---
title: "Phytoestrogens from Chinese Medicinal Plants for Breast Cancer Prevention and Treatment"
id: "pubmed-42660842"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42660842"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42660842/"
doi: "10.3881/j.issn.1000-503X.16899"
published_at: "2026-08-30T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Phytoestrogens from Chinese Medicinal Plants for Breast Cancer Prevention and Treatment
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42660842
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42660842/)
- **DOI:** [10.3881/j.issn.1000-503X.16899](https://doi.org/10.3881%2Fj.issn.1000-503X.16899)
- **Published At:** 2026-08-30T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Phytoestrogens are plant-derived natural compounds whose chemical structures resemble the endogenous estrogen **17β-estradiol** and can produce estrogenic or anti-estrogenic effects by binding to **estrogen receptors**. - Recent studies indicate that **phytoestrogens** show promise in both prevention and treatment contexts for **breast cancer**, and they are present as active components in Chinese medicinal plants and in traditional Chinese medicine formulas. - Proposed mechanisms include competitive binding to estrogen receptors with resulting anti-estrogenic activity, regulation of cell proliferation and apoptosis, and modulation of multiple intracellular signaling cascades. - Specific signaling pathways implicated are the **Wnt/β-catenin** pathway, the **PI3K–Akt (phosphatidylinositol 3-kinase–protein kinase B)** pathway, and the **P53** pathway; phytoestrogens may influence these to reduce tumor cell growth and induce apoptosis. - Additional antitumor actions reported include inhibition of tumor angiogenesis and effects on metabolic and immune functions that could contribute to prevention or therapeutic benefit. - The reviewed evidence comes from studies of single active compounds, whole medicinal plants, and compound formulations used in traditional Chinese medicine; the review seeks to synthesize these data to inform clinical research. - The article frames its conclusions as providing a theoretical basis for further clinical investigation of traditional Chinese medicine approaches using phytoestrogens for breast cancer prevention and treatment. - The source is a review article indexed in PubMed (PMID 42660842) and lists MeSH terms including Breast Neoplasms, Phytoestrogens, and Drugs, Chinese Herbal, indicating a focus on pharmacology and therapeutic use.
## Clinical Analysis & Structured Key Points
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Affiliations Expand ### Affiliation * 1 College of Pharmacy & Institute of Materia Medica，Shandong First Medical University & Shandong Academy of Medical Sciences，Jinan 250117，China. * PMID: **42660842** * DOI: [ 10.3881/j.issn.1000-503X.16899 ](https://doi.org/10.3881/j.issn.1000-503x.16899) Item in Clipboard Review # Research Progressin the Prevention and Treatment of Breast Cancer With Phytoestrogens from Chinese Medicinal Plants Feng-Xia Dong et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2026. Show details Display options Display options Format Abstract PubMed PMID Zhongguo Yi Xue Ke Xue Yuan Xue Bao Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Zhongguo+Yi+Xue+Ke+Xue+Yuan+Xue+Bao%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Zhongguo+Yi+Xue+Ke+Xue+Yuan+Xue+Bao%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660842/) . 2026 Aug 30;48(4):733-741. doi: 10.3881/j.issn.1000-503X.16899. ### Authors [Feng-Xia Dong](https://pubmed.ncbi.nlm.nih.gov/?term=Dong+FX&cauthor_id=42660842)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42660842/#short-view-affiliation-1 "College of Pharmacy & Institute of Materia Medica，Shandong First Medical University & Shandong Academy of Medical Sciences，Jinan 250117，China."), [Hong-Rong Fei](https://pubmed.ncbi.nlm.nih.gov/?term=Fei+HR&cauthor_id=42660842)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42660842/#short-view-affiliation-1 "College of Pharmacy & Institute of Materia Medica，Shandong First Medical University & Shandong Academy of Medical Sciences，Jinan 250117，China."), [Xue-Qin Hou](https://pubmed.ncbi.nlm.nih.gov/?term=Hou+XQ&cauthor_id=42660842)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42660842/#short-view-affiliation-1 "College of Pharmacy & Institute of Materia Medica，Shandong First Medical University & Shandong Academy of Medical Sciences，Jinan 250117，China."), [Lu-Yu Ma](https://pubmed.ncbi.nlm.nih.gov/?term=Ma+LY&cauthor_id=42660842)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42660842/#short-view-affiliation-1 "College of Pharmacy & Institute of Materia Medica，Shandong First Medical University & Shandong Academy of Medical Sciences，Jinan 250117，China.") ### Affiliation * 1 College of Pharmacy & Institute of Materia Medica，Shandong First Medical University & Shandong Academy of Medical Sciences，Jinan 250117，China. * PMID: **42660842** * DOI: [ 10.3881/j.issn.1000-503X.16899 ](https://doi.org/10.3881/j.issn.1000-503x.16899) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract in [ English, ](https://pubmed.ncbi.nlm.nih.gov/42660842/#eng-abstract) [ Chinese ](https://pubmed.ncbi.nlm.nih.gov/42660842/#zho-abstract) Phytoestrogens are a class of natural compounds existing in plants，with their chemical structures similar to that of the endogenous estrogen 17β-estradiol in mammals.They can exert estrogenic or anti-estrogenic biological effects by binding to estrogen receptors，and have a wide range of effects on diseases caused by estrogen disorders in the body.Recent studies have discovered that phytoestrogens have significant effects in the prevention and treatment of breast cancer.This article reviews the research progress in the prevention and treatment of breast cancer with phytoestrogens from the active components of Chinese medicinal plants，Chinese medicinal plants，and traditional Chinese medicine compound formulas，as well as the related mechanisms. Specifically，the phytoestrogens exert anti-estrogenic effects by binding to estrogen receptors，regulate cell proliferation and apoptosis signaling pathways （such as the Wnt/β-catenin signaling pathway，phosphatidylinositol 3-kinase-protein kinase B signaling pathway，and P53 signaling pathway），inhibit tumor angiogenesis，and modulate metabolism and immune function.The review aims to provide a theoretical basis for clinical research on the prevention and treatment of breast cancer with traditional Chinese medicine. 植物雌激素是一类存在于植物中的天然化合物，其化学结构与哺乳动物内源性雌激素17β-雌二醇相似，可通过与雌激素受体相互结合而发挥类雌激素或抗雌激素的生物学效应，对体内雌激素紊乱引起的疾病有广泛作用。近年研究发现，植物雌激素在乳腺癌防治方面有明显作用。本文通过回顾中药单体、中草药和中药复方中的植物雌激素防治乳腺癌的研究及相关机制，如与雌激素受体结合发挥抗雌激素作用、调节细胞增殖与凋亡信号通路（如Wnt/β-连环蛋白信号通路、磷脂酰肌醇3激酶-蛋白激酶B信号通路和P53信号通路）、抑制肿瘤血管生成、调节新陈代谢与免疫功能等，以期为中医药防治乳腺癌的临床研究提供理论依据。. **Keywords:** breast cancer; mechanism of action; phytoestrogen; prevention and treatment; traditional Chinese medicine. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ Phytoestrogens and breast cancer: In vitro anticancer activities of isoflavones, lignans, coumestans, stilbenes and their analogs and derivatives. ](https://pubmed.ncbi.nlm.nih.gov/30257383/) Basu P, Maier C.Basu P, et al.Biomed Pharmacother. 2018 Nov;107:1648-1666. doi: 10.1016/j.biopha.2018.08.100. Epub 2018 Sep 8.Biomed Pharmacother. 2018.PMID: 30257383Review. * [ Molecular Mechanisms of Anticancer Effects of Phytoestrogens in Breast Cancer. ](https://pubmed.ncbi.nlm.nih.gov/28079011/) Hsieh CJ, Hsu YL, Huang YF, Tsai EM.Hsieh CJ, et al.Curr Protein Pept Sci. 2018;19(3):323-332. doi: 10.2174/1389203718666170111121255.Curr Protein Pept Sci. 2018.PMID: 28079011Review. * [ Interactions of isoflavones and other plant derived estrogens with estrogen receptors for prevention and treatment of breast cancer-considerations concerning related efficacy and safety. ](https://pubmed.ncbi.nlm.nih.gov/23274118/) Leclercq G, Jacquot Y.Leclercq G, et al.J Steroid Biochem Mol Biol. 2014 Jan;139:237-44. doi: 10.1016/j.jsbmb.2012.12.010. Epub 2012 Dec 27.J Steroid Biochem Mol Biol. 2014.PMID: 23274118Review. * [ Bioassays for estrogenic activity: development and validation of estrogen receptor (ERalpha/ERbeta) and breast cancer proliferation bioassays to measure serum estrogenic activity in clinical studies. ](https://pubmed.ncbi.nlm.nih.gov/19382890/) Li J, Lee L, Gong Y, Shen P, Wong SP, Wise SD, Yong EL.Li J, et al.Assay Drug Dev Technol. 2009 Feb;7(1):80-9. doi: 10.1089/adt.2008.154.Assay Drug Dev Technol. 2009.PMID: 19382890Clinical Trial. * [ [Research progress in phytoestrogens of traditional Chinese medicine]. ](https://pubmed.ncbi.nlm.nih.gov/29218931/) Zhao Y, Zheng HX, Xu Y, Lin N.Zhao Y, et al.Zhongguo Zhong Yao Za Zhi. 2017 Sep;42(18):3474-3487. doi: 10.19540/j.cnki.cjcmm.2017.0135.Zhongguo Zhong Yao Za Zhi. 2017.PMID: 29218931Review.Chinese. 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