between-group effect size for change in self-efficacy was 4.92 (95% CI 0.75 to 9.08), statistically significant (p = 0.021), favoring nurse navigation. - The authors conclude that tailored nurse navigation delivered across the colorectal cancer treatment course significantly increased patients' self-efficacy. - Conflict of interest: the authors declared no competing interests. Specific intervention components, duration per patient, eligibility criteria details, and secondary outcomes were not reported in the source abstract.
## Clinical Analysis & Structured Key Points
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Niels.Qvist@rsyd.dk.") Affiliations Expand ### Affiliations * 1 Reserch Unit for Gynaecology and Obstetrics, Odense University Hospital, University of Southern Denmark, Odense, Denmark. * 2 Research Unit of General Practice, Department of Public Health, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. * 3 Research Unit of Oncology, Family Focused Healthcare Research Centre (FaCe), Odense University Hospital, University of Southern Denmark, Odense, Denmark. * 4 Department of Surgery, Slagelse Hospital, Slagelse, Denmark. * 5 Research Unit for Surgery, Odense University Hospital, University of Southern Denmark, Odense, Denmark. Niels.Qvist@rsyd.dk. * PMID: **42557451** * DOI: [ 10.1007/s00520-026-11035-9 ](https://doi.org/10.1007/s00520-026-11035-9) Item in Clipboard Randomized Controlled Trial # Improving self-efficacy through nurse navigation in patients during treatment for colorectal cancer: a randomized controlled trial Marianne Kirstine Thygesen et al. Support Care Cancer. 2026. Show details Display options Display options Format Abstract PubMed PMID Support Care Cancer Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Support+Care+Cancer%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Support+Care+Cancer%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42557451/) . 2026 Aug 6;34(9):830. doi: 10.1007/s00520-026-11035-9. ### Authors [Marianne Kirstine Thygesen](https://pubmed.ncbi.nlm.nih.gov/?term=Thygesen+MK&cauthor_id=42557451)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42557451/#short-view-affiliation-1 "Reserch Unit for Gynaecology and Obstetrics, Odense University Hospital, University of Southern Denmark, Odense, Denmark."), [Sonja Wehberg](https://pubmed.ncbi.nlm.nih.gov/?term=Wehberg+S&cauthor_id=42557451)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42557451/#short-view-affiliation-2 "Research Unit of General Practice, Department of Public Health, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark."), [Karin B Dieperink](https://pubmed.ncbi.nlm.nih.gov/?term=Dieperink+KB&cauthor_id=42557451)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42557451/#short-view-affiliation-3 "Research Unit of Oncology, Family Focused Healthcare Research Centre \(FaCe\), Odense University Hospital, University of Southern Denmark, Odense, Denmark."), [Jens Søndergaard](https://pubmed.ncbi.nlm.nih.gov/?term=S%C3%B8ndergaard+J&cauthor_id=42557451)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42557451/#short-view-affiliation-2 "Research Unit of General Practice, Department of Public Health, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark."), [Sharaf K Perdawood](https://pubmed.ncbi.nlm.nih.gov/?term=Perdawood+SK&cauthor_id=42557451)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42557451/#short-view-affiliation-4 "Department of Surgery, Slagelse Hospital, Slagelse, Denmark."), [Niels Qvist](https://pubmed.ncbi.nlm.nih.gov/?term=Qvist+N&cauthor_id=42557451)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42557451/#short-view-affiliation-5 "Research Unit for Surgery, Odense University Hospital, University of Southern Denmark, Odense, Denmark. Niels.Qvist@rsyd.dk.") ### Affiliations * 1 Reserch Unit for Gynaecology and Obstetrics, Odense University Hospital, University of Southern Denmark, Odense, Denmark. * 2 Research Unit of General Practice, Department of Public Health, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. * 3 Research Unit of Oncology, Family Focused Healthcare Research Centre (FaCe), Odense University Hospital, University of Southern Denmark, Odense, Denmark. * 4 Department of Surgery, Slagelse Hospital, Slagelse, Denmark. * 5 Research Unit for Surgery, Odense University Hospital, University of Southern Denmark, Odense, Denmark. Niels.Qvist@rsyd.dk. * PMID: **42557451** * DOI: [ 10.1007/s00520-026-11035-9 ](https://doi.org/10.1007/s00520-026-11035-9) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Purpose:** We hypothesized that a nursing navigator intervention with needs assessment, distress evaluation, and emotional support from diagnosis to follow-up would improve self-efficacy compared with standard care in colorectal cancer. **Methods:** Patients with a physician-verified suspicion of colorectal cancer following colonoscopy were assessed for eligibility. Those who fulfilled inclusion criteria and consented were randomized to either intervention (nurse navigation) or standard care during the following cancer treatment trajectory. Five special educated nurse navigators delivered the intervention. Self-efficacy was assessed using the short form of the Cancer Behavior Inventory questionnaire (CBI-B) at baseline before randomization and at treatment completion or within 1 year at the latest. The group difference between CBI-B changes from baseline to follow-up was assessed in a population-averaged linear regression model employing generalized estimating equations. **Results:** Of 271 included participants, 222 were completed cases (115 in standard care, 107 in intervention). Based on 4888 observations, self-efficacy under standard care increased by a 2.06 score (CI -0.84; 4.97) and by 6.98 (CI 3.99; 9.97) under intervention. Estimated effect size was 4.92 (CI 0.75; 9.08), which was statistically significant (p = 0.021). **Conclusions:** Tailored nurse navigation across the course of colorectal cancer treatment significantly increased patients' self-efficacy. **Keywords:** Cancer Behavior Inventory questionnaire; Colorectal cancer; Nurse navigation; Randomized controlled trial; Self-efficacy. © 2026. The Author(s). [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declarations. Conflict of interest: The authors declare no competing interests. ## Similar articles * [ Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas. ](https://pubmed.ncbi.nlm.nih.gov/36321557/) Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P.Crider K, et al.Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217.Cochrane Database Syst Rev. 2022.Update in: [Cochrane Database Syst Rev. 2026 Feb 18;2:CD014217. doi: 10.1002/14651858.CD014217.pub2.](https://pubmed.ncbi.nlm.nih.gov/41705996/)PMID: 36321557Free PMC article.Updated. * [ The effectiveness of a self-efficacy-enhancing intervention for Chinese patients with colorectal cancer: a randomized controlled trial with 6-month follow up. ](https://pubmed.ncbi.nlm.nih.gov/24406033/) Zhang M, Chan SW, You L, Wen Y, Peng L, Liu W, Zheng M.Zhang M, et al.Int J Nurs Stud. 2014 Aug;51(8):1083-92. doi: 10.1016/j.ijnurstu.2013.12.005. Epub 2013 Dec 17.Int J Nurs Stud. 2014.PMID: 24406033Clinical Trial. * [ Effect of a Nurse Navigation Intervention on Mental Symptoms in Patients With Psychological Vulnerability and Breast Cancer: The REBECCA Randomized Clinical Trial. ](https://pubmed.ncbi.nlm.nih.gov/37351885/) Bidstrup PE, Johansen C, Kroman N, Belmonte F, Duriaud H, Dalton SO, Andersen KG, Mertz B.Bidstrup PE, et al.JAMA Netw Open. 2023 Jun 1;6(6):e2319591. doi: 10.1001/jamanetworkopen.2023.19591.JAMA Netw Open. 2023.PMID: 37351885Free PMC article.Clinical Trial. * [ Short-term efficacy of a computer-tailored physical activity intervention for prostate and colorectal cancer patients and survivors: a randomized controlled trial. ](https://pubmed.ncbi.nlm.nih.gov/30376857/) Golsteijn RHJ, Bolman C, Volders E, Peels DA, de Vries H, Lechner L.Golsteijn RHJ, et al.Int J Behav Nutr Phys Act. 2018 Oct 30;15(1):106. doi: 10.1186/s12966-018-0734-9.Int J Behav Nutr Phys Act. 2018.PMID: 30376857Free PMC article.Clinical Trial. * [ The effectiveness of patient navigation programs for adult cancer patients undergoing treatment: a systematic review. ](https://pubmed.ncbi.nlm.nih.gov/27536800/) Tho PC, Ang E.Tho PC, et al.JBI Database System Rev Implement Rep. 2016 Feb;14(2):295-321. doi: 10.11124/jbisrir-2016-2324.JBI Database System Rev Implement Rep. 2016.PMID: 27536800 [ See all similar articles ](https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed&from_uid=42557451) ## References 1. 1. Lu D, Andersson TM, Fall K, Hultman CM, Czene K, Valdimarsdóttir U, Fang F (2016) Clinical diagnosis of mental disorders immediately before and after cancer diagnosis: a nationwide matched cohort study in Sweden. JAMA Oncol 2:1188–1196. - [DOI](https://doi.org/10.1001/jamaoncol.2016.0483) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/27124325/) 2. 1. Bandura A (2001) Social cognitive theory: an agentic perspective. Annu Rev Psychol 52:1–26. - [DOI](https://doi.org/10.1146/annurev.psych.52.1.1) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/11148297/) 3. 1. Akin S, Guner CK (2019) Investigation of the relationship among fatigue, self-efficacy and quality of life during chemotherapy in patients with breast, lung or gastrointestinal cancer. Eur J Cancer Care (Engl) 28. - [DOI](https://doi.org/10.1111/ecc.12898) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/30039883/) 4. 1. Omran S, McMillan S (2018) Symptom severity, anxiety, depression, self- efficacy and quality of life in patients with cancer. 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Eur J Psychiatry 39. - [DOI](https://doi.org/10.1016/eipysy.2025.10038) Show all 34 references ## Publication types * Randomized Controlled Trial Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Randomized+Controlled+Trial%22%5Bpt%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Randomized+Controlled+Trial) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42557451/) ## MeSH terms * Aged Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Aged%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Aged) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42557451/) * Colorectal Neoplasms* / nursing Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Colorectal+Neoplasms%2Fnursing%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Colorectal+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42557451/) * Colorectal Neoplasms* / psychology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Colorectal+Neoplasms%2Fpsychology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Colorectal+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42557451/) * Colorectal Neoplasms* / therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Colorectal+Neoplasms%2Ftherapy%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Colorectal+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42557451/) * Female Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Female%22%5BMeSH%5D&sort=date
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