---
title: "Temporal Atlas of the Nuclear Androgen Receptor Proximal Interactome in Prostate Cancer Cells"
id: "biorxiv-8-a-temporal-atlas-of-the-nuclear-androgen-receptor-proximal-interactome"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-8-a-temporal-atlas-of-the-nuclear-androgen-receptor-proximal-interactome"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.08.03.742470v1?rss=1"
published_at: "2026-08-06T12:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Temporal Atlas of the Nuclear Androgen Receptor Proximal Interactome in Prostate Cancer Cells
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-8-a-temporal-atlas-of-the-nuclear-androgen-receptor-proximal-interactome
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.08.03.742470v1?rss=1)
- **Published At:** 2026-08-06T12:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- The study builds a minute-scale temporal atlas of the **androgen receptor** (AR) proximal interactome inside the nucleus using proximity-labeling quantitative mass spectrometry (PL-qMS). - Experiments were performed in androgen-treated **LNCaP** prostate cancer cells and sampled across six time points to resolve temporal dynamics. - The dataset captures 84.2% of the previously cataloged AR-interactome and identifies 3,378 nuclear AR-proximal interacting proteins (**AR-PIPs**). - The temporal atlas reproduces the established cyclic sequential recruitment model at AR-regulated chromatin loci as described by classical ChIP methods. - The approach recovered 100% of previously known AR interactors reported in the Launonen 2021 ChIP-SICAP chromatome, demonstrating concordance with prior chromatin-focused datasets. - Within the canonical chromatin recruitment signature, the authors report a time-resolved **translation-to-transcription handoff**, with cap-binding proteins **eIF4G** and **4E-BP1** transiently proximal to AR at the earliest time points. - The transient proximity of eIF4G and 4E-BP1 to nuclear AR was verified by proximity ligation assay (PLA). - The atlas converts the static AR coregulator catalog into a temporally resolved, quantitative framework for AR-dependent transcriptional regulation. - The work is presented as a preprint and has not been peer-reviewed; copyright and licensing details are reported by the authors.
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Ptak, [ View ORCID Profile](http://orcid.org/0000-0001-6352-6737)Jimmy Eng, Lilliana Radoshevich, [ View ORCID Profile](http://orcid.org/0000-0002-4243-2931)Michael E. Wright doi: https://doi.org/10.64898/2026.08.03.742470 This article is a preprint and has not been certified by peer review [[what does this mean?](https://www.biorxiv.org/about/FAQ#unrefereed)]. Celeste C. Ptak 1 University of Iowa, Carver College of Medicine; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Celeste%2BC.%2BPtak%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Ptak%20CC&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ACeleste%2BC.%2BPtak%2B) Jimmy Eng 2 University of Washington; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Jimmy%2BEng%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Eng%20J&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AJimmy%2BEng%2B) * [ORCID record for Jimmy Eng](http://orcid.org/0000-0001-6352-6737 "Open in new tab") Lilliana Radoshevich 3 National Jewish Health; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Lilliana%2BRadoshevich%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Radoshevich%20L&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ALilliana%2BRadoshevich%2B) Michael E. Wright 4 University of Iowa * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Michael%2BE.%2BWright%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Wright%20ME&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AMichael%2BE.%2BWright%2B) * [ORCID record for Michael E. Wright](http://orcid.org/0000-0002-4243-2931 "Open in new tab") * For correspondence: michael-e-wright@uiowa.edu * [Abstract](https://www.biorxiv.org/content/10.64898/2026.08.03.742470v1)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_art/node:5684250/1) * [Info/History](https://www.biorxiv.org/content/10.64898/2026.08.03.742470v1.article-info)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_info/node:5684250/1) * [Metrics](https://www.biorxiv.org/content/10.64898/2026.08.03.742470v1.article-metrics)[](https://www.biorxiv.org/panels_ajax_tab/article_tab_metrics/node:5684250/1) * [ Preview PDF](https://www.biorxiv.org/content/10.64898/2026.08.03.742470v1.full.pdf+html)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_pdf/node:5684250/1) ![Loading](https://www.biorxiv.org/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif) ## Abstract Androgen receptor-interacting proteins (AR-IPs) comprise nearly 1,000 cataloged partners, yet how AR engages this interactome inside the nucleus, in what temporal order, and through what molecular handoffs, remains uncharted. Here, we construct a minute-scale temporal atlas of the nuclear AR proximal interactome by proximity-labeling quantitative mass spectrometry (PL-qMS) in androgen-treated LNCaP prostate cancer cells, capturing 84.2% of the known AR-interactome and resolving 3,378 nuclear AR-proximal interacting proteins (AR-PIPs) across six time points. The atlas recapitulates the cyclic sequential recruitment model established at AR-regulated loci by classical ChIP and recovers 100% of previously known AR interactors from the Launonen 2021 ChIP-SICAP chromatome. Embedded within this canonical chromatin signature, we uncover a time-resolved translation-to-transcription handoff in which cap-binding eIF4G and 4E-BP1 are transiently AR-proximal at the earliest time points, verified by PLA. The atlas converts the AR coregulator catalog into a temporally resolved quantitative framework for AR-dependent transcription. Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a [CC-BY-NC-ND 4.0 International license](http://creativecommons.org/licenses/by-nc-nd/4.0/). bioRxiv and medRxiv thank the following for their generous financial support: > The Chan Zuckerberg Initiative, Cold Spring Harbor Laboratory, the Sergey Brin Family Foundation, California Institute of Technology, Centre National de la Recherche Scientifique, Fred Hutchinson Cancer Center, Imperial College London, Massachusetts Institute of Technology, Stanford University, The University of Edinburgh, University of Washington, and Vrije Universiteit Amsterdam. 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