---
title: "Smartphone-enabled gold nanoparticle colorimetry for detecting KAT5 activity in circulating tumor"
id: "pubmed-42401467"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42401467"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42401467/"
doi: "10.1016/j.aca.2026.345761"
published_at: "2026-09-22T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Smartphone-enabled gold nanoparticle colorimetry for detecting KAT5 activity in circulating tumor
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42401467
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42401467/)
- **DOI:** [10.1016/j.aca.2026.345761](https://doi.org/10.1016%2Fj.aca.2026.345761)
- **Published At:** 2026-09-22T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The study presents a **colorimetric** sensing platform that converts **KAT5** enzymatic activity into a visible plasmonic signal via coordination-regulated aggregation of gold nanoparticles (AuNPs). - Zn2+ coordinates with ethylenediamine (en) to form **Zn(en)2^2+** complexes that induce AuNP aggregation and a color change; formation of Zn(en)2^2+ is suppressed when Zn2+ binds thiol-containing coenzyme A (CoA). - CoA is generated in the **KAT5-catalyzed acetylation** reaction; its thiol binds Zn2+, preventing Zn(en)2^2+ formation and thereby inhibiting AuNP aggregation—linking KAT5 activity to a colorimetric readout. - The system achieves a reported detection limit of **1.9 pg/mL (3σ/slope)** for KAT5 activity as measured by plasmonic response. - Portable quantification was implemented using smartphone image processing, quantifying the color change by the blue-to-red (B/R) ratio from images. - The platform was applied to measure histone acetylation in cancer cells and in circulating tumor cell (CTC)-like models undergoing epithelial–mesenchymal transition (EMT), showing dynamic KAT5 activity changes. - Authors propose potential uses in **liquid biopsy**, early cancer diagnosis, and precision medicine because the assay is simple, portable, and enzyme-activity based. - The work emphasizes coordination chemistry (Zn2+, en, thiol) and localized surface plasmon resonance of AuNPs as the detection mechanism. - Declaration: authors reported no competing interests. - Details such as complete experimental protocols, sample preparation, or clinical validation metrics beyond those in the abstract were not reported in the PubMed abstract and would require consulting the full text for replication or clinical implementation specifics.
## Clinical Analysis & Structured Key Points
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Epub 2026 May 28. # Coordination-induced gold nanoparticle assembly for smartphone-enabled detection of KAT5 activity in circulating tumor cells [Xingyu Zhao](https://pubmed.ncbi.nlm.nih.gov/?term=Zhao+X&cauthor_id=42401467)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42401467/#full-view-affiliation-1 "School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China; State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, PR China."), [Caizhao Cheng](https://pubmed.ncbi.nlm.nih.gov/?term=Cheng+C&cauthor_id=42401467)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42401467/#full-view-affiliation-2 "School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China; Ningbo Huayi Ningchuang Intelligent Technology Co., Ltd., Ningbo, 315105, PR China."), [Jiayun Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+J&cauthor_id=42401467)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42401467/#full-view-affiliation-3 "School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China; Hunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha, 410114, PR China."), [Jinglu Yao](https://pubmed.ncbi.nlm.nih.gov/?term=Yao+J&cauthor_id=42401467)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42401467/#full-view-affiliation-4 "School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China."), [Qingqing Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+Q&cauthor_id=42401467)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42401467/#full-view-affiliation-4 "School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China."), [Yufang Hu](https://pubmed.ncbi.nlm.nih.gov/?term=Hu+Y&cauthor_id=42401467)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42401467/#full-view-affiliation-5 "School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China; State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, PR China; Ningbo Huayi Ningchuang Intelligent Technology Co., Ltd., Ningbo, 315105, PR China. Electronic address: huyufang@nbu.edu.cn."), [Zhihe Qing](https://pubmed.ncbi.nlm.nih.gov/?term=Qing+Z&cauthor_id=42401467)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42401467/#full-view-affiliation-6 "Hunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha, 410114, PR China.") Affiliations Expand ### Affiliations * 1 School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China; State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, PR China. * 2 School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China; Ningbo Huayi Ningchuang Intelligent Technology Co., Ltd., Ningbo, 315105, PR China. * 3 School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China; Hunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha, 410114, PR China. * 4 School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China. * 5 School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China; State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, PR China; Ningbo Huayi Ningchuang Intelligent Technology Co., Ltd., Ningbo, 315105, PR China. Electronic address: huyufang@nbu.edu.cn. * 6 Hunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha, 410114, PR China. * PMID: **42401467** * DOI: [ 10.1016/j.aca.2026.345761 ](https://doi.org/10.1016/j.aca.2026.345761) Item in Clipboard # Coordination-induced gold nanoparticle assembly for smartphone-enabled detection of KAT5 activity in circulating tumor cells Xingyu Zhao et al. Anal Chim Acta. 2026. Show details Display options Display options Format Abstract PubMed PMID Anal Chim Acta Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Anal+Chim+Acta%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Anal+Chim+Acta%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42401467/) . 2026 Sep 22:1416:345761. doi: 10.1016/j.aca.2026.345761. Epub 2026 May 28. ### Authors [Xingyu Zhao](https://pubmed.ncbi.nlm.nih.gov/?term=Zhao+X&cauthor_id=42401467)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42401467/#short-view-affiliation-1 "School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China; State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, PR China."), [Caizhao Cheng](https://pubmed.ncbi.nlm.nih.gov/?term=Cheng+C&cauthor_id=42401467)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42401467/#short-view-affiliation-2 "School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China; Ningbo Huayi Ningchuang Intelligent Technology Co., Ltd., Ningbo, 315105, PR China."), [Jiayun Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+J&cauthor_id=42401467)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42401467/#short-view-affiliation-3 "School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China; Hunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha, 410114, PR China."), [Jinglu Yao](https://pubmed.ncbi.nlm.nih.gov/?term=Yao+J&cauthor_id=42401467)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42401467/#short-view-affiliation-4 "School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China."), [Qingqing Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+Q&cauthor_id=42401467)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42401467/#short-view-affiliation-4 "School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China."), [Yufang Hu](https://pubmed.ncbi.nlm.nih.gov/?term=Hu+Y&cauthor_id=42401467)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42401467/#short-view-affiliation-5 "School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China; State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, PR China; Ningbo Huayi Ningchuang Intelligent Technology Co., Ltd., Ningbo, 315105, PR China. Electronic address: huyufang@nbu.edu.cn."), [Zhihe Qing](https://pubmed.ncbi.nlm.nih.gov/?term=Qing+Z&cauthor_id=42401467)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42401467/#short-view-affiliation-6 "Hunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha, 410114, PR China.") ### Affiliations * 1 School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China; State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, PR China. * 2 School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China; Ningbo Huayi Ningchuang Intelligent Technology Co., Ltd., Ningbo, 315105, PR China. * 3 School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China; Hunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha, 410114, PR China. * 4 School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China. * 5 School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China; State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, PR China; Ningbo Huayi Ningchuang Intelligent Technology Co., Ltd., Ningbo, 315105, PR China. Electronic address: huyufang@nbu.edu.cn. * 6 Hunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha, 410114, PR China. * PMID: **42401467** * DOI: [ 10.1016/j.aca.2026.345761 ](https://doi.org/10.1016/j.aca.2026.345761) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract Lysine acetyltransferase 5 (KAT5) plays a critical role in epigenetic regulation and is closely associated with the progression of various cancers, particularly hepatocellular carcinoma. However, convenient and portable methods for monitoring KAT5 activity remain limited. Herein, we report a coordination-regulated colorimetric sensing platform based on the localized surface plasmon resonance of gold nanoparticles (AuNPs) for KAT5 activity detection. In this strategy, Zn2+ coordinates with ethylenediamine (en) to form Zn(en)22+ complexes, which induce AuNPs aggregation and a distinct plasmonic color change. In the presence of coenzyme A (CoA), generated during the KAT5-catalyzed acetylation reaction, Zn2+ preferentially binds to thiol-containing CoA, suppressing Zn(en)22+ formation and inhibiting AuNPs aggregation. As a result, KAT5 activity is indirectly converted into a measurable colorimetric signal with a detection limit of 1.9 pg/mL (3σ/slope). To enable portable analysis, smartphone-based image processing was integrated, using the blue-to-red (B/R) ratio for quantification. The platform was further applied to investigate histone acetylation in cancer cells and circulating tumor cell (CTCs)-like models during epithelial-mesenchymal transition, revealing dynamic changes in KAT5 activity. This coordination-mediated AuNPs strategy provides a simple and portable tool for monitoring cancer-related enzymatic activity, with potential applications in liquid biopsy, early cancer diagnosis, and precision medicine. **Keywords:** Biosensing; Cell; Gold nanoparticle; Lysine acetyltransferase 5; Smartphone. Copyright © 2026 Elsevier B.V. All rights reserved. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ## Similar articles * [ A novel colorimetric aptasensor for detection of chloramphenicol based on lanthanum ion-assisted gold nanoparticle aggregation and smartphone imaging. ](https://pubmed.ncbi.nlm.nih.gov/31641824/) Wu YY, Liu BW, Huang P, Wu FY.Wu YY, et al.Anal Bioanal Chem. 2019 Nov;411(28):7511-7518. doi: 10.1007/s00216-019-02149-7. Epub 2019 Oct 22.Anal Bioanal Chem. 2019.PMID: 31641824 * [ Smartphone-assisted colorimetric sensing of enzyme-substrate system using pH-responsive gold nanoparticle assembly. ](https://pubmed.ncbi.nlm.nih.gov/34482869/) Zou L, Mai C, Li M, Lai Y.Zou L, et al.Anal Chim Acta. 2021 Sep 15;1178:338804. doi: 10.1016/j.aca.2021.338804. Epub 2021 Jun 28.Anal Chim Acta. 2021.PMID: 34482869 * [ Nano-gold mediated aptasensor for colorimetric monitoring of acrylamide: Smartphone readout strategy for on-site food control. ](https://pubmed.ncbi.nlm.nih.gov/36030731/) Khoshbin Z, Moeenfard M, Abnous K, Taghdisi SM.Khoshbin Z, et al.Food Chem. 2023 Jan 15;399:133983. doi: 10.1016/j.foodchem.2022.133983. Epub 2022 Aug 20.Food Chem. 2023.PMID: 36030731 * [ A gold nanoparticle-based colorimetric strategy for DNA detection: principles and novel approaches. ](https://pubmed.ncbi.nlm.nih.gov/40405833/) Phuong NTT, Nguyen HA, Trinh TND, Trinh KTL.Phuong NTT, et al.Anal Methods. 2025 Jun 5;17(22):4496-4509. doi: 10.1039/d5ay00148j.Anal Methods. 2025.PMID: 40405833Review. * [ Sensing of circulating cancer biomarkers with metal nanoparticles. ](https://pubmed.ncbi.nlm.nih.gov/31555790/) Pallares RM , Thanh NTK , Su X .Pallares RM , et al.Nanoscale. 2019 Nov 28;11(46):22152-22171. doi: 10.1039/c9nr03040a.Nanoscale. 2019.PMID: 31555790Review. 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