---
title: "RAS–SLC11A2 molecular framework links iron metabolism to PCOS cardiometabolic risk"
id: "pubmed-42678751"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42678751"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42678751/"
doi: "10.1080/10641963.2026.2711737"
published_at: "2026-09-01T22:13:33.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# RAS–SLC11A2 molecular framework links iron metabolism to PCOS cardiometabolic risk
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42678751
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42678751/)
- **DOI:** [10.1080/10641963.2026.2711737](https://doi.org/10.1080%2F10641963.2026.2711737)
- **Published At:** 2026-09-01T22:13:33.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The study used integrated **multi-omics** approaches to investigate mechanisms linking polycystic ovary syndrome (PCOS) with increased cardiometabolic risk, focusing on the renin-angiotensin system (RAS) and iron metabolism. - Transcriptomics and single-cell RNA sequencing revealed consistent dysregulation of **SLC11A2** in PCOS datasets, implicating iron transport in disease pathways. - SLC11A2-associated signatures connected to **iron metabolism**, inflammatory response, and **oxidative stress** pathways across PCOS and cardiometabolic conditions. - Genetic analyses, including Mendelian randomization, supported **RAS-related** regulation influencing susceptibility to hypertension and indicated shared genetic architecture between PCOS and cardiometabolic traits. - Network and single-cell analyses mapped SLC11A2-associated molecular patterns to disease-relevant cell types; machine learning identified molecular signatures capable of classifying disease states. - Molecular docking and in vitro functional assays evaluated therapeutic candidates; **gentiopicroside** reduced inflammatory and oxidative stress phenotypes such as IL-6 expression and reactive oxygen species accumulation in experimental assays. - The authors conclude an **RAS–SLC11A2** molecular framework links iron dysregulation to PCOS-associated cardiometabolic risk, providing mechanistic connections among ovarian dysfunction, inflammation, oxidative stress, and hypertension. - The study proposes **gentiopicroside** as a promising therapeutic candidate based on its effects on inflammatory and oxidative stress markers in the performed assays. - Keywords highlighted by the authors include **Iron metabolism**, **Polycystic ovary syndrome**, **SLC11A2**, **gentiopicroside**, **hypertension**, and **renin-angiotensin system**.
## Clinical Analysis & Structured Key Points
Clipboard, Search History, and several other advanced features are temporarily unavailable. [ Skip to main page content ](https://pubmed.ncbi.nlm.nih.gov/42678751/#article-details) ![U.S. flag](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png) An official website of the United States government Here's how you know ![Dot gov](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg) **The .gov means it’s official.** Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. ![Https](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg) **The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [ ![NIH NLM Logo](https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg) ](https://www.ncbi.nlm.nih.gov/) [Log in](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42678751%2F) Show account info Close #### Account Logged in as: **username** * [Dashboard](https://www.ncbi.nlm.nih.gov/myncbi/) * [Publications](https://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/) * [Account settings](https://www.ncbi.nlm.nih.gov/account/settings/) * [Log out](https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/42678751/) [Access keys](https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys) [NCBI Homepage](https://www.ncbi.nlm.nih.gov) [MyNCBI Homepage](https://pubmed.ncbi.nlm.nih.gov/myncbi/) [Main Content](https://pubmed.ncbi.nlm.nih.gov/42678751/#maincontent) [Main Navigation](https://pubmed.ncbi.nlm.nih.gov/42678751/) [ ![pubmed logo](https://cdn.ncbi.nlm.nih.gov/pubmed/af7de7da-df5d-41c6-8de4-8c266af8ccfb/core/images/pubmed-logo-blue.svg) ](https://pubmed.ncbi.nlm.nih.gov/) [ ](https://pubmed.ncbi.nlm.nih.gov/42678751/ "Show search bar") Search: [](https://pubmed.ncbi.nlm.nih.gov/42678751/ "Clear search input")Search [Advanced](https://pubmed.ncbi.nlm.nih.gov/advanced/) [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/clipboard/) [ User Guide ](https://pubmed.ncbi.nlm.nih.gov/help/) Save Email Send to * [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/42678751/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42678751%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42678751%2F%23open-collections-panel) * [Citation manager](https://pubmed.ncbi.nlm.nih.gov/42678751/) Display options Display options Format Abstract PubMed PMID ## Save citation to file Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel ## Email citation Email address has not been verified. Go to [ My NCBI account settings ](https://account.ncbi.nlm.nih.gov/settings/) to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel ### Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42678751/) Add Cancel ### Add to My Bibliography * My Bibliography Unable to load your delegates due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42678751/) Add Cancel ## Your saved search Name of saved search: Search terms: [Test search terms](https://pubmed.ncbi.nlm.nih.gov/42678751/) Would you like email updates of new search results? Saved Search Alert Radio Buttons * Yes * No Email: ([change](https://www.ncbi.nlm.nih.gov/account/settings/)) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel ## Create a file for external citation management software Create file Cancel ## Your RSS Feed Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy ### Actions Cite Collections Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42678751/) Add Cancel Permalink Permalink Copy Display options Display options Format Abstract PubMed PMID ### Page navigation * [ Title & authors ](https://pubmed.ncbi.nlm.nih.gov/42678751/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42678751/#abstract) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42678751/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42678751/#substances) Title & authors Abstract MeSH terms Substances Clin Exp Hypertens Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Clin+Exp+Hypertens%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Clin+Exp+Hypertens%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42678751/) . 2026 Dec 31;48(1):2711737. doi: 10.1080/10641963.2026.2711737. Epub 2026 Sep 1. # Integrated multi-omics analyses identify an RAS-SLC11A2-associated molecular framework linking iron metabolism with PCOS-related cardiometabolic risk [Sihan Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+S&cauthor_id=42678751)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42678751/#full-view-affiliation-1 "Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China."), [Yu Xu](https://pubmed.ncbi.nlm.nih.gov/?term=Xu+Y&cauthor_id=42678751)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42678751/#full-view-affiliation-1 "Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China."), [Tingting Cao](https://pubmed.ncbi.nlm.nih.gov/?term=Cao+T&cauthor_id=42678751)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42678751/#full-view-affiliation-1 "Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China."), [Kun Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+K&cauthor_id=42678751)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42678751/#full-view-affiliation-1 "Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China."), [Lina Jia](https://pubmed.ncbi.nlm.nih.gov/?term=Jia+L&cauthor_id=42678751)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42678751/#full-view-affiliation-2 "School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, People's Republic of China."), [Jianning Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+J&cauthor_id=42678751)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42678751/#full-view-affiliation-1 "Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China.") Affiliations Expand ### Affiliations * 1 Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China. * 2 School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, People's Republic of China. * PMID: **42678751** * DOI: [ 10.1080/10641963.2026.2711737 ](https://doi.org/10.1080/10641963.2026.2711737) Item in Clipboard # Integrated multi-omics analyses identify an RAS-SLC11A2-associated molecular framework linking iron metabolism with PCOS-related cardiometabolic risk Sihan Zhang et al. Clin Exp Hypertens. 2026. Show details Display options Display options Format Abstract PubMed PMID Clin Exp Hypertens Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Clin+Exp+Hypertens%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Clin+Exp+Hypertens%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42678751/) . 2026 Dec 31;48(1):2711737. doi: 10.1080/10641963.2026.2711737. Epub 2026 Sep 1. ### Authors [Sihan Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+S&cauthor_id=42678751)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42678751/#short-view-affiliation-1 "Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China."), [Yu Xu](https://pubmed.ncbi.nlm.nih.gov/?term=Xu+Y&cauthor_id=42678751)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42678751/#short-view-affiliation-1 "Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China."), [Tingting Cao](https://pubmed.ncbi.nlm.nih.gov/?term=Cao+T&cauthor_id=42678751)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42678751/#short-view-affiliation-1 "Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China."), [Kun Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+K&cauthor_id=42678751)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42678751/#short-view-affiliation-1 "Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China."), [Lina Jia](https://pubmed.ncbi.nlm.nih.gov/?term=Jia+L&cauthor_id=42678751)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42678751/#short-view-affiliation-2 "School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, People's Republic of China."), [Jianning Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+J&cauthor_id=42678751)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42678751/#short-view-affiliation-1 "Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China.") ### Affiliations * 1 Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China. * 2 School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, People's Republic of China. * PMID: **42678751** * DOI: [ 10.1080/10641963.2026.2711737 ](https://doi.org/10.1080/10641963.2026.2711737) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Introduction:** PCOS is a common endocrine disorder with elevated cardiometabolic risk, yet the role of the renin-angiotensin system (RAS)-iron metabolism axis in this comorbidity remains unclear. We explored its underlying mechanisms and evaluated the therapeutic potential of gentiopicroside. **Methods:** Integrated multi-omics analyses combining transcriptomics, single-cell RNA sequencing, Mendelian randomization, machine learning, molecular docking, and _in vitro_ functional assays were performed to identify shared molecular pathways and therapeutic targets across PCOS, hypertension, NAFLD, and T2DM. **Results:** SLC11A2 was consistently dysregulated in PCOS transcriptomic datasets, and associated with iron metabolism, inflammatory response and oxidative stress pathways. Genetic analyses validated RAS-related regulation in hypertension susceptibility and revealed shared genetic architecture between PCOS and cardiometabolic traits. Network and single-cell analyses characterized SLC11A2-associated molecular patterns in disease-relevant cell types; machine learning identified disease-classifying molecular signatures. Gentiopicroside alleviated inflammatory and oxidative stress phenotypes, including reduced IL-6 expression and reactive oxygen species accumulation. **Conclusion:** This study defines an RAS-SLC11A2 molecular framework linking iron metabolism dysregulation to PCOS-related cardiometabolic risk, elucidating the mechanisms connecting ovarian dysfunction, inflammation, oxidative stress and hypertension, and supports gentiopicroside as a promising therapeutic candidate. **Keywords:** Iron metabolism; Polycystic ovary syndrome; SLC11A2; gentiopicroside; hypertension; renin-angiotensin system. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## MeSH terms * Cardiometabolic Risk Factors Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cardiometabolic+Risk+Factors%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cardiometabolic+Risk+Factors) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42678751/) * Female Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Female%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Female) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42678751/) * Humans Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Humans) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42678751/) * Iron* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Iron%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Iron) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42678751/) * Multiomics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Multiomics%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Multiomics) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42678751/) * Oxidative Stress Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Oxidative+Stress%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Oxidative+Stress) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42678751/) * Polycystic Ovary Syndrome* / complications Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Polycystic+Ovary+Syndrome%2Fcomplications%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Polycystic+Ovary+Syndrome) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42678751/) * Polycystic Ovary Syndrome* / drug therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Polycystic+Ovary+Syndrome%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Polycystic+Ovary+Syndrome) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42678751/) * Polycystic Ovary Syndrome* / genetics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Polycystic+Ovary+Syndrome%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Polycystic+Ovary+Syndrome) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42678751/) * Polycystic Ovary Syndrome* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Polycystic+Ovary+Syndrome%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Polycystic+Ovary+Syndrome) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42678751/) * Renin-Angiotensin System* / genetics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Renin-Angiotensin+System%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Renin-Angiotensin+System) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42678751/) * Renin-Angiotensin System* / physiology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Renin-Angiotensin+System%2Fphysiology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Renin-Angiotensin+System) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42678751/) ## Substances * Iron Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Iron%22%5Bnm%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=%22Iron%22) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42678751/) [x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM **Send To** * [Clipboard](https://pubmed.ncbi.nlm.nih.gov/42678751/) * [Email](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42678751%2F%23open-email-panel) * [Save](https://pubmed.ncbi.nlm.nih.gov/42678751/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42678751%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42678751%2F%23open-collections-panel) * [Citation Manager](https://pubmed.ncbi.nlm.nih.gov/42678751/) [x] NCBI Literature Resources [MeSH](https://www.ncbi.nlm.nih.gov/mesh/) [PMC](https://www.ncbi.nlm.nih.gov/pmc/) [Bookshelf](https://www.ncbi.nlm.nih.gov/books) [Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited. Follow NCBI [ Twitter ](https://twitter.com/ncbi) [ Facebook ](https://www.facebook.com/ncbi.nlm) [ LinkedIn ](https://www.linkedin.com/company/ncbinlm) [ GitHub ](https://github.com/ncbi) [ ](https://ncbiinsights.ncbi.nlm.nih.gov/) [Connect with NLM](https://www.nlm.nih.gov/socialmedia/index.html) * [ Twitter ](https://twitter.com/NLM_NIH) * [ SM-Facebook ](https://www.facebook.com/nationallibraryofmedicine) * [ SM-Youtube ](https://www.youtube.com/user/NLMNIH) National Library of Medicine [8600 Rockville Pike Bethesda, MD 20894](https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323) [Web Policies](https://www.nlm.nih.gov/web_policies.html) [FOIA](https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office) [HHS Vulnerability Disclosure](https://www.hhs.gov/vulnerability-disclosure-policy/index.html) [Help](https://support.nlm.nih.gov/?pagename=pubmed%3Apubmed%3Aabstract%3ANONE) [Accessibility](https://www.nlm.nih.gov/accessibility.html) [Careers](https://www.nlm.nih.gov/careers/careers.html) * [NLM](https://www.nlm.nih.gov/) * [NIH](https://www.nih.gov/) * [HHS](https://www.hhs.gov/) * [USA.gov](https://www.usa.gov/)
## Related Clinical Research

- [Cardiac findings and follow-up in pediatric neurofibromatosis type 1: single-center cohort results](https://medichelpline.com/clinical-feed/pubmed-42760384.md) (DOI: 10.1007/s00431-026-07417-0)
- [Autologous DC-CIK Cell Therapy Combined with Multidisciplinary Care in Advanced Pancreatic Cancer:](https://medichelpline.com/clinical-feed/frontiers-in-immunology-17-multidisciplinary-treatment-incorporating-autologous-dc-cik-cell-therapy.md)
- [Healthy lifestyle and pan-cancer risk: UK Biobank prospective analysis](https://medichelpline.com/clinical-feed/british-journal-of-cancer-2-healthy-lifestyle-and-cancer-risk-a-pan-cancer-analysis-in-the-uk-biobank.md)
- [Combining lymphocyte markers with CA125 and HE4 to improve early endometrial cancer diagnosis in p](https://medichelpline.com/clinical-feed/pubmed-42726666.md) (DOI: 10.1080/01443615.2026.2719764)
- [BioBERT Clinical Text and Sparse Multi-Omics Components for Breast Cancer Survival Prediction: Cro](https://medichelpline.com/clinical-feed/medrxiv-2-biobert-derived-clinical-textrepresentations-and-sparse-principalcomponents-of.md)

## Navigation
- [← Back to Oncology Feed](https://medichelpline.com/clinical-feed/oncology.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.