---
title: "Single-center retrospective study of spatially fractionated radiation therapy for advanced/recurre"
id: "pubmed-42764222"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42764222"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42764222/"
doi: "10.3760/cma.j.cn112152-20250717-00344"
published_at: "2026-09-23T00:00:00.000Z"
evidence_level: "English Abstract"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Single-center retrospective study of spatially fractionated radiation therapy for advanced/recurre
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42764222
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42764222/)
- **DOI:** [10.3760/cma.j.cn112152-20250717-00344](https://doi.org/10.3760%2Fcma.j.cn112152-20250717-00344)
- **Published At:** 2026-09-23T00:00:00.000Z
- **Evidence Rating:** English Abstract
## Executive GIST (TL;DR)
- This is a single-center, retrospective clinical study examining the efficacy and safety of **spatially fractionated radiation therapy** in patients with **advanced/recurrent metastatic malignant tumors**. - The article is published in Zhonghua Zhong Liu Za Zhi (2026 Sep 23;48(9):1166-1174) with PMID 42764222 and DOI 10.3760/cma.j.cn112152-20250717-00344. - The article is reported as being written in Chinese; a full-text link is provided through the Chinese Medical Association Publishing House. - The study was authored by L N Chen and colleagues from the Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (Shenzhen), with one author affiliated also with the Beijing campus. - The PubMed entry lists the article type as clinical research but the abstract content and study-specific details (patient numbers, inclusion/exclusion criteria, radiation dose and fractionation, device/technique specifics, efficacy endpoints, safety/adverse event data, statistical methods, follow-up duration, and numerical outcomes) are not reported in the PubMed summary provided. - Because the PubMed page shown contains metadata only, outcome data and recommendations from the study are not available from this source; readers must consult the full text for methods, results, and conclusions. - The metadata confirms the study focus and design (single-center retrospective) but does not provide results, preventing evidence synthesis or clinical interpretation based on this PubMed record alone. - The DOI and PMID enable retrieval of the full-text article; clinicians and researchers interested in the study should access the original Chinese-language full text for complete methodology, numeric results, and safety findings before applying findings to practice.
## Clinical Analysis & Structured Key Points
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information](https://pubmed.ncbi.nlm.nih.gov/42764222/#related-links) * [ Grants and funding ](https://pubmed.ncbi.nlm.nih.gov/42764222/#grants) * [ LinkOut - more resources ](https://pubmed.ncbi.nlm.nih.gov/42764222/#linkout) Title & authors Abstract Conflict of interest statement Similar articles Publication types MeSH terms Related information Grants and funding LinkOut - more resources Zhonghua Zhong Liu Za Zhi Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Zhonghua+Zhong+Liu+Za+Zhi%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Zhonghua+Zhong+Liu+Za+Zhi%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42764222/) . 2026 Sep 23;48(9):1166-1174. doi: 10.3760/cma.j.cn112152-20250717-00344. # [A single-center retrospective study on the efficacy and safety of spatially fractionated radiation therapy in patients with advanced/recurrent metastatic malignant tumors] [Article in Chinese] [L N Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+LN&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#full-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [Z T Dai](https://pubmed.ncbi.nlm.nih.gov/?term=Dai+ZT&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#full-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [W J Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+WJ&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#full-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [L L Feng](https://pubmed.ncbi.nlm.nih.gov/?term=Feng+LL&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#full-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [J Q Lei](https://pubmed.ncbi.nlm.nih.gov/?term=Lei+JQ&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#full-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [X Y Xiang](https://pubmed.ncbi.nlm.nih.gov/?term=Xiang+XY&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#full-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [S M Jia](https://pubmed.ncbi.nlm.nih.gov/?term=Jia+SM&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#full-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [Y J Jia](https://pubmed.ncbi.nlm.nih.gov/?term=Jia+YJ&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#full-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [X Y Su](https://pubmed.ncbi.nlm.nih.gov/?term=Su+XY&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#full-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [Y T Tan](https://pubmed.ncbi.nlm.nih.gov/?term=Tan+YT&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#full-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [T D Lei](https://pubmed.ncbi.nlm.nih.gov/?term=Lei+TD&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#full-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [N Hu](https://pubmed.ncbi.nlm.nih.gov/?term=Hu+N&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#full-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [E Z Quan](https://pubmed.ncbi.nlm.nih.gov/?term=Quan+EZ&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#full-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [Q Xiao](https://pubmed.ncbi.nlm.nih.gov/?term=Xiao+Q&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#full-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [J Jin](https://pubmed.ncbi.nlm.nih.gov/?term=Jin+J&cauthor_id=42764222)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#full-view-affiliation-2 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.") Affiliations Expand ### Affiliations * 1 Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China. * 2 Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. * PMID: **42764222** * DOI: [ 10.3760/cma.j.cn112152-20250717-00344 ](https://doi.org/10.3760/cma.j.cn112152-20250717-00344) Item in Clipboard # [A single-center retrospective study on the efficacy and safety of spatially fractionated radiation therapy in patients with advanced/recurrent metastatic malignant tumors] [Article in Chinese] L N Chen et al. Zhonghua Zhong Liu Za Zhi. 2026. Show details Display options Display options Format Abstract PubMed PMID Zhonghua Zhong Liu Za Zhi Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Zhonghua+Zhong+Liu+Za+Zhi%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Zhonghua+Zhong+Liu+Za+Zhi%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42764222/) . 2026 Sep 23;48(9):1166-1174. doi: 10.3760/cma.j.cn112152-20250717-00344. ### Authors [L N Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+LN&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#short-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [Z T Dai](https://pubmed.ncbi.nlm.nih.gov/?term=Dai+ZT&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#short-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [W J Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+WJ&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#short-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [L L Feng](https://pubmed.ncbi.nlm.nih.gov/?term=Feng+LL&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#short-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [J Q Lei](https://pubmed.ncbi.nlm.nih.gov/?term=Lei+JQ&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#short-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [X Y Xiang](https://pubmed.ncbi.nlm.nih.gov/?term=Xiang+XY&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#short-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [S M Jia](https://pubmed.ncbi.nlm.nih.gov/?term=Jia+SM&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#short-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [Y J Jia](https://pubmed.ncbi.nlm.nih.gov/?term=Jia+YJ&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#short-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [X Y Su](https://pubmed.ncbi.nlm.nih.gov/?term=Su+XY&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#short-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [Y T Tan](https://pubmed.ncbi.nlm.nih.gov/?term=Tan+YT&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#short-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [T D Lei](https://pubmed.ncbi.nlm.nih.gov/?term=Lei+TD&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#short-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [N Hu](https://pubmed.ncbi.nlm.nih.gov/?term=Hu+N&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#short-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [E Z Quan](https://pubmed.ncbi.nlm.nih.gov/?term=Quan+EZ&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#short-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China."), [Q Xiao](https://pubmed.ncbi.nlm.nih.gov/?term=Xiao+Q&cauthor_id=42764222)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764222/#short-view-affiliation-1 "Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital,
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