---
title: "Satisfaction with Treatment Decision-Making and Long-Term Experiences in mCRPC Life-Prolonging The"
id: "pubmed-42760521"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42760521"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42760521/"
doi: "10.1186/s12904-026-02336-1"
published_at: "2026-09-19T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Satisfaction with Treatment Decision-Making and Long-Term Experiences in mCRPC Life-Prolonging The
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42760521
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42760521/)
- **DOI:** [10.1186/s12904-026-02336-1](https://doi.org/10.1186%2Fs12904-026-02336-1)
- **Published At:** 2026-09-19T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This longitudinal observational study evaluated **treatment decision-making (TDM)** satisfaction and long-term experiences of life-prolonging treatments in patients with metastatic castration-resistant prostate cancer (**mCRPC**). - Participants (n = 122, mean age 75.3 years) were followed for an average of 18.3 months and completed a study-specific questionnaire every three months for up to two years from the start of any first line of life-prolonging treatment after mCRPC diagnosis. - **Satisfaction with TDM** was measured at the start of each new treatment line; treatment experiences were measured using participants' first and last completed questionnaires. Medical data were extracted from records. - Overall satisfaction with TDM at the start of first, second and third lines was generally high, but participants reported lower satisfaction regarding discussions about how treatment could affect their life situation. - Treatment experiences were largely positive initially, but there was a statistically significant decline from the first to the last follow-up in willingness to choose the same treatment (p = 0.04) and to recommend it to others (p = 0.01). - Among participants who received only one line of treatment, the decrease in treatment endorsement from first to last follow-up was significant (p = 0.02); no significant change was observed for those who received two or more lines. - Authors interpret the modest decline in satisfaction over time as a potential need to strengthen communication and adopt a more **person-centered** and **palliative care** approach, shifting from a disease-centered focus. - Ethical approval was obtained from the Swedish Ethical Review Authority under multiple Dnr numbers; written informed consent was obtained and authors declared no competing interests.
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Affiliations Expand ### Affiliations * 1 Department of Nursing Science, Sophiahemmet University, Valhallavägen 91 hus D, Box 5605, Stockholm, 114 86, Sweden. paula.routier@shh.se. * 2 Department of Nursing Science, Sophiahemmet University, Valhallavägen 91 hus D, Box 5605, Stockholm, 114 86, Sweden. * 3 Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. * 4 Department of Health Care Sciences, Marie Cederschiöld University College, Stockholm, Sweden. * 5 Department of Nursing, Umeå University, Umeå, Sweden. * 6 Department of Oncology, Sundsvall County Hospital, Sundsvall, Sweden. * PMID: **42760521** * DOI: [ 10.1186/s12904-026-02336-1 ](https://doi.org/10.1186/s12904-026-02336-1) Item in Clipboard Observational Study # Satisfaction with treatment decision-making and long-term experiences of life-prolonging treatments for metastatic castration-resistant prostate cancer Paula Routier Cañigueral et al. BMC Palliat Care. 2026. Show details Display options Display options Format Abstract PubMed PMID BMC Palliat Care Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22BMC+Palliat+Care%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22BMC+Palliat+Care%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42760521/) . 2026 Sep 19;25(1):278. doi: 10.1186/s12904-026-02336-1. ### Authors [Paula Routier Cañigueral](https://pubmed.ncbi.nlm.nih.gov/?term=Routier+Ca%C3%B1igueral+P&cauthor_id=42760521)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42760521/#short-view-affiliation-1 "Department of Nursing Science, Sophiahemmet University, Valhallavägen 91 hus D, Box 5605, Stockholm, 114 86, Sweden. paula.routier@shh.se."), [Agneta Wennman-Larsen](https://pubmed.ncbi.nlm.nih.gov/?term=Wennman-Larsen+A&cauthor_id=42760521)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42760521/#short-view-affiliation-2 "Department of Nursing Science, Sophiahemmet University, Valhallavägen 91 hus D, Box 5605, Stockholm, 114 86, Sweden.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42760521/#short-view-affiliation-3 "Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden."), [Sandra Doveson](https://pubmed.ncbi.nlm.nih.gov/?term=Doveson+S&cauthor_id=42760521)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42760521/#short-view-affiliation-2 "Department of Nursing Science, Sophiahemmet University, Valhallavägen 91 hus D, Box 5605, Stockholm, 114 86, Sweden.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42760521/#short-view-affiliation-4 "Department of Health Care Sciences, Marie Cederschiöld University College, Stockholm, Sweden."), [Ulrika Rönningås](https://pubmed.ncbi.nlm.nih.gov/?term=R%C3%B6nning%C3%A5s+U&cauthor_id=42760521)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42760521/#short-view-affiliation-5 "Department of Nursing, Umeå University, Umeå, Sweden.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42760521/#short-view-affiliation-6 "Department of Oncology, Sundsvall County Hospital, Sundsvall, Sweden."), [Maja Holm](https://pubmed.ncbi.nlm.nih.gov/?term=Holm+M&cauthor_id=42760521)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42760521/#short-view-affiliation-2 "Department of Nursing Science, Sophiahemmet University, Valhallavägen 91 hus D, Box 5605, Stockholm, 114 86, Sweden.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42760521/#short-view-affiliation-4 "Department of Health Care Sciences, Marie Cederschiöld University College, Stockholm, Sweden.") ### Affiliations * 1 Department of Nursing Science, Sophiahemmet University, Valhallavägen 91 hus D, Box 5605, Stockholm, 114 86, Sweden. paula.routier@shh.se. * 2 Department of Nursing Science, Sophiahemmet University, Valhallavägen 91 hus D, Box 5605, Stockholm, 114 86, Sweden. * 3 Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. * 4 Department of Health Care Sciences, Marie Cederschiöld University College, Stockholm, Sweden. * 5 Department of Nursing, Umeå University, Umeå, Sweden. * 6 Department of Oncology, Sundsvall County Hospital, Sundsvall, Sweden. * PMID: **42760521** * DOI: [ 10.1186/s12904-026-02336-1 ](https://doi.org/10.1186/s12904-026-02336-1) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Background:** Treatments in the phase of metastatic castration-resistant prostate cancer (mCRPC) aim to prolong survival and reduce the symptom burden. The fast development of life-prolonging therapies makes treatment decision-making (TDM) complex, weighting survival against possible side-effects and quality of life, especially in a real-world context. This study aimed to describe satisfaction with TDM at start of the first, second and third line of life-prolonging treatment and to describe and compare long-term treatment experiences when receiving one or several lines of treatment in patients with mCRPC. **Methods:** A longitudinal observational study. Participants completed a study-specific questionnaire every three months for up to two years from the start of any first line of life-prolonging treatment after mCRPC. Satisfaction with TDM was measured at the start of each new treatment line while treatment experiences were measured using the first and last completed questionnaire of each participant. Medical data was obtained from medical records. Descriptive statistics were used to present data while inferential statistics were used for analysis of group comparisons and over time changes. **Results:** A total of 122 participants (mean age 75.3 years) with an average follow-up time of 18.3 months were included. Satisfaction with TDM was generally high at the start of the first, second and third line of treatment, but lower regarding discussions on how treatment could affect their life situation. Treatment experiences were positive, yet there was a significant decrease from the first to the last follow-up in whether they would choose (p = 0.04) and recommend (p = 0.01) the same treatment to others. For participants who received one line of treatment, a significant decrease was found between the first and the last follow-up (p = 0.02), while no differences were found for those who received two or more lines. **Conclusions:** Despite high satisfaction with aspects of TDM and the treatment given it is important to discuss how the treatment can impact the patient's life situation. The slightly decreased satisfaction over time on the treatment received could reflect a possible need to strengthen communication between patients and healthcare professionals, shifting from a disease-centered perspective towards a more person-centered and palliative care approach. **Keywords:** Castration-resistant; Metastatic prostate cancer; Palliative care; Person-centered care; Prostatic neoplasm; Treatment decision-making; Treatment experiences. © 2026. The Author(s). [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declarations. Ethics approval and consent to participate: The study was granted ethical approval by the Swedish Ethical Review Authority, Dnr 2014/341-21/2, Dnr 2016/851-32 and Dnr 2016/2230-32 and was performed in compliance with the ethical principles for medical research involving human participants from the Declaration of Helsinki. Written informed consent was obtained from all the participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. ## References 1. 1. Shickh S, Leventakos K, Lewis MA, Bombard Y, Montori VM. Shared Decision Making in the Care of Patients With Cancer. Am Soc Clin Oncol Educ Book. 2023;43e389516. . 2. 1. Kim K, Heinze K, Xu J, Kurtz M, Park H, Foradori M, et al. Theories of Health Care Decision Making at the End of Life: A Meta-Ethnography. West J Nurs Res. 2018;40(12):1861–84. . - [DOI](https://doi.org/10.1177/0193945917723010) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/28816094/) 3. 1. Reyna VF, Nelson WL, Han PK, Pignone MP. Decision making and cancer. Am Psychol. 2015;70(2):105–18. . - [DOI](https://doi.org/10.1037/a0036834) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/25730718/) - [PMC](https://pmc.ncbi.nlm.nih.gov/articles/4347999/) 4. 1. An A, Hui D. Immunotherapy Versus Hospice: Treatment Decision-Making in the Modern Era of Novel Cancer Therapies. Curr Oncol Rep. 2022;24(3):285–94. . - [DOI](https://doi.org/10.1007/s11912-022-01203-5) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/35113356/) 5. 1. Rostoft S, van den Bos F, Pedersen R, Hamaker ME. Shared decision-making in older patients with cancer - What does the patient want? J Geriatr Oncol. 2021;12(3):339–42. . - [DOI](https://doi.org/10.1016/j.jgo.2020.08.001) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/32839118/) Show all 45 references ## Publication types * Observational Study Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Observational+Study%22%5Bpt%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Observational+Study) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42760521/) ## MeSH terms * Aged Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Aged%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Aged) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42760521/) * Aged, 80 and over Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Aged%2C+80+and+over%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Aged%2C+80+and+over) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42760521/) * Decision Making* Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Decision+Making%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Decision+Making) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42760521/) * Humans Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Humans) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42760521/) * Longitudinal Studies Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Longitudinal+Studies%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Longitudinal+Studies) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42760521/) * Male Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Male%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Male) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42760521/) * Patient Satisfaction* Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Patient+Satisfaction%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Patient+Satisfaction) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42760521/) * Prostatic Neoplasms, Castration-Resistant* / psychology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Prost
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