---
title: "Platelet lipid rafts: membrane microdomains as disease hubs and precision therapeutic targets"
id: "pubmed-42235332"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42235332"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42235332/"
doi: "10.1016/j.bbrc.2026.154039"
published_at: "2026-08-20T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Platelet lipid rafts: membrane microdomains as disease hubs and precision therapeutic targets
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42235332
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42235332/)
- **DOI:** [10.1016/j.bbrc.2026.154039](https://doi.org/10.1016%2Fj.bbrc.2026.154039)
- **Published At:** 2026-08-20T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Lipid rafts are dynamic membrane microdomains enriched in **cholesterol** and sphingolipids that organize signalling complexes. - Platelets are an optimal model for studying raft biology because they are **anucleate** and have a high cholesterol-to-phospholipid ratio, which accentuates raft-dependent processes. - **Platelet lipid rafts** recruit membrane receptors (for example, **GPIb-IX-V** and **GPVI**) and downstream tyrosine kinases (Syk and Src family kinases) to coordinate adhesion, aggregation, phosphatidylserine exposure, and release of inflammatory mediators. - By organizing these processes, platelet lipid rafts influence physiological and pathological events including **thrombosis**, immune regulation, and **tumour metastasis**. - The review summarizes pathogenic roles of platelet lipid rafts across multiple diseases: atherosclerosis, sepsis, antiphospholipid syndrome, Alzheimer’s disease, and cancer. - Mechanistic pathways linking raft dysfunction to disease include aberrant signal activation, release of procoagulant microvesicles, and altered intercellular crosstalk. - Emerging therapeutic approaches aim to modulate raft function by altering cholesterol content, changing protein composition, or disrupting raft architecture to enable more personalised antithrombotic strategies. - The review positions lipid-raft–targeted interventions as promising avenues for precision therapy but does not provide clinical trial results or specific drug recommendations in the abstract.
## Clinical Analysis & Structured Key Points
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Epub 2026 May 26. # Platelet lipid rafts: Disease regulatory hubs and precision therapeutic targets in membrane microdomains [Aihua Zhao](https://pubmed.ncbi.nlm.nih.gov/?term=Zhao+A&cauthor_id=42235332)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42235332/#full-view-affiliation-1 "Laboratory Medicine Center, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province, 730030, China."), [Qinglin Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+Q&cauthor_id=42235332)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42235332/#full-view-affiliation-1 "Laboratory Medicine Center, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province, 730030, China."), [Xiangli Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+X&cauthor_id=42235332)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42235332/#full-view-affiliation-1 "Laboratory Medicine Center, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province, 730030, China."), [Yan Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+Y&cauthor_id=42235332)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42235332/#full-view-affiliation-2 "Department of Geriatrics, Huashan Hospital, Fudan University, Shanghai, 200040, China."), [Zhicheng Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+Z&cauthor_id=42235332)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42235332/#full-view-affiliation-3 "Department of Transfusion Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China. Electronic address: wangzhicheng@fudan.edu.cn."), [Zihua Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+Z&cauthor_id=42235332)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42235332/#full-view-affiliation-4 "Laboratory Medicine Center, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province, 730030, China; Department of Blood Transfusion Service, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province, 730030, China. Electronic address: ery_liuzh@lzu.edu.cn.") Affiliations Expand ### Affiliations * 1 Laboratory Medicine Center, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province, 730030, China. * 2 Department of Geriatrics, Huashan Hospital, Fudan University, Shanghai, 200040, China. * 3 Department of Transfusion Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China. Electronic address: wangzhicheng@fudan.edu.cn. * 4 Laboratory Medicine Center, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province, 730030, China; Department of Blood Transfusion Service, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province, 730030, China. Electronic address: ery_liuzh@lzu.edu.cn. * PMID: **42235332** * DOI: [ 10.1016/j.bbrc.2026.154039 ](https://doi.org/10.1016/j.bbrc.2026.154039) Item in Clipboard Review # Platelet lipid rafts: Disease regulatory hubs and precision therapeutic targets in membrane microdomains Aihua Zhao et al. Biochem Biophys Res Commun. 2026. Show details Display options Display options Format Abstract PubMed PMID Biochem Biophys Res Commun Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biochem+Biophys+Res+Commun%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Biochem+Biophys+Res+Commun%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42235332/) . 2026 Aug 20:827:154039. doi: 10.1016/j.bbrc.2026.154039. Epub 2026 May 26. ### Authors [Aihua Zhao](https://pubmed.ncbi.nlm.nih.gov/?term=Zhao+A&cauthor_id=42235332)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42235332/#short-view-affiliation-1 "Laboratory Medicine Center, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province, 730030, China."), [Qinglin Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+Q&cauthor_id=42235332)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42235332/#short-view-affiliation-1 "Laboratory Medicine Center, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province, 730030, China."), [Xiangli Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+X&cauthor_id=42235332)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42235332/#short-view-affiliation-1 "Laboratory Medicine Center, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province, 730030, China."), [Yan Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+Y&cauthor_id=42235332)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42235332/#short-view-affiliation-2 "Department of Geriatrics, Huashan Hospital, Fudan University, Shanghai, 200040, China."), [Zhicheng Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+Z&cauthor_id=42235332)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42235332/#short-view-affiliation-3 "Department of Transfusion Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China. Electronic address: wangzhicheng@fudan.edu.cn."), [Zihua Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+Z&cauthor_id=42235332)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42235332/#short-view-affiliation-4 "Laboratory Medicine Center, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province, 730030, China; Department of Blood Transfusion Service, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province, 730030, China. Electronic address: ery_liuzh@lzu.edu.cn.") ### Affiliations * 1 Laboratory Medicine Center, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province, 730030, China. * 2 Department of Geriatrics, Huashan Hospital, Fudan University, Shanghai, 200040, China. * 3 Department of Transfusion Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China. Electronic address: wangzhicheng@fudan.edu.cn. * 4 Laboratory Medicine Center, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province, 730030, China; Department of Blood Transfusion Service, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province, 730030, China. Electronic address: ery_liuzh@lzu.edu.cn. * PMID: **42235332** * DOI: [ 10.1016/j.bbrc.2026.154039 ](https://doi.org/10.1016/j.bbrc.2026.154039) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract Lipid rafts are dynamic membrane microdomains enriched in cholesterol and sphingolipids. Platelets, with their unique anucleate nature and a high cholesterol-to-phospholipid ratio, serve as an optimal model for studying lipid raft functionality. These microdomains regulate key platelet processes-including adhesion, aggregation, phosphatidylserine exposure, and the release of inflammatory mediators-by recruiting receptors such as GPIb-IX-V and GPVI, and downstream signalling molecules like Syk and Src family kinases. Consequently, platelet lipid rafts modulate a spectrum of physiological and pathological events, from thrombosis and immune regulation to tumour metastasis. This review delineates the pathogenic roles of platelet lipid rafts in atherosclerosis, sepsis, antiphospholipid syndrome, Alzheimer's disease, and cancer, elucidating underlying mechanisms such as aberrant signal activation, procoagulant microvesicle release, and intercellular crosstalk. Furthermore, we explore emerging therapeutic strategies that target the cholesterol content, protein composition, or dynamic architecture of lipid rafts, offering novel perspectives for personalised antithrombotic regimens. **Keywords:** Inflammatory response; Lipid raft-targeted therapy; Platelet lipid rafts; Signal transduction; Thrombotic disorders. Copyright © 2026 Elsevier Inc. All rights reserved. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ## Similar articles * [ RETRACTED: The glycoprotein Ib-IX-V complex mediates localization of factor XI to lipid rafts on the platelet membrane. ](https://pubmed.ncbi.nlm.nih.gov/12517745/) Baglia FA, Shrimpton CN, López JA, Walsh PN.Baglia FA, et al.J Biol Chem. 2003 Jun 13;278(24):21744-50. doi: 10.1074/jbc.M212991200. Epub 2003 Jan 6.J Biol Chem. 2003.PMID: 12517745 * [ Lipid rafts as major platforms for signaling regulation in cancer. ](https://pubmed.ncbi.nlm.nih.gov/25465296/) Mollinedo F, Gajate C.Mollinedo F, et al.Adv Biol Regul. 2015 Jan;57:130-46. doi: 10.1016/j.jbior.2014.10.003. Epub 2014 Oct 27.Adv Biol Regul. 2015.PMID: 25465296Review. * [ Platelet membrane lipid rafts protein composition varies following GPVI and CLEC-2 receptors activation. ](https://pubmed.ncbi.nlm.nih.gov/30677554/) Izquierdo I, Barrachina MN, Hermida-Nogueira L, Casas V, Eble JA, Carrascal M, Abián J, García Á.Izquierdo I, et al.J Proteomics. 2019 Mar 20;195:88-97. doi: 10.1016/j.jprot.2019.01.014. Epub 2019 Jan 22.J Proteomics. 2019.PMID: 30677554 * [ The platelet glycoprotein Ib-IX-V complex anchors lipid rafts to the membrane skeleton: implications for activation-dependent cytoskeletal translocation of signaling molecules. ](https://pubmed.ncbi.nlm.nih.gov/19874464/) Munday AD, Gaus K, López JA.Munday AD, et al.J Thromb Haemost. 2010 Jan;8(1):163-72. doi: 10.1111/j.1538-7836.2009.03656.x. Epub 2009 Oct 23.J Thromb Haemost. 2010.PMID: 19874464 * [ Function of Platelet Glycosphingolipid Microdomains/Lipid Rafts. ](https://pubmed.ncbi.nlm.nih.gov/32748854/) Komatsuya K, Kaneko K, Kasahara K.Komatsuya K, et al.Int J Mol Sci. 2020 Aug 2;21(15):5539. doi: 10.3390/ijms21155539.Int J Mol Sci. 2020.PMID: 32748854Free PMC article.Review. 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