---
title: "Splicing and Prognosis in Advanced Small Intestine Neuroendocrine Tumors"
id: "biorxiv-3-from-splicing-to-survival-understanding-the-molecular-basis-of-prognostic"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-3-from-splicing-to-survival-understanding-the-molecular-basis-of-prognostic"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.10.22.760955v1?rss=1"
published_at: "2026-10-25T12:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Splicing and Prognosis in Advanced Small Intestine Neuroendocrine Tumors
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-3-from-splicing-to-survival-understanding-the-molecular-basis-of-prognostic
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.10.22.760955v1?rss=1)
- **Published At:** 2026-10-25T12:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- The preprint examines molecular determinants of prognosis in advanced **Small intestine neuroendocrine tumors** (SI-NETs), with an emphasis on RNA splicing as a mechanistic axis driving survival differences. - Authors are based primarily in Spain and include oncologists, pathologists, surgeons and cell biology researchers; corresponding author contact is justo@uco.es. - The manuscript is posted on bioRxiv as an unrefereed preprint under DOI https://doi.org/10.64898/2026.10.22.760955; supplementary material and a preview PDF are available on the article page. - The article text available in the provided source begins with a statement that SI-NETs have a high metastatic rate and few effective therapies; this framing sets the clinical need but does not include reported experimental data in the supplied excerpt. - The source excerpt does not contain detailed methods, cohort characteristics, sequencing platforms, statistical endpoints, or specific molecular results; those elements were not reported in the supplied content. - Because the supplied content is incomplete, there are multiple unresolved items that readers and clinicians will need clarified in the full preprint or subsequent peer-reviewed publication: sample sizes, criteria for advanced disease, splicing analysis pipelines, survival endpoints, and any proposed biomarkers for clinical use. - The investigators listed multiple institutional affiliations (including University of Córdoba, Vall d'Hebron University Hospital/VHIO, Hospital Universitario 12 de Octubre and others), indicating a multidisciplinary team combining cell biology and clinical oncology expertise. - The preprint status means the findings have not undergone peer review; clinicians should treat mechanistic claims and potential clinical implications as preliminary until validated and published.
## Clinical Analysis & Structured Key Points
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Victor Garcia-Vioque 1 Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Victor%2BGarcia-Vioque%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Garcia-Vioque%20V&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AVictor%2BGarcia-Vioque%2B) Alejandro Garcia-Alvarez 2 Medical Oncology Department, Vall dHebron University Hospital. Vall dHebron Institute of Oncology (VHIO), Barcelona, Spain; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Alejandro%2BGarcia-Alvarez%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Garcia-Alvarez%20A&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AAlejandro%2BGarcia-Alvarez%2B) Maria Trinidad Moreno-Montilla 1 Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Maria%2BTrinidad%2BMoreno-Montilla%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Moreno-Montilla%20MT&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AMaria%2BTrinidad%2BMoreno-Montilla%2B) Jorge Hernando 2 Medical Oncology Department, Vall dHebron University Hospital. Vall dHebron Institute of Oncology (VHIO), Barcelona, Spain; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Jorge%2BHernando%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Hernando%20J&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AJorge%2BHernando%2B) Ricardo Blazquez-Encinas 1 Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Ricardo%2BBlazquez-Encinas%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Blazquez-Encinas%20R&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ARicardo%2BBlazquez-Encinas%2B) Amparo Garcia 3 Nuclear Medicine Department, Vall dHebron University Hospital, Barcelona, Spain; 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Vall dHebron Institute of Oncology (VHIO), Barcelona, Spain; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Jaume%2BCapdevila%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Capdevila%20J&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AJaume%2BCapdevila%2B) Justo P Castano 1 Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Justo%2BP%2BCastano%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Castano%20JP&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AJusto%2BP%2BCastano%2B) * [ORCID record for Justo P Castano](http://orcid.org/0000-0002-3145-7287 "Open in new tab") * For correspondence: justo@uco.es * [Abstract](https://www.biorxiv.org/content/10.64898/2026.10.22.760955v1)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_art/node:5901323/1) * [Info/History](https://www.biorxiv.org/content/10.64898/2026.10.22.760955v1.article-info)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_info/node:5901323/1) * [Metrics](https://www.biorxiv.org/content/10.64898/2026.10.22.760955v1.article-metrics)[](https://www.biorxiv.org/panels_ajax_tab/article_tab_metrics/node:5901323/1) * [Supplementary material](https://www.biorxiv.org/content/10.64898/2026.10.22.760955v1.supplementary-material)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_data/node:5901323/1) * [ Preview PDF](https://www.biorxiv.org/content/10.64898/2026.10.22.760955v1.full.pdf+html)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_pdf/node:5901323/1) ![Loading](https://www.biorxiv.org/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif) ## Abstract Small intestine neuroendocrine tumors (SI-NETs) represent a challenging neoplasm due to their high rate of metastasis and the limited availability of effective therapies. Recent e
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