---
title: "Rituximab Maintenance with Ibrutinib-Based Regimens in Younger, Untreated Mantle Cell Lymphoma — T"
id: "pubmed-42447409"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42447409"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42447409/"
doi: "10.1200/JCO-26-00705"
published_at: "2026-09-20T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Rituximab Maintenance with Ibrutinib-Based Regimens in Younger, Untreated Mantle Cell Lymphoma — T
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42447409
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42447409/)
- **DOI:** [10.1200/JCO-26-00705](https://doi.org/10.1200%2FJCO-26-00705)
- **Published At:** 2026-09-20T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The source is a randomized controlled trial report titled the TRIANGLE trial, published in Journal of Clinical Oncology (J Clin Oncol) with DOI 10.1200/JCO-26-00705 and PMID 42447409. - The study population is described as **younger, untreated patients with mantle cell lymphoma (MCL)**. - The intervention under investigation was adding **rituximab maintenance** to an **ibrutinib-containing therapy** backbone. - The article lists numerous authors across multiple European centers and the European MCL Network, indicating a multi-institutional cooperative trial. - Affiliations include institutions in Italy, Germany, the Netherlands, Spain, Sweden, Poland, Denmark, Switzerland, Norway, Czech Republic, Belgium, Israel, Portugal, Finland and others. - The PubMed entry identifies the article as a Randomized Controlled Trial and provides full-text access via PubMed Central. - Publication details reported: J Clin Oncol. 2026 Sep 20;44(27):2582-2589. Epub 2026 Jul 14. - The provided source excerpt includes title, authors, affiliations, trial name, journal citation, and links to full text but does not include the abstract, methods, numerical results, efficacy endpoints, safety findings, or conclusions in the excerpt supplied. - Because the source text presented here is truncated, trial design specifics (randomization scheme, sample size, inclusion/exclusion criteria), primary and secondary endpoints, statistical outcomes, and safety/adverse-event data were not reported in the supplied excerpt. - Readers are directed to the full-text PMC link for complete methods and results; those details were not available in the portion of the source used to produce this summary.
## Clinical Analysis & Structured Key Points
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Epub 2026 Jul 14. # Rituximab Maintenance Added to Ibrutinib-Containing Therapy in Younger, Untreated Patients With Mantle Cell Lymphoma: Results From the TRIANGLE Trial [Marco Ladetto](https://pubmed.ncbi.nlm.nih.gov/?term=Ladetto+M&cauthor_id=42447409)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-1 "Dipartimento di Medicina Traslazionale, Università del Piemonte Orientale and SCDU Ematologia AOU Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy."), [Katja Gutmair](https://pubmed.ncbi.nlm.nih.gov/?term=Gutmair+K&cauthor_id=42447409)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-2 "Institute for Medical Information Processing, Biometry, and Epidemiology \(IBE\), LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-3 "Pettenkofer School of Public Health, Munich, Germany."), [Rita Tavarozzi](https://pubmed.ncbi.nlm.nih.gov/?term=Tavarozzi+R&cauthor_id=42447409)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-1 "Dipartimento di Medicina Traslazionale, Università del Piemonte Orientale and SCDU Ematologia AOU Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy."), [Alexandra Pawlikowski](https://pubmed.ncbi.nlm.nih.gov/?term=Pawlikowski+A&cauthor_id=42447409)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-4 "Department of Medicine III, LMU University Hospital, Munich, Germany."), [Michael Schomaker](https://pubmed.ncbi.nlm.nih.gov/?term=Schomaker+M&cauthor_id=42447409)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-5 "Department of Statistics, Ludwig-Maximilians Universität München, Munich, Germany.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-6 "Munich Center for Machine Learning \(MCML\), Ludwig-Maximilians University Munich, Munich, Germany."), [Jeanette Doorduijn](https://pubmed.ncbi.nlm.nih.gov/?term=Doorduijn+J&cauthor_id=42447409)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-7 "Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands."), [Eva Giné](https://pubmed.ncbi.nlm.nih.gov/?term=Gin%C3%A9+E&cauthor_id=42447409)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-8 "Hematology Department, Hospital Clínic de Barcelona, IDIBAPS, Barcelona, Spain."), [Mats Jerkeman](https://pubmed.ncbi.nlm.nih.gov/?term=Jerkeman+M&cauthor_id=42447409)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-9 "Department of Oncology, Lund University and Skane University Hospital, Lund, Sweden."), [Jan Walewski](https://pubmed.ncbi.nlm.nih.gov/?term=Walewski+J&cauthor_id=42447409)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-10 "Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland."), [Martin Hutchings](https://pubmed.ncbi.nlm.nih.gov/?term=Hutchings+M&cauthor_id=42447409)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-11 "Department of Haematology and Phase 1 Unit, Rigshospitalet, Copenhagen, Denmark."), [Ulrich Mey](https://pubmed.ncbi.nlm.nih.gov/?term=Mey+U&cauthor_id=42447409)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-12 "Oncology and Hematology, Kantonsspital Graubuenden, Chur, Switzerland.")[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-13 "Swiss Cancer Institute \(formerly Swiss Group for Clinical Cancer Research-SAKK\), Bern, Switzerland."), [Jon Riise](https://pubmed.ncbi.nlm.nih.gov/?term=Riise+J&cauthor_id=42447409)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-14 "Department of Oncology, Oslo University Hospital, Oslo, Norway.")[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-15 "Institute of Clinical Medicine, University of Oslo, Oslo, Norway."), [Marek Trneny](https://pubmed.ncbi.nlm.nih.gov/?term=Trneny+M&cauthor_id=42447409)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-16 "First Faculty of Medicine, Charles University Hospital, Prague, Czech Republic."), [Vibeke K J Vergote](https://pubmed.ncbi.nlm.nih.gov/?term=Vergote+VKJ&cauthor_id=42447409)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-17 "Department of Hematology, University Hospitals Leuven, Leuven, Belgium."), [Netanel A Horowitz](https://pubmed.ncbi.nlm.nih.gov/?term=Horowitz+NA&cauthor_id=42447409)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-18 "The Department of Hematology and BMT, Rambam Health Care Campus, Haifa, Israel.")[ 19 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-19 "The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel."), [Maria Gomes da Silva](https://pubmed.ncbi.nlm.nih.gov/?term=Gomes+da+Silva+M&cauthor_id=42447409)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-20 "Hematology Department, Instituto Portugues de Oncologia de Lisboa, Lisboa, Portugal."), [Sirpa Leppä](https://pubmed.ncbi.nlm.nih.gov/?term=Lepp%C3%A4+S&cauthor_id=42447409)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-21 "Comprehensive Cancer Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland."), [Linmiao Jiang](https://pubmed.ncbi.nlm.nih.gov/?term=Jiang+L&cauthor_id=42447409)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-2 "Institute for Medical Information Processing, Biometry, and Epidemiology \(IBE\), LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-3 "Pettenkofer School of Public Health, Munich, Germany."), [Stephan Stilgenbauer](https://pubmed.ncbi.nlm.nih.gov/?term=Stilgenbauer+S&cauthor_id=42447409)[ 22 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-22 "Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany."), [Andrea Kerkhoff](https://pubmed.ncbi.nlm.nih.gov/?term=Kerkhoff+A&cauthor_id=42447409)[ 23 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-23 "Medizinische Klinik A, Universitätsklinikum Münster, Münster, Germany."), [Ron D Jachimowicz](https://pubmed.ncbi.nlm.nih.gov/?term=Jachimowicz+RD&cauthor_id=42447409)[ 24 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-24 "Department I of Internal Medicine, Center for Integrated Oncology and University Hospital Cologne, University of Cologne, Cologne, Germany.")[ 25 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-25 "Max Planck Institute for Biology of Ageing, Cologne, Germany."), [Georg Heß](https://pubmed.ncbi.nlm.nih.gov/?term=He%C3%9F+G&cauthor_id=42447409)[ 26 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-26 "Department of Hematology and Medical Oncology, Medical School of the Johannes Gutenberg-University, Mainz, Germany."), [Tom van Meerten](https://pubmed.ncbi.nlm.nih.gov/?term=van+Meerten+T&cauthor_id=42447409)[ 27 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-27 "Department of Hematology, University Medical Center Groningen, Groningen, the Netherlands."), [Stefan Wirths](https://pubmed.ncbi.nlm.nih.gov/?term=Wirths+S&cauthor_id=42447409)[ 28 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-28 "Department of Hematology, Oncology, Clinical Immunology and Rheumatology, Center for Internal Medicine, University Hospital Tuebingen, Tübingen, Germany."), [Peter Herhaus](https://pubmed.ncbi.nlm.nih.gov/?term=Herhaus+P&cauthor_id=42447409)[ 29 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-29 "Department of Internal Medicine III, Technical University of Munich, School of Medicine and Health, TUM University Hospital, Munich, Germany."), [Urban Novak](https://pubmed.ncbi.nlm.nih.gov/?term=Novak+U&cauthor_id=42447409)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-13 "Swiss Cancer Institute \(formerly Swiss Group for Clinical Cancer Research-SAKK\), Bern, Switzerland.")[ 30 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-30 "Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland."), [Judith Dierlamm](https://pubmed.ncbi.nlm.nih.gov/?term=Dierlamm+J&cauthor_id=42447409)[ 31 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-31 "Department of Internal Medicine II, UKE Hamburg, Hamburg, Germany."), [Mathias Hänel](https://pubmed.ncbi.nlm.nih.gov/?term=H%C3%A4nel+M&cauthor_id=42447409)[ 32 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-32 "Department of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany."), [Christine Hanoun](https://pubmed.ncbi.nlm.nih.gov/?term=Hanoun+C&cauthor_id=42447409)[ 33 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-33 "Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany."), [Kristina Sonnevi](https://pubmed.ncbi.nlm.nih.gov/?term=Sonnevi+K&cauthor_id=42447409)[ 34 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-34 "Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden."), [Carlo Visco](https://pubmed.ncbi.nlm.nih.gov/?term=Visco+C&cauthor_id=42447409)[ 35 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-35 "Azienda Ospedaliera Universitaria Integrata, Ematologia e Trapianto di midollo osseo and Department of Engineering for Innovative Medicine, Verona, Italy."), [Claudia Castellino](https://pubmed.ncbi.nlm.nih.gov/?term=Castellino+C&cauthor_id=42447409)[ 36 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-36 "Ematologia Az. Ospedaliera S. Croce e Carle, Cuneo, Italy."), [Roberto Massimo Lemoli](https://pubmed.ncbi.nlm.nih.gov/?term=Lemoli+RM&cauthor_id=42447409)[ 37 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-37 "Department of Internal Medicine \(DiMI\), University of Genoa, Genoa, Italy.")[ 38 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-38 "Department of Hematology, Department of Oncology and Hematology \(DIPOE\) IRCCS AOM San Martino Hospital, Genoa, Italy."), [Vittorio Ruggero Zilioli](https://pubmed.ncbi.nlm.nih.gov/?term=Zilioli+VR&cauthor_id=42447409)[ 39 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-39 "Division of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy."), [Carola Boccomini](https://pubmed.ncbi.nlm.nih.gov/?term=Boccomini+C&cauthor_id=42447409)[ 40 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-40 "S.C. Ematologia-A.O.U. Città della Salute e della Scienza di Torino, Torino, Italy."), [Christiane Pott](https://pubmed.ncbi.nlm.nih.gov/?term=Pott+C&cauthor_id=42447409)[ 41 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-41 "Department of Medicine II, University Hospital Schleswig-Holstein-Campus Kiel, Kiel, Germany."), [Wolfram Klapper](https://pubmed.ncbi.nlm.nih.gov/?term=Klapper+W&cauthor_id=42447409)[ 42 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-42 "Department of Pathology, Hematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein - Campus Kiel, Kiel, Germany."), [Christian Schmidt](https://pubmed.ncbi.nlm.nih.gov/?term=Schmidt+C&cauthor_id=42447409)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-4 "Department of Medicine III, LMU University Hospital, Munich, Germany."), [Martin Dreyling](https://pubmed.ncbi.nlm.nih.gov/?term=Dreyling+M&cauthor_id=42447409)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-4 "Department of Medicine III, LMU University Hospital, Munich, Germany."), [Eva Hoster](https://pubmed.ncbi.nlm.nih.gov/?term=Hoster+E&cauthor_id=42447409)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-2 "Institute for Medical Information Processing, Biometry, and Epidemiology \(IBE\), LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42447409/#full-view-affiliation-3 "Pettenkofer School of Public Health, Munich, Germany."); [European MCL Network](https://pubmed.ncbi.nlm.nih.gov/?term=European+MCL+Network%5BCorporate+Author%5D) Affiliations Expand ### Affiliations * 1 Dipartimento di Medicina Traslazionale, Università del Piemonte Orientale and SCDU Ematologia AOU Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy. * 2 Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany. * 3 Pettenkofer School of Public Health, Munich, Germany. * 4 Department of Medicine III, LMU University Hospital, Munich, Germany. * 5 Department of Statistics, Ludwig-Maximilians Universität München, Munich, Germany. * 6 Munich Center f
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