---
title: "PML-driven sumoylation of PML::RARA-bound repressors and hematopoietic progenitor immortalization"
id: "pubmed-42663568"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42663568"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42663568/"
doi: "10.1084/jem.20252333"
published_at: "2026-08-28T20:37:11.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# PML-driven sumoylation of PML::RARA-bound repressors and hematopoietic progenitor immortalization
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42663568
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42663568/)
- **DOI:** [10.1084/jem.20252333](https://doi.org/10.1084%2Fjem.20252333)
- **Published At:** 2026-08-28T20:37:11.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This PubMed record (PMID 42663568, DOI 10.1084/jem.20252333) reports a 2026 J Exp Med article titled “PML-driven sumoylation of PML::RARA-bound repressors drives hematopoietic progenitor immortalization.” - The title indicates a mechanistic focus on **PML::RARA** fusion interactions, **sumoylation** driven by PML, and resulting **hematopoietic progenitor immortalization**, a process relevant to leukemogenesis. - The manuscript lists multiple contributing authors and French institutional affiliations including Collège de France, Université Paris-Cité, Sorbonne Université, and Assistance Publique–Hôpitaux de Paris; two authors contributed equally. - Publication metadata: J Exp Med, 2026 Sep 7;223(9):e20252333. Epub 2026 Aug 28. - The PubMed abstract in the provided source is truncated; the full abstract, experimental methods, results, and conclusions are not available in the supplied content. - Because the source body is incomplete, specific experimental approaches, key data, quantitative results, and precise mechanistic details beyond what the title states are not reported here. - The title implies relevance to acute promyelocytic leukemia (**APL**) biology given the PML::RARA fusion, but confirmation of disease context, model systems, or therapeutic implications is not reported in the provided text. - Readers should consult the full article (DOI 10.1084/jem.20252333) for complete data, methods, and conclusions; those elements were not present in the supplied source content.
## Clinical Analysis & Structured Key Points
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Epub 2026 Aug 28. # PML-driven sumoylation of PML::RARA-bound repressors drives hematopoietic progenitor immortalization [Hsin Chieh Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+HC&cauthor_id=42663568)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#full-view-affiliation-1 "Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, CIRB, Institut National de la Santé et de la Recherche Médicale UMR 1050, Centre National de la Recherche Scientifique UMR 7241 , Equipe Labellisée par la Ligue contre le Cancer, Paris, France.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#full-view-affiliation-2 "Université Paris-Cité, Institut National de la Santé et de la Recherche Médicale U1342, Centre National de la Recherche Scientifique EMR8000, Institut de Recherche Saint-Louis, Hôpital Saint-Louis , Paris, France."), [Emmanuel Laplantine](https://pubmed.ncbi.nlm.nih.gov/?term=Laplantine+E&cauthor_id=42663568)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#full-view-affiliation-1 "Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, CIRB, Institut National de la Santé et de la Recherche Médicale UMR 1050, Centre National de la Recherche Scientifique UMR 7241 , Equipe Labellisée par la Ligue contre le Cancer, Paris, France.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#full-view-affiliation-2 "Université Paris-Cité, Institut National de la Santé et de la Recherche Médicale U1342, Centre National de la Recherche Scientifique EMR8000, Institut de Recherche Saint-Louis, Hôpital Saint-Louis , Paris, France."), [Cécile Esnault](https://pubmed.ncbi.nlm.nih.gov/?term=Esnault+C&cauthor_id=42663568)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#full-view-affiliation-1 "Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, CIRB, Institut National de la Santé et de la Recherche Médicale UMR 1050, Centre National de la Recherche Scientifique UMR 7241 , Equipe Labellisée par la Ligue contre le Cancer, Paris, France.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#full-view-affiliation-2 "Université Paris-Cité, Institut National de la Santé et de la Recherche Médicale U1342, Centre National de la Recherche Scientifique EMR8000, Institut de Recherche Saint-Louis, Hôpital Saint-Louis , Paris, France."), [Michiko Niwa-Kawakita](https://pubmed.ncbi.nlm.nih.gov/?term=Niwa-Kawakita+M&cauthor_id=42663568)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#full-view-affiliation-1 "Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, CIRB, Institut National de la Santé et de la Recherche Médicale UMR 1050, Centre National de la Recherche Scientifique UMR 7241 , Equipe Labellisée par la Ligue contre le Cancer, Paris, France.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#full-view-affiliation-2 "Université Paris-Cité, Institut National de la Santé et de la Recherche Médicale U1342, Centre National de la Recherche Scientifique EMR8000, Institut de Recherche Saint-Louis, Hôpital Saint-Louis , Paris, France."), [Yi Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+Y&cauthor_id=42663568)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#full-view-affiliation-1 "Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, CIRB, Institut National de la Santé et de la Recherche Médicale UMR 1050, Centre National de la Recherche Scientifique UMR 7241 , Equipe Labellisée par la Ligue contre le Cancer, Paris, France.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#full-view-affiliation-2 "Université Paris-Cité, Institut National de la Santé et de la Recherche Médicale U1342, Centre National de la Recherche Scientifique EMR8000, Institut de Recherche Saint-Louis, Hôpital Saint-Louis , Paris, France."), [Viviane De Almeida Bastos](https://pubmed.ncbi.nlm.nih.gov/?term=De+Almeida+Bastos+V&cauthor_id=42663568)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#full-view-affiliation-3 "Sorbonne Université, UMS 37 PASS, P3S, Institut National de la Santé et de la Recherche Médicale , Paris, France."), [Marie-Claude Geoffroy](https://pubmed.ncbi.nlm.nih.gov/?term=Geoffroy+MC&cauthor_id=42663568)[#](https://pubmed.ncbi.nlm.nih.gov/42663568/#full-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#full-view-affiliation-1 "Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, CIRB, Institut National de la Santé et de la Recherche Médicale UMR 1050, Centre National de la Recherche Scientifique UMR 7241 , Equipe Labellisée par la Ligue contre le Cancer, Paris, France.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#full-view-affiliation-2 "Université Paris-Cité, Institut National de la Santé et de la Recherche Médicale U1342, Centre National de la Recherche Scientifique EMR8000, Institut de Recherche Saint-Louis, Hôpital Saint-Louis , Paris, France."), [Hugues de Thé](https://pubmed.ncbi.nlm.nih.gov/?term=de+Th%C3%A9+H&cauthor_id=42663568)[#](https://pubmed.ncbi.nlm.nih.gov/42663568/#full-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#full-view-affiliation-1 "Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, CIRB, Institut National de la Santé et de la Recherche Médicale UMR 1050, Centre National de la Recherche Scientifique UMR 7241 , Equipe Labellisée par la Ligue contre le Cancer, Paris, France.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#full-view-affiliation-2 "Université Paris-Cité, Institut National de la Santé et de la Recherche Médicale U1342, Centre National de la Recherche Scientifique EMR8000, Institut de Recherche Saint-Louis, Hôpital Saint-Louis , Paris, France.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#full-view-affiliation-4 "Laboratoire d'hématologie Moléculaire, Assistance Publique-Hôpitaux de Paris, Hôpital St. Louis, Paris, France.") Affiliations Expand ### Affiliations * 1 Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, CIRB, Institut National de la Santé et de la Recherche Médicale UMR 1050, Centre National de la Recherche Scientifique UMR 7241 , Equipe Labellisée par la Ligue contre le Cancer, Paris, France. * 2 Université Paris-Cité, Institut National de la Santé et de la Recherche Médicale U1342, Centre National de la Recherche Scientifique EMR8000, Institut de Recherche Saint-Louis, Hôpital Saint-Louis , Paris, France. * 3 Sorbonne Université, UMS 37 PASS, P3S, Institut National de la Santé et de la Recherche Médicale , Paris, France. * 4 Laboratoire d'hématologie Moléculaire, Assistance Publique-Hôpitaux de Paris, Hôpital St. Louis, Paris, France. # Contributed equally. * PMID: **42663568** * DOI: [ 10.1084/jem.20252333 ](https://doi.org/10.1084/jem.20252333) Item in Clipboard # PML-driven sumoylation of PML::RARA-bound repressors drives hematopoietic progenitor immortalization Hsin Chieh Wu et al. J Exp Med. 2026. Show details Display options Display options Format Abstract PubMed PMID J Exp Med Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22J+Exp+Med%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22J+Exp+Med%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42663568/) . 2026 Sep 7;223(9):e20252333. doi: 10.1084/jem.20252333. Epub 2026 Aug 28. ### Authors [Hsin Chieh Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+HC&cauthor_id=42663568)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#short-view-affiliation-1 "Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, CIRB, Institut National de la Santé et de la Recherche Médicale UMR 1050, Centre National de la Recherche Scientifique UMR 7241 , Equipe Labellisée par la Ligue contre le Cancer, Paris, France.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#short-view-affiliation-2 "Université Paris-Cité, Institut National de la Santé et de la Recherche Médicale U1342, Centre National de la Recherche Scientifique EMR8000, Institut de Recherche Saint-Louis, Hôpital Saint-Louis , Paris, France."), [Emmanuel Laplantine](https://pubmed.ncbi.nlm.nih.gov/?term=Laplantine+E&cauthor_id=42663568)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#short-view-affiliation-1 "Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, CIRB, Institut National de la Santé et de la Recherche Médicale UMR 1050, Centre National de la Recherche Scientifique UMR 7241 , Equipe Labellisée par la Ligue contre le Cancer, Paris, France.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#short-view-affiliation-2 "Université Paris-Cité, Institut National de la Santé et de la Recherche Médicale U1342, Centre National de la Recherche Scientifique EMR8000, Institut de Recherche Saint-Louis, Hôpital Saint-Louis , Paris, France."), [Cécile Esnault](https://pubmed.ncbi.nlm.nih.gov/?term=Esnault+C&cauthor_id=42663568)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#short-view-affiliation-1 "Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, CIRB, Institut National de la Santé et de la Recherche Médicale UMR 1050, Centre National de la Recherche Scientifique UMR 7241 , Equipe Labellisée par la Ligue contre le Cancer, Paris, France.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#short-view-affiliation-2 "Université Paris-Cité, Institut National de la Santé et de la Recherche Médicale U1342, Centre National de la Recherche Scientifique EMR8000, Institut de Recherche Saint-Louis, Hôpital Saint-Louis , Paris, France."), [Michiko Niwa-Kawakita](https://pubmed.ncbi.nlm.nih.gov/?term=Niwa-Kawakita+M&cauthor_id=42663568)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#short-view-affiliation-1 "Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, CIRB, Institut National de la Santé et de la Recherche Médicale UMR 1050, Centre National de la Recherche Scientifique UMR 7241 , Equipe Labellisée par la Ligue contre le Cancer, Paris, France.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#short-view-affiliation-2 "Université Paris-Cité, Institut National de la Santé et de la Recherche Médicale U1342, Centre National de la Recherche Scientifique EMR8000, Institut de Recherche Saint-Louis, Hôpital Saint-Louis , Paris, France."), [Yi Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+Y&cauthor_id=42663568)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#short-view-affiliation-1 "Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, CIRB, Institut National de la Santé et de la Recherche Médicale UMR 1050, Centre National de la Recherche Scientifique UMR 7241 , Equipe Labellisée par la Ligue contre le Cancer, Paris, France.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#short-view-affiliation-2 "Université Paris-Cité, Institut National de la Santé et de la Recherche Médicale U1342, Centre National de la Recherche Scientifique EMR8000, Institut de Recherche Saint-Louis, Hôpital Saint-Louis , Paris, France."), [Viviane De Almeida Bastos](https://pubmed.ncbi.nlm.nih.gov/?term=De+Almeida+Bastos+V&cauthor_id=42663568)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#short-view-affiliation-3 "Sorbonne Université, UMS 37 PASS, P3S, Institut National de la Santé et de la Recherche Médicale , Paris, France."), [Marie-Claude Geoffroy](https://pubmed.ncbi.nlm.nih.gov/?term=Geoffroy+MC&cauthor_id=42663568)[#](https://pubmed.ncbi.nlm.nih.gov/42663568/#short-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#short-view-affiliation-1 "Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, CIRB, Institut National de la Santé et de la Recherche Médicale UMR 1050, Centre National de la Recherche Scientifique UMR 7241 , Equipe Labellisée par la Ligue contre le Cancer, Paris, France.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#short-view-affiliation-2 "Université Paris-Cité, Institut National de la Santé et de la Recherche Médicale U1342, Centre National de la Recherche Scientifique EMR8000, Institut de Recherche Saint-Louis, Hôpital Saint-Louis , Paris, France."), [Hugues de Thé](https://pubmed.ncbi.nlm.nih.gov/?term=de+Th%C3%A9+H&cauthor_id=42663568)[#](https://pubmed.ncbi.nlm.nih.gov/42663568/#short-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#short-view-affiliation-1 "Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, CIRB, Institut National de la Santé et de la Recherche Médicale UMR 1050, Centre National de la Recherche Scientifique UMR 7241 , Equipe Labellisée par la Ligue contre le Cancer, Paris, France.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#short-view-affiliation-2 "Université Paris-Cité, Institut National de la Santé et de la Recherche Médicale U1342, Centre National de la Recherche Scientifique EMR8000, Institut de Recherche Saint-Louis, Hôpital Saint-Louis , Paris, France.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42663568/#short-view-affiliation-4 "Laboratoire d'hématologie Moléculaire, Assistance Publique-Hôpitaux de Paris, Hôpital St. Louis, Paris, France.") ### Affiliations * 1 Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, CIRB, Institut National de la Santé et de la Recherche Médicale UMR 1050, Centre National de la Recherche Scientifique UMR 7241 , Equipe Labellisée par la Ligue contre le Cancer, Paris, France. * 2 Université Paris-Cité, Institut National de la Santé et de la Recherche Médicale U1342, Centre National de la Recherche Scientifique EMR8000, Institut de Recherche Saint-Louis, Hôpital Saint-Louis , Paris, France. * 3 Sorbonne Université, UMS 37 PASS, P3S, Institut National de la Santé et de la Recherche Médicale , Paris, France. * 4 Laboratoire d'hématologie Moléculaire, Assistance Publique-Hôpitaux de Paris, Hôpital St. Louis, Paris, France. # Contributed equally. * PMID: **42663568** * DOI: [ 10.1084/jem.20252333 ](https://doi.org/10.1084/jem.20252333) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract While acute promyelocytic leukemia (APL) is always
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