---
title: "Phase II Feasibility Study of Pembrolizumab Plus Metformin in Metastatic Head and Neck Cancer"
id: "pubmed-42347882"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42347882"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42347882/"
doi: "10.1158/1078-0432.CCR-26-0874"
published_at: "2026-09-15T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Phase II Feasibility Study of Pembrolizumab Plus Metformin in Metastatic Head and Neck Cancer
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42347882
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42347882/)
- **DOI:** [10.1158/1078-0432.CCR-26-0874](https://doi.org/10.1158%2F1078-0432.CCR-26-0874)
- **Published At:** 2026-09-15T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This PubMed entry describes a clinical Phase II feasibility trial combining **pembrolizumab** and **metformin** in patients with **metastatic head and neck cancer**. - The study is published in Clinical Cancer Research (Clin Cancer Res) with DOI 10.1158/1078-0432.CCR-26-0874 and PubMed ID 42347882. - Publication date listed as 2026 Sep 15; volume 32, issue 18, pages 4016–4025. - The article is designated a Clinical Trial and a free full text is available through PubMed Central (PMCID: PMC13436289). - Lead and contributing authors are affiliated primarily with the University of Cincinnati (Division of Hematology/Oncology and related centers) and include Olga Zamulko, Sam Nusbaum, Andrew Osterburg, and multiple coauthors. Other affiliations include the NIH Tech Transfer Office and St. Elizabeth Healthcare. - Affiliations include academic departments covering Hematology/Oncology, Pulmonology/Critical Care, Radiation Oncology, Biostatistics and Data Science, and a cancer center. - The PubMed entry includes links to the full-text host (Clinical Cancer Research at AACR Journals) and to the free PMC version. - The PubMed record provides bibliographic and administrative metadata (authors, affiliations, PMID, PMCID, DOI) but the provided source excerpt does not include the study abstract, methods, patient numbers, endpoints, safety or efficacy results, or conclusions. - Because the excerpt lacks trial details and outcomes, readers should consult the linked full text at the journal or the PMC article for complete methods, eligibility criteria, dosing, statistical design, and study results.
## Clinical Analysis & Structured Key Points
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Feasibility Study Combining Pembrolizumab and Metformin in Patients with Metastatic Head and Neck Cancer [Olga Zamulko](https://pubmed.ncbi.nlm.nih.gov/?term=Zamulko+O&cauthor_id=42347882)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-1 "Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio."), [Sam Nusbaum](https://pubmed.ncbi.nlm.nih.gov/?term=Nusbaum+S&cauthor_id=42347882)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-1 "Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio."), [Andrew Osterburg](https://pubmed.ncbi.nlm.nih.gov/?term=Osterburg+A&cauthor_id=42347882)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-2 "Division of Pulmonology, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio."), [McKenzie Crist](https://pubmed.ncbi.nlm.nih.gov/?term=Crist+M&cauthor_id=42347882)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-3 "Tech Transfer Office, National Institute of Health, Bethesda, Maryland."), [Maria Lehn](https://pubmed.ncbi.nlm.nih.gov/?term=Lehn+M&cauthor_id=42347882)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-1 "Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio."), [Ilaina Monroe](https://pubmed.ncbi.nlm.nih.gov/?term=Monroe+I&cauthor_id=42347882)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-4 "University of Cincinnati Cancer Center, University of Cincinnati, Cincinnati, Ohio."), [Audrey Romano](https://pubmed.ncbi.nlm.nih.gov/?term=Romano+A&cauthor_id=42347882)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-4 "University of Cincinnati Cancer Center, University of Cincinnati, Cincinnati, Ohio."), [Casey L Allen](https://pubmed.ncbi.nlm.nih.gov/?term=Allen+CL&cauthor_id=42347882)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-4 "University of Cincinnati Cancer Center, University of Cincinnati, Cincinnati, Ohio."), [Allie Forsythe](https://pubmed.ncbi.nlm.nih.gov/?term=Forsythe+A&cauthor_id=42347882)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-4 "University of Cincinnati Cancer Center, University of Cincinnati, Cincinnati, Ohio."), [Muhammad Kashif Riaz](https://pubmed.ncbi.nlm.nih.gov/?term=Riaz+MK&cauthor_id=42347882)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-5 "St. Elizabeth Healthcare, Edgewood, Kentucky."), [Christopher Lemmon](https://pubmed.ncbi.nlm.nih.gov/?term=Lemmon+C&cauthor_id=42347882)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-1 "Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio."), [Vinita Takiar](https://pubmed.ncbi.nlm.nih.gov/?term=Takiar+V&cauthor_id=42347882)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-6 "Department of Radiation Oncology, University of Cincinnati, Cincinnati, Ohio."), [Jianmin Pan](https://pubmed.ncbi.nlm.nih.gov/?term=Pan+J&cauthor_id=42347882)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-7 "Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio.")[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-8 "Cancer Data Science Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.")[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-9 "Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio."), [Shesh N Rai](https://pubmed.ncbi.nlm.nih.gov/?term=Rai+SN&cauthor_id=42347882)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-7 "Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio.")[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-8 "Cancer Data Science Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.")[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-9 "Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio."), [Michael Borchers](https://pubmed.ncbi.nlm.nih.gov/?term=Borchers+M&cauthor_id=42347882)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-2 "Division of Pulmonology, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio."), [Dalia El-Gamal](https://pubmed.ncbi.nlm.nih.gov/?term=El-Gamal+D&cauthor_id=42347882)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-1 "Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio."), [Trisha M Wise-Draper](https://pubmed.ncbi.nlm.nih.gov/?term=Wise-Draper+TM&cauthor_id=42347882)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#full-view-affiliation-1 "Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio.") Affiliations Expand ### Affiliations * 1 Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio. * 2 Division of Pulmonology, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio. * 3 Tech Transfer Office, National Institute of Health, Bethesda, Maryland. * 4 University of Cincinnati Cancer Center, University of Cincinnati, Cincinnati, Ohio. * 5 St. Elizabeth Healthcare, Edgewood, Kentucky. * 6 Department of Radiation Oncology, University of Cincinnati, Cincinnati, Ohio. * 7 Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio. * 8 Cancer Data Science Center, University of Cincinnati College of Medicine, Cincinnati, Ohio. * 9 Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio. * PMID: **42347882** * PMCID: [ PMC13436289 ](https://pmc.ncbi.nlm.nih.gov/articles/PMC13436289/) * DOI: [ 10.1158/1078-0432.CCR-26-0874 ](https://doi.org/10.1158/1078-0432.ccr-26-0874) Item in Clipboard Clinical Trial # A Phase II Feasibility Study Combining Pembrolizumab and Metformin in Patients with Metastatic Head and Neck Cancer Olga Zamulko et al. Clin Cancer Res. 2026. Show details Display options Display options Format Abstract PubMed PMID Clin Cancer Res Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Clin+Cancer+Res%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Clin+Cancer+Res%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42347882/) . 2026 Sep 15;32(18):4016-4025. doi: 10.1158/1078-0432.CCR-26-0874. ### Authors [Olga Zamulko](https://pubmed.ncbi.nlm.nih.gov/?term=Zamulko+O&cauthor_id=42347882)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-1 "Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio."), [Sam Nusbaum](https://pubmed.ncbi.nlm.nih.gov/?term=Nusbaum+S&cauthor_id=42347882)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-1 "Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio."), [Andrew Osterburg](https://pubmed.ncbi.nlm.nih.gov/?term=Osterburg+A&cauthor_id=42347882)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-2 "Division of Pulmonology, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio."), [McKenzie Crist](https://pubmed.ncbi.nlm.nih.gov/?term=Crist+M&cauthor_id=42347882)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-3 "Tech Transfer Office, National Institute of Health, Bethesda, Maryland."), [Maria Lehn](https://pubmed.ncbi.nlm.nih.gov/?term=Lehn+M&cauthor_id=42347882)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-1 "Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio."), [Ilaina Monroe](https://pubmed.ncbi.nlm.nih.gov/?term=Monroe+I&cauthor_id=42347882)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-4 "University of Cincinnati Cancer Center, University of Cincinnati, Cincinnati, Ohio."), [Audrey Romano](https://pubmed.ncbi.nlm.nih.gov/?term=Romano+A&cauthor_id=42347882)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-4 "University of Cincinnati Cancer Center, University of Cincinnati, Cincinnati, Ohio."), [Casey L Allen](https://pubmed.ncbi.nlm.nih.gov/?term=Allen+CL&cauthor_id=42347882)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-4 "University of Cincinnati Cancer Center, University of Cincinnati, Cincinnati, Ohio."), [Allie Forsythe](https://pubmed.ncbi.nlm.nih.gov/?term=Forsythe+A&cauthor_id=42347882)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-4 "University of Cincinnati Cancer Center, University of Cincinnati, Cincinnati, Ohio."), [Muhammad Kashif Riaz](https://pubmed.ncbi.nlm.nih.gov/?term=Riaz+MK&cauthor_id=42347882)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-5 "St. Elizabeth Healthcare, Edgewood, Kentucky."), [Christopher Lemmon](https://pubmed.ncbi.nlm.nih.gov/?term=Lemmon+C&cauthor_id=42347882)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-1 "Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio."), [Vinita Takiar](https://pubmed.ncbi.nlm.nih.gov/?term=Takiar+V&cauthor_id=42347882)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-6 "Department of Radiation Oncology, University of Cincinnati, Cincinnati, Ohio."), [Jianmin Pan](https://pubmed.ncbi.nlm.nih.gov/?term=Pan+J&cauthor_id=42347882)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-7 "Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio.")[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-8 "Cancer Data Science Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.")[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-9 "Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio."), [Shesh N Rai](https://pubmed.ncbi.nlm.nih.gov/?term=Rai+SN&cauthor_id=42347882)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-7 "Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio.")[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-8 "Cancer Data Science Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.")[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-9 "Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio."), [Michael Borchers](https://pubmed.ncbi.nlm.nih.gov/?term=Borchers+M&cauthor_id=42347882)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-2 "Division of Pulmonology, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio."), [Dalia El-Gamal](https://pubmed.ncbi.nlm.nih.gov/?term=El-Gamal+D&cauthor_id=42347882)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-1 "Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio."), [Trisha M Wise-Draper](https://pubmed.ncbi.nlm.nih.gov/?term=Wise-Draper+TM&cauthor_id=42347882)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42347882/#short-view-affiliation-1 "Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio.") ### Affiliations * 1 Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio. * 2 Division of Pulmonology, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio. * 3 Tech Transfer Office, National Institute of Health, Bethesda, Maryland. * 4 University of Cincinnati Cancer Center, University of Cincinnati, Cincinnati, Ohio. * 5 St. Elizabeth Healthcare, Edgewood, Kentucky. * 6 Department of Radiation Oncology, University of Cincinnati, Cincinnati, Ohio. * 7
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