---
title: "Tetrastigma hemsleyanum ELN miR-396b Inhibits Pancreatic Cancer Cell Growth via IL33 Repression"
id: "pubmed-42335656"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42335656"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42335656/"
doi: "10.1016/j.bbrc.2026.154163"
published_at: "2026-09-03T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Tetrastigma hemsleyanum ELN miR-396b Inhibits Pancreatic Cancer Cell Growth via IL33 Repression
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42335656
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42335656/)
- **DOI:** [10.1016/j.bbrc.2026.154163](https://doi.org/10.1016%2Fj.bbrc.2026.154163)
- **Published At:** 2026-09-03T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Plant-derived exosome-like nanovesicles (ELNs) were isolated from Tetrastigma hemsleyanum and characterized by nanoparticle tracking analysis and zeta potential measurement. The ELNs were shown to be taken up by pancreatic cancer cells using PKH67 fluorescence labeling. - ELN treatment inhibited pancreatic cancer cell proliferation in a dose-dependent manner as measured by CCK-8 and colony formation assays. - Small RNA sequencing and RT-qPCR identified **miR-396b** as a highly enriched cargo within T. hemsleyanum ELNs. - Overexpression of **miR-396b**, like ELN treatment, reduced pancreatic cancer cell proliferation and decreased expression of **IL33** at the mRNA and protein levels. - Bioinformatic prediction and dual-luciferase reporter assays demonstrated that **miR-396b** directly binds the 3' untranslated region of **IL33**, and mutation of the predicted binding site abolished miR-396b-mediated suppression of reporter activity. - Rescue experiments showed that inhibition of miR-396b attenuated ELN-mediated growth suppression, whereas re-expression of IL33 partially reversed the anti-proliferative effect of miR-396b overexpression, supporting a functional **miR-396b/IL33** axis. - Authors conclude that ELN-delivered **miR-396b** is a major functional cargo mediating anti-proliferative effects in pancreatic ductal adenocarcinoma (PDAC) cells through direct repression of **IL33**. - The study notes that additional ELN cargos and in vivo validation were not addressed and warrant further investigation.
## Clinical Analysis & Structured Key Points
Clipboard, Search History, and several other advanced features are temporarily unavailable. [ Skip to main page content ](https://pubmed.ncbi.nlm.nih.gov/42335656/#article-details) ![U.S. flag](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png) An official website of the United States government Here's how you know ![Dot gov](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg) **The .gov means it’s official.** Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. ![Https](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg) **The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [ ![NIH NLM Logo](https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg) ](https://www.ncbi.nlm.nih.gov/) [Log in](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42335656%2F) Show account info Close #### Account Logged in as: **username** * [Dashboard](https://www.ncbi.nlm.nih.gov/myncbi/) * [Publications](https://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/) * [Account settings](https://www.ncbi.nlm.nih.gov/account/settings/) * [Log out](https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/42335656/) [Access keys](https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys) [NCBI Homepage](https://www.ncbi.nlm.nih.gov) [MyNCBI Homepage](https://pubmed.ncbi.nlm.nih.gov/myncbi/) [Main Content](https://pubmed.ncbi.nlm.nih.gov/42335656/#maincontent) [Main Navigation](https://pubmed.ncbi.nlm.nih.gov/42335656/) [ ![pubmed logo](https://cdn.ncbi.nlm.nih.gov/pubmed/af7de7da-df5d-41c6-8de4-8c266af8ccfb/core/images/pubmed-logo-blue.svg) ](https://pubmed.ncbi.nlm.nih.gov/) [ ](https://pubmed.ncbi.nlm.nih.gov/42335656/ "Show search bar") Search: [](https://pubmed.ncbi.nlm.nih.gov/42335656/ "Clear search input")Search [Advanced](https://pubmed.ncbi.nlm.nih.gov/advanced/) [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/clipboard/) [ User Guide ](https://pubmed.ncbi.nlm.nih.gov/help/) Save Email Send to * [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/42335656/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42335656%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42335656%2F%23open-collections-panel) * [Citation manager](https://pubmed.ncbi.nlm.nih.gov/42335656/) Display options Display options Format Abstract PubMed PMID ## Save citation to file Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel ## Email citation Email address has not been verified. Go to [ My NCBI account settings ](https://account.ncbi.nlm.nih.gov/settings/) to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel ### Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42335656/) Add Cancel ### Add to My Bibliography * My Bibliography Unable to load your delegates due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42335656/) Add Cancel ## Your saved search Name of saved search: Search terms: [Test search terms](https://pubmed.ncbi.nlm.nih.gov/42335656/) Would you like email updates of new search results? Saved Search Alert Radio Buttons * Yes * No Email: ([change](https://www.ncbi.nlm.nih.gov/account/settings/)) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel ## Create a file for external citation management software Create file Cancel ## Your RSS Feed Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy ### Full text links [![Elsevier Science full text link](https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif) Elsevier Science ](https://linkinghub.elsevier.com/retrieve/pii/S0006-291X\(26\)00927-7 "See full text options at Elsevier Science") [ Full text links ](https://pubmed.ncbi.nlm.nih.gov/42335656/) ### Actions Cite Collections Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42335656/) Add Cancel Permalink Permalink Copy Display options Display options Format Abstract PubMed PMID ### Page navigation * [ Title & authors ](https://pubmed.ncbi.nlm.nih.gov/42335656/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42335656/#abstract) * [ Conflict of interest statement ](https://pubmed.ncbi.nlm.nih.gov/42335656/#conflict-of-interest) * [Similar articles](https://pubmed.ncbi.nlm.nih.gov/42335656/#similar) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42335656/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42335656/#substances) * [Related information](https://pubmed.ncbi.nlm.nih.gov/42335656/#related-links) * [ LinkOut - more resources ](https://pubmed.ncbi.nlm.nih.gov/42335656/#linkout) Title & authors Abstract Conflict of interest statement Similar articles MeSH terms Substances Related information LinkOut - more resources Biochem Biophys Res Commun Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biochem+Biophys+Res+Commun%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Biochem+Biophys+Res+Commun%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42335656/) . 2026 Sep 3:829:154163. doi: 10.1016/j.bbrc.2026.154163. Epub 2026 Jun 17. # Tetrastigma hemsleyanum ELN-derived miR-396b suppresses pancreatic cancer cell proliferation by targeting IL33 [Mengjie Lv](https://pubmed.ncbi.nlm.nih.gov/?term=Lv+M&cauthor_id=42335656)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42335656/#full-view-affiliation-1 "School of Life Sciences, Anhui Medical University, Hefei, China."), [Wenjing Ding](https://pubmed.ncbi.nlm.nih.gov/?term=Ding+W&cauthor_id=42335656)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42335656/#full-view-affiliation-1 "School of Life Sciences, Anhui Medical University, Hefei, China."), [Menglin Zhou](https://pubmed.ncbi.nlm.nih.gov/?term=Zhou+M&cauthor_id=42335656)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42335656/#full-view-affiliation-1 "School of Life Sciences, Anhui Medical University, Hefei, China."), [Taihe Xiang](https://pubmed.ncbi.nlm.nih.gov/?term=Xiang+T&cauthor_id=42335656)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42335656/#full-view-affiliation-2 "College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, China. Electronic address: xthcn@hznu.edu.cn."), [Daoxiang Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+D&cauthor_id=42335656)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42335656/#full-view-affiliation-3 "School of Life Sciences, Anhui Medical University, Hefei, China. Electronic address: zhangdaoxiang@ahmu.edu.cn.") Affiliations Expand ### Affiliations * 1 School of Life Sciences, Anhui Medical University, Hefei, China. * 2 College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, China. Electronic address: xthcn@hznu.edu.cn. * 3 School of Life Sciences, Anhui Medical University, Hefei, China. Electronic address: zhangdaoxiang@ahmu.edu.cn. * PMID: **42335656** * DOI: [ 10.1016/j.bbrc.2026.154163 ](https://doi.org/10.1016/j.bbrc.2026.154163) Item in Clipboard # Tetrastigma hemsleyanum ELN-derived miR-396b suppresses pancreatic cancer cell proliferation by targeting IL33 Mengjie Lv et al. Biochem Biophys Res Commun. 2026. Show details Display options Display options Format Abstract PubMed PMID Biochem Biophys Res Commun Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biochem+Biophys+Res+Commun%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Biochem+Biophys+Res+Commun%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42335656/) . 2026 Sep 3:829:154163. doi: 10.1016/j.bbrc.2026.154163. Epub 2026 Jun 17. ### Authors [Mengjie Lv](https://pubmed.ncbi.nlm.nih.gov/?term=Lv+M&cauthor_id=42335656)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42335656/#short-view-affiliation-1 "School of Life Sciences, Anhui Medical University, Hefei, China."), [Wenjing Ding](https://pubmed.ncbi.nlm.nih.gov/?term=Ding+W&cauthor_id=42335656)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42335656/#short-view-affiliation-1 "School of Life Sciences, Anhui Medical University, Hefei, China."), [Menglin Zhou](https://pubmed.ncbi.nlm.nih.gov/?term=Zhou+M&cauthor_id=42335656)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42335656/#short-view-affiliation-1 "School of Life Sciences, Anhui Medical University, Hefei, China."), [Taihe Xiang](https://pubmed.ncbi.nlm.nih.gov/?term=Xiang+T&cauthor_id=42335656)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42335656/#short-view-affiliation-2 "College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, China. Electronic address: xthcn@hznu.edu.cn."), [Daoxiang Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+D&cauthor_id=42335656)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42335656/#short-view-affiliation-3 "School of Life Sciences, Anhui Medical University, Hefei, China. Electronic address: zhangdaoxiang@ahmu.edu.cn.") ### Affiliations * 1 School of Life Sciences, Anhui Medical University, Hefei, China. * 2 College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, China. Electronic address: xthcn@hznu.edu.cn. * 3 School of Life Sciences, Anhui Medical University, Hefei, China. Electronic address: zhangdaoxiang@ahmu.edu.cn. * PMID: **42335656** * DOI: [ 10.1016/j.bbrc.2026.154163 ](https://doi.org/10.1016/j.bbrc.2026.154163) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Background:** Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies and remains largely refractory to current therapeutic strategies. Plant-derived exosome-like nanovesicles (ELNs) have recently emerged as promising natural nanocarriers capable of delivering bioactive molecules across kingdoms; however, their functional cargos and molecular mechanisms in PDAC remain poorly understood. **Methods:** ELNs were isolated from Tetrastigma hemsleyanum and characterized by nanoparticle tracking analysis and zeta potential measurement. Cellular uptake was evaluated using PKH67 fluorescence labeling. Small RNA sequencing and RT-qPCR were performed to identify abundant ELN-associated miRNAs. The biological effects of ELNs and miR-396b were assessed by CCK-8 and colony formation assays. Transcriptomic profiling was conducted to identify downstream targets, and IL33 was validated by RT-qPCR, immunoblotting, bioinformatic prediction, and dual-luciferase reporter assays. Rescue experiments were further performed to investigate the functional involvement of the miR-396b/IL33 axis. **Results:** T. hemsleyanum-derived ELNs were efficiently internalized by pancreatic cancer cells and inhibited cell proliferation in a dose-dependent manner. Small RNA sequencing identified miR-396b as a highly enriched ELN cargo. Both ELN treatment and miR-396b overexpression significantly reduced IL33 expression. Mechanistically, miR-396b directly bound the IL33 3' untranslated region and suppressed reporter activity, whereas mutation of the predicted binding site abolished this inhibitory effect. Functional rescue experiments demonstrated that inhibition of miR-396b attenuated ELN-mediated growth suppression, while IL33 re-expression partially reversed the anti-proliferative effects induced by miR-396b overexpression, indicating that the miR-396b/IL33 axis contributes substantially to the biological activity of ELNs. **Conclusions:** This study identifies miR-396b as a major functional cargo of T. hemsleyanum-derived ELNs and demonstrates that ELN-delivered miR-396b suppresses pancreatic cancer cell proliferation, at least in part, through direct repression of IL33. These findings provide mechanistic insight into a cross-kingdom ELN-miRNA-IL33 regulatory pathway and support the potential of plant-derived ELNs as a bioactive nanoplatform for PDAC intervention. Nevertheless, additional ELN cargos and in vivo validation warrant further investigation. **Keywords:** Exosome-like nanovesicles; IL33; Pancreatic ductal adenocarcinoma; Tetrastigma hemsleyanum; miR-396b. Copyright © 2026 Elsevier Inc. All rights reserved. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interest The authors declare that they have no conflicts of interest. ## Similar articles * [ Cancer-associated fibroblast-derived exosome Leptin promotes malignant biological lineage in pancreatic ductal adenocarcinoma by regulating ABL2 via miR-224-3p. ](https://pubmed.ncbi.nlm.nih.gov/39298063/) Zhang L, Chen Y, Dai Y, Mou W, Deng P, Jin Y, Xu J, Jin Y.Zhang L, et al.Mol Biol Rep. 2024 Sep 19;51(1):995. doi: 10.1007/s11033-024-09928-1.Mol Biol Rep. 2024.PMID: 39298063Free PMC article. * [ Downregulated miR-98-5p promotes PDAC proliferation and metastasis by reversely regulating MAP4K4. ](https://pubmed.ncbi.nlm.nih.gov/29970191/) Fu Y, Liu X, Chen Q, Liu T, Lu C, Yu J, Miao Y, Wei J.Fu Y, et al.J Exp Clin Cancer Res. 2018 Jul 3;37(1):130. doi: 10.1186/s13046-018-0807-2.J Exp Clin Cancer Res. 2018.PMID: 29970191Free PMC article. * [ Macrophage-derived exosomal microRNA-501-3p promotes progression of pancreatic ductal adenocarcinoma through the TGFBR3-mediated TGF-β signaling pathway. ](https://pubmed.ncbi.nlm.nih.gov/31307515/) Yin Z, Ma T, Huang B, Lin L, Zhou Y, Yan J, Zou Y, Chen S.Yin Z, et al.J Exp Clin Cancer Res. 2019 Jul 15;38(1):310. doi: 10.1186/s13046-019-1313-x.J Exp Clin Cancer Res. 2019.PMID: 31307515Free PMC article. * [ UNC93B1 promotes pancreatic cancer progression through modulation of cGAS-STING signaling. ](https://pubmed.ncbi.nlm.nih.gov/41716413/) Yang H, Li Y, Su J, Zhang H, Zhu W, Shen K, Xu W.Yang H, et al.Front Immunol. 2026 Feb 4;17:1718849. doi: 10.3389/fimmu.2026.1718849. eCollection 2026.Front Immunol. 2026.PMID: 41716413Free PMC article. * [ LncRNA H19/miR-194/PFTK1 axis modulates the cell proliferation and migration of pancreatic cancer. ](https://pubmed.ncbi.nlm.nih.gov/30474270/) Sun Y, Zhu Q, Yang W, Shan Y, Yu Z, Zhang Q, Wu H.Sun Y, et al.J Cell Biochem. 2019 Mar;120(3):3874-3886. doi: 10.1002/jcb.27669. Epub 2018 Nov 26.J Cell Biochem. 2019.PMID: 30474270 [ See all similar articles ](https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed&from_uid=42335656) ## MeSH terms * Carcinoma, Pancreatic Ductal* / drug therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Carcinoma%2C+Pancreatic+Ductal%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Carcinoma%2C+Pancreatic+Ductal) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42335656/) * Carcinoma, Pancreatic Ductal* / genetics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Carcinoma%2C+Pancreatic+Ductal%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Carcinoma%2C+Pancreatic+Ductal) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42335656/) * Carcinoma, Pancreatic Ductal* / pathology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Carcinoma%2C+Pancreatic+Ductal%2Fpathology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Carcinoma%2C+Pancreatic+Ductal) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42335656/) * Cell Line, Tumor Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell+Line%2C+Tumor%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Line%2C+Tumor) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42335656/) * Cell Proliferation / drug effects Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell+Proliferation%2Fdrug+effects%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Proliferation) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42335656/) * Exosomes* / chemistry Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Exosomes%2Fchemistry%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Exosomes) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42335656/) * Gene Expression Regulation, Neoplastic / drug effects Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Gene+Expression+Regulation%2C+Neoplastic%2Fdrug+effects%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Gene+Expression+Regulation%2C+Neoplastic) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42335656/) * Humans Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Humans) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42335656/) * MicroRNAs* / genetics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22MicroRNAs%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=MicroRNAs) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42335656/) * MicroRNAs* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22MicroRNAs%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=MicroRNAs) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42335656/) * Pancreatic Neoplasms* / drug therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Pancreatic+Neoplasms%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Pancreatic+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42335656/) * Pancreatic Neoplasms* / genetics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Pancreatic+Neoplasms%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Pancreatic+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42335656/) * Pancreatic Neoplasms* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Pancreatic+Neoplasms%2Fmetabolism%22
## Related Clinical Research

- [Artificial intelligence applications for dyspnoea management in advanced lung cancer: scoping revi](https://medichelpline.com/clinical-feed/bmj-open-1-applications-of-artificial-intelligence-in-dyspnoea-management-for-patients.md)
- [WHO publishes country-comparable childhood cancer survival data on WHO data portal](https://medichelpline.com/clinical-feed/who-0-2-country-comparable-childhood-cancer-survival-data-now-available-through-who.md)
- [Symptom network analysis in gastric cancer: tools, core and bridge symptoms, and temporal patterns](https://medichelpline.com/clinical-feed/plos-one-4-application-of-symptom-network-analysis-among-patients-with-gastric-cancer-a.md)
- [Impact of Adjuvant Immune Checkpoint Inhibitors on HRQoL in Renal Cell Carcinoma: Qualitative RAMP](https://medichelpline.com/clinical-feed/plos-one-10-health-related-quality-of-life-with-adjuvant-immune-checkpoint-inhibition-in.md)
- [Laparoscopic vs Open Resection for Noncurable Stage IV Colon Cancer: 3-Year JCOG1107 Results](https://medichelpline.com/clinical-feed/pubmed-42461618.md) (DOI: 10.1097/DCR.0000000000004373)

## Navigation
- [← Back to Oncology Feed](https://medichelpline.com/clinical-feed/oncology.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.