---
title: "Pilomatricoma Presenting in an Octogenarian: Rare Late-Life Scalp Tumor Case Report"
id: "pubmed-42638289"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42638289"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42638289/"
doi: "10.12659/AJCR.953320"
published_at: "2026-08-25T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Pilomatricoma Presenting in an Octogenarian: Rare Late-Life Scalp Tumor Case Report
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42638289
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42638289/)
- **DOI:** [10.12659/AJCR.953320](https://doi.org/10.12659%2FAJCR.953320)
- **Published At:** 2026-08-25T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- **Pilomatricoma** (Malherbe's calcifying epithelioma) is a benign adnexal tumor that arises from hair follicle matrix cells and is typically seen in children and young adults. Presentation in older adults is exceptionally rare. - The reported case involves an 86-year-old man with a tender, subcutaneous scalp cyst that enlarged from about 5 cm to 8 cm over several months, an atypically large or “giant” pilomatricoma for this age group. - The patient had multiple significant comorbidities: coronary artery disease, insulin-requiring type 2 diabetes mellitus, advanced chronic kidney disease, hypertension, dyslipidemia, and chronic obstructive pulmonary disease, increasing anesthetic and surgical risk. - Initial biopsy suggested pilomatricoma without malignant features, but because of clinical progression and clinicopathological discordance, malignancy remained a concern and influenced management decisions. - Due to high anesthetic risk, clinicians initially elected close surveillance rather than immediate surgery. Subsequent bleeding from the lesion prompted surgical excision. - Surgical histopathology confirmed a benign pilomatricoma with clear margins. There were no malignant histologic features reported in the final specimen. - Postoperative recovery was uneventful, and outpatient follow-up was arranged. Specific follow-up duration and additional management details were not reported in the source. - The authors emphasize that **giant pilomatricoma** can mimic malignancy in older patients and that age and rapid growth should not exclude pilomatricoma from the differential diagnosis. They support **complete surgical excision** for definitive diagnosis and management. - The case highlights diagnostic challenges, the need to weigh anesthetic risk against progression, and that clinicopathological discordance may necessitate excision for clarification. Details such as imaging, exact operative technique, or histologic microdescriptions beyond benign confirmation were not reported in the abstract.
## Clinical Analysis & Structured Key Points
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Affiliations Expand ### Affiliations * 1 Department of Surgical Oncology, Head and Neck Unit, Institut de Cancérologie de Lorraine, Université de Lorraine, Vandœuvre-lès-Nancy, France. * 2 CRAN, CNRS, UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy, France. * 3 Department of Surgical Oncology, Head and Neck Unit, Institut de Cancérologie de Lorraine, Université de Lorraine, Vandoeuvre-les-Nancy, France. * PMID: **42638289** * DOI: [ 10.12659/AJCR.953320 ](https://doi.org/10.12659/ajcr.953320) Item in Clipboard Case Reports # Pilomatricoma in an Octogenarian: A Case Report of an Exceptional Late-Life Presentation Oliwia Gunia et al. Am J Case Rep. 2026. Show details Display options Display options Format Abstract PubMed PMID Am J Case Rep Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Am+J+Case+Rep%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Am+J+Case+Rep%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42638289/) . 2026 Aug 25:27:e953320. doi: 10.12659/AJCR.953320. ### Authors [Oliwia Gunia](https://pubmed.ncbi.nlm.nih.gov/?term=Gunia+O&cauthor_id=42638289)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42638289/#short-view-affiliation-1 "Department of Surgical Oncology, Head and Neck Unit, Institut de Cancérologie de Lorraine, Université de Lorraine, Vandœuvre-lès-Nancy, France."), [Maëlys Bresson](https://pubmed.ncbi.nlm.nih.gov/?term=Bresson+M&cauthor_id=42638289)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42638289/#short-view-affiliation-1 "Department of Surgical Oncology, Head and Neck Unit, Institut de Cancérologie de Lorraine, Université de Lorraine, Vandœuvre-lès-Nancy, France."), [Claude Depardieu](https://pubmed.ncbi.nlm.nih.gov/?term=Depardieu+C&cauthor_id=42638289)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42638289/#short-view-affiliation-1 "Department of Surgical Oncology, Head and Neck Unit, Institut de Cancérologie de Lorraine, Université de Lorraine, Vandœuvre-lès-Nancy, France."), [Gilles Dolivet](https://pubmed.ncbi.nlm.nih.gov/?term=Dolivet+G&cauthor_id=42638289)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42638289/#short-view-affiliation-1 "Department of Surgical Oncology, Head and Neck Unit, Institut de Cancérologie de Lorraine, Université de Lorraine, Vandœuvre-lès-Nancy, France.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42638289/#short-view-affiliation-2 "CRAN, CNRS, UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy, France."), [Giacomo Gravante](https://pubmed.ncbi.nlm.nih.gov/?term=Gravante+G&cauthor_id=42638289)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42638289/#short-view-affiliation-3 "Department of Surgical Oncology, Head and Neck Unit, Institut de Cancérologie de Lorraine, Université de Lorraine, Vandoeuvre-les-Nancy, France."), [Romina Mastronicola](https://pubmed.ncbi.nlm.nih.gov/?term=Mastronicola+R&cauthor_id=42638289)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42638289/#short-view-affiliation-1 "Department of Surgical Oncology, Head and Neck Unit, Institut de Cancérologie de Lorraine, Université de Lorraine, Vandœuvre-lès-Nancy, France.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42638289/#short-view-affiliation-2 "CRAN, CNRS, UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy, France.") ### Affiliations * 1 Department of Surgical Oncology, Head and Neck Unit, Institut de Cancérologie de Lorraine, Université de Lorraine, Vandœuvre-lès-Nancy, France. * 2 CRAN, CNRS, UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy, France. * 3 Department of Surgical Oncology, Head and Neck Unit, Institut de Cancérologie de Lorraine, Université de Lorraine, Vandoeuvre-les-Nancy, France. * PMID: **42638289** * DOI: [ 10.12659/AJCR.953320 ](https://doi.org/10.12659/ajcr.953320) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract BACKGROUND Pilomatricoma, also known as Malherbe's calcifying epithelioma, is a benign adnexal tumor originating from hair follicle matrix cells and occurs predominantly in children and young adults. Its presentation in an older adult is exceptionally rare and can pose diagnostic challenges. We report a rare case of pilomatricoma in an 86-year-old patient. CASE REPORT We report the case of an 86-year-old man who presented with a tender, subcutaneous cyst on the right scalp. The lesion had been evolving for several months, enlarging from approximately 5 cm to 8 cm. His medical history included multiple comorbidities: coronary artery disease, insulin-requiring type 2 diabetes mellitus, advanced chronic kidney disease, hypertension, dyslipidemia, and chronic obstructive pulmonary disease. Initial biopsy suggested pilomatricoma without malignant features; however, clinicopathological discordance and tumor progression raised suspicion of malignancy. Owing to significant anesthetic risk, initial management consisted of close surveillance. Following the onset of bleeding, surgical excision was performed. Histopathological analysis confirmed a benign pilomatricoma with clear margins. Postoperative recovery was uneventful, and follow-up was scheduled. CONCLUSIONS Giant pilomatricoma can present atypically in older patients, mimicking malignancy and leading to diagnostic uncertainty. This case underscores the importance of considering this diagnosis despite age and rapid growth, and supports complete surgical excision for definitive diagnosis and management. 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