---
title: "Rare genetic variant linked to 25-fold higher lung cancer risk in never-smokers"
id: "stat-news-0-stat-why-do-never-smokers-get-lung-cancer-in-some-cases-rare-genetic-variant"
canonical_url: "https://medichelpline.com/clinical-feed/stat-news-0-stat-why-do-never-smokers-get-lung-cancer-in-some-cases-rare-genetic-variant"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "STAT News"
source_url: "https://www.statnews.com/2026/09/17/rare-gene-variant-boosts-lung-cancer-risk-25-fold-in-non-smokers/?utm_campaign=rss"
published_at: "2026-09-17T18:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Rare genetic variant linked to 25-fold higher lung cancer risk in never-smokers
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/stat-news-0-stat-why-do-never-smokers-get-lung-cancer-in-some-cases-rare-genetic-variant
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** STAT News
- **Source URL:** [Original Journal Publication](https://www.statnews.com/2026/09/17/rare-gene-variant-boosts-lung-cancer-risk-25-fold-in-non-smokers/?utm_campaign=rss)
- **Published At:** 2026-09-17T18:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- Researchers reported a **rare genetic variant** associated with about **25-fold** higher odds of lung cancer, based on a study published in the journal **Science**. - The finding emerged from analysis of a very large dataset provided by **23andMe**, illustrating the value of population-scale genetic data for detecting rare risk factors. - The variant is substantially more common in people from **Southern Appalachia** than in other U.S. regions, according to the report. - Investigators and experts say the variant likely explains only a small fraction of lung cancers that occur in **never-smokers**, so it does not account for the broader rise in such cases. - The study reinforces that some never-smoker lung cancers can be tied to distinct risk factors, with potential implications for **screening** and **treatment** strategies. - The article notes that details such as the variant’s exact identity, prevalence, effect estimates beyond the 25-fold odds statement, biological mechanism, sample size, and clinical recommendations were not reported in the source excerpt.
## Clinical Analysis & Structured Key Points
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In some cases, rare genetic variant may be a factor ## Researchers say study of huge dataset ties variant, more common in Southern Appalachia, to increased risk * [Manage alerts for this article](https://www.statnews.com/my-account/edit/#emails) * [Save this story for later](https://www.statnews.com/my-account/saved/) * [Share this article](https://www.statnews.com/2026/09/17/rare-gene-variant-boosts-lung-cancer-risk-25-fold-in-non-smokers/?utm_campaign=rss) ![](https://www.statnews.com/wp-content/uploads/2026/09/F0013020-Lung_cancer_CT_scan-645x645.jpg) A CT scan of a chest showing a large cancerous tumor (yellow, far left) in the left lung (purple).MIRIAM MASLO/SCIENCE PHOTO LIBRARY ![](https://www.statnews.com/wp-content/uploads/2021/02/andrew-j-avatar-small-1-80x80.png) By [Andrew Joseph](https://www.statnews.com/staff/andrew-joseph/) Sept. 17, 2026 Europe Correspondent ![](https://www.statnews.com/wp-content/uploads/2021/02/andrew-j-avatar-small-1-80x80.png) [Andrew Joseph](https://www.statnews.com/staff/andrew-joseph/) 1. [](https://x.com/DrewQJoseph "X") andrew.joseph@statnews.com Andrew covers the biopharma industry, scientific research, and public health across the continent. You can reach Andrew confidentially on Signal at drewqjoseph.71. For years, researchers have known that, among people diagnosed with lung cancer, [the prevalence of nonsmokers](https://www.statnews.com/2021/01/26/growing-share-of-lung-cancer-turning-up-in-never-smokers/) has been increasing. But they have been trying to determine what factors — whether genetic, environmental, or something else — might put these “never-smokers” at heightened risk. Now, researchers have identified a very rare genetic variant that is associated with 25-fold higher odds of lung cancer, [they reported](http://www.science.org/doi/10.1126/science.aec0473) in the journal Science on Thursday. In the U.S., the variant is far more common among people in Southern Appalachia than in other regions. Advertisement Experts said that the variant likely only plays a role in a small portion of never-smoker lung cancer cases. But the research provides further evidence that these types of tumors [can be tied to distinct risk factors](https://www.statnews.com/2021/09/06/never-smokers-lung-cancers-genetically-different-from-smokers-tumors/), which may in turn require thinking differently about screening programs and treatment strategies. More broadly, the new study highlights the types of narrow but crucial discoveries that can be made by turning to large datasets replete with health information from millions of people. In this case, the investigators relied on genetic data from 23andMe. STAT+ Exclusive Story Already have an account? 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