---
title: "Talquetamab (GPRC5D×CD3) adverse events and management in relapsed/refractory multiple myeloma — M"
id: "pubmed-42679119"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42679119"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42679119/"
doi: "10.1080/16078454.2026.2702681"
published_at: "2026-09-01T22:13:32.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Talquetamab (GPRC5D×CD3) adverse events and management in relapsed/refractory multiple myeloma — M
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42679119
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42679119/)
- **DOI:** [10.1080/16078454.2026.2702681](https://doi.org/10.1080%2F16078454.2026.2702681)
- **Published At:** 2026-09-01T22:13:32.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The article reports on clinical features and management of **GPRC5D-associated adverse events** in patients with **relapsed/refractory multiple myeloma** treated with the novel **GPRC5D × CD3 bispecific** antibody **talquetamab** in the MonumenTAL-1 China cohort. - The publication is a clinical trial report appearing in Hematology (2026) with PubMed ID **42679119** and DOI **10.1080/16078454.2026.2702681**. - First and senior author affiliations include the State Key Laboratory of Experimental Hematology and multiple Chinese academic hematology departments; industry coauthors are affiliated with Johnson & Johnson research and medical affairs teams in China, Spain, and the USA. - The article title and metadata indicate the focus is on describing clinical presentation and management of adverse events specifically linked to **GPRC5D** targeting by talquetamab in this cohort. - The source record on PubMed provides bibliographic details, authorship, affiliations, and identifiers but does not include the abstract text or trial results in the captured content. - Key trial-specific data (patient numbers, baseline characteristics, adverse event incidence and grading, timelines, management algorithms, response rates, safety outcomes, and follow-up) were not reported in the source content provided. - Because the PubMed page content provided is limited to metadata and header information, specific clinical recommendations, management protocols, and outcome data cannot be summarized from this source.
## Clinical Analysis & Structured Key Points
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Epub 2026 Sep 1. # Clinical features and management of GPRC5D-associated adverse events in novel GPRC5D × CD3 bispecific talquetamab-treated relapsed/refractory multiple myeloma patients: the MonumenTAL-1 China cohort experience [Gang An](https://pubmed.ncbi.nlm.nih.gov/?term=An+G&cauthor_id=42679119)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-1 "State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-2 "Tianjin Institutes of Health Science, Tianjin, China."), [Jie Jin](https://pubmed.ncbi.nlm.nih.gov/?term=Jin+J&cauthor_id=42679119)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-3 "Hematology Department, First Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, China."), [Zhen Cai](https://pubmed.ncbi.nlm.nih.gov/?term=Cai+Z&cauthor_id=42679119)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-3 "Hematology Department, First Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, China."), [Hongmei Jing](https://pubmed.ncbi.nlm.nih.gov/?term=Jing+H&cauthor_id=42679119)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-4 "Hematology Department, Peking University Third Hospital, Beijing, China."), [Chengcheng Fu](https://pubmed.ncbi.nlm.nih.gov/?term=Fu+C&cauthor_id=42679119)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-5 "Hematology Department, First Affiliated Hospital, Soochow University, Suzhou, China."), [Pengcheng He](https://pubmed.ncbi.nlm.nih.gov/?term=He+P&cauthor_id=42679119)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-6 "Hematology Department, First Affiliated Hospital, Xi'an Jiaotong University, Shaanxi, China."), [Zhongjun Xia](https://pubmed.ncbi.nlm.nih.gov/?term=Xia+Z&cauthor_id=42679119)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-7 "Hematology Department, Sun Yat-sen University Cancer Center, Guangzhou, China."), [Qianqian Xu](https://pubmed.ncbi.nlm.nih.gov/?term=Xu+Q&cauthor_id=42679119)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-8 "Medical Affairs Department, Johnson & Johnson, Beijing, China."), [Rui Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+R&cauthor_id=42679119)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-9 "Research and Development Department, Johnson & Johnson, Beijing, China."), [Liang Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+L&cauthor_id=42679119)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-10 "Research and Development Department, Johnson & Johnson, Shanghai, China."), [Xue Gai](https://pubmed.ncbi.nlm.nih.gov/?term=Gai+X&cauthor_id=42679119)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-9 "Research and Development Department, Johnson & Johnson, Beijing, China."), [Hong Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+H&cauthor_id=42679119)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-9 "Research and Development Department, Johnson & Johnson, Beijing, China."), [Dian Zhu](https://pubmed.ncbi.nlm.nih.gov/?term=Zhu+D&cauthor_id=42679119)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-10 "Research and Development Department, Johnson & Johnson, Shanghai, China."), [Xinchao Luo](https://pubmed.ncbi.nlm.nih.gov/?term=Luo+X&cauthor_id=42679119)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-10 "Research and Development Department, Johnson & Johnson, Shanghai, China."), [Michela Campagna](https://pubmed.ncbi.nlm.nih.gov/?term=Campagna+M&cauthor_id=42679119)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-11 "Research and Development Department, Johnson & Johnson, Madrid, Spain."), [Tara J Masterson](https://pubmed.ncbi.nlm.nih.gov/?term=Masterson+TJ&cauthor_id=42679119)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-12 "Research and Development Department, Johnson & Johnson, Raritan, NJ, USA."), [Bonnie W Lau](https://pubmed.ncbi.nlm.nih.gov/?term=Lau+BW&cauthor_id=42679119)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-12 "Research and Development Department, Johnson & Johnson, Raritan, NJ, USA."), [Thomas Renaud](https://pubmed.ncbi.nlm.nih.gov/?term=Renaud+T&cauthor_id=42679119)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-12 "Research and Development Department, Johnson & Johnson, Raritan, NJ, USA."), [Christoph Heuck](https://pubmed.ncbi.nlm.nih.gov/?term=Heuck+C&cauthor_id=42679119)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-13 "Research and Development Department, Johnson & Johnson, Spring House, PA, USA."), [Lugui Qiu](https://pubmed.ncbi.nlm.nih.gov/?term=Qiu+L&cauthor_id=42679119)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-1 "State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#full-view-affiliation-2 "Tianjin Institutes of Health Science, Tianjin, China.") Affiliations Expand ### Affiliations * 1 State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China. * 2 Tianjin Institutes of Health Science, Tianjin, China. * 3 Hematology Department, First Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, China. * 4 Hematology Department, Peking University Third Hospital, Beijing, China. * 5 Hematology Department, First Affiliated Hospital, Soochow University, Suzhou, China. * 6 Hematology Department, First Affiliated Hospital, Xi'an Jiaotong University, Shaanxi, China. * 7 Hematology Department, Sun Yat-sen University Cancer Center, Guangzhou, China. * 8 Medical Affairs Department, Johnson & Johnson, Beijing, China. * 9 Research and Development Department, Johnson & Johnson, Beijing, China. * 10 Research and Development Department, Johnson & Johnson, Shanghai, China. * 11 Research and Development Department, Johnson & Johnson, Madrid, Spain. * 12 Research and Development Department, Johnson & Johnson, Raritan, NJ, USA. * 13 Research and Development Department, Johnson & Johnson, Spring House, PA, USA. * PMID: **42679119** * DOI: [ 10.1080/16078454.2026.2702681 ](https://doi.org/10.1080/16078454.2026.2702681) Item in Clipboard Clinical Trial # Clinical features and management of GPRC5D-associated adverse events in novel GPRC5D × CD3 bispecific talquetamab-treated relapsed/refractory multiple myeloma patients: the MonumenTAL-1 China cohort experience Gang An et al. Hematology. 2026. Show details Display options Display options Format Abstract PubMed PMID Hematology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Hematology%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Hematology%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42679119/) . 2026 Dec 31;31(1):2702681. doi: 10.1080/16078454.2026.2702681. Epub 2026 Sep 1. ### Authors [Gang An](https://pubmed.ncbi.nlm.nih.gov/?term=An+G&cauthor_id=42679119)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-1 "State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-2 "Tianjin Institutes of Health Science, Tianjin, China."), [Jie Jin](https://pubmed.ncbi.nlm.nih.gov/?term=Jin+J&cauthor_id=42679119)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-3 "Hematology Department, First Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, China."), [Zhen Cai](https://pubmed.ncbi.nlm.nih.gov/?term=Cai+Z&cauthor_id=42679119)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-3 "Hematology Department, First Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, China."), [Hongmei Jing](https://pubmed.ncbi.nlm.nih.gov/?term=Jing+H&cauthor_id=42679119)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-4 "Hematology Department, Peking University Third Hospital, Beijing, China."), [Chengcheng Fu](https://pubmed.ncbi.nlm.nih.gov/?term=Fu+C&cauthor_id=42679119)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-5 "Hematology Department, First Affiliated Hospital, Soochow University, Suzhou, China."), [Pengcheng He](https://pubmed.ncbi.nlm.nih.gov/?term=He+P&cauthor_id=42679119)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-6 "Hematology Department, First Affiliated Hospital, Xi'an Jiaotong University, Shaanxi, China."), [Zhongjun Xia](https://pubmed.ncbi.nlm.nih.gov/?term=Xia+Z&cauthor_id=42679119)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-7 "Hematology Department, Sun Yat-sen University Cancer Center, Guangzhou, China."), [Qianqian Xu](https://pubmed.ncbi.nlm.nih.gov/?term=Xu+Q&cauthor_id=42679119)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-8 "Medical Affairs Department, Johnson & Johnson, Beijing, China."), [Rui Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+R&cauthor_id=42679119)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-9 "Research and Development Department, Johnson & Johnson, Beijing, China."), [Liang Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+L&cauthor_id=42679119)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-10 "Research and Development Department, Johnson & Johnson, Shanghai, China."), [Xue Gai](https://pubmed.ncbi.nlm.nih.gov/?term=Gai+X&cauthor_id=42679119)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-9 "Research and Development Department, Johnson & Johnson, Beijing, China."), [Hong Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+H&cauthor_id=42679119)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-9 "Research and Development Department, Johnson & Johnson, Beijing, China."), [Dian Zhu](https://pubmed.ncbi.nlm.nih.gov/?term=Zhu+D&cauthor_id=42679119)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-10 "Research and Development Department, Johnson & Johnson, Shanghai, China."), [Xinchao Luo](https://pubmed.ncbi.nlm.nih.gov/?term=Luo+X&cauthor_id=42679119)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-10 "Research and Development Department, Johnson & Johnson, Shanghai, China."), [Michela Campagna](https://pubmed.ncbi.nlm.nih.gov/?term=Campagna+M&cauthor_id=42679119)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-11 "Research and Development Department, Johnson & Johnson, Madrid, Spain."), [Tara J Masterson](https://pubmed.ncbi.nlm.nih.gov/?term=Masterson+TJ&cauthor_id=42679119)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-12 "Research and Development Department, Johnson & Johnson, Raritan, NJ, USA."), [Bonnie W Lau](https://pubmed.ncbi.nlm.nih.gov/?term=Lau+BW&cauthor_id=42679119)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-12 "Research and Development Department, Johnson & Johnson, Raritan, NJ, USA."), [Thomas Renaud](https://pubmed.ncbi.nlm.nih.gov/?term=Renaud+T&cauthor_id=42679119)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-12 "Research and Development Department, Johnson & Johnson, Raritan, NJ, USA."), [Christoph Heuck](https://pubmed.ncbi.nlm.nih.gov/?term=Heuck+C&cauthor_id=42679119)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-13 "Research and Development Department, Johnson & Johnson, Spring House, PA, USA."), [Lugui Qiu](https://pubmed.ncbi.nlm.nih.gov/?term=Qiu+L&cauthor_id=42679119)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-1 "State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679119/#short-view-affiliation-2 "Tianjin Institutes of Health Science, Tianjin, China.") ### Affiliations * 1 State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China. * 2 Tianjin Institutes of Health Science, Tianjin, China. * 3 Hematology Department, First Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, China. * 4 Hematology Department, Peking University Third Hospital, Beijing, China. * 5 Hematology Department, First Affiliated Hospital, Soochow University, Suzhou, China. * 6 Hematology Department, First Affiliated Hospital, Xi'an Jiaotong University, Shaanxi, China. * 7 Hematology Department, Sun Yat-sen University Cancer Center, Guangzhou, China. * 8 Medical Affairs Department, Johnson & Johnson, Beijing, China. * 9 Research and Development Department, Johnson & Johnson, Beijing, Chi
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