---
title: "Splenic Epstein-Barr Virus–Positive Inflammatory Follicular Dendritic Cell Sarcoma: Case Report an"
id: "pubmed-42660846"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42660846"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42660846/"
doi: "10.3881/j.issn.1000-503X.16881"
published_at: "2026-08-30T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Splenic Epstein-Barr Virus–Positive Inflammatory Follicular Dendritic Cell Sarcoma: Case Report an
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42660846
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42660846/)
- **DOI:** [10.3881/j.issn.1000-503X.16881](https://doi.org/10.3881%2Fj.issn.1000-503X.16881)
- **Published At:** 2026-08-30T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Splenic Epstein-Barr virus–positive inflammatory follicular dendritic cell sarcoma (**EBV+IFDCS**) is a rare, low-grade malignant tumor predominantly associated with **Epstein-Barr virus** infection. - Most patients with splenic EBV+IFDCS are **asymptomatic**; lesions are frequently discovered incidentally during routine physical examinations or imaging. - A minority of patients may present with non-specific abdominal symptoms such as **abdominal distension** or **abdominal pain**, but there are no pathognomonic clinical features. - Early clinical diagnosis is difficult because of the lack of specific signs or symptoms; clinicians should consider EBV+IFDCS in the differential diagnosis of splenic masses. - **Pathological examination** remains the diagnostic gold standard for splenic EBV+IFDCS; histopathology and demonstration of EBV association are central to confirming the diagnosis. - The source article reports a single case of splenic EBV+IFDCS and includes discussion of its clinicopathological characteristics together with a review of related literature. - The published report is a case report and review in Zhongguo Yi Xue Ke Xue Yuan Xue Bao (2026) with PMID 42660846 and DOI 10.3881/j.issn.1000-503X.16881. - Specific patient-level details (age, sex, imaging findings, operative approach, histologic descriptors, immunophenotype, EBV testing method, management, and outcome) were not reported in the accessible abstract and therefore cannot be summarized from the source. - The article is indexed with MeSH terms including Follicular Dendritic Cell Sarcoma, Epstein-Barr Virus Infections, and Splenic Neoplasms, indicating its focus on virology and splenic involvement. - The case report aims to raise awareness of this uncommon splenic neoplasm and to summarize clinicopathological features drawn from the literature to aid recognition and diagnosis.
## Clinical Analysis & Structured Key Points
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Affiliations Expand ### Affiliations * 1 School of Medicine，Northwest Minzu University，Lanzhou 730030，China. * 2 Department of Pathology，The 940th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army，Lanzhou 730050，China. * PMID: **42660846** * DOI: [ 10.3881/j.issn.1000-503X.16881 ](https://doi.org/10.3881/j.issn.1000-503x.16881) Item in Clipboard Review # Splenic Epstein-Barr Virus-Positive Inflammatory Follicular Dendritic Cell Sarcoma：Report of One Case Hai-Ting Zhu et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2026. Show details Display options Display options Format Abstract PubMed PMID Zhongguo Yi Xue Ke Xue Yuan Xue Bao Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Zhongguo+Yi+Xue+Ke+Xue+Yuan+Xue+Bao%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Zhongguo+Yi+Xue+Ke+Xue+Yuan+Xue+Bao%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660846/) . 2026 Aug 30;48(4):760-765. doi: 10.3881/j.issn.1000-503X.16881. ### Authors [Hai-Ting Zhu](https://pubmed.ncbi.nlm.nih.gov/?term=Zhu+HT&cauthor_id=42660846)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42660846/#short-view-affiliation-1 "School of Medicine，Northwest Minzu University，Lanzhou 730030，China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42660846/#short-view-affiliation-2 "Department of Pathology，The 940th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army，Lanzhou 730050，China."), [Xiao-Dong Guo](https://pubmed.ncbi.nlm.nih.gov/?term=Guo+XD&cauthor_id=42660846)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42660846/#short-view-affiliation-2 "Department of Pathology，The 940th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army，Lanzhou 730050，China."), [Guan-Wei Gao](https://pubmed.ncbi.nlm.nih.gov/?term=Gao+GW&cauthor_id=42660846)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42660846/#short-view-affiliation-1 "School of Medicine，Northwest Minzu University，Lanzhou 730030，China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42660846/#short-view-affiliation-2 "Department of Pathology，The 940th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army，Lanzhou 730050，China."), [Cai-Ling Shao](https://pubmed.ncbi.nlm.nih.gov/?term=Shao+CL&cauthor_id=42660846)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42660846/#short-view-affiliation-2 "Department of Pathology，The 940th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army，Lanzhou 730050，China."), [Peng-Fei Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+PF&cauthor_id=42660846)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42660846/#short-view-affiliation-2 "Department of Pathology，The 940th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army，Lanzhou 730050，China."), [Yan-Li Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+YL&cauthor_id=42660846)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42660846/#short-view-affiliation-1 "School of Medicine，Northwest Minzu University，Lanzhou 730030，China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42660846/#short-view-affiliation-2 "Department of Pathology，The 940th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army，Lanzhou 730050，China.") ### Affiliations * 1 School of Medicine，Northwest Minzu University，Lanzhou 730030，China. * 2 Department of Pathology，The 940th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army，Lanzhou 730050，China. * PMID: **42660846** * DOI: [ 10.3881/j.issn.1000-503X.16881 ](https://doi.org/10.3881/j.issn.1000-503x.16881) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract in [ English, ](https://pubmed.ncbi.nlm.nih.gov/42660846/#eng-abstract) [ Chinese ](https://pubmed.ncbi.nlm.nih.gov/42660846/#zho-abstract) Splenic Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma （EBV+IFDCS） is a rare low-grade malignant tumor typically associated with Epstein-Barr virus infection.Most patients are asymptomatic，and the splenic mass is often discovered incidentally during routine physical examinations.A minority of patients may present with symptoms such as abdominal distension or pain.Due to the lack of specific clinical manifestations，early diagnosis of EBV+IFDCS is challenging.Pathological examination is the gold standard for the diagnosis of splenic EBV+IFDCS.This article reports a case of splenic EBV+IFDCS and discusses its clinicopathological features with a review of the related literature. 脾脏EB病毒阳性炎性滤泡树突细胞肉瘤（EBV+IFDCS）是一种罕见的低度恶性肿瘤，通常与EB病毒感染相关。多数患者无明显症状，常通过体检偶然发现脾脏占位，少数患者可能出现腹胀、腹痛等症状。EBV+IFDCS由于缺乏特异性临床表现，早期诊断较为困难。病理检查是诊断脾脏EBV+IFDCS的金标准。本文报告1例脾脏EBV+IFDCS并结合文献对其临床病理特征进行探讨。. **Keywords:** Epstein-Barr virus; inflammatory follicular dendritic cell sarcoma; splenic neoplasm. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma with significant granuloma: case report and literature review. ](https://pubmed.ncbi.nlm.nih.gov/38365739/) Nie C, Xie X, Li H, Li Y, Chen Z, Li Y, Li Z.Nie C, et al.Diagn Pathol. 2024 Feb 16;19(1):34. doi: 10.1186/s13000-024-01457-6.Diagn Pathol. 2024.PMID: 38365739Free PMC article.Review. * [ Clinicopathological Analysis of Epstein-Barr Virus-Positive Inflammatory Follicular Dendritic Cell Sarcoma of the Spleen: A Case Report. ](https://pubmed.ncbi.nlm.nih.gov/38802163/) Yang YH, Shi HQ, Cai JW, Wang SK.Yang YH, et al.Ann Clin Lab Sci. 2024 Mar;54(2):254-257.Ann Clin Lab Sci. 2024.PMID: 38802163 * [ Genomic and Transcriptomic Landscape of Epstein-Barr Virus-Positive Inflammatory Follicular Dendritic Cell Sarcoma: A Multicenter Study. ](https://pubmed.ncbi.nlm.nih.gov/40784486/) Li Y, Weng ZL, Fei HX, Li HF, Liu YN, Zhang LL, Zhang Q, Weng X, Wang YY, Huang WY, Cao ZX, Yang KY, Chen XL, Gao J, Yang WS, Liu F, Yong JJ, Yun JP, Zhang H, Huang YH.Li Y, et al.Mod Pathol. 2025 Oct;38(10):100864. doi: 10.1016/j.modpat.2025.100864. Epub 2025 Aug 8.Mod Pathol. 2025.PMID: 40784486 * [ Targeted genomic DNA sequencing (506-gene panel) and whole-exome sequencing analysis of EBV-positive inflammatory follicular dendritic cell sarcoma. ](https://pubmed.ncbi.nlm.nih.gov/42374265/) You Z, Chen S, Chen X, Chen X, Wang C.You Z, et al.BMC Cancer. 2026 Jun 29;26(1):852. doi: 10.1186/s12885-026-16402-7.BMC Cancer. 2026.PMID: 42374265Free PMC article. * [ Epstein-Barr Virus-Positive Inflammatory Follicular Dendritic Cell Sarcoma Presenting as a Colonic Polyp: Report of a Case with a Literature Review. ](https://pubmed.ncbi.nlm.nih.gov/37512154/) Hu J, Huang D, Xu C, Chen Y, Ma H, Shen Z.Hu J, et al.Medicina (Kaunas). 2023 Jul 21;59(7):1341. doi: 10.3390/medicina59071341.Medicina (Kaunas). 2023.PMID: 37512154Free PMC article.Review. [ See all similar articles ](https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed&from_uid=42660846) ## Publication types * Case Reports Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Case+Reports%22%5Bpt%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Case+Reports) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660846/) * Review Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Review%22%5Bpt%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Review) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660846/) ## MeSH terms * Dendritic Cell Sarcoma, Follicular* / virology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Dendritic+Cell+Sarcoma%2C+Follicular%2Fvirology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Dendritic+Cell+Sarcoma%2C+Follicular) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660846/) * Epstein-Barr Virus Infections* Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Epstein-Barr+Virus+Infections%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Epstein-Barr+Virus+Infections) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660846/) * Herpesvirus 4, Human Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Herpesvirus+4%2C+Human%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Herpesvirus+4%2C+Human) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660846/) * Humans Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Humans) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660846/) * Splenic Neoplasms* / virology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Splenic+Neoplasms%2Fvirology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Splenic+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660846/) [x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM **Send To** * [Clipboard](https://pubmed.ncbi.nlm.nih.gov/42660846/) * [Email](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42660846%2F%23open-email-panel) * [Save](https://pubmed.ncbi.nlm.nih.gov/42660846/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42660846%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42660846%2F%23open-collections-panel) * [Citation Manager](https://pubmed.ncbi.nlm.nih.gov/42660846/) [x] NCBI Literature Resources [MeSH](https://www.ncbi.nlm.nih.gov/mesh/) [PMC](https://www.ncbi.nlm.nih.gov/pmc/) [Bookshelf](https://www.ncbi.nlm.nih.gov/books) [Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 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